Objective： To evaluate the effect and safety of acupuncture therapy on patients with moderate to severe allergic rhinitis. Methods： A non-randomized controlled design was used to compare between the acupuncture grou...Objective： To evaluate the effect and safety of acupuncture therapy on patients with moderate to severe allergic rhinitis. Methods： A non-randomized controlled design was used to compare between the acupuncture group and the medication group. The acupuncture group received 8-week acupuncture therapy, and the medication group received budesonide nasal spray with cetirizine tablets for 8 weeks. The clinical symptoms and signs were analyzed before treatment, at 4 and 8 weeks after the start of treatment, and at 12 weeks after the end of treatment. Furthermore, the clinical efficacy and safety indicators were compared between the two groups. Results： A total of 76 participants consisting of 38 in each of the two groups were enrolled. The scores of each clinical symptom and sign, including sneezing, runny nose, stuffy nose, nasal itching, and turbinate edema, and the total scores decreased over time in both groups （all P〈0.05）; and no difference was found in the scores between the two groups （P〉0.05）. There was no statistically significant difference in the effective rates of the acupuncture group at 4 and 8 weeks after the start of treatment as well as at 12-week follow-up compared with those of the medication group （83.3% vs. 91.2%, and 94.4 % vs. 85.3%; and 80.6 % vs. 82.4%, all P〉0.05）. Experimental items including blood routine, urine routine, aspartate transaminase, alanine aminotransferase, urea nitrogen and creatinine were all in the normal reference ranges during the treatment in the acupuncture group. Conclusions： Acupuncture therapy has a comparable effect to the medication treatment on patients with moderate to severe allergic rhinitis, and it is safe with no severe adverse effects.展开更多
Objective:To investigate the clinical effect of wrist–ankle acupuncture combined with pinching along the spine on allergic rhinitis(AR)in children.Methods:A total of 65 children with AR were collected from February 2...Objective:To investigate the clinical effect of wrist–ankle acupuncture combined with pinching along the spine on allergic rhinitis(AR)in children.Methods:A total of 65 children with AR were collected from February 2017 through to December 2018 and they were randomly divided into a combined treatment group with wrist–ankle acupuncture,pinching along the spine and western medication(combined treatment group,32 cases)and a western medication group(33 cases).In the western medication group,loratadine was prescribed for oral administration.In the combined treatment group,on the base of the medication as the western medication group,the wrist–ankle acupuncture was adopted in combination with pinching along the spine.Before and after treatment,the symptoms and physical signs were scored and the clinical effect was observed in the children of the two groups.Results:After the treatment and in the follow-up,the scores of the symptoms and physical signs in the combined treatment group were lower than those of the western medication group,indicating a statistical significance(all P<0.05).The total effective rate was 93.7%in the combined treatment group,which was higher than 63.63%in the western medication group,indicating a statistical significance(P<0.05).Conclusion:The combined treatment of wrist–ankle acupuncture combined with pinching along the spine and loratadine effectively relieves the clinical symptoms and the physical signs in AR children.The clinical effect of this combined treatment is better than the simple use of loratadine.展开更多
OBJECTIVE: To compare the efficacy of an acupuncture regimen for persistent allergic rhinitis(PER), aimed at improving a patient's mind or Shen in Traditional Chinese Medicine, to that of a second-generation H1-re...OBJECTIVE: To compare the efficacy of an acupuncture regimen for persistent allergic rhinitis(PER), aimed at improving a patient's mind or Shen in Traditional Chinese Medicine, to that of a second-generation H1-receptor antagonist, cetirizine hydrochloride.METHODS: This multicenter, randomized, controlled clinical trial on PER will be conducted at three institutions in China. The total study period will be 9 weeks. After a 1-week preparatory screening period, 240 eligible participants with PER willbe randomized to receive acupuncture or pharmacotherapy(1∶1) for 4 weeks with a 4-week follow-up. The primary outcome will be changes in7-day average total nasal symptom score. Secondary outcome measures include rhinoconjunctivitis quality of life questionnaire score and total non-nasal symptom score.RESULTS:The presence and seriousness of psychological and emotional impairments should be considered in therapeutic programs for allergic rhinitis.No clinical trial for treating allergic rhinitis via acupuncture regulation of psychological and emotionalactivitieshasbeenreported.CONCLUSION:The findings of the trial will allow us to determine the effects of the mind(Shen)-regulation treatment approach. We will also be able to confirm if the effects of acupuncture are equivalent to those of the conventional drug cetirizine hydrochloride.展开更多
Background： Allergic rhinitis is a nasal mucosa inflammatory disorder that is induced by exposure to an allergen which results in four major symptoms, including anterior or posterior rhinorrhea, sneezing, nasal itchi...Background： Allergic rhinitis is a nasal mucosa inflammatory disorder that is induced by exposure to an allergen which results in four major symptoms, including anterior or posterior rhinorrhea, sneezing, nasal itching and nasal congestion. Allergic rhinitis may result in sleep disturbance, fatigue, depression of mood-cognitive function and quality of life impairment. Objective： This study examined the efficacy and safety of herbal steam bath used for the reduction of allergic rhinitis symptoms, and evaluated treatment satisfaction and improvements in quality of life among participating patients with allergic rhinitis. Design, setting, participants and intervention： A single-blind randomized controlled trial was conducted at Thai Traditional and Alternative Medicine Hospital between June and December 2016, using 64 subjects, equally divided into two groups. The treatment group received herbal steam bath and the control group received steam bath without herbs for 30 rain 3 times a week for 4 consecutive weeks. Main outcome measures： Allergic rhinitis symptoms, such as itchy nose, runny nose, sneezing, nasal congestion and watery eyes, were measured using the visual analog scale at weeks 0, 1, 2, 3 and 4. Quality of life was assessed at week 0 and week 4. Results： The characteristics （sex, age, marital status, education, allergic rhinitis symptoms and frequency of symptoms） at the baseline were not statistically different （P 〉 0.05） between the two test groups. Anterior or posterior rhinorrhea symptoms, including sneezing, nasal itching and nasal congestion, were statistically reduced over the course of the treatment, but reductions were not significantly different between the control and treatment groups. The treatment group, however, was shown to be significantly more satisfied with the treatment than the control group （P 〈 0.05）. Conclusion： Both treatments appear to be able to significantly reduce the symptoms of allergic rhinitis. However, there was no difference in the effectiveness of steam bath with herbs and steam bath without herbs. Trial registration： This trial was registered in the Thai Clinical Trial Registry with the identifier TCTR20170712002.展开更多
OBJECTIVE: To use evidence-based medicine to explore the efficacy of acupoint application(AA) for allergic rhinitis(AR) at different time points and its safety. METHODS: We searched 7 databases(Pub Med, Cochrane, Emba...OBJECTIVE: To use evidence-based medicine to explore the efficacy of acupoint application(AA) for allergic rhinitis(AR) at different time points and its safety. METHODS: We searched 7 databases(Pub Med, Cochrane, Embase, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, and China Biology Medicine disc) as well as the international clinical trial registration platform from January 2010 to March 2020 for randomized controlled trials(RCTs) comparing the efficacy of AA versus placebo, Western Medicine or other alternative therapies on AR. Risk of bias was assessed according to the Cochrane handbook, and statistical analysis was performed using Rev Man 5.3. Outcomes included the total effective rate, recurrence rate, total nasal symptom score(TNSS), visual analogue scale(VAS), quality of life measured by the Rhinitis Quality of Life Questionnaire(RQLQ) or Short Form-36(SF-36), adverse events, and biomarkers including immunoglobulin E(Ig E), peripheral blood eosinophil count(EOS), interleukin-4(IL-4), and interferon gamma(INF-γ). RESULTS: Twenty-eight RCTs involving 3282 participants were included. The short-term and long-term efficacy of AA was significantly better than placebo, including better total effective rate [RR: 3.05, 95%CI(1.84, 5.07), after treatment;RR: 9.29, 95%CI(2.57, 33.66), at 6 months], lower recurrence rate [RR: 0.55, 95%CI(0.45, 0.66), at 6 months;RR: 0.65, 95%CI(0.57, 0.74), at 1 year], lower TNSS [MD:-3.09, 95%CI(-3.58,-2.61), after treatment], and lower RQLQ [MD:-14.79, 95%CI(-21.49,-8.10), after treatment;MD:-11.92, 95%CI(-17.40,-6.45), at 4-6 months]. Compared with Western Medicine, AA had better long-term total effective rate [RR: 1.33, 95%CI(1.05, 1.69), at 3 months;RR: 1.49, 95%CI 1.22 to 1.81, at 1 year) and lower recurrence rate [RR: 0.48, 95%CI(0.39, 0.58), at 6 months;RR: 0.45, 95%CI(0.33, 0.60), at 1 year]. AA had better long-term total effective rate versus acupuncture [RR: 2.06, 95% CI(1.28, 3.31), at 1 year] or oral Chinese medicine [RR: 1.21, 95% CI(1.09, 1.34), ≥ 6 months]. Both AA and Western Medicine can reduce serum levels of Ig E, EOS, and IL-4 after treatment. The main adverse event of AA was local skin reaction without systemic side effects. CONCLUSIONS: The short-term(within one month) and long-term(at 3 months, 6 months and 1 year) efficacy of acupoint application on AR was better than that of placebo. The long-term efficacy of acupoint application was superior to that of Western Medicine(at 3 months, 6 months and 1 year), oral Chinese medicine(at more than 6 months) and acupuncture(at 1 year). AA can reduce serum Ig E, EOS, and IL-4 level of AR patients in a short run. Acupoint application is safe, but severe skin reactions can reduce patient compliance.展开更多
目的:系统评价穴位敷贴对小儿过敏性鼻炎的治疗效果。方法:计算机检索Cochrane图书馆、Pubmed、Embase、Web of Science、CNKI、VIP、CBM、万方数据库中有关穴位敷贴治疗小儿过敏性鼻炎的随机对照试验,检索时限均为建库至2022年10月。由...目的:系统评价穴位敷贴对小儿过敏性鼻炎的治疗效果。方法:计算机检索Cochrane图书馆、Pubmed、Embase、Web of Science、CNKI、VIP、CBM、万方数据库中有关穴位敷贴治疗小儿过敏性鼻炎的随机对照试验,检索时限均为建库至2022年10月。由2名研究人员进行文献筛选、提取资料并评价纳入研究质量后,采用RevMan5.3软件进行Meta分析。结果:共纳入20项随机对照研究,Meta分析结果表明,试验组总有效率[RR=1.23,95%CI(1.18,1.29),Z=9.09,P<0.00001]、痊愈率[RR=1.49,95%CI(1.06,2.09),Z=2.29,P<0.05]均高于对照组,其差异具有统计学意义;且穴位敷贴能缓解小儿过敏性鼻炎患者鼻塞[SMD=-1.11,95%CI(-1.66,-0.56),Z=3.95,P<0.001]、鼻痒[SMD=-0.83,95%CI(-1.16,-0.49),Z=4.81,P<0.00001]、喷嚏[SMD=-0.72,95%CI(-1.06,-0.38),Z=4.18,P<0.0001]、流涕[SMD=-0.98,95%CI(-1.63,-0.33),Z=2.97,P=0.003]等症状,其差异具有统计学意义。结论:穴位敷贴治疗小儿过敏性鼻炎安全且有效,但受研究的样本量及质量影响,本研究结论仍需更多高质量、大样本的随机双盲试验予以证实。展开更多
基金Supported by the Key Project of Zhejiang Province Pharmaceutical Administration,China(No.2010ZZ001)Key Disciplines in Integrative Medicine of Zhejiang Province,China(No.2012-XK-A04)
文摘Objective： To evaluate the effect and safety of acupuncture therapy on patients with moderate to severe allergic rhinitis. Methods： A non-randomized controlled design was used to compare between the acupuncture group and the medication group. The acupuncture group received 8-week acupuncture therapy, and the medication group received budesonide nasal spray with cetirizine tablets for 8 weeks. The clinical symptoms and signs were analyzed before treatment, at 4 and 8 weeks after the start of treatment, and at 12 weeks after the end of treatment. Furthermore, the clinical efficacy and safety indicators were compared between the two groups. Results： A total of 76 participants consisting of 38 in each of the two groups were enrolled. The scores of each clinical symptom and sign, including sneezing, runny nose, stuffy nose, nasal itching, and turbinate edema, and the total scores decreased over time in both groups （all P〈0.05）; and no difference was found in the scores between the two groups （P〉0.05）. There was no statistically significant difference in the effective rates of the acupuncture group at 4 and 8 weeks after the start of treatment as well as at 12-week follow-up compared with those of the medication group （83.3% vs. 91.2%, and 94.4 % vs. 85.3%; and 80.6 % vs. 82.4%, all P〉0.05）. Experimental items including blood routine, urine routine, aspartate transaminase, alanine aminotransferase, urea nitrogen and creatinine were all in the normal reference ranges during the treatment in the acupuncture group. Conclusions： Acupuncture therapy has a comparable effect to the medication treatment on patients with moderate to severe allergic rhinitis, and it is safe with no severe adverse effects.
文摘Objective:To investigate the clinical effect of wrist–ankle acupuncture combined with pinching along the spine on allergic rhinitis(AR)in children.Methods:A total of 65 children with AR were collected from February 2017 through to December 2018 and they were randomly divided into a combined treatment group with wrist–ankle acupuncture,pinching along the spine and western medication(combined treatment group,32 cases)and a western medication group(33 cases).In the western medication group,loratadine was prescribed for oral administration.In the combined treatment group,on the base of the medication as the western medication group,the wrist–ankle acupuncture was adopted in combination with pinching along the spine.Before and after treatment,the symptoms and physical signs were scored and the clinical effect was observed in the children of the two groups.Results:After the treatment and in the follow-up,the scores of the symptoms and physical signs in the combined treatment group were lower than those of the western medication group,indicating a statistical significance(all P<0.05).The total effective rate was 93.7%in the combined treatment group,which was higher than 63.63%in the western medication group,indicating a statistical significance(P<0.05).Conclusion:The combined treatment of wrist–ankle acupuncture combined with pinching along the spine and loratadine effectively relieves the clinical symptoms and the physical signs in AR children.The clinical effect of this combined treatment is better than the simple use of loratadine.
基金Supported by Capital Research on the Clinical Characteristic Application Projects,Beijing Municipal Science & Technology Commission(No.D101100050010022)
文摘OBJECTIVE: To compare the efficacy of an acupuncture regimen for persistent allergic rhinitis(PER), aimed at improving a patient's mind or Shen in Traditional Chinese Medicine, to that of a second-generation H1-receptor antagonist, cetirizine hydrochloride.METHODS: This multicenter, randomized, controlled clinical trial on PER will be conducted at three institutions in China. The total study period will be 9 weeks. After a 1-week preparatory screening period, 240 eligible participants with PER willbe randomized to receive acupuncture or pharmacotherapy(1∶1) for 4 weeks with a 4-week follow-up. The primary outcome will be changes in7-day average total nasal symptom score. Secondary outcome measures include rhinoconjunctivitis quality of life questionnaire score and total non-nasal symptom score.RESULTS:The presence and seriousness of psychological and emotional impairments should be considered in therapeutic programs for allergic rhinitis.No clinical trial for treating allergic rhinitis via acupuncture regulation of psychological and emotionalactivitieshasbeenreported.CONCLUSION:The findings of the trial will allow us to determine the effects of the mind(Shen)-regulation treatment approach. We will also be able to confirm if the effects of acupuncture are equivalent to those of the conventional drug cetirizine hydrochloride.
文摘Background： Allergic rhinitis is a nasal mucosa inflammatory disorder that is induced by exposure to an allergen which results in four major symptoms, including anterior or posterior rhinorrhea, sneezing, nasal itching and nasal congestion. Allergic rhinitis may result in sleep disturbance, fatigue, depression of mood-cognitive function and quality of life impairment. Objective： This study examined the efficacy and safety of herbal steam bath used for the reduction of allergic rhinitis symptoms, and evaluated treatment satisfaction and improvements in quality of life among participating patients with allergic rhinitis. Design, setting, participants and intervention： A single-blind randomized controlled trial was conducted at Thai Traditional and Alternative Medicine Hospital between June and December 2016, using 64 subjects, equally divided into two groups. The treatment group received herbal steam bath and the control group received steam bath without herbs for 30 rain 3 times a week for 4 consecutive weeks. Main outcome measures： Allergic rhinitis symptoms, such as itchy nose, runny nose, sneezing, nasal congestion and watery eyes, were measured using the visual analog scale at weeks 0, 1, 2, 3 and 4. Quality of life was assessed at week 0 and week 4. Results： The characteristics （sex, age, marital status, education, allergic rhinitis symptoms and frequency of symptoms） at the baseline were not statistically different （P 〉 0.05） between the two test groups. Anterior or posterior rhinorrhea symptoms, including sneezing, nasal itching and nasal congestion, were statistically reduced over the course of the treatment, but reductions were not significantly different between the control and treatment groups. The treatment group, however, was shown to be significantly more satisfied with the treatment than the control group （P 〈 0.05）. Conclusion： Both treatments appear to be able to significantly reduce the symptoms of allergic rhinitis. However, there was no difference in the effectiveness of steam bath with herbs and steam bath without herbs. Trial registration： This trial was registered in the Thai Clinical Trial Registry with the identifier TCTR20170712002.
基金Supported by the Key Science and Technology Projects of Zhejiang Province:Research and Application of Key Techniques for Prevention and Treatment of Allergic Diseases of the Respiratory Tract by Summer Treatment of Winter Disease of Acupoint Application (No. 2014C03046-2)。
文摘OBJECTIVE: To use evidence-based medicine to explore the efficacy of acupoint application(AA) for allergic rhinitis(AR) at different time points and its safety. METHODS: We searched 7 databases(Pub Med, Cochrane, Embase, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, and China Biology Medicine disc) as well as the international clinical trial registration platform from January 2010 to March 2020 for randomized controlled trials(RCTs) comparing the efficacy of AA versus placebo, Western Medicine or other alternative therapies on AR. Risk of bias was assessed according to the Cochrane handbook, and statistical analysis was performed using Rev Man 5.3. Outcomes included the total effective rate, recurrence rate, total nasal symptom score(TNSS), visual analogue scale(VAS), quality of life measured by the Rhinitis Quality of Life Questionnaire(RQLQ) or Short Form-36(SF-36), adverse events, and biomarkers including immunoglobulin E(Ig E), peripheral blood eosinophil count(EOS), interleukin-4(IL-4), and interferon gamma(INF-γ). RESULTS: Twenty-eight RCTs involving 3282 participants were included. The short-term and long-term efficacy of AA was significantly better than placebo, including better total effective rate [RR: 3.05, 95%CI(1.84, 5.07), after treatment;RR: 9.29, 95%CI(2.57, 33.66), at 6 months], lower recurrence rate [RR: 0.55, 95%CI(0.45, 0.66), at 6 months;RR: 0.65, 95%CI(0.57, 0.74), at 1 year], lower TNSS [MD:-3.09, 95%CI(-3.58,-2.61), after treatment], and lower RQLQ [MD:-14.79, 95%CI(-21.49,-8.10), after treatment;MD:-11.92, 95%CI(-17.40,-6.45), at 4-6 months]. Compared with Western Medicine, AA had better long-term total effective rate [RR: 1.33, 95%CI(1.05, 1.69), at 3 months;RR: 1.49, 95%CI 1.22 to 1.81, at 1 year) and lower recurrence rate [RR: 0.48, 95%CI(0.39, 0.58), at 6 months;RR: 0.45, 95%CI(0.33, 0.60), at 1 year]. AA had better long-term total effective rate versus acupuncture [RR: 2.06, 95% CI(1.28, 3.31), at 1 year] or oral Chinese medicine [RR: 1.21, 95% CI(1.09, 1.34), ≥ 6 months]. Both AA and Western Medicine can reduce serum levels of Ig E, EOS, and IL-4 after treatment. The main adverse event of AA was local skin reaction without systemic side effects. CONCLUSIONS: The short-term(within one month) and long-term(at 3 months, 6 months and 1 year) efficacy of acupoint application on AR was better than that of placebo. The long-term efficacy of acupoint application was superior to that of Western Medicine(at 3 months, 6 months and 1 year), oral Chinese medicine(at more than 6 months) and acupuncture(at 1 year). AA can reduce serum Ig E, EOS, and IL-4 level of AR patients in a short run. Acupoint application is safe, but severe skin reactions can reduce patient compliance.
文摘目的:系统评价穴位敷贴对小儿过敏性鼻炎的治疗效果。方法:计算机检索Cochrane图书馆、Pubmed、Embase、Web of Science、CNKI、VIP、CBM、万方数据库中有关穴位敷贴治疗小儿过敏性鼻炎的随机对照试验,检索时限均为建库至2022年10月。由2名研究人员进行文献筛选、提取资料并评价纳入研究质量后,采用RevMan5.3软件进行Meta分析。结果:共纳入20项随机对照研究,Meta分析结果表明,试验组总有效率[RR=1.23,95%CI(1.18,1.29),Z=9.09,P<0.00001]、痊愈率[RR=1.49,95%CI(1.06,2.09),Z=2.29,P<0.05]均高于对照组,其差异具有统计学意义;且穴位敷贴能缓解小儿过敏性鼻炎患者鼻塞[SMD=-1.11,95%CI(-1.66,-0.56),Z=3.95,P<0.001]、鼻痒[SMD=-0.83,95%CI(-1.16,-0.49),Z=4.81,P<0.00001]、喷嚏[SMD=-0.72,95%CI(-1.06,-0.38),Z=4.18,P<0.0001]、流涕[SMD=-0.98,95%CI(-1.63,-0.33),Z=2.97,P=0.003]等症状,其差异具有统计学意义。结论:穴位敷贴治疗小儿过敏性鼻炎安全且有效,但受研究的样本量及质量影响,本研究结论仍需更多高质量、大样本的随机双盲试验予以证实。
文摘目的探究自拟二小汤(小青龙汤合小柴胡汤)治疗肺气虚寒型变应性鼻炎患者疗效及其对调节性T细胞(regulatory cells,Tregs)相关因子的作用。方法将64例患者随机分为观察组、对照组各32例。观察组应用自拟二小汤治疗,对照组采用氯雷他定片治疗。治疗28 d后,观察两组症状评分、血清中转化生长因子-β(transforming growth factor-β,TGF-β)、白介素10(interleukin-10,IL-10)、白细胞介素17(interleukin 17,IL-17)含量以及生活质量。结果治疗后,观察组的打喷嚏、鼻痒、鼻塞症状评分低于对照组(P<0.05);观察组血清中TGF-β、IL-10高于对照组(P<0.05),IL-17低于对照组(P<0.05);观察组鼻结膜炎生存量表(rhinoconjunctivitis quality of life scale,RQLQ评分)优于对照组(P<0.05)。结论自拟二小汤可以改善变应性鼻炎临床症状,提升患者血清中TGF-β、IL-10的含量,降低IL-17的含量,明显改善患者生活质量,效果全面优于氯雷他定片,值得临床进一步研究其机理及远期疗效。
