Exploring the synergy types and optimization paths between Poverty Alleviation Effectiveness and Rural Revitalization is necessary for achieving the two centenary goals.Taking poverty alleviation counties in Hunan Pro...Exploring the synergy types and optimization paths between Poverty Alleviation Effectiveness and Rural Revitalization is necessary for achieving the two centenary goals.Taking poverty alleviation counties in Hunan Province,China as an example,our study proposed an indicator to measure the synergistic development between Poverty Alleviation Effectiveness and Rural Revitalization using the multi-index integrated evaluation method.Then,the coupling types were classified based on both the proposed indicator and regional characteristics.Besides,the corresponding optimization path for each coupling type was proposed to promote the synergistic development of Poverty Alleviation and Rural Revitalization.Results are as follows:1)Lower synergy focused on the southwestern Hunan,while low synergy is widely distributed(such as the west,southwest,northwest,and midland).Moderate synergy is in the midland,such as Huaihua and Chenzhou cities.High synergy is distributed in Yongzhou,Huaihua,Xiangxi cities,etc.Besides,only Hecheng City belongs to the higher synergy.2)This paper proposes corresponding development paths for different development characteristics and main problems from multiple perspectives of the protection system,industrial planning,and rural market.Continuously consolidate and enhance the effectiveness of Poverty Alleviation and Rural Revitalization to achieve coupled and synergistic development of the two systems.Our research results can provide theoretical support for implementing Poverty Alleviation and Rural Revitalization in Hunan Province,China.展开更多
This study was conducted to investigate the alleviating effect of exogenous hydrogen sulfide on chestnut seedlings under salt stress. The effects of different concentrations of (0, 0.1, 0.2, 0.5, 1.0 and 2.0 mmol/L)...This study was conducted to investigate the alleviating effect of exogenous hydrogen sulfide on chestnut seedlings under salt stress. The effects of different concentrations of (0, 0.1, 0.2, 0.5, 1.0 and 2.0 mmol/L) sodium hydrosulfide (NariS) on the photosynthesis of 'Hongli 2' chestnut seedlings and the chlorophyll content, proline content and malondialdehyde (MDA) content in chestnut leaves under 100 mM NaCI stress were investigated. According to the results, spraying exogenous NariS had positive effects on photosynthesis of chestnut leaves. The application of NariS could alleviate the damage caused by salt stress on the leaves of chestnut seedlings to different degrees. Compared with the sole treatment with 100 mmol/L NaCI, the chlorophyll content and the proline content were improved. Moreover, MDA content had a significant drop, which effectively reduced the damage of cell membrane under salt stress, The alleviating effect was not obvious with the in- crease of treatment concentration, and the 0.5 and 1.0 mmol/L NariS treatments exhibited better effects.展开更多
The hydroponic culture experiments of soybean bean seedlings were conducted to investigate the effect of lanthanum (La) on nitrogen metabolism under two different levels of elevated UV-B radiation (UV-B, 280-320 nm...The hydroponic culture experiments of soybean bean seedlings were conducted to investigate the effect of lanthanum (La) on nitrogen metabolism under two different levels of elevated UV-B radiation (UV-B, 280-320 nm). The whole process of nitrogen metabolism involves uptake and transport of nitrate, nitrate assimilation, ammonium assimilation, amino acid biosynthesis, and protein synthesis. Compared with the control, UV-B radiation with the intensity of low level 0.15 W/m^2 and high level 0.45 W/m^2 significantly affected the whole nitrogen metabolism in soybean seedlings (p 〈 0.05). It restricted uptake and transport of NO3^-, inhibited activity of some key nitrogen-metabolism-related enzymes, such as: nitrate reductase (NR) to the nitrate reduction, glutamine systhetase (GS) and glutamine synthase (GOGAT) to the ammonia assimilation, while it increased the content of free amino acids and decreased that of soluble protein as well. The damage effect of high level of UV-B radiation on nitrogen metabolism was greater than that of low level. And UV-B radiation promoted the activity of the anti-adversity enzyme glutamate dehydrogenase (GDH), which reduced the toxicity of excess ammonia in plant. After pretreatment with the optimum concentration of La (20 mg/L), La could increase the activity of NR, GS, GOGAT, and GDH, and ammonia assimilation, but decrease nitrate and ammonia accumulation. In conclusion, La could relieve the damage effect of UV-B radiation on plant by regulating nitrogen metabolism process, and its alleviating effect under low level was better than that under the high one.展开更多
Using rapes as test materials, the fastness expression and alleviation effect of rapes were studied under Cd stress condition, as the rapeseeds were dipped in the single element(La, Ce, Nd, Pr)and mixed rare earth(RE)...Using rapes as test materials, the fastness expression and alleviation effect of rapes were studied under Cd stress condition, as the rapeseeds were dipped in the single element(La, Ce, Nd, Pr)and mixed rare earth(RE). The results indicate that, under Cd stress, the dry and fresh weight are increased by both the single element and mixed rare earth treatment, and the fastness of rape is improved.The single element of rare earth decreases the Cd content in rape roots and transmits Cd to the edible parts above the ground in which the alleviation effect of Ce is most significant.La treatment takes the second place, so that the poisonous effect of heavy metal Cd is eased.The mixed rare earth doesn't alleviate the assimilation of Cd in rape roots, but accelerates the transfer of Cd to the parts above the ground. The research puts forward that the alleviation of rare earth on Cd stress has connection with the decrease of Ca content.展开更多
In order to investigate the resistance performance of an ultra-high-speed aerodynamically alleviated marine vehicle(AAMV),finite volume method(FVM)-based computational fluid dynamics(CFD)software STAR CCM+is used to s...In order to investigate the resistance performance of an ultra-high-speed aerodynamically alleviated marine vehicle(AAMV),finite volume method(FVM)-based computational fluid dynamics(CFD)software STAR CCM+is used to simulate the forward motion of this vehicle.The calculated results are validated as they reach good agreement with experimental data.Comparing the motions of models with and without aero-wings,the hybrid aerodynamic and hydrodynamic mechanism of this novel hull is discussed.Study is subsequently performed that how step configuration,spray rail and deadrise angle act on hull behavior and resistance.The results show that models with double steps and spray rail possess better resistance characteristics at high speeds,and planing surface with variable deadrise angle could further improve the overall navigation performance.展开更多
Current antibody–drug conjugates(ADCs)suffer from low tissue penetration and significant side effects,largely due to the permanent linkage and/or premature release of cytotoxic payloads.Herein,we developed a prodrug...Current antibody–drug conjugates(ADCs)suffer from low tissue penetration and significant side effects,largely due to the permanent linkage and/or premature release of cytotoxic payloads.Herein,we developed a prodrug–antibody conjugate(ProADC)strategy by conjugating a bioorthogonal-activatable prodrug with an antibody that allowed on-target release and on-demand activation of cytotoxic drugs at a tumor site.The bioorthogonal-caged prodrug exhibited an enhanced permeability into and on-demand activation within cancer cells,while the pH-sensitive ADC linker allowed on-target release of the anticancer agent.Together,the ProADCs showed enhanced tumor penetration and alleviated side effects for use as an on-target and on-demand chemotherapy agents.展开更多
基金Under the auspices of the National Natural Science Foundation of China(No.41971219,41571168)Natural Science Foundation of Hunan Province(No.2020JJ4372)Philosophy and Social Science Fund Project of Hunan Province(No.18ZDB015)。
文摘Exploring the synergy types and optimization paths between Poverty Alleviation Effectiveness and Rural Revitalization is necessary for achieving the two centenary goals.Taking poverty alleviation counties in Hunan Province,China as an example,our study proposed an indicator to measure the synergistic development between Poverty Alleviation Effectiveness and Rural Revitalization using the multi-index integrated evaluation method.Then,the coupling types were classified based on both the proposed indicator and regional characteristics.Besides,the corresponding optimization path for each coupling type was proposed to promote the synergistic development of Poverty Alleviation and Rural Revitalization.Results are as follows:1)Lower synergy focused on the southwestern Hunan,while low synergy is widely distributed(such as the west,southwest,northwest,and midland).Moderate synergy is in the midland,such as Huaihua and Chenzhou cities.High synergy is distributed in Yongzhou,Huaihua,Xiangxi cities,etc.Besides,only Hecheng City belongs to the higher synergy.2)This paper proposes corresponding development paths for different development characteristics and main problems from multiple perspectives of the protection system,industrial planning,and rural market.Continuously consolidate and enhance the effectiveness of Poverty Alleviation and Rural Revitalization to achieve coupled and synergistic development of the two systems.Our research results can provide theoretical support for implementing Poverty Alleviation and Rural Revitalization in Hunan Province,China.
基金Supported by National Natural Science Foundation of China(31301733,31501742)Youth Foundation of Shandong Academy of Agricultural Sciences(2016YQN29)the Special Fund for Agricultural Fine Seed Project in Shandong Province(2016LZGC012)~~
文摘This study was conducted to investigate the alleviating effect of exogenous hydrogen sulfide on chestnut seedlings under salt stress. The effects of different concentrations of (0, 0.1, 0.2, 0.5, 1.0 and 2.0 mmol/L) sodium hydrosulfide (NariS) on the photosynthesis of 'Hongli 2' chestnut seedlings and the chlorophyll content, proline content and malondialdehyde (MDA) content in chestnut leaves under 100 mM NaCI stress were investigated. According to the results, spraying exogenous NariS had positive effects on photosynthesis of chestnut leaves. The application of NariS could alleviate the damage caused by salt stress on the leaves of chestnut seedlings to different degrees. Compared with the sole treatment with 100 mmol/L NaCI, the chlorophyll content and the proline content were improved. Moreover, MDA content had a significant drop, which effectively reduced the damage of cell membrane under salt stress, The alleviating effect was not obvious with the in- crease of treatment concentration, and the 0.5 and 1.0 mmol/L NariS treatments exhibited better effects.
基金Project supported by the National Natural Science Foundation of China(No.30570323)Foundation of State Developing and Reforming Committee(No.IFZ20051210)
文摘The hydroponic culture experiments of soybean bean seedlings were conducted to investigate the effect of lanthanum (La) on nitrogen metabolism under two different levels of elevated UV-B radiation (UV-B, 280-320 nm). The whole process of nitrogen metabolism involves uptake and transport of nitrate, nitrate assimilation, ammonium assimilation, amino acid biosynthesis, and protein synthesis. Compared with the control, UV-B radiation with the intensity of low level 0.15 W/m^2 and high level 0.45 W/m^2 significantly affected the whole nitrogen metabolism in soybean seedlings (p 〈 0.05). It restricted uptake and transport of NO3^-, inhibited activity of some key nitrogen-metabolism-related enzymes, such as: nitrate reductase (NR) to the nitrate reduction, glutamine systhetase (GS) and glutamine synthase (GOGAT) to the ammonia assimilation, while it increased the content of free amino acids and decreased that of soluble protein as well. The damage effect of high level of UV-B radiation on nitrogen metabolism was greater than that of low level. And UV-B radiation promoted the activity of the anti-adversity enzyme glutamate dehydrogenase (GDH), which reduced the toxicity of excess ammonia in plant. After pretreatment with the optimum concentration of La (20 mg/L), La could increase the activity of NR, GS, GOGAT, and GDH, and ammonia assimilation, but decrease nitrate and ammonia accumulation. In conclusion, La could relieve the damage effect of UV-B radiation on plant by regulating nitrogen metabolism process, and its alleviating effect under low level was better than that under the high one.
文摘Using rapes as test materials, the fastness expression and alleviation effect of rapes were studied under Cd stress condition, as the rapeseeds were dipped in the single element(La, Ce, Nd, Pr)and mixed rare earth(RE). The results indicate that, under Cd stress, the dry and fresh weight are increased by both the single element and mixed rare earth treatment, and the fastness of rape is improved.The single element of rare earth decreases the Cd content in rape roots and transmits Cd to the edible parts above the ground in which the alleviation effect of Ce is most significant.La treatment takes the second place, so that the poisonous effect of heavy metal Cd is eased.The mixed rare earth doesn't alleviate the assimilation of Cd in rape roots, but accelerates the transfer of Cd to the parts above the ground. The research puts forward that the alleviation of rare earth on Cd stress has connection with the decrease of Ca content.
基金Project supported by the National Natural Science Foundation of China(Grant No.51479181).
文摘In order to investigate the resistance performance of an ultra-high-speed aerodynamically alleviated marine vehicle(AAMV),finite volume method(FVM)-based computational fluid dynamics(CFD)software STAR CCM+is used to simulate the forward motion of this vehicle.The calculated results are validated as they reach good agreement with experimental data.Comparing the motions of models with and without aero-wings,the hybrid aerodynamic and hydrodynamic mechanism of this novel hull is discussed.Study is subsequently performed that how step configuration,spray rail and deadrise angle act on hull behavior and resistance.The results show that models with double steps and spray rail possess better resistance characteristics at high speeds,and planing surface with variable deadrise angle could further improve the overall navigation performance.
文摘Current antibody–drug conjugates(ADCs)suffer from low tissue penetration and significant side effects,largely due to the permanent linkage and/or premature release of cytotoxic payloads.Herein,we developed a prodrug–antibody conjugate(ProADC)strategy by conjugating a bioorthogonal-activatable prodrug with an antibody that allowed on-target release and on-demand activation of cytotoxic drugs at a tumor site.The bioorthogonal-caged prodrug exhibited an enhanced permeability into and on-demand activation within cancer cells,while the pH-sensitive ADC linker allowed on-target release of the anticancer agent.Together,the ProADCs showed enhanced tumor penetration and alleviated side effects for use as an on-target and on-demand chemotherapy agents.