BACKGROUND Delayed inflammatory reactions(DIRs)in alloplast rhinoplasty are a rare complication that may occur several months to years after surgery.The exact causes and mechanisms are unclear,but several triggering f...BACKGROUND Delayed inflammatory reactions(DIRs)in alloplast rhinoplasty are a rare complication that may occur several months to years after surgery.The exact causes and mechanisms are unclear,but several triggering factors,including infections,trauma,dental procedures,and vaccination,have been reported.CASE SUMMARY A 39-year-old male patient who had undergone augmentation rhinoplasty 8 years ago had DIRs after the administration of the first dose of the mRNA Pfizer coronavirus disease 2019(COVID-19)vaccine.He suddenly had tender,erythematous swelling on his face 6 d after vaccination.As there was no improvement in the patient’s condition after the conservative treatment,surgical removal of an alloplastic nasal implant was performed.Immediately after the surgery,the DIRs and accompanying symptoms ameliorated rapidly.A histological study conducted during surgery was fibrosis and small fragments of the hyaline cartilage.CONCLUSION The correlation between DIRs and COVID-19 vaccination has not been reported yet and the exact mechanism is unclear.Because the uncontrolled inflammatory reactions on the nose leave serious sequelae,surgeons should be conscious of the correlation between COVID-19 vaccines and DIRs associated with nasal alloplastic implants.And further histological or microbiological studies should be performed to determine the cause of DIRs.展开更多
Porous polyethylene (PP or Medpor?) is an alloplastic material used worldwide for craniofacial reconstruction. Although several clinical studies are available, how this material alters osteoblast activity to promote b...Porous polyethylene (PP or Medpor?) is an alloplastic material used worldwide for craniofacial reconstruction. Although several clinical studies are available, how this material alters osteoblast activity to promote bone formation is poorly understood. To study how PP can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. PP causes induction of osteoblast transcriptional factor RUNX2 and of the bone related genes osteocalcin (BGLAP) and alkaline phosphatase (ALPL). In contrast the expression of ENG was decreased in stem cells treated with PP respect to untreated cells, indicating the differentiation effect of this biomaterial on stem cells. The obtained results can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects.展开更多
The selection of ideal posttraumatic augmentation rhinoplasty materials and technical strategies has always been a pressing challenge.Owing to the complexity of the traumatic nasal anatomical structure,such procedures...The selection of ideal posttraumatic augmentation rhinoplasty materials and technical strategies has always been a pressing challenge.Owing to the complexity of the traumatic nasal anatomical structure,such procedures are more complicated than ordinary cosmetic rhinoplasty.The choice of reconstruction material should emphasize its inherent characteristics,such as biocompatibility,anti-infective ability,strength,and plasticity.With the development of rhinoplasty,the choice of material is less limited and composite materials have become mainstream.This review outlines current composite materials and techniques in posttraumatic augmentation rhinoplasty.展开更多
We report on a case of TMJ reankylosis (heterotopic bone) following total TMJ alloplastic reconstruction in a 40-year-old Black male. The heterotopic bone was excised following removal of the fossa component. The foss...We report on a case of TMJ reankylosis (heterotopic bone) following total TMJ alloplastic reconstruction in a 40-year-old Black male. The heterotopic bone was excised following removal of the fossa component. The fossa component was re-inserted, and the periarticular tissue was grafted with fat procured from the abdomen. Patient was placed on an aggressive physiotherapy programme which was monitored for a period of 6 months. He returned for review one year later with a mouth opening of 27 mm. We present also a short review of the literature on heterotopic bone formation. This case is of particular interest in that despite the heterotopic bone around it;the prosthesis was preserved after the bone was removed.展开更多
基金Supported by the 2016 Yeungnam University Research Grants.
文摘BACKGROUND Delayed inflammatory reactions(DIRs)in alloplast rhinoplasty are a rare complication that may occur several months to years after surgery.The exact causes and mechanisms are unclear,but several triggering factors,including infections,trauma,dental procedures,and vaccination,have been reported.CASE SUMMARY A 39-year-old male patient who had undergone augmentation rhinoplasty 8 years ago had DIRs after the administration of the first dose of the mRNA Pfizer coronavirus disease 2019(COVID-19)vaccine.He suddenly had tender,erythematous swelling on his face 6 d after vaccination.As there was no improvement in the patient’s condition after the conservative treatment,surgical removal of an alloplastic nasal implant was performed.Immediately after the surgery,the DIRs and accompanying symptoms ameliorated rapidly.A histological study conducted during surgery was fibrosis and small fragments of the hyaline cartilage.CONCLUSION The correlation between DIRs and COVID-19 vaccination has not been reported yet and the exact mechanism is unclear.Because the uncontrolled inflammatory reactions on the nose leave serious sequelae,surgeons should be conscious of the correlation between COVID-19 vaccines and DIRs associated with nasal alloplastic implants.And further histological or microbiological studies should be performed to determine the cause of DIRs.
文摘Porous polyethylene (PP or Medpor?) is an alloplastic material used worldwide for craniofacial reconstruction. Although several clinical studies are available, how this material alters osteoblast activity to promote bone formation is poorly understood. To study how PP can induce osteoblast differentiation in mesenchymal stem cells, the expression levels of bone related genes and mesenchymal stem cells marker were analyzed, using real time Reverse Transcription-Polymerase Chain Reaction. PP causes induction of osteoblast transcriptional factor RUNX2 and of the bone related genes osteocalcin (BGLAP) and alkaline phosphatase (ALPL). In contrast the expression of ENG was decreased in stem cells treated with PP respect to untreated cells, indicating the differentiation effect of this biomaterial on stem cells. The obtained results can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects.
文摘The selection of ideal posttraumatic augmentation rhinoplasty materials and technical strategies has always been a pressing challenge.Owing to the complexity of the traumatic nasal anatomical structure,such procedures are more complicated than ordinary cosmetic rhinoplasty.The choice of reconstruction material should emphasize its inherent characteristics,such as biocompatibility,anti-infective ability,strength,and plasticity.With the development of rhinoplasty,the choice of material is less limited and composite materials have become mainstream.This review outlines current composite materials and techniques in posttraumatic augmentation rhinoplasty.
文摘We report on a case of TMJ reankylosis (heterotopic bone) following total TMJ alloplastic reconstruction in a 40-year-old Black male. The heterotopic bone was excised following removal of the fossa component. The fossa component was re-inserted, and the periarticular tissue was grafted with fat procured from the abdomen. Patient was placed on an aggressive physiotherapy programme which was monitored for a period of 6 months. He returned for review one year later with a mouth opening of 27 mm. We present also a short review of the literature on heterotopic bone formation. This case is of particular interest in that despite the heterotopic bone around it;the prosthesis was preserved after the bone was removed.
