In the presence of BiCl3/Al or BiCl3/Fe, in THF-H2O, allylic (benzylic) bromides or α-bromoketones react with diorganyl diselenides to give allylic (benzylic) selenides orα-organylselenocarbonyl compounds respective...In the presence of BiCl3/Al or BiCl3/Fe, in THF-H2O, allylic (benzylic) bromides or α-bromoketones react with diorganyl diselenides to give allylic (benzylic) selenides orα-organylselenocarbonyl compounds respectively in moderate to good yields.展开更多
A convenient method for the chlorination in allylic position was developed by using the aqueous solution of sodium hypochlorite(2%_5% active chlorine) and an acid as chlorination reagent in a diphase system. The metho...A convenient method for the chlorination in allylic position was developed by using the aqueous solution of sodium hypochlorite(2%_5% active chlorine) and an acid as chlorination reagent in a diphase system. The method has the advantage of cheap reagents, mild reaction conditions and good yields. The quantity and the feeding rate of the chlorination reagent can be controlled easily. The method is particularly suitable for the chlorination in laboratories.展开更多
A novel chiral phosphine-triazine ligand was synthesized from chiral α-phenylethylamine through a three-step procedure. In a model reaction of Pd-catalyzed allylic alkylation of rac-1,3-diphenylprop-2-en-1-y1 pivalat...A novel chiral phosphine-triazine ligand was synthesized from chiral α-phenylethylamine through a three-step procedure. In a model reaction of Pd-catalyzed allylic alkylation of rac-1,3-diphenylprop-2-en-1-y1 pivalate with dimethyl malonate, good enantioselectivity (90% e.e.) was obtained by using this ligand.展开更多
Microwave-assisted allylic oxidation at C-13 position of 14-deoxysinenxan A was described. This new method (150℃/10 min/5 bar on microwave synthesizer) led to a better yield of compound 1 and shorter reaction time.
Allylic alcohols react with aryl iodides in the presence of tri-n-butylamine and a catalytic amount of a silica-bound bidentate sulfur palladium (0) complex to form 3-arylaldehydes or ketones in good yields.
A highly efficient asymmetric allylic alkylation of cyclic and acyclic carbon nucleophiles with vinyl epoxides has been developed,which exhibits good functional group compatibility,high atomic and step economy.This pr...A highly efficient asymmetric allylic alkylation of cyclic and acyclic carbon nucleophiles with vinyl epoxides has been developed,which exhibits good functional group compatibility,high atomic and step economy.This protocol utilizes a strategy of synergistic catalysis with a chiral N,N'-dioxide/Ni~Ⅱ complex and an achiral Pd~0 catalyst,generating a series of multisubstituted allylic alcohols with a quaternary carbon stereocenter in high yield and excellent regio-,Z/E-and enantioselectivity under mild conditions.Further transformations of the product demonstrate the potential utility of this protocol in the synthesis of allyl alcohol derivatives and natural product analogues.Experimental studies revealed that the N,N′-dioxide/metal complexes play an important role in controlling the Z/E-and enantioselectivity.The density functional theory(DFT) calculations further demonstrated that multiple C–H···π interactions between the aromatic rings of the two substrates and the amide moiety in the ligand stabilized the dominant transition state.展开更多
Comprehensive Summary Pd-catalyzed asymmetric allylic C—H functionalization has emerged as a powerful tool to access chiral,densely functionalized molecules from easily accessible alkenes,enabling the increase of the...Comprehensive Summary Pd-catalyzed asymmetric allylic C—H functionalization has emerged as a powerful tool to access chiral,densely functionalized molecules from easily accessible alkenes,enabling the increase of the step-or atom-economy by minimizing functional group manipulations for preparing allylating reagents.Due to the inadequacy of stereoselection strategies,the asymmetric allylic C—H functionalization is still in the early stage.In this essay,we will describe our journey to identification of asymmetric catalytic systems,mechanism of allylic C—H activation,control of stereo-and regioselectivity,and applications in asymmetric synthesis.展开更多
In contrast to the stereocontrol of the stereocenter at the allyl unit,the asymmetric induction of prochiral nucleophiles remains a challenge in Pd-catalyzed asymmetric allylic substitutions due to the remote distance...In contrast to the stereocontrol of the stereocenter at the allyl unit,the asymmetric induction of prochiral nucleophiles remains a challenge in Pd-catalyzed asymmetric allylic substitutions due to the remote distance between the chiral catalyst and the stereocenter established at prochiral nucleophile.Much effort has been devoted to solving this challenge through the elaborate design of chiral ligands.Recently,synergistic catalysis has gained increasing attention owing to its potential advantages over the traditional single palladium catalysis,such as improvement of reactivity and selectivity.This strategy,including bimetallic catalysis and Pd/organocatalysis,not only broadens the scope of prochiral nucleophiles,but also provides a simple and unified method for the stereocontrol of prochiral nucleophiles.This review summarizes the brief history and advances in this field.展开更多
Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed.The protocol offers a straightforward method for the synthesi...Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed.The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way.This cascade reaction proceeds under mild conditions with excellent functional group compatibility.Furthermore,the catalytic asymmetric version has also been explored.展开更多
A new palladium-catalyzed annulative allylic alkylation(AAA)reaction of 2-(indol-2-yl)phenols with dual allylic electrophiles such as isobutylene dicarbonate and butene dicarbonate is described,leading to the regiosel...A new palladium-catalyzed annulative allylic alkylation(AAA)reaction of 2-(indol-2-yl)phenols with dual allylic electrophiles such as isobutylene dicarbonate and butene dicarbonate is described,leading to the regioselective synthesis of tetracyclic medium-sized cyclic ethers possessing a bridged aryl-indole scaf-fold,namely,benzo[2,3]oxocino[4,5-b]indoles and benzo[2,3]oxepino[4,5-b]indoles,in good to excellent yields.This protocol demonstrates a broad substrate scope,good compatibility with substituents and high regioselectivity,providing a catalytic and flexible method for creating bridged aryl-indole skeletons.展开更多
We report an unprecedented Pd-catalyzed asymmetric allylic alkylation of 1-(indol-2-yl)cyclobutanols followed by anα-iminol rearrangement.High yields with excellent chemo-,regio-,diastereo-,and enantioselectivities h...We report an unprecedented Pd-catalyzed asymmetric allylic alkylation of 1-(indol-2-yl)cyclobutanols followed by anα-iminol rearrangement.High yields with excellent chemo-,regio-,diastereo-,and enantioselectivities have been realized,affording a wide range of enantioenriched 2-spirocyclicindolines bearing two contiguous stereocenters.The facial selectivity of the ensuing rearrangement is controlled by the subtle difference of the substituents on the all-carbon quaternary stereogenic center formed in the allylic alkylation step.Nonactivated racemic terminal allylic alcohols are utilized as efficient electrophiles via kinetic resolution pathways for the first time in Pd-catalyzed asymmetric allylic alkylation.The role of Et3B additive is pivotal to activating allylic alcohols toward the formation of π-allylpalladium species and suppressing N/O allylic alkylation of indole with enhanced C3-nucleophilicity.Electrospray ionization high-resolution mass spectrometry(ESIHRMS)experiments provided strong evidence for the existence of the key nucleophilic boron anionic species,which fully accounts for the essential role of the Et_(3)B additive.The study of the mechanism indicates that the real catalytically active species is an electronic π-cinnamyl-palladium complex coordinated by two phosphoramidite ligands,which is consistent with the observed nonlinear effect and control experiments and is further confirmed by X-ray structure analysis.展开更多
1.Introduction The past few decades have witnessed extensive studies on transition metal-catalyzed C-H bond activations and subsequent carbon-carbon and/or carbon-heteroatom bond formations because these methods provi...1.Introduction The past few decades have witnessed extensive studies on transition metal-catalyzed C-H bond activations and subsequent carbon-carbon and/or carbon-heteroatom bond formations because these methods provide more atom-and step-economical pathways than those traditional transformations starting from prefunctionalized substrates.展开更多
Highly regiodivergent copper-catalyzed allylic/propargylic difluoromethylation reactions by employing different ligands are described. When 5,6-dimethyl-1,10-phenanthroline was used as the ligand, exclusively α-diflu...Highly regiodivergent copper-catalyzed allylic/propargylic difluoromethylation reactions by employing different ligands are described. When 5,6-dimethyl-1,10-phenanthroline was used as the ligand, exclusively α-difluoromethylated products were obtained, while γ-selective difluoromethylated products were generated when N-heterocyclic carbene-SIPr was used as the ligand. Likewise, high α- vs. γ-selectivities were achieved in the presence of similar copper catalysts for the reactions of propargyl bromides. Moreover, a copper-catalyzed asymmetric allylic difluoromethylation reaction with moderate to good enantioselectivity by the use of chiral ligands was developed.展开更多
We developed a modified protocol for the oxidation of 2,3-allenyl alcohols using CuCI with l : 1 combination of phenanthroline and bipyridine as the catalyst. To further investigate the applicability of this system, ...We developed a modified protocol for the oxidation of 2,3-allenyl alcohols using CuCI with l : 1 combination of phenanthroline and bipyridine as the catalyst. To further investigate the applicability of this system, other types of alcohols such as allylic and propargylic alcohols have been tested: we found that both allylic and propargylic alcohols may be oxidized to the corresponding aldehydes or ketones using molecular oxygen in air as the oxidant with moderate to excellent yields.展开更多
The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The...The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.展开更多
A highly regio-and enantioselective allylic C–H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions a...A highly regio-and enantioselective allylic C–H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes,delivering structurally diverse chiral β-branched α-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo-and enantioselectivities.展开更多
To further investigate the influence of metal ions on the allylic rearrangement of 3,4,5,6-tetrahydrophthalic an- hydride during the hydrothermal reaction, metal ions such as manganese(Ⅱ), zinc(Ⅱ) and cadmium(...To further investigate the influence of metal ions on the allylic rearrangement of 3,4,5,6-tetrahydrophthalic an- hydride during the hydrothermal reaction, metal ions such as manganese(Ⅱ), zinc(Ⅱ) and cadmium(Ⅱ) have been employed in the synthesis, which leads to the formation of three new lamellar coordination polymers, [MnⅡs(μ3-OH)3(1-chec)(1,2-chedc)(2,3-chedc)2(H20)] (3Mn), [ZnⅡs(μ3-OH)3(1-chec)(1,2-chedc)(2,3-chedc)2(H20)] (4Zn), and [CdⅡ3(μ3-OH)2(1,2-chedc)2] (5Cd) (1-chec=cyclohexene-l-carboxylate, 1,2-chedc=cyclohexene-1,2- dicarboxylate, 2,3-chedc=cyclohexene-1,2-dicarboxylate). Interestingly, the allylic rearrangement reaction is metal-dependent, which occurs only in 3Mn and 4Zn, resulting in the formation of one chiral carbon atom of the corresponding dicarboxylate ligands in both compounds. In addition, the magnetic property of compound 3Mn was studied, which revealed strong antiferromagnetic interactions between the metal centers.展开更多
基金the Natural Science Foundation of the Education Commission of Jiangsu Province
文摘In the presence of BiCl3/Al or BiCl3/Fe, in THF-H2O, allylic (benzylic) bromides or α-bromoketones react with diorganyl diselenides to give allylic (benzylic) selenides orα-organylselenocarbonyl compounds respectively in moderate to good yields.
文摘A convenient method for the chlorination in allylic position was developed by using the aqueous solution of sodium hypochlorite(2%_5% active chlorine) and an acid as chlorination reagent in a diphase system. The method has the advantage of cheap reagents, mild reaction conditions and good yields. The quantity and the feeding rate of the chlorination reagent can be controlled easily. The method is particularly suitable for the chlorination in laboratories.
文摘A novel chiral phosphine-triazine ligand was synthesized from chiral α-phenylethylamine through a three-step procedure. In a model reaction of Pd-catalyzed allylic alkylation of rac-1,3-diphenylprop-2-en-1-y1 pivalate with dimethyl malonate, good enantioselectivity (90% e.e.) was obtained by using this ligand.
文摘Microwave-assisted allylic oxidation at C-13 position of 14-deoxysinenxan A was described. This new method (150℃/10 min/5 bar on microwave synthesizer) led to a better yield of compound 1 and shorter reaction time.
文摘Allylic alcohols react with aryl iodides in the presence of tri-n-butylamine and a catalytic amount of a silica-bound bidentate sulfur palladium (0) complex to form 3-arylaldehydes or ketones in good yields.
基金supported by the National Natural Science Foundation of China (U19A2014)Sichuan University(2020SCUNL204)。
文摘A highly efficient asymmetric allylic alkylation of cyclic and acyclic carbon nucleophiles with vinyl epoxides has been developed,which exhibits good functional group compatibility,high atomic and step economy.This protocol utilizes a strategy of synergistic catalysis with a chiral N,N'-dioxide/Ni~Ⅱ complex and an achiral Pd~0 catalyst,generating a series of multisubstituted allylic alcohols with a quaternary carbon stereocenter in high yield and excellent regio-,Z/E-and enantioselectivity under mild conditions.Further transformations of the product demonstrate the potential utility of this protocol in the synthesis of allyl alcohol derivatives and natural product analogues.Experimental studies revealed that the N,N′-dioxide/metal complexes play an important role in controlling the Z/E-and enantioselectivity.The density functional theory(DFT) calculations further demonstrated that multiple C–H···π interactions between the aromatic rings of the two substrates and the amide moiety in the ligand stabilized the dominant transition state.
基金the National Key R&D Program of China(2021YFA1500100)Youth Innovation Promotion Association CAS(2020448)+3 种基金NSFC(22171254 and 22188101)Anhui Provincial Natural Science Foundation(2108085MB58)USTC Research Funds of the DoubleFirst-Class Initiative(YD2060002024)Start-up Research Fund from University of Science and Technology of China(KY2060000216).
文摘Comprehensive Summary Pd-catalyzed asymmetric allylic C—H functionalization has emerged as a powerful tool to access chiral,densely functionalized molecules from easily accessible alkenes,enabling the increase of the step-or atom-economy by minimizing functional group manipulations for preparing allylating reagents.Due to the inadequacy of stereoselection strategies,the asymmetric allylic C—H functionalization is still in the early stage.In this essay,we will describe our journey to identification of asymmetric catalytic systems,mechanism of allylic C—H activation,control of stereo-and regioselectivity,and applications in asymmetric synthesis.
基金supported by the National Natural Science Foundation of China(21831005,21991112,22171183)the Science and Technology Commission of Shanghai Municipality(19JC1430100)。
文摘In contrast to the stereocontrol of the stereocenter at the allyl unit,the asymmetric induction of prochiral nucleophiles remains a challenge in Pd-catalyzed asymmetric allylic substitutions due to the remote distance between the chiral catalyst and the stereocenter established at prochiral nucleophile.Much effort has been devoted to solving this challenge through the elaborate design of chiral ligands.Recently,synergistic catalysis has gained increasing attention owing to its potential advantages over the traditional single palladium catalysis,such as improvement of reactivity and selectivity.This strategy,including bimetallic catalysis and Pd/organocatalysis,not only broadens the scope of prochiral nucleophiles,but also provides a simple and unified method for the stereocontrol of prochiral nucleophiles.This review summarizes the brief history and advances in this field.
基金supported by the National Key Research and Development Program of China(2021YFA0804900)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2022R01007)Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism。
文摘Palladium-catalyzed allylic alkylation enabled by ketone umpolung via Pudovik addition/[1,2]-phospha-Brook rearrangement with phosphites has been developed.The protocol offers a straightforward method for the synthesis of potentially bioactive homoallylic alcohol phosphonates in an efficient and economical way.This cascade reaction proceeds under mild conditions with excellent functional group compatibility.Furthermore,the catalytic asymmetric version has also been explored.
基金the National Natural Science Foundation of China(Nos.21971090 and 22271123).
文摘A new palladium-catalyzed annulative allylic alkylation(AAA)reaction of 2-(indol-2-yl)phenols with dual allylic electrophiles such as isobutylene dicarbonate and butene dicarbonate is described,leading to the regioselective synthesis of tetracyclic medium-sized cyclic ethers possessing a bridged aryl-indole scaf-fold,namely,benzo[2,3]oxocino[4,5-b]indoles and benzo[2,3]oxepino[4,5-b]indoles,in good to excellent yields.This protocol demonstrates a broad substrate scope,good compatibility with substituents and high regioselectivity,providing a catalytic and flexible method for creating bridged aryl-indole skeletons.
基金supported by the NSFC(nos.21525207,21772147,and 220711186)the Huibei Province Natural Science Foundation(no.2020CFA036)+1 种基金Support by the Fundamental Research Funds for the Central Universitiesthe Program of Introducing Talents of Discipline to Universities of China(111 Program)is also appreciated.
文摘We report an unprecedented Pd-catalyzed asymmetric allylic alkylation of 1-(indol-2-yl)cyclobutanols followed by anα-iminol rearrangement.High yields with excellent chemo-,regio-,diastereo-,and enantioselectivities have been realized,affording a wide range of enantioenriched 2-spirocyclicindolines bearing two contiguous stereocenters.The facial selectivity of the ensuing rearrangement is controlled by the subtle difference of the substituents on the all-carbon quaternary stereogenic center formed in the allylic alkylation step.Nonactivated racemic terminal allylic alcohols are utilized as efficient electrophiles via kinetic resolution pathways for the first time in Pd-catalyzed asymmetric allylic alkylation.The role of Et3B additive is pivotal to activating allylic alcohols toward the formation of π-allylpalladium species and suppressing N/O allylic alkylation of indole with enhanced C3-nucleophilicity.Electrospray ionization high-resolution mass spectrometry(ESIHRMS)experiments provided strong evidence for the existence of the key nucleophilic boron anionic species,which fully accounts for the essential role of the Et_(3)B additive.The study of the mechanism indicates that the real catalytically active species is an electronic π-cinnamyl-palladium complex coordinated by two phosphoramidite ligands,which is consistent with the observed nonlinear effect and control experiments and is further confirmed by X-ray structure analysis.
基金We thank the National Natural Science Foundation of China (Nos. 21871145, 21672107 and 91856104) for financial support.
文摘1.Introduction The past few decades have witnessed extensive studies on transition metal-catalyzed C-H bond activations and subsequent carbon-carbon and/or carbon-heteroatom bond formations because these methods provide more atom-and step-economical pathways than those traditional transformations starting from prefunctionalized substrates.
基金The Nationa authors gratefully acknowledge the financial support from Natural Science Foundation of China (21625206, 21632009, 21372247, 21572258, 21572259, 21421002) and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB20000000) and the Syngenta Ph.D. Fellowship (Y. Gu and C. Lu).
文摘Highly regiodivergent copper-catalyzed allylic/propargylic difluoromethylation reactions by employing different ligands are described. When 5,6-dimethyl-1,10-phenanthroline was used as the ligand, exclusively α-difluoromethylated products were obtained, while γ-selective difluoromethylated products were generated when N-heterocyclic carbene-SIPr was used as the ligand. Likewise, high α- vs. γ-selectivities were achieved in the presence of similar copper catalysts for the reactions of propargyl bromides. Moreover, a copper-catalyzed asymmetric allylic difluoromethylation reaction with moderate to good enantioselectivity by the use of chiral ligands was developed.
文摘We developed a modified protocol for the oxidation of 2,3-allenyl alcohols using CuCI with l : 1 combination of phenanthroline and bipyridine as the catalyst. To further investigate the applicability of this system, other types of alcohols such as allylic and propargylic alcohols have been tested: we found that both allylic and propargylic alcohols may be oxidized to the corresponding aldehydes or ketones using molecular oxygen in air as the oxidant with moderate to excellent yields.
基金Supported by the National Natural Science Foundation of China (Grant No. 20772084)
文摘The enantioselective O-allylic alkylation of acetophenone oxime with various Morita-Baylis-Hillman (MBH) carbonates has been accomplished by the catalysis of a commercially available cinchona alkaloid (DHQD)2PHAL. The corresponding O-allylic products were obtained in moderate to excellent yields up to 96% ee.
基金Ministry of Science and Technology of China(2015CB856600)the National Natural Science Foundation of China(21672197,21602214)the Chinese Academy of Sciences(XDB20020000).
文摘A highly regio-and enantioselective allylic C–H alkylation of 1,4-dienes with glycine Schiff bases has been established by chiral palladium-phosphoramidite catalysis. This reaction can proceed under mild conditions and tolerate a wide scope of 1,4-dienes,delivering structurally diverse chiral β-branched α-amino acid surrogates in moderate to high yields and with high levels of regio-, Z/E-, diastereo-and enantioselectivities.
文摘To further investigate the influence of metal ions on the allylic rearrangement of 3,4,5,6-tetrahydrophthalic an- hydride during the hydrothermal reaction, metal ions such as manganese(Ⅱ), zinc(Ⅱ) and cadmium(Ⅱ) have been employed in the synthesis, which leads to the formation of three new lamellar coordination polymers, [MnⅡs(μ3-OH)3(1-chec)(1,2-chedc)(2,3-chedc)2(H20)] (3Mn), [ZnⅡs(μ3-OH)3(1-chec)(1,2-chedc)(2,3-chedc)2(H20)] (4Zn), and [CdⅡ3(μ3-OH)2(1,2-chedc)2] (5Cd) (1-chec=cyclohexene-l-carboxylate, 1,2-chedc=cyclohexene-1,2- dicarboxylate, 2,3-chedc=cyclohexene-1,2-dicarboxylate). Interestingly, the allylic rearrangement reaction is metal-dependent, which occurs only in 3Mn and 4Zn, resulting in the formation of one chiral carbon atom of the corresponding dicarboxylate ligands in both compounds. In addition, the magnetic property of compound 3Mn was studied, which revealed strong antiferromagnetic interactions between the metal centers.