Gastric cancer(GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis,as...Gastric cancer(GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis,as best exemplified by elucidating the fundamental role of several major signaling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these signaling pathways,such as gene mutations,copy number variants,aberrant gene methylation and histone modification,nucleosome positioning,and microRNAs. Some of these genetic/epigenetic alterations represent effective diagnostic and prognostic biomarkers and therapeutic targets for GC. This information has now opened unprecedented opportunities for better understanding of the molecular mechanisms of gastric carcinogenesis and the development of novel therapeutic strategies for this cancer. The pathogenetic mechanisms of GC are the focus of this review.展开更多
Neoproterozoic is a very important time in the history of the Earth, during which occurred supercontinent breakup, low-latitude glaciation, and biotic diversification. These concern a series of interdisciplinary studi...Neoproterozoic is a very important time in the history of the Earth, during which occurred supercontinent breakup, low-latitude glaciation, and biotic diversification. These concern a series of interdisciplinary studies involving ancient plate motion, climate change and life evolution, re-sulting in many forefront topics of general interest in the earth sciences. These include exact ages bracketing the Cryogenian System and glaciations, initial age and lasted duration of supercontinent breakup, dynamic reconstruction of China continents in supercontinental configurations, the nature of rift magmatism and extent of hydrothermal altera-tion, paleoclimatic implication of water-rock interaction and low-18O magmatism, and relationship between superconti-nental evolution and global change. A number of outstanding advances in the above aspects have being made by Chinese scientists, leaving many important issues to be resolved: (1) did the Cryogenian start at either 800 to 820 Ma or 760 to 780 Ma? (2) was South China in the supercontinental con-figuration located in either southeast to Australia or north to India? (3) are Paleoproterozoic to Archean ages of crustal rocks a valid parameter in distinguishing North China from South China? Available observations suggest that Neopro-terozoic mantle superwelling occurred as conspicuous mag-matism in South China but as cryptical magmatism in North China. Mid-Neoproterozoic mantle superplume event and its derived rift-magmatism would not only result in the supercontinental demise, but also play a very important role in the generation and evolution of the snowball Earth event by initiating the global glaciation, causing the local degla-ciation and terminating the snowball Earth event.展开更多
The epidosites are interpreted to form in upflow zones at the base of ore-forming oceanic hydrothermal systems that vent as black smokers on the sea floor. This study presents new field, major and trace element, and o...The epidosites are interpreted to form in upflow zones at the base of ore-forming oceanic hydrothermal systems that vent as black smokers on the sea floor. This study presents new field, major and trace element, and oxygen isotope data for the recently discovered epidosites in the ca. 1.0 Ga Miaowan （庙湾） ophiolite located near the northern margin of the Yangtze craton. The ep-idosites occur mainly in the cores of strongly de-formed, lensoidal amphibolites. Field observations, major and trace elements and oxygen isotopes sug-gest that the epidosites were formed by metasoma-tism of ocean floor basalts, diabase dykes, and gabbros during seafloor hydrothermal alteration.展开更多
基金Supported by National Key Program for Developing Basic Research,No.2010CB933903the National Natural Science Foundation of China,No.81171969,No.81272933 and No.81372217the Fundamental Research Funds for the Central Universities
文摘Gastric cancer(GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis,as best exemplified by elucidating the fundamental role of several major signaling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these signaling pathways,such as gene mutations,copy number variants,aberrant gene methylation and histone modification,nucleosome positioning,and microRNAs. Some of these genetic/epigenetic alterations represent effective diagnostic and prognostic biomarkers and therapeutic targets for GC. This information has now opened unprecedented opportunities for better understanding of the molecular mechanisms of gastric carcinogenesis and the development of novel therapeutic strategies for this cancer. The pathogenetic mechanisms of GC are the focus of this review.
基金supported by the National Natural Science Foundation of China(Grant No.40033010)the Chinese Academy of Sciences(Grant No.KZCX2-107).
文摘Neoproterozoic is a very important time in the history of the Earth, during which occurred supercontinent breakup, low-latitude glaciation, and biotic diversification. These concern a series of interdisciplinary studies involving ancient plate motion, climate change and life evolution, re-sulting in many forefront topics of general interest in the earth sciences. These include exact ages bracketing the Cryogenian System and glaciations, initial age and lasted duration of supercontinent breakup, dynamic reconstruction of China continents in supercontinental configurations, the nature of rift magmatism and extent of hydrothermal altera-tion, paleoclimatic implication of water-rock interaction and low-18O magmatism, and relationship between superconti-nental evolution and global change. A number of outstanding advances in the above aspects have being made by Chinese scientists, leaving many important issues to be resolved: (1) did the Cryogenian start at either 800 to 820 Ma or 760 to 780 Ma? (2) was South China in the supercontinental con-figuration located in either southeast to Australia or north to India? (3) are Paleoproterozoic to Archean ages of crustal rocks a valid parameter in distinguishing North China from South China? Available observations suggest that Neopro-terozoic mantle superwelling occurred as conspicuous mag-matism in South China but as cryptical magmatism in North China. Mid-Neoproterozoic mantle superplume event and its derived rift-magmatism would not only result in the supercontinental demise, but also play a very important role in the generation and evolution of the snowball Earth event by initiating the global glaciation, causing the local degla-ciation and terminating the snowball Earth event.
基金supported by the China Postdoctoral Science Foundation (No. 20100471203)the Ministry of Land and Resources (No. 1212010670104)+1 种基金the National Natural Science Foundation of China (Nos. 91014002, 40821061, 41272242)Ministry of Education of China (Nos. B07039 and TGRC201024)
文摘The epidosites are interpreted to form in upflow zones at the base of ore-forming oceanic hydrothermal systems that vent as black smokers on the sea floor. This study presents new field, major and trace element, and oxygen isotope data for the recently discovered epidosites in the ca. 1.0 Ga Miaowan （庙湾） ophiolite located near the northern margin of the Yangtze craton. The ep-idosites occur mainly in the cores of strongly de-formed, lensoidal amphibolites. Field observations, major and trace elements and oxygen isotopes sug-gest that the epidosites were formed by metasoma-tism of ocean floor basalts, diabase dykes, and gabbros during seafloor hydrothermal alteration.
