A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, a- and b-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou,...A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, a- and b-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides.展开更多
基金This work was supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(No.KSCX2-YW-N-036).
文摘A new cyclic nonapeptide, amanexitide (1), along with the known cyclopeptides, a- and b-amanitins, was isolated from the fruiting bodies of Amanita exitialis, a newly described poisonous mushroom endemic to Guangzhou, Guangdong Province, China. Its amino acid composition and absolute configuration were determined by chemical degradation and derivatization followed by chiral GC analysis. Its amino acid sequence was elucidated by extensive analysis of ESIMS/MS and FTICRMS data. The occurrence of 1 in this mushroom is interesting because it has a structure closely related to antamanide, a cyclic decapeptide with antidote activity against amatoxins and phallotoxins, occurring in A. phalloides.
