5,10,15,20-Tetrakis（4-amidinolphenyl）porphyrin, its Zn complex and amidinolphenyl bispophyrin interacting with calf thymus DNA were investigated by fluorescence emission spectra and fluorescence life time measuremen...5,10,15,20-Tetrakis（4-amidinolphenyl）porphyrin, its Zn complex and amidinolphenyl bispophyrin interacting with calf thymus DNA were investigated by fluorescence emission spectra and fluorescence life time measurements were also shown. The binding modes of these compounds were recorded and lifetimes of luminescence were meas- ured as a function of the nature to understand the interaction with DNA. The results suggest those amidinopor-phyrins are promising new photodynamic therapeutic agents.展开更多
The interactions of Morin and its Cu(Ⅱ)-, Zn(Ⅱ)-complexes with calf thymus DNA have been studied by using fluorimetric and electrochemical methods. Cu(Ⅱ)-, Zn(Ⅱ)-complexes have different spectra and electrochemica...The interactions of Morin and its Cu(Ⅱ)-, Zn(Ⅱ)-complexes with calf thymus DNA have been studied by using fluorimetric and electrochemical methods. Cu(Ⅱ)-, Zn(Ⅱ)-complexes have different spectra and electrochemical characteristics from that of Morin in the presence of DNA. The results suggest that Morin and its complexes can both bind to DNA, but the binding mode is different. The complexes bind to DNA mainly like EB by intercalation, while Morin binds in a non-intercalating mode.展开更多
文摘5,10,15,20-Tetrakis（4-amidinolphenyl）porphyrin, its Zn complex and amidinolphenyl bispophyrin interacting with calf thymus DNA were investigated by fluorescence emission spectra and fluorescence life time measurements were also shown. The binding modes of these compounds were recorded and lifetimes of luminescence were meas- ured as a function of the nature to understand the interaction with DNA. The results suggest those amidinopor-phyrins are promising new photodynamic therapeutic agents.
文摘The interactions of Morin and its Cu(Ⅱ)-, Zn(Ⅱ)-complexes with calf thymus DNA have been studied by using fluorimetric and electrochemical methods. Cu(Ⅱ)-, Zn(Ⅱ)-complexes have different spectra and electrochemical characteristics from that of Morin in the presence of DNA. The results suggest that Morin and its complexes can both bind to DNA, but the binding mode is different. The complexes bind to DNA mainly like EB by intercalation, while Morin binds in a non-intercalating mode.
