Background Photodynamic therapy （PDT） with 5-aminolevulinic acid （ALA） is an emerging technique for the treatment of genital human papillomavirus （HPV）-induced benign and premalignant lesions. We report here in ...Background Photodynamic therapy （PDT） with 5-aminolevulinic acid （ALA） is an emerging technique for the treatment of genital human papillomavirus （HPV）-induced benign and premalignant lesions. We report here in a case series of condyloma acuminata （CA） in pregnancy successfully treated with ALA-PDT. Methods Five pregnant patients with CA received three to four times treatment respectively. Patients were followed up for 6-23 months after treatment. Results The clearance rate of genital warts was 100%. No recurrence was found during the follow-up period. Major adverse events reported were mild erosion, pain, and local edema. All pregnancies resulted in healthy live births without delivery complications. Conclusions PDT with topical ALA seems to be safe and effective in the treatment of CA in pregnancy. It demonstrated high clearance rate of warts, was well-tolerated by patients, and showed no adverse effects on mothers or fetuses. ALA-PDT may be an ideal strategy of treatment for pregnant women with CA.展开更多
文摘Background Photodynamic therapy （PDT） with 5-aminolevulinic acid （ALA） is an emerging technique for the treatment of genital human papillomavirus （HPV）-induced benign and premalignant lesions. We report here in a case series of condyloma acuminata （CA） in pregnancy successfully treated with ALA-PDT. Methods Five pregnant patients with CA received three to four times treatment respectively. Patients were followed up for 6-23 months after treatment. Results The clearance rate of genital warts was 100%. No recurrence was found during the follow-up period. Major adverse events reported were mild erosion, pain, and local edema. All pregnancies resulted in healthy live births without delivery complications. Conclusions PDT with topical ALA seems to be safe and effective in the treatment of CA in pregnancy. It demonstrated high clearance rate of warts, was well-tolerated by patients, and showed no adverse effects on mothers or fetuses. ALA-PDT may be an ideal strategy of treatment for pregnant women with CA.
