5-O-Benzoyl- 1,2-O-isopropylidene- α-D-erythro-ketofuranose-3-ulose-3-aminothiose 3 was synthesized and characterized by spectral analysis, and its crystal structure was determined by X-ray diffraction analysis. The ...5-O-Benzoyl- 1,2-O-isopropylidene- α-D-erythro-ketofuranose-3-ulose-3-aminothiose 3 was synthesized and characterized by spectral analysis, and its crystal structure was determined by X-ray diffraction analysis. The crystal belongs to orthorhombic, space group P212121 with a=6.6276(13), b=10.993(2), c=25.027(5)(A), β=90°, V=1823.4(6)(A)3, Z=4, C16H20N3O5S, Mr=366.41, Dc=1.335 g/cm^3,μ=0.208 mm^-1, F(000)=772, S=1.007, the final R=0.0465 and wR=0.1061 for 3251 observed reflections (I 〉 2σ(I)). Four hydrogen bonds are observed. The absolute configuration of this molecule was confirmed by comparing with that of the original material.展开更多
1,2-O-Isopropylidene-5-O-p-toluenesulfonyl-α-D-erythro-pentofuranos-3-ulose 1 was treated with thiourea and aminothiourea to give a D-ribose derivative 2 bearing a 2-amino 1,3-thiazine ring and a thiosemicarbazone de...1,2-O-Isopropylidene-5-O-p-toluenesulfonyl-α-D-erythro-pentofuranos-3-ulose 1 was treated with thiourea and aminothiourea to give a D-ribose derivative 2 bearing a 2-amino 1,3-thiazine ring and a thiosemicarbazone derivative 5, respectively. 2 was acylated with Ac20 and propandioic acid to afford two acylation derivatives 3 and 4, respectively. Reduction of 5 with NaBH4 in methanol produced a hydrothiosemicarbazone derivative 6. The absolute configuration of 2 was confirmed by X-ray crystallographic analysis. The structures of all products were elucidated by IR, NMR and HRMS spectra.展开更多
基金National Natural Science Foundation of China (No. 20472075)
文摘5-O-Benzoyl- 1,2-O-isopropylidene- α-D-erythro-ketofuranose-3-ulose-3-aminothiose 3 was synthesized and characterized by spectral analysis, and its crystal structure was determined by X-ray diffraction analysis. The crystal belongs to orthorhombic, space group P212121 with a=6.6276(13), b=10.993(2), c=25.027(5)(A), β=90°, V=1823.4(6)(A)3, Z=4, C16H20N3O5S, Mr=366.41, Dc=1.335 g/cm^3,μ=0.208 mm^-1, F(000)=772, S=1.007, the final R=0.0465 and wR=0.1061 for 3251 observed reflections (I 〉 2σ(I)). Four hydrogen bonds are observed. The absolute configuration of this molecule was confirmed by comparing with that of the original material.
基金the National Natural Science Foundation of China(No.20472075)for financial support of this work.
文摘1,2-O-Isopropylidene-5-O-p-toluenesulfonyl-α-D-erythro-pentofuranos-3-ulose 1 was treated with thiourea and aminothiourea to give a D-ribose derivative 2 bearing a 2-amino 1,3-thiazine ring and a thiosemicarbazone derivative 5, respectively. 2 was acylated with Ac20 and propandioic acid to afford two acylation derivatives 3 and 4, respectively. Reduction of 5 with NaBH4 in methanol produced a hydrothiosemicarbazone derivative 6. The absolute configuration of 2 was confirmed by X-ray crystallographic analysis. The structures of all products were elucidated by IR, NMR and HRMS spectra.
基金supported by the National Natural Science Foundation of China(Grant No.20462006)Xinjiang Key Laboratory of Plant Resources & Natural Products Chemistry
基金Projects(51504073,51404081,51672275)supported by the National Natural Science Foundation of ChinaProject(2012CBA01202)supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology,China+1 种基金Project(QianJiaoKeHe KY[2015]433)supported by the Research Program of the Education Department of Guizhou Province,ChinaProject(XJG20141104)supported by the Research Program of Talented Scholars of Guizhou Institute of Technology,China