[Objective] The paper was to explore the effect of different sowing dates and densities on individual morphological development of super short-season insect-resistant cotton,confirm their effects on vegetative and rep...[Objective] The paper was to explore the effect of different sowing dates and densities on individual morphological development of super short-season insect-resistant cotton,confirm their effects on vegetative and reproductive growth of cotton,so as to provide theoretical and practical guidance for sowing date and density management of cotton planting in Jidong cotton growing region in Yellow River Basin.[Method] With super short-season insect-resistant cotton"546"as materials,the effects of different sowing dates(sowing dateⅠ:May 20;sowing dateⅡ:June 2;sowing date Ⅲ:June 14)and densities(low density:120 000 plants/hm2;middle density:150 000 plants/hm2;high density:180 000 plants/hm2)on individual morphological development of super short-season insect-resistant cotton were explored.[Result] Different sowing dates and density treatments significantly affected the individual morphological development of super short-season insect-resistant cotton"546".The effectiveness of sowing date was higher than the effectiveness of density,and the effectiveness of sowing date on development of number of individual fruit branches was higher than that on plant height and stem diameter.[Conclusion] The regulation of sowing date and density during the cultivation process of super short-season insect-resistant cotton "546" in Jidong cotton growing region in Yellow River Basin could effectively promote vegetative and reproductive growth of cotton,strengthening its production base.展开更多
On the basis of scientific practice,Marx scientifically illustrated the three phases of human development,and put forward that"individual character"is the highest stage of development.He correctly revealed t...On the basis of scientific practice,Marx scientifically illustrated the three phases of human development,and put forward that"individual character"is the highest stage of development.He correctly revealed the man's all-round development thought and implementation approach.As a theoretical source and logical starting point,Lenin combined it with real life.On the one hand,Lenin developed Marx's people theory into a more specific"overall development of individuals"generally,and improved the practical level;on the other hand,he self-consciously implemented the thought in practice so that Marxist theory was pushed to a higher new state.展开更多
On October 14,2023,a symposium themed“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”was held in Changchun,Jilin Province,China.More than fifty experts,scholars,and r...On October 14,2023,a symposium themed“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”was held in Changchun,Jilin Province,China.More than fifty experts,scholars,and researchers from national institutions and universities engaged in discussions and exchanges on human rights on the Chinese path to modernization,including the path,practice,knowledge systems,and civilization forms of human rights.This symposium played a significant role in advancing the construction of the disciplinary system,academic system,and discourse system of human rights in China.展开更多
The children’s Go training market is experiencing vigorous growth but also faces several challenges.As the importance of Go in cultural education increases,the market expands,with growing demand and involvement from ...The children’s Go training market is experiencing vigorous growth but also faces several challenges.As the importance of Go in cultural education increases,the market expands,with growing demand and involvement from training and educational institutions.However,the market encounters difficulties such as a shortage of high-quality Go coaches,uniformity in training content and methods,and high training costs.To address these issues,measures can be taken to strengthen the team of Go coaches,diversify training content and methods,and optimize the training cost structure,thereby promoting the healthy development of the children’s Go training market.展开更多
The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work consid...The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work considers the principal institutional mechanisms that contributed to this development.First,flexibly planned parenthood gradually promoted gender equality and openness in society facilitated by systematic“awards,grants,and loans”initiatives to support women’s higher education economically.Second,compulsory education ensured that left-out and migrant children had access to higher education.Third,effective connectivity across different education types bridged education gaps between those with different levels of education.Fourth,China made great efforts to invite and integrate international experiences that promoted the development of women’s higher education.Looking beyond these achievements,we also discuss the future trends of women’s higher education in China.展开更多
The development, cytological characters and ultrastructure of phloem ganglion in the nodal region of Phyllostachys edulis (Carr.) H. de Lehaie, a most economically important bamboo, were investigated and the possi...The development, cytological characters and ultrastructure of phloem ganglion in the nodal region of Phyllostachys edulis (Carr.) H. de Lehaie, a most economically important bamboo, were investigated and the possible physiological function of this special structure was proposed. The phloem ganglion derived directly from procambium is situated at the sites where the vascular bundle forks and is present in pairs. The phloem ganglion is spindle_like in appearance and usually consists of 4 to 6 layers. Two kinds of cells in the ganglion could be distinguished. In the middle, there are two layers of filiform cells with pointed ends so that there are no normal sieve plates. Nevertheless, there are many pits on the lateral wall of the filiform cells. The other type of cells located at both ends of the spindle which possess an intermediate form between the filiform cell and the normal sieve tube. The walls of these cells towards the filiform cells are strongly convex forming a special sieve plate. Ultrastructure study showed that cells in the ganglion are connected by enriched plasmodesma. During early differentiation, the paramural body and the ingrowth of cell wall could be observed. It indicates that the cells of phloem ganglion have the character of transfer cells. The organelles in the mature cells are mainly plastids with abundant accumulation of proteins of crystalline structure. The above_mentioned results suggest that the physiological function of the phloem ganglion is closely related with substance transport.展开更多
Various individual organs (tepal, flower bud, inflorescence branch, inflorescence, adult vegetative bud and juvenile vegetative bud) were directly regenerated respectively by callus in Dracaena fragrans cv. massangean...Various individual organs (tepal, flower bud, inflorescence branch, inflorescence, adult vegetative bud and juvenile vegetative bud) were directly regenerated respectively by callus in Dracaena fragrans cv. massangeana Hort. During the regeneration of these individual organs some regularity phenomena were observed. Firstly, the kind range of the individual organs, which are directly regenerated in vitro, is in close relationship to the differentiated stages of the organs used for explant excision during plant ontogeny. The explants excised from the epigeous organ that is differentiated at some stage (stage A) during plant ontogeny must be able to separately regenerate all of those individual epigeous organs: ones differentiated slightly later than the stage A, ones differentiated at the stage A and all ones differentiated earlier than the stage A. Secondly, within this range which kind of organ is regenerated depends on the exogenous auxin concentrations in medium. With the gradual increase of 2,4-D concentration from 0.005 mg/L to 0.5 mg/L, the kinds of regenerated organs will change by the order as follows: vegetative bud, inflorescence, inflorescence branch, flower bud, tepal. These regularities will be able to be used for inducing the direct regeneration of a given epigeous organ in angiosperms.展开更多
Naipaul's novel A bend in the river illustrates the social confusion and people's destitution and wasting time in African countries after their national independence. An important reason is the president's self-pub...Naipaul's novel A bend in the river illustrates the social confusion and people's destitution and wasting time in African countries after their national independence. An important reason is the president's self-publicity, tyrannical hess and destructiveness. Whereas the author's subjective suspicion is visible in democratic development of African countries. Indeed, in a country development, it is quite necessary to depend on its citizen, observing public feelings; controlling a state with science; benefiting citizen; utilizing resources; constructing homestead, intending creation with a harmonious and stable way.展开更多
Teachers are the backbones of any educational institutions. They not only play vital roles in students' development;they also directly affect the stature of their respective scholastic organizations. Highly qualif...Teachers are the backbones of any educational institutions. They not only play vital roles in students' development;they also directly affect the stature of their respective scholastic organizations. Highly qualified instructors produce competent and well-rounded students— learners who are more than ready to face the quirks and challenges of the labor force. This paper primarily discusses the following questions: What is teacher's professional development? What is higher vocational teacher's professional development? And how can scholastic institutions promote it? The conclusion states that the characteristics of higher vocational education directly influence the higher vocational teacher's professional development; therefore, it must be nurtured and promoted for the development of all the stakeholders of learning institutions – students, teachers, management staff,the learning institution itself, and the nation as a whole.展开更多
The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Tooth crown development has been studied intensively during the last f...The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Tooth crown development has been studied intensively during the last few decades, but root development remains not well understood. Here we review the root development processes, including cell fate determination, induction of odontoblast and cementoblast differentiation, interaction of root epithelium and mesenchyme, and other molecular mechanisms. This review summarizes our current understanding of the signaling cascades and mechanisms involved in root development. It also sets the stage for de novo tooth regeneration.展开更多
The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded versio...The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded version of the protocol was written for professional health care providers with a consumer version tailored for family caregivers. The underlying mid-range theory is presented along with a seminal study that was followed by further research in the United States, Canada, Great Britain, France, Sweden, Norway, Japan and Taiwan. Key studies are summarized. Given its efficacy when implemented by research staff, studies have advanced to testing the intervention under real-life conditions when implemented and evaluated by trained nursing assistants in long-term care facilities and visiting family members. In addition, one study evaluated the implementation of music by family members in the home setting. Initial research focused on agitation as the dependent variable with subsequent research indicating a more holistic response such as positive affect, expressed satisfaction, and meaningful interaction with others. The article advances by describing on-line programs designed to train health care professionals in the assessment, implementation and evaluation of individualized music. In addition, Gerdner has written a story for apicture book intended for children and their families(in press). The story models principles of individualized music to elicit positive memories, reduce anxiety and agitation, and promote communication. The article concludes with implications for future research.展开更多
The Ca 2+-binding protein of the EF-hand type,S100B,exerts both intracellular and extracellular regulatory activities.As an intracellular regulator,S100B is involved in the regulation of energy metabolism,transcriptio...The Ca 2+-binding protein of the EF-hand type,S100B,exerts both intracellular and extracellular regulatory activities.As an intracellular regulator,S100B is involved in the regulation of energy metabolism,transcription,protein phosphorylation,cell proliferation,survival,differentiation and motility,and Ca 2+ homeostasis,by interacting with a wide array of proteins(i.e.,enzymes,enzyme substrates,cytoskeletal subunits,scaffold/adaptor proteins,transcription factors,ubiquitin E3 ligases,ion channels) in a restricted number of cell types.As an extracellular signal,S100B engages the pattern recognition receptor,receptor for advanced glycation end-products(RAGE),on immune cells as well as on neuronal,astrocytic and microglial cells,vascular smooth muscle cells,skeletal myoblasts and cardiomyocytes.However,RAGE may not be the sole receptor activated by S100B,the protein being able to enhance bFGF-FGFR1 signaling by interacting with FGFR1-bound bFGF in particular cell types.Moreover,extracellular effects of S100B vary depending on its local concentration.Increasing evidence suggests that at the concentration found in extracellular fluids in normal physiological conditions and locally upon acute tissue injury,which is up to a few nM levels,S100B exerts trophic effects in the central and peripheral nervous system and in skeletal muscle tissue thus participating in tissue homeostasis.The present commentary summarizes results implicating intracellular and extracellular S100B in tissue development,repair and regeneration.展开更多
The implementation of strategies to achieve the Sustainable Development Goals(SDGs)is frequently hindered by potential trade-offs between priorities for either environmental protection or human well-being.However,ecos...The implementation of strategies to achieve the Sustainable Development Goals(SDGs)is frequently hindered by potential trade-offs between priorities for either environmental protection or human well-being.However,ecosystem services(ES)-based solutions can offer possible co-benefits for SDGs implementation that are often overlooked or underexploited.In this study,we cover this gap and investigate how experts from different countries value the SDGs and relate them with ES.A total of 66 countries participated to the survey,and answers were grouped into three macro-regions:Asia;Europe,North America,and Oceania(ENO);Latin America,Caribbean and Africa(LA).Results show that the most prioritized SDGs in the three macro-regions are usually those related to essential material needs and environmental conditions,such as SDG2(Zero Hunger),SDG1(No Poverty),and SDG6(Clean Water).At a global scale,the number of prioritized synergies between SDGs and ES largely exceeded trade-offs.The highest amount of synergies was observed for SDG1(No Poverty),mainly with SDG2,SDG3(Good Health),SDG5(Gender Equality),and SDG8(Economic Growth).Other major synergies among SDGs include SDG14-15(Life below water-Life on land),SDG5-10(Gender Equity-Reduced Inequality),and SDG1-2(No poverty-Zero Hunger).At a global scale,SDG15,SDG13,SDG14,and SDG6 were closely related to ES like climate regulation,freshwater,food,water purification,biodiversity,and education.SDG11(Sustainable Cities)and SDG3 were also relevant in Asia and in LA,respectively.Overall,this study shows the potential to couple future policies that can implement SDGs’strategies while adopting ES-based solutions in different regions of the world.展开更多
Classically Alzheimer's disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an...Classically Alzheimer's disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease (lacunar infarcts, white matter hyperintensities and microbleeds), may magnify the effects of mild Alzheimer's disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. "Vascular hypothesis" of Alzheimer's disease would open a window for new approaches and treatments.展开更多
The time period between 2020 and 2035 is vital for China to achieve its second centennial goal.During this period,China must avoid the middle-income trap and achieve socialist modernization.To accomplish this goal,Chi...The time period between 2020 and 2035 is vital for China to achieve its second centennial goal.During this period,China must avoid the middle-income trap and achieve socialist modernization.To accomplish this goal,China must maintain a certain pace of economic growth and strive to double its real GDP per capita by 2035.However,by the current growth trajectory,China’s average economic growth rate is expected to stay at approximately 3.8%over the period between 2020-2035.This makes the GDP per capita growth target hard to achieve.Even when in a high-quality development stage,China should speed up economic growth while enhancing growth quality.Speed and quality are interdependent rather than contradictory with each other.To ramp up economic growth potentials,China must proceed with market-oriented reforms and shift economic growth drivers.To improve economic growth quality,household consumption should be increased to unleash China’s full potential,not only as the factory floor of the world but also one of world’s biggest markets,i.e.“dual circulations.”With appropriate policy response,China’s economy will be poised to achieve the goal of doubling real GDP per capita by 2035,marking a large stride in its economic aggregate and urban and rural household per capita incomes.展开更多
How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated i...How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases.展开更多
Neuroprotection and neuroregeneration are two of the most promising disease-modifying ther- apies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriat...Neuroprotection and neuroregeneration are two of the most promising disease-modifying ther- apies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinsoffs disease. Several neurotrophic fac- tors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.展开更多
Crohn’s disease(CD)is a chronic inflammatory disorder of the gastrointestinal tract with an increasing incidence worldwide.Comprehensive therapy for CD focuses on symptom control and healing the intestinal mucosa to ...Crohn’s disease(CD)is a chronic inflammatory disorder of the gastrointestinal tract with an increasing incidence worldwide.Comprehensive therapy for CD focuses on symptom control and healing the intestinal mucosa to improve the quality of life and prevent complications.Surgical intervention plays a vital role in comprehensive therapy.However,deciding the optimal timing for surgical intervention has long been a focus of controversy.This review provides insights into the timing of surgery for CD and guides clinicians in daily treatment.展开更多
Since 1986. a brand-new modern industrial city, full of vigor and vitality, has been towering aloftrapidly in what used to be salt marsh in the western part of Bohai Bay of China. With an annual out-put value of RMB ?...Since 1986. a brand-new modern industrial city, full of vigor and vitality, has been towering aloftrapidly in what used to be salt marsh in the western part of Bohai Bay of China. With an annual out-put value of RMB ? 14 billion. it has become one of the most lively and energetic areas of Tianjin andeven throughout the country for opening to the outside world and for developing exportoriented econo-展开更多
基金Supported by Natural Science Foundation of Heibei Province(C2007000444)Hebei Science and Technology Support Program(10220208)~~
文摘[Objective] The paper was to explore the effect of different sowing dates and densities on individual morphological development of super short-season insect-resistant cotton,confirm their effects on vegetative and reproductive growth of cotton,so as to provide theoretical and practical guidance for sowing date and density management of cotton planting in Jidong cotton growing region in Yellow River Basin.[Method] With super short-season insect-resistant cotton"546"as materials,the effects of different sowing dates(sowing dateⅠ:May 20;sowing dateⅡ:June 2;sowing date Ⅲ:June 14)and densities(low density:120 000 plants/hm2;middle density:150 000 plants/hm2;high density:180 000 plants/hm2)on individual morphological development of super short-season insect-resistant cotton were explored.[Result] Different sowing dates and density treatments significantly affected the individual morphological development of super short-season insect-resistant cotton"546".The effectiveness of sowing date was higher than the effectiveness of density,and the effectiveness of sowing date on development of number of individual fruit branches was higher than that on plant height and stem diameter.[Conclusion] The regulation of sowing date and density during the cultivation process of super short-season insect-resistant cotton "546" in Jidong cotton growing region in Yellow River Basin could effectively promote vegetative and reproductive growth of cotton,strengthening its production base.
基金2015SJB065,general project of university philosophy&social science,2015
文摘On the basis of scientific practice,Marx scientifically illustrated the three phases of human development,and put forward that"individual character"is the highest stage of development.He correctly revealed the man's all-round development thought and implementation approach.As a theoretical source and logical starting point,Lenin combined it with real life.On the one hand,Lenin developed Marx's people theory into a more specific"overall development of individuals"generally,and improved the practical level;on the other hand,he self-consciously implemented the thought in practice so that Marxist theory was pushed to a higher new state.
文摘On October 14,2023,a symposium themed“The Chinese Path to Modernization and the Promotion of Free and Comprehensive Human Development”was held in Changchun,Jilin Province,China.More than fifty experts,scholars,and researchers from national institutions and universities engaged in discussions and exchanges on human rights on the Chinese path to modernization,including the path,practice,knowledge systems,and civilization forms of human rights.This symposium played a significant role in advancing the construction of the disciplinary system,academic system,and discourse system of human rights in China.
基金2024 National College Student Innovation Training Program“Three Kingdoms Go”-Enlightenment of Teaching and Learning Go(Project No.G20240402)。
文摘The children’s Go training market is experiencing vigorous growth but also faces several challenges.As the importance of Go in cultural education increases,the market expands,with growing demand and involvement from training and educational institutions.However,the market encounters difficulties such as a shortage of high-quality Go coaches,uniformity in training content and methods,and high training costs.To address these issues,measures can be taken to strengthen the team of Go coaches,diversify training content and methods,and optimize the training cost structure,thereby promoting the healthy development of the children’s Go training market.
基金“Promoting research by writing”:Exploring the code of writing,supported by the Special Fund for basic scientific research of the Central University,Northwestern Polytechnical University(project no.KCJS23WT25).“Research on the construction of the linking-up curriculum system:Taking the industry characteristic research university as an example”was established by the Ministry of Education’s Youth Fund for Humanities and Social Sciences,the Department of Social Sciences of the Ministry of Education(project no.23YJC880099).
文摘The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work considers the principal institutional mechanisms that contributed to this development.First,flexibly planned parenthood gradually promoted gender equality and openness in society facilitated by systematic“awards,grants,and loans”initiatives to support women’s higher education economically.Second,compulsory education ensured that left-out and migrant children had access to higher education.Third,effective connectivity across different education types bridged education gaps between those with different levels of education.Fourth,China made great efforts to invite and integrate international experiences that promoted the development of women’s higher education.Looking beyond these achievements,we also discuss the future trends of women’s higher education in China.
基金InternationalFoundationforScience Sweden +1 种基金D/ 2 1 69_1 FoundationoftheEducationMinistryofChina .
文摘The development, cytological characters and ultrastructure of phloem ganglion in the nodal region of Phyllostachys edulis (Carr.) H. de Lehaie, a most economically important bamboo, were investigated and the possible physiological function of this special structure was proposed. The phloem ganglion derived directly from procambium is situated at the sites where the vascular bundle forks and is present in pairs. The phloem ganglion is spindle_like in appearance and usually consists of 4 to 6 layers. Two kinds of cells in the ganglion could be distinguished. In the middle, there are two layers of filiform cells with pointed ends so that there are no normal sieve plates. Nevertheless, there are many pits on the lateral wall of the filiform cells. The other type of cells located at both ends of the spindle which possess an intermediate form between the filiform cell and the normal sieve tube. The walls of these cells towards the filiform cells are strongly convex forming a special sieve plate. Ultrastructure study showed that cells in the ganglion are connected by enriched plasmodesma. During early differentiation, the paramural body and the ingrowth of cell wall could be observed. It indicates that the cells of phloem ganglion have the character of transfer cells. The organelles in the mature cells are mainly plastids with abundant accumulation of proteins of crystalline structure. The above_mentioned results suggest that the physiological function of the phloem ganglion is closely related with substance transport.
文摘Various individual organs (tepal, flower bud, inflorescence branch, inflorescence, adult vegetative bud and juvenile vegetative bud) were directly regenerated respectively by callus in Dracaena fragrans cv. massangeana Hort. During the regeneration of these individual organs some regularity phenomena were observed. Firstly, the kind range of the individual organs, which are directly regenerated in vitro, is in close relationship to the differentiated stages of the organs used for explant excision during plant ontogeny. The explants excised from the epigeous organ that is differentiated at some stage (stage A) during plant ontogeny must be able to separately regenerate all of those individual epigeous organs: ones differentiated slightly later than the stage A, ones differentiated at the stage A and all ones differentiated earlier than the stage A. Secondly, within this range which kind of organ is regenerated depends on the exogenous auxin concentrations in medium. With the gradual increase of 2,4-D concentration from 0.005 mg/L to 0.5 mg/L, the kinds of regenerated organs will change by the order as follows: vegetative bud, inflorescence, inflorescence branch, flower bud, tepal. These regularities will be able to be used for inducing the direct regeneration of a given epigeous organ in angiosperms.
文摘Naipaul's novel A bend in the river illustrates the social confusion and people's destitution and wasting time in African countries after their national independence. An important reason is the president's self-publicity, tyrannical hess and destructiveness. Whereas the author's subjective suspicion is visible in democratic development of African countries. Indeed, in a country development, it is quite necessary to depend on its citizen, observing public feelings; controlling a state with science; benefiting citizen; utilizing resources; constructing homestead, intending creation with a harmonious and stable way.
文摘Teachers are the backbones of any educational institutions. They not only play vital roles in students' development;they also directly affect the stature of their respective scholastic organizations. Highly qualified instructors produce competent and well-rounded students— learners who are more than ready to face the quirks and challenges of the labor force. This paper primarily discusses the following questions: What is teacher's professional development? What is higher vocational teacher's professional development? And how can scholastic institutions promote it? The conclusion states that the characteristics of higher vocational education directly influence the higher vocational teacher's professional development; therefore, it must be nurtured and promoted for the development of all the stakeholders of learning institutions – students, teachers, management staff,the learning institution itself, and the nation as a whole.
基金supported by grants from the NIDCR, NIH (DE012711 and DE014078) to Yang ChaiNational Natural Science Foundation of China (81170943)+1 种基金Beijing Natural Science Foundation (7122051)Funding for Talents in Beijing (D) (2010D003034000012) to Xiao-Feng Huang
文摘The root is crucial for the physiological function of the tooth, and a healthy root allows an artificial crown to function as required clinically. Tooth crown development has been studied intensively during the last few decades, but root development remains not well understood. Here we review the root development processes, including cell fate determination, induction of odontoblast and cementoblast differentiation, interaction of root epithelium and mesenchyme, and other molecular mechanisms. This review summarizes our current understanding of the signaling cascades and mechanisms involved in root development. It also sets the stage for de novo tooth regeneration.
文摘The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded version of the protocol was written for professional health care providers with a consumer version tailored for family caregivers. The underlying mid-range theory is presented along with a seminal study that was followed by further research in the United States, Canada, Great Britain, France, Sweden, Norway, Japan and Taiwan. Key studies are summarized. Given its efficacy when implemented by research staff, studies have advanced to testing the intervention under real-life conditions when implemented and evaluated by trained nursing assistants in long-term care facilities and visiting family members. In addition, one study evaluated the implementation of music by family members in the home setting. Initial research focused on agitation as the dependent variable with subsequent research indicating a more holistic response such as positive affect, expressed satisfaction, and meaningful interaction with others. The article advances by describing on-line programs designed to train health care professionals in the assessment, implementation and evaluation of individualized music. In addition, Gerdner has written a story for apicture book intended for children and their families(in press). The story models principles of individualized music to elicit positive memories, reduce anxiety and agitation, and promote communication. The article concludes with implications for future research.
基金Supported by Ministero dell'Università e della Ricerca,No. PRIN 2007LNKSYS,No.2007AWZTHH_004 and No.2009WBFZYM_002Association Fran aise contre les Myopathies,No. Project 12992+1 种基金Associazione Italiana per la Ricerca sul Cancro,No. Project 6021Fondazione Cassa di Risparmio di Perugia,No. 2007.0218.020,No.2009.020.0021 and No.2012.0241.021
文摘The Ca 2+-binding protein of the EF-hand type,S100B,exerts both intracellular and extracellular regulatory activities.As an intracellular regulator,S100B is involved in the regulation of energy metabolism,transcription,protein phosphorylation,cell proliferation,survival,differentiation and motility,and Ca 2+ homeostasis,by interacting with a wide array of proteins(i.e.,enzymes,enzyme substrates,cytoskeletal subunits,scaffold/adaptor proteins,transcription factors,ubiquitin E3 ligases,ion channels) in a restricted number of cell types.As an extracellular signal,S100B engages the pattern recognition receptor,receptor for advanced glycation end-products(RAGE),on immune cells as well as on neuronal,astrocytic and microglial cells,vascular smooth muscle cells,skeletal myoblasts and cardiomyocytes.However,RAGE may not be the sole receptor activated by S100B,the protein being able to enhance bFGF-FGFR1 signaling by interacting with FGFR1-bound bFGF in particular cell types.Moreover,extracellular effects of S100B vary depending on its local concentration.Increasing evidence suggests that at the concentration found in extracellular fluids in normal physiological conditions and locally upon acute tissue injury,which is up to a few nM levels,S100B exerts trophic effects in the central and peripheral nervous system and in skeletal muscle tissue thus participating in tissue homeostasis.The present commentary summarizes results implicating intracellular and extracellular S100B in tissue development,repair and regeneration.
基金This work was supported by National Key R&D Program of China(Grant No.2017YFA0604700)National Natural Science Foundation of China(Grant No.4181101243)+2 种基金the Fundamental Research Funds for the Central UniversitiesFrancesco Cherubini was supported by Nor-wegian Research Council(Grant No.286773)Paulo Pereira was sup-ported by the European Social Fund project LINESAM(Grant No.09.3.3-LMT-K-712-01-0104).
文摘The implementation of strategies to achieve the Sustainable Development Goals(SDGs)is frequently hindered by potential trade-offs between priorities for either environmental protection or human well-being.However,ecosystem services(ES)-based solutions can offer possible co-benefits for SDGs implementation that are often overlooked or underexploited.In this study,we cover this gap and investigate how experts from different countries value the SDGs and relate them with ES.A total of 66 countries participated to the survey,and answers were grouped into three macro-regions:Asia;Europe,North America,and Oceania(ENO);Latin America,Caribbean and Africa(LA).Results show that the most prioritized SDGs in the three macro-regions are usually those related to essential material needs and environmental conditions,such as SDG2(Zero Hunger),SDG1(No Poverty),and SDG6(Clean Water).At a global scale,the number of prioritized synergies between SDGs and ES largely exceeded trade-offs.The highest amount of synergies was observed for SDG1(No Poverty),mainly with SDG2,SDG3(Good Health),SDG5(Gender Equality),and SDG8(Economic Growth).Other major synergies among SDGs include SDG14-15(Life below water-Life on land),SDG5-10(Gender Equity-Reduced Inequality),and SDG1-2(No poverty-Zero Hunger).At a global scale,SDG15,SDG13,SDG14,and SDG6 were closely related to ES like climate regulation,freshwater,food,water purification,biodiversity,and education.SDG11(Sustainable Cities)and SDG3 were also relevant in Asia and in LA,respectively.Overall,this study shows the potential to couple future policies that can implement SDGs’strategies while adopting ES-based solutions in different regions of the world.
文摘Classically Alzheimer's disease and vascular dementia have been considered as two different entities, with their own clinical criteria, but relatively recent epidemiological and clinicopathological studies suggest an overlap between them sharing not only most of the risk factors and some clinical aspects but also pathophysiological mechanisms. Cerebrovascular lesions, especially small vessel disease (lacunar infarcts, white matter hyperintensities and microbleeds), may magnify the effects of mild Alzheimer's disease pathology and promote the progression of cognitive decline and may also be a precursor of neuronal damage and dementia. "Vascular hypothesis" of Alzheimer's disease would open a window for new approaches and treatments.
文摘The time period between 2020 and 2035 is vital for China to achieve its second centennial goal.During this period,China must avoid the middle-income trap and achieve socialist modernization.To accomplish this goal,China must maintain a certain pace of economic growth and strive to double its real GDP per capita by 2035.However,by the current growth trajectory,China’s average economic growth rate is expected to stay at approximately 3.8%over the period between 2020-2035.This makes the GDP per capita growth target hard to achieve.Even when in a high-quality development stage,China should speed up economic growth while enhancing growth quality.Speed and quality are interdependent rather than contradictory with each other.To ramp up economic growth potentials,China must proceed with market-oriented reforms and shift economic growth drivers.To improve economic growth quality,household consumption should be increased to unleash China’s full potential,not only as the factory floor of the world but also one of world’s biggest markets,i.e.“dual circulations.”With appropriate policy response,China’s economy will be poised to achieve the goal of doubling real GDP per capita by 2035,marking a large stride in its economic aggregate and urban and rural household per capita incomes.
基金supported by the NIH grants R01DE025866 from NIDCRR01AR070877 from NIAMSsupported by the 111 Project, MOE (B14038), China
文摘How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases.
基金supported by grants from the Irish Research Council(R13702 and R15897SVH/AS/G’OK)+3 种基金the Health Research Board of Ireland(HRA/2009/127GO’K/AS)Science Foundation Ireland(10/RFP/NES2786GO’K)
文摘Neuroprotection and neuroregeneration are two of the most promising disease-modifying ther- apies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinsoffs disease. Several neurotrophic fac- tors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.
文摘Crohn’s disease(CD)is a chronic inflammatory disorder of the gastrointestinal tract with an increasing incidence worldwide.Comprehensive therapy for CD focuses on symptom control and healing the intestinal mucosa to improve the quality of life and prevent complications.Surgical intervention plays a vital role in comprehensive therapy.However,deciding the optimal timing for surgical intervention has long been a focus of controversy.This review provides insights into the timing of surgery for CD and guides clinicians in daily treatment.
文摘Since 1986. a brand-new modern industrial city, full of vigor and vitality, has been towering aloftrapidly in what used to be salt marsh in the western part of Bohai Bay of China. With an annual out-put value of RMB ? 14 billion. it has become one of the most lively and energetic areas of Tianjin andeven throughout the country for opening to the outside world and for developing exportoriented econo-