Lymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma

AIM:Clinicopathologic factors predicting overall survival (OS) would help identify a subset to benefit from adjuvant therapy. METHODS: One hundred and sixty-nine patients patients from 1984 to 2009 with curative resections for pancreatic adenocarcinoma were included. Tumors were staged by American Joint Committee on Cancer 7th edition criteria. Univariate and multivariable analyses were performed using Kaplan-Meier methodology or Cox proportional hazard models. Log-rank tests were performed. Statistical inferences were assessed by two-sided 5% significance level. RESULTS: Median age was 67.1 (57.2-73.0) years with equal gender distribution. Tumors were in the head (89.3%) or body/tail (10.7%). On univariate analysis, adjuvant therapy, lymph node (LN) ratio, histologic grade, negative margin status, absence of peripancreatic extension, and T stage were associated with improved OS. Adjuvant therapy, LN ratio, histologic grade, number of nodes examined, negative LN status, and absence of peripancreatic extension were associated with improved recurrence-free survival (RFS). On multivariable analysis, LN ratio and carbohydrate antigen (CA) 19-9 levels were associated with OS. LN ratio was associated with RFS. CONCLUSION: The LN ratio and CA 19-9 levels are independent prognostic factors following curative resections of pancreatic cancer.

Life Sciences and the Overall Quality of Society

Human survival and develop-ment are closely linked with the lifesciences. Agriculture, population,medicine, the environment andecology, all of them are inseparablefrom the development of life sci-ences and technologies, and it is onlife sciences that the human racedepends for sustainable economicdevelopment in the future.

The Coupling Coordination Evolution Research of Economy - Ecology - Society System in Xinjiang：Based on the Interaction Perspective of Water Resources

Under the water resources perspective,coupling coordination of economy-ecology-society system in Xinjiang was taken as the research object. By building the coupling evaluation index system of the water resources-economy-ecology-society system,quantitative evaluation and analysis of the coupling coordination of the water resources-economy-ecology-society system from 2001 to 2014 were conducted. The results showed that benefit indexes of economic system and social system grew rapidly,while benefit indexes of water resources system and ecosystem fluctuated smoothly from 2001 to 2014; coupling state of the whole system was at rival stage,and coupling coordination was reluctant coordination type,and the coupling index was slightly higher than the coupling coordination index. Moreover,it showed that the more the coupling systems,the lower indices of coupling and the coupling coordination.

CONFERENCE At-A-Glance SOCIETY FOR ACUPUNCTURE RESEARCH“Translational Research in Acupuncture:Bridging Science,Practice and Community” Chapel Hill,NC,March 19-21,2010

THURSDAY,March 18 Pre-Conference Workshops"lntroduction to current issues in acupunclure research""ConsideratiOns for developing COllaboration research between AOM COlleges and conventionaI medicalinstitutions"

High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer

AIM:To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9(CA 19-9)level in gastric cancer.METHODS:Between January 2005 and December2006,1960 patients underwent surgery for histologically confirmed gastric cancer.Of these,163 patients had elevated serum levels of CA 19-9 preoperatively,and1628 patients had normal serum levels of CA 19-9 preoperatively.For this study,325 patients were selected from the group of 1628 patients by age,sex,and cancer stage to serve as controls.Statistically significant differences in survival rates were calculated using the log-rank test.A P value less than 0.05 was considered statistically significant and was determined using SAS software.RESULTS:The baseline characteristics showed some differences between the two groups with regard to histology.Overall survival(OS)in the elevated and nonelevated group was 37.90 and 68.67 mo,respectively(P<0.001).N stage(P=0.001)was a significant predictor of disease-free survival by multivariate analysis.Also,N stage(P<0.001),and the presence of peritoneal metastasis(P<0.001)remained independent factors in predicting OS by multivariate analysis.Additionally,preoperative serum CA 19-9 levels were significantly associated with OS in univariate(P=0.009)and multivariate(P=0.021)analyses.CONCLUSION:Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer.

Prognostic efficacy of inflammation-based markers in patients with curative colorectal cancer resection

AIM To evaluate the prognostic significance of neutrophilto-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), lymphocyte-to-monocyte ratio(LMR), and prognostic nutritional index(PNI) and other clinicopathological factors in patients undergoing curative resection of colon cancer.METHODS183 patients with histologically proven colorectal cancer who had undergone potentially curative resection between 2010 and 2016 at Ankara Numune Training and Research Hospital were retrospectively analyzed and clinicopathological characteristics included age, sex, tumor type, grade, size and localization, the number of metastatic and total number of lymph nodes removed, vascular and perineural invasion of the tumor, TNM stages, tumor marker levels(CEA, CA19-9, AFP, CA-125, CA15-3), complete blood counts, albumin levels, overall survival(months), NLR, PLR, LMR and PNI ratios were retrospectively reviewed and analyzed from the electronic database. The primary outcome measure was overall survival.RESULTS Regarding overall survival, on univariate analysis the following variables were significantly associated with poor outcome following resection: T-stage(P = 0.037), lymph node invasion(P = 0.037), cancer stage(P = 0.034), CEA(P = 0.042), CA19-9(P = 0.004), and PNI(P = 0.001). To evaluate the independent prognostic value, multivariate Cox proportional hazard analysis to control for other prognostic factors was used. Using cancer-specific death as an end point for NLR, PLR, LMR, PNI and CA19-9 the optimal cut off values were calculated by ROC analysis. Regarding overall survival, on multivariate analysis high CA19-9(HR = 1.001, 95%CI: 1.00-1.002, P = 0.012) and low PNI(HR = 0.938, 95%CI: 0.891-0.987, P = 0.014) were the only variables independently associated with shortened overall survival. Patients with a PNI < 35 had a median OS of 52.25 mo. In contrast, patients with an PNI > 35 had a median OS of 66 mo. Patients with a CA 19-9 < 17 had a median OS of 66 mo and in patients with a CA19-9 > 17 had a median OS of 53.76 mo.CONCLUSION This study shows that decrease in the PNI and increase in CA 19-9 is associated with poor survival in patients with resectable colon cancer.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

总体国家安全观视阈下智库安全治理对策研究

[目的/意义]智库是开展政策理论研究的决策咨询机构和专业力量。以高水平安全保障高质量发展格局,对智库安全治理体系和能力建设提出新要求。智库安全治理与国家安全治理现代化体系建设息息相关,开展智库安全治理的风险挑战及对策路径研究具有重要意义。[方法/过程]本文基于总体国家安全观的整体性安全视阈,深入分析智库安全治理的价值意蕴,运用风险社会理论探讨当前我国智库安全治理存在的风险挑战,为规避智库安全风险、强化智库安全治理水平提出对策路径。[结果/结论]智库安全是国家安全的重要组成部分。当前我国智库安全治理面临外部环境风险加剧、智库数字化转型、智库安全治理体制机制不健全等困境。从环境风险、技术风险和制度风险三个角度出发,本文提出防范与化解外部环境风险、强化数字化智库安全治理技术支撑和完善智库安全治理制度规范等智库安全治理的针对性对策,以提升中国特色新型智库安全治理水平和建设质量。

社区教育发展的海南经验及优化对策

海南省近年来高度重视社区教育,努力探索城乡社区教育发展路径。在省社区教育指导中心统筹指导和海南开放大学(海南社区教育大学)的引领下,全省初步建立了社区教育管理组织和教育机构,形成多种管理模式和运行机制,推动了海南社区教育快速起步和特色发展。但在工作实践中,全省社区教育发展不够平衡,工作中还存在一些具体困难和问题。针对存在的问题,文章在进一步完善“四级”社区教育服务网络、加强政府统筹和部门协同、完善制度保障、开展社区教育标准化建设、推进地方终身教育立法等方面提出了对策,以促进海南社区教育高质量发展。

和谐社会构建中城乡群众体育统筹发展的战略思考

通过对我国城乡群众体育发展现状的典型调查,反映出现阶段城乡群众体育发展的不均衡性,揭示了城乡统筹是群众体育协调发展的现实必要性。依据构建和谐社会的需求,分别对我国群众体育城乡统筹的内涵理解、理论选择、发展原则进行了理论探讨,在此基础上,提出了城乡统筹的群众体育发展战略对策。

全面建成小康社会进程中休闲体育发展的角色定位

全面小康社会经历了提出、总结、建设及建成等阶段,是休闲体育发展的前提条件,二者关联紧密。全面建成小康社会进程中休闲体育面临余暇难度、富裕不足、病态风行、人际淡化、生态破坏等挑战,同时也是其不断推进的机遇。因此,需将休闲体育的角色定位为:刺激体育消费、拉动经济增长的新引擎;加强社会治理、提升政治文明的稳定器;提高人口质量、促进健康发展的动力源;改变生活方式、承接健身战略的新手段及融入城乡规划、建设生态文明的推动者。

生态化技术创新与和谐社会构建

生态化技术创新是一种新的技术创新观,与构建和谐社会的生态文明、经济社会全面协调发展、坚持以人为本的发展理念相契合。本文从自然生态、经济生态、社会生态、人的生态化等方面探讨了生态化技术创新对构建和谐社会的推动作用。

经济法对社会整体利益的维护

社会整体利益因事关人类社会整体生存和发展而成为所有法律部门共同维护的对象,但不同法律部门在法律体系中的具体功能有别,其各自对社会整体利益维护的路径也有异。基于市场失灵有损社会整体利益、国家干预是克服市场失灵的有效途径等认知,国家制定经济法确认和规范国家干预,为旨在克服市场失灵的国家干预提供法律手段和制度框架,并通过在经济法的法益结构中作出凸显社会整体利益的制度安排,最终实现对社会整体利益的维护。

我国高校大学生心理健康教育现状与发展趋势

长期以来,大学生心理健康教育在我国高校对大学生的教育中的作用没有得到应有的重视。文章从大学生心理健康教育的历史、现状进行梳理,探索适应全面建设小康社会需要的高素质人才培养所必需的大学生心理健康教育模式,以期为新时期我国高等教育提供有益的参考。

关于品德与社会课程整体建设的几点思考

品德与社会课程是在小学中高年级开设的一门以儿童社会生活为基础，促进学生良好品德形成和社会性发展的综合课程。这门课程在课程设计、课程内容、教学理念、教学形式上，都发生了许多可喜可贺的变化。但是，经过十余年教学实践的检验，发现在课程定位、内容选取、教材呈现、资源开发、教师队伍建设、教学评价、课程管理等方面也还存在着有待进一步研究和改进的问题。希望这些问题能够引起课程标准研制者、教材编写者、教学实践者和教育行政管理者的共同关注，加强品德与社会课程的整体建设，真正实现本课程在义务教育中所承载的教育功能。

和谐社会背景下统筹城乡职业教育发展战略探讨

统筹城乡职业教育发展,是统筹城乡发展的重要组成部分,是推进职业教育发展、打破城乡二元体制、促进教育公平、推动新农村建设的重要举措。统筹城乡职业教育发展应坚持主导性、渐进性、发展性、系统性原则,要在师资队伍建设、人才培养模式、配套制度、城乡合作机制等方面给予相应的政策保障。

福利与人权

多数人认为人权是政治问题 ,在经济学领域 ,也很少有人讨论人权。其实 ,人的经济行为都在追求福利最大 ,这是每一个从事经济活动的人都应有的权利。福利和人权的关系理应属于伦理经济学范畴。从经济学的深层意义去讨论经济、人权、福利、人的全面发展的关系 ,应该是今后一段时期在理论经济学界要引起重视的课题。

西部退耕还林工程对农村建设全面小康社会的影响评价——以甘肃省安定区为例

在介绍农村全面小康内涵的基础上，通过设置评价指标体系，以甘肃省安定区为例，利用实地调查资料及统计资料，从经济发展、生活质量、社会进步与科教、生态与人居环境4个方面，评价了西部退耕还林工程对农村建设全面小康社会的影响。同时，根据工程实施中存在的问题，提出了巩固退耕还林成果。建设农村全面小康社会的对策建议。

发展传播学视野中的媒介理论变迁

发展传播理论是20世纪下半叶以来围绕传播与社会发展问题兴起的理论范式。由于全球大众传播领域的迅猛发展以及全球政治经济结构的变化,发展传播理论经历了自身理论范式的转换,并面对全球化的新发展视野。重新审视20世纪50年代以来发展传播学视野中大众媒介的角色与功能,在构建和谐社会、全面建设小康社会的国内环境以及全球化的语境中具有重要意义。

发展绿色外贸促进湖北省少数民族地区实现全面小康——以湖北省长阳土家族自治县的高山蔬菜产业为例

十六大提出要全面建设小康社会,建设农村小康社会。湖北省民族地区作为经济贫困地区,尤其要采取各种措施实现小康。本文以湖北长阳土家族自治县的高山蔬菜产业为例,阐述了发展绿色外贸是湖北省民族地区实现全面小康的重要途径,并根据现阶段存在的问题,提出了若干经营策略。