Objective:To explore the antibacterial mechanism of the active components of Xiangsu powder through the network pharmacological approach.Methods:TCMSP database was used to search and obtain the active components of Xi...Objective:To explore the antibacterial mechanism of the active components of Xiangsu powder through the network pharmacological approach.Methods:TCMSP database was used to search and obtain the active components of Xiangsu powder and its corresponding action targets,and its network relationship was defined.Target points associated with antibacterial effect were searched in Genecards database,and core target genes of antibacterial effect were obtained by mnapping the target points..Finally,the GO biological process and KEGG metabolic pathway were analyzed in the DAVID database.Results:There were 129 active components,250 targets,and 66 biological processes(40 biological processes,13 molcular functions,13 cell compositions)and 35 related signaling pathways.Among theim,quercetin may be the main substance that plays a role in the drugs contained in Xiangsu powder,followed by flavonol kaempferol and favonoid luteolin.Antibacterial targets such as TNF,Casp3,PTGS2,ACTB,STAT1 and NFKB1 are mostly involved in antiviral,anti-inflammatory and immune pathways.It mainly plays a role in the hepatitis B pathway and tunor necrosis factor signaling pathway.Conclusion:Quercetin,kaempferol,luteolin and other active components in Xiangsu powder can participate in the action process of Toll-like receptor pathway,TNF signaling pathway and other pathways through acting on TNF,Casp3,PTGS2,etc.,and finally achieve the purpose of antibacterial.展开更多
基金This study was supported by Jiangxi Innovation and Entrepreneurship Training Program for College Students(S202010412079)Study on the design of mask for TCM epidemic prevention based on incense therapy.
文摘Objective:To explore the antibacterial mechanism of the active components of Xiangsu powder through the network pharmacological approach.Methods:TCMSP database was used to search and obtain the active components of Xiangsu powder and its corresponding action targets,and its network relationship was defined.Target points associated with antibacterial effect were searched in Genecards database,and core target genes of antibacterial effect were obtained by mnapping the target points..Finally,the GO biological process and KEGG metabolic pathway were analyzed in the DAVID database.Results:There were 129 active components,250 targets,and 66 biological processes(40 biological processes,13 molcular functions,13 cell compositions)and 35 related signaling pathways.Among theim,quercetin may be the main substance that plays a role in the drugs contained in Xiangsu powder,followed by flavonol kaempferol and favonoid luteolin.Antibacterial targets such as TNF,Casp3,PTGS2,ACTB,STAT1 and NFKB1 are mostly involved in antiviral,anti-inflammatory and immune pathways.It mainly plays a role in the hepatitis B pathway and tunor necrosis factor signaling pathway.Conclusion:Quercetin,kaempferol,luteolin and other active components in Xiangsu powder can participate in the action process of Toll-like receptor pathway,TNF signaling pathway and other pathways through acting on TNF,Casp3,PTGS2,etc.,and finally achieve the purpose of antibacterial.
