With the change of people’s lifestyle and diet,the incidence of anorectal diseases is increasing year by year.Anal fistula is a common anorectal disease.Because it cannot heal by itself,surgery has become the main tr...With the change of people’s lifestyle and diet,the incidence of anorectal diseases is increasing year by year.Anal fistula is a common anorectal disease.Because it cannot heal by itself,surgery has become the main treatment method.Due to the particularity of wound location and physiological structure,the wound is easily contaminated by bacteria,so dressing change after surgery plays a decisive role in wound healing.Modern western medicine and traditional Chinese medicine have different dressing changing methods respectively.In this paper,we reviewed commonly used dressing changing methods of traditional Chinese and western medicine after anal fistula surgery.展开更多
In the study of the mechanism of wound healing after anal fistula surgery,how to scientifically and efficiently promote wound healing is of great significance.At present,modern medical treatment of wounds after anal f...In the study of the mechanism of wound healing after anal fistula surgery,how to scientifically and efficiently promote wound healing is of great significance.At present,modern medical treatment of wounds after anal fistula surgery mostly focuses on physical therapy intervention,new wound dressing and packing,and external application of growth factors.However,these therapies have many problems,and there is still no consensus on their clinical use.Traditional Chinese Medicine(TCM)has several methods to promote wound healing,such as oral administration,rubbing,and fumigation,which have a long history and obvious efficacy,but research in this area is relatively scattered and lacks classification and summarizing.Therefore,this paper analyzes and summarizes the existing research on TCM for promotion of wound healing after anal fistula surgery,carries out targeted analyses according to different clinical syndromes and treatment methods,and analyzes the defects in current research and anticipates future research trends in order to provide theoretical support for the advantages of TCM in promoting wound healing after anal fistula surgery.展开更多
Anal fistula is a common disease in anorectal department that typically describes a miscommunication between the anorectum and the perianal skin. At present, surgical treatment is effective for anal fistulae, but the ...Anal fistula is a common disease in anorectal department that typically describes a miscommunication between the anorectum and the perianal skin. At present, surgical treatment is effective for anal fistulae, but the formation of fistula is different due to individual difference, consequently leading to a limited efficacy of surgical treatment. TCM has recently shown its unique advantages in accelerating the wound healing after anal fistula surgery, but the standards for syndrome differentiation of anal fistulae are still in deficiency. Thereby, this article mainly explored the key points of common syndromes, TCM nursing methods and health guidance of anal fistulae, in order to further develop the advantages of TCM and standardize related nursing management .展开更多
Diabetes mellitus(DM)is a complex disease that often causes multiple systemic complications that have become a major international public health problem.Diabetic foot(DF)is one of the severe and frequent chronic compl...Diabetes mellitus(DM)is a complex disease that often causes multiple systemic complications that have become a major international public health problem.Diabetic foot(DF)is one of the severe and frequent chronic complications of DM due to vascular lesions and neuropathy.DF ulcers(DFU)affect approximately 15%of people with DM and are the leading cause of death and disability.The prevalence and recurrence of DF are worrisome,and morbidity and mortality are also on the rise,which poses a substantial socioeconomic burden.Treating DF is difficult for clinicians and requires multidisciplinary cooperation,combining local and systemic therapy to reduce amputation and case-fatality rates.Traditional Chinese Medicine(TCM)has received extensive attention due to noticeable therapeutic effects and few adverse reactions.In recent years,research on DF treatment by TCM has been increasing,and further progress has been made.TCM includes oral medication,injectable preparations,and adjuvant therapy.This article reviews the relevant research on TCM-related adjuvant therapy for DF.We describe current progress in TCM in terms of external application,acupuncture,massage,acupoint injection,foot bath,fumigation,and moxibustion,as well as the mechanisms involved.展开更多
Background:Skin wound healing depends on the progress of different but overlapping stages of healing,including hemostasis,inflammatory,proliferative and remodeling.Failure of these stages to occur in a timely and grad...Background:Skin wound healing depends on the progress of different but overlapping stages of healing,including hemostasis,inflammatory,proliferative and remodeling.Failure of these stages to occur in a timely and gradual manner may result in non-healing pathological wounds.Macrophages and neutrophils have been shown to play an essential role in the inflammatory responses of wound tissue,and their active plasticity allows them to modulate tissue damage and repair functions.The ability of macrophages and neutrophils to regulate the occurrence and resolution of inflammatory processes is essential for the treatment of pathological wound healing.Methods:Mice were categorized into negative control,streptozotocin,streptozotocin+puerarin and puerarin groups.The traditional Chinese medicine extract puerarin was selected to treat different groups of mice with a full-thickness skin defect wound.Cells of the RAW264.7 cell line were stimulated under different puerarin conditions.Then,real time quantitative polymerase chain reaction(RT-qPCR),western blot,immunofluorescence and other assays were carried out to explore the effect of puerarin on wound healing and its molecular mechanism.Results:Animal experiments found that the wound healing of diabetic mice treated with puerarin was significantly accelerated,and histological analysis found that puerarin treatment markedly decreased the infiltration of macrophages and neutrophils in wound tissue.Through western blot,RT-qPCR and immunofluorescence experiments,it was observed that puerarin treatment remarkably inhibited nuclear factor kinase B(NF-κB)and mitogen-activated protein kinase(MAPK)signaling pathways,downregulated the expression of inflammatory cytokines and induced the M2 polarization of macrophages.At the cellular level,we also observed that puerarin improved M2 macrophage polarization and inhibited inflammatory pathway activation in a high-glucose culture.Conclusion:Puerarin has a significant therapeutic effect on wound healing in diabetic mice.The therapeutic effect is achieved by regulating macrophage polarization through suppressing NF-κB and MAPK signaling cascades.展开更多
基金Shaanxi Provincial Key Research and Development Program(Project number:2021SF-351)。
文摘With the change of people’s lifestyle and diet,the incidence of anorectal diseases is increasing year by year.Anal fistula is a common anorectal disease.Because it cannot heal by itself,surgery has become the main treatment method.Due to the particularity of wound location and physiological structure,the wound is easily contaminated by bacteria,so dressing change after surgery plays a decisive role in wound healing.Modern western medicine and traditional Chinese medicine have different dressing changing methods respectively.In this paper,we reviewed commonly used dressing changing methods of traditional Chinese and western medicine after anal fistula surgery.
基金Shaanxi Natural Science Basic Research Project:Study on the Mechanism of“Wei Nong Zhang Rou”Promoting Wound Healing from the Correlation between Hygrothermal Synthesis and NF-κB/AQP Pathway(No.2020JM-588)National Natural Science Foundation of China:Study on the Mechanism of Inhibiting Wound Inflammation after Anal Fistula Surgery by“Wei Nong Zhang Rou”Method Based on MicroRNA Mediated Macrophage Polarization in Exosomes from Wound Seepage(No.82174384)。
文摘In the study of the mechanism of wound healing after anal fistula surgery,how to scientifically and efficiently promote wound healing is of great significance.At present,modern medical treatment of wounds after anal fistula surgery mostly focuses on physical therapy intervention,new wound dressing and packing,and external application of growth factors.However,these therapies have many problems,and there is still no consensus on their clinical use.Traditional Chinese Medicine(TCM)has several methods to promote wound healing,such as oral administration,rubbing,and fumigation,which have a long history and obvious efficacy,but research in this area is relatively scattered and lacks classification and summarizing.Therefore,this paper analyzes and summarizes the existing research on TCM for promotion of wound healing after anal fistula surgery,carries out targeted analyses according to different clinical syndromes and treatment methods,and analyzes the defects in current research and anticipates future research trends in order to provide theoretical support for the advantages of TCM in promoting wound healing after anal fistula surgery.
文摘Anal fistula is a common disease in anorectal department that typically describes a miscommunication between the anorectum and the perianal skin. At present, surgical treatment is effective for anal fistulae, but the formation of fistula is different due to individual difference, consequently leading to a limited efficacy of surgical treatment. TCM has recently shown its unique advantages in accelerating the wound healing after anal fistula surgery, but the standards for syndrome differentiation of anal fistulae are still in deficiency. Thereby, this article mainly explored the key points of common syndromes, TCM nursing methods and health guidance of anal fistulae, in order to further develop the advantages of TCM and standardize related nursing management .
文摘Diabetes mellitus(DM)is a complex disease that often causes multiple systemic complications that have become a major international public health problem.Diabetic foot(DF)is one of the severe and frequent chronic complications of DM due to vascular lesions and neuropathy.DF ulcers(DFU)affect approximately 15%of people with DM and are the leading cause of death and disability.The prevalence and recurrence of DF are worrisome,and morbidity and mortality are also on the rise,which poses a substantial socioeconomic burden.Treating DF is difficult for clinicians and requires multidisciplinary cooperation,combining local and systemic therapy to reduce amputation and case-fatality rates.Traditional Chinese Medicine(TCM)has received extensive attention due to noticeable therapeutic effects and few adverse reactions.In recent years,research on DF treatment by TCM has been increasing,and further progress has been made.TCM includes oral medication,injectable preparations,and adjuvant therapy.This article reviews the relevant research on TCM-related adjuvant therapy for DF.We describe current progress in TCM in terms of external application,acupuncture,massage,acupoint injection,foot bath,fumigation,and moxibustion,as well as the mechanisms involved.
基金supported by The National Natural Science Foundation of China(81974288).
文摘Background:Skin wound healing depends on the progress of different but overlapping stages of healing,including hemostasis,inflammatory,proliferative and remodeling.Failure of these stages to occur in a timely and gradual manner may result in non-healing pathological wounds.Macrophages and neutrophils have been shown to play an essential role in the inflammatory responses of wound tissue,and their active plasticity allows them to modulate tissue damage and repair functions.The ability of macrophages and neutrophils to regulate the occurrence and resolution of inflammatory processes is essential for the treatment of pathological wound healing.Methods:Mice were categorized into negative control,streptozotocin,streptozotocin+puerarin and puerarin groups.The traditional Chinese medicine extract puerarin was selected to treat different groups of mice with a full-thickness skin defect wound.Cells of the RAW264.7 cell line were stimulated under different puerarin conditions.Then,real time quantitative polymerase chain reaction(RT-qPCR),western blot,immunofluorescence and other assays were carried out to explore the effect of puerarin on wound healing and its molecular mechanism.Results:Animal experiments found that the wound healing of diabetic mice treated with puerarin was significantly accelerated,and histological analysis found that puerarin treatment markedly decreased the infiltration of macrophages and neutrophils in wound tissue.Through western blot,RT-qPCR and immunofluorescence experiments,it was observed that puerarin treatment remarkably inhibited nuclear factor kinase B(NF-κB)and mitogen-activated protein kinase(MAPK)signaling pathways,downregulated the expression of inflammatory cytokines and induced the M2 polarization of macrophages.At the cellular level,we also observed that puerarin improved M2 macrophage polarization and inhibited inflammatory pathway activation in a high-glucose culture.Conclusion:Puerarin has a significant therapeutic effect on wound healing in diabetic mice.The therapeutic effect is achieved by regulating macrophage polarization through suppressing NF-κB and MAPK signaling cascades.
