The analgesic effect of Semen Coicis was observed with the sequential trial in 26 cases of severe functional dysmenorrhea. The results showed that the markedly effective rate was 90%, which was much better than th... The analgesic effect of Semen Coicis was observed with the sequential trial in 26 cases of severe functional dysmenorrhea. The results showed that the markedly effective rate was 90%, which was much better than that of the control group treated by indomethacin plus subcutaneous injection of atropine (P≤0.01).展开更多
Chronic musculoskeletal pain(CMP)is a common occurrence in clinical practice and there are a variety of options for the treatment of it.However,the pharmacological therapy is still considered to be a primary treatment...Chronic musculoskeletal pain(CMP)is a common occurrence in clinical practice and there are a variety of options for the treatment of it.However,the pharmacological therapy is still considered to be a primary treatment.The recent years have witnessed the emergence of opioid crisis,yet there are no relevant guidelines on how to treat CMP with non-opioid analgesics properly.The Chinese Medical Association for the Study of Pain convened a panel meeting to develop clinical practice consensus for the treatment of CMP with non-opioid analgesics.The purpose of this consensus is to present the application of nonsteroidal antiinflammatory drugs,serotonin norepinephrine reuptake inhibitors,serotonin and norepinephrine reuptake inhibitors,muscle relaxants,ion channel drugs and topical drugs in CMP.展开更多
胰腺癌是一种具有高度侵袭性的肿瘤,嗜神经生长是胰腺癌的重要生物学特点,其对神经的侵犯给患者带来极大的疼痛负担,严重影响患者生存质量和生存意志。世界卫生组织(World Health Organization,WHO)癌痛“三阶梯镇痛原则”是传统治疗癌...胰腺癌是一种具有高度侵袭性的肿瘤,嗜神经生长是胰腺癌的重要生物学特点,其对神经的侵犯给患者带来极大的疼痛负担,严重影响患者生存质量和生存意志。世界卫生组织(World Health Organization,WHO)癌痛“三阶梯镇痛原则”是传统治疗癌性疼痛的治疗方案,但由于其毒副作用明显、疗效差、易成瘾、易耐药以及医师临床用药不规范等因素,无法满足患者病情需要。近年来,随着介人技术的发展以及广泛的临床试验的开展,介入作为癌痛管理的“第四阶梯”,其治疗手段以及各种影像引导方式的发展与应用,如神经毁损术、^(125)I粒子植入术、患者自控镇痛泵技术、鞘内药物输注系统植入术等,临床疗效得到了有力证明,为癌痛患者提供了方便、安全、有效的治疗方式。展开更多
Treatment of health problems that accompany aging often includes pharmacotherapy. It is thus common for older adults—and, increasingly, younger adults—to be on multiple medications, either prescription or over-the-c...Treatment of health problems that accompany aging often includes pharmacotherapy. It is thus common for older adults—and, increasingly, younger adults—to be on multiple medications, either prescription or over-the-counter (OTC). With the consumption of multiple medications, drug-drug interactions (DDIs) are a concern. The site of drug-drug interactions is often at the level of drug metabolism. If a drug inhibits (or enhances) the metabolism of another, the blood level (therapeutic effect) can be decreased below the required level, or adverse effects can increase. Because most currently used drugs are metabolized via cytochrome P450-catalyzed pathways, drug discovers seek drugs that are metabolized by alternate pathways. Medicinal chemists have come upon a strategy—the incorporation of oxetane rings in the drug structure—that increases the likelihood that a drug will not be metabolized via CYP450. The same modification gives other desirable physical properties to the molecule. Although there are no guarantees that there will be fewer DDIs or an absence of other unexpected problems, the strategy could pave the way for new drugs that are safer and easier to use with concomitant medications.展开更多
Objective: In order to manage the varied pathophysiological features of sickle cell disease (SCD), an array of drugs has to be used. The specific drugs used, however, depend on the locality. This study was aimed at fi...Objective: In order to manage the varied pathophysiological features of sickle cell disease (SCD), an array of drugs has to be used. The specific drugs used, however, depend on the locality. This study was aimed at finding out the drug regimen prescribed by clinicians to sickle cell disease patients who attended a Sickle Cell Clinic in Kumasi, Ghana. Method: The setting for the study is the Sickle Cell Clinic at the Komfo Anokye Teaching Hospital, Ghana, and a questionnaire was used as the study instrument. Information on drug prescription on each day of clinic visit was extracted from the medical records of the patients. Results: The drugs prescribed were “routine drugs” for SCD patients, analgesics, narcotics, anti-malarials, antibiotics, haematinics and miscellaneous drugs. The top ten commonly prescribed drugs were folic acid, diclofenac, ibuprofen, B-complex, routine drugs, artesunate/amodiaquin, paracetamol, penicillin V, amoxiclav and zincovit. Conclusion: Within the year, the drugs prescribed included those that could prevent vitamin and zinc deficiency due to continuing haemolysis, those that could mitigate the pain and inflammation from vaso-occlusion and reperfusion injury, as well as antibiotics to combat infections. Being a malarial-endemic region, prophylaxis with daraprim and symptomatic malaria fever therapy were common practices. This study has thus shown that the well-being of SCD patients in our typical tropical terrain, depends on haematinic vitamin/mineral supplements, anti-malarials, analgesics-anti-inflammatory, antipyretics and antibiotics.展开更多
目的对下肢缺血性疼痛患者不同镇痛药物方案的应用情况进行分析,对临床用药提供参考。方法选取2018年10月1日至2022年10月31日下肢缺血性疼痛住院患者作为研究对象,采用回顾分析法对患者镇痛药物方案进行分析,收集患者基本情况、镇痛药...目的对下肢缺血性疼痛患者不同镇痛药物方案的应用情况进行分析,对临床用药提供参考。方法选取2018年10月1日至2022年10月31日下肢缺血性疼痛住院患者作为研究对象,采用回顾分析法对患者镇痛药物方案进行分析,收集患者基本情况、镇痛药物使用情况、疼痛视觉模拟量表(VAS)评分、不良反应等进行分析。结果共入组患者71例,按照镇痛方案分阿片类药物组30例、阿片类药物+非甾体抗炎药组(NSAIDs)32例和坐骨神经阻滞组9例。3组患者性别、年龄、病程、合并疾病及吸烟史的比较,差异无统计学意义(P>0.05);坐骨神经阻滞组VAS评分下降值和阿片类药物组、阿片类药物联合NSAIDs组比较,差异有统计学意义(分别为6.667±1.658 vs 3.567±0.817,t=7.716,P<0.001;6.667±1.658 vs 3.938±0.982,t=6.271,P<0.001)。阿片类药物组和阿片类药物联合NSAIDs组比较,差异无统计学意义(P>0.05)。3组不良反应和安全性比较,差异无统计学意义(P>0.05)。结论下肢缺血性疼痛镇痛药物方案有多种模式,相对于单用阿片类药物或阿片类药物联用NSAIDs,坐骨神经阻滞的应用在患者疼痛主诉和VAS评分下降改善明显,不良反应较少,值得临床应用推广。展开更多
文摘 The analgesic effect of Semen Coicis was observed with the sequential trial in 26 cases of severe functional dysmenorrhea. The results showed that the markedly effective rate was 90%, which was much better than that of the control group treated by indomethacin plus subcutaneous injection of atropine (P≤0.01).
文摘Chronic musculoskeletal pain(CMP)is a common occurrence in clinical practice and there are a variety of options for the treatment of it.However,the pharmacological therapy is still considered to be a primary treatment.The recent years have witnessed the emergence of opioid crisis,yet there are no relevant guidelines on how to treat CMP with non-opioid analgesics properly.The Chinese Medical Association for the Study of Pain convened a panel meeting to develop clinical practice consensus for the treatment of CMP with non-opioid analgesics.The purpose of this consensus is to present the application of nonsteroidal antiinflammatory drugs,serotonin norepinephrine reuptake inhibitors,serotonin and norepinephrine reuptake inhibitors,muscle relaxants,ion channel drugs and topical drugs in CMP.
文摘胰腺癌是一种具有高度侵袭性的肿瘤,嗜神经生长是胰腺癌的重要生物学特点,其对神经的侵犯给患者带来极大的疼痛负担,严重影响患者生存质量和生存意志。世界卫生组织(World Health Organization,WHO)癌痛“三阶梯镇痛原则”是传统治疗癌性疼痛的治疗方案,但由于其毒副作用明显、疗效差、易成瘾、易耐药以及医师临床用药不规范等因素,无法满足患者病情需要。近年来,随着介人技术的发展以及广泛的临床试验的开展,介入作为癌痛管理的“第四阶梯”,其治疗手段以及各种影像引导方式的发展与应用,如神经毁损术、^(125)I粒子植入术、患者自控镇痛泵技术、鞘内药物输注系统植入术等,临床疗效得到了有力证明,为癌痛患者提供了方便、安全、有效的治疗方式。
文摘Treatment of health problems that accompany aging often includes pharmacotherapy. It is thus common for older adults—and, increasingly, younger adults—to be on multiple medications, either prescription or over-the-counter (OTC). With the consumption of multiple medications, drug-drug interactions (DDIs) are a concern. The site of drug-drug interactions is often at the level of drug metabolism. If a drug inhibits (or enhances) the metabolism of another, the blood level (therapeutic effect) can be decreased below the required level, or adverse effects can increase. Because most currently used drugs are metabolized via cytochrome P450-catalyzed pathways, drug discovers seek drugs that are metabolized by alternate pathways. Medicinal chemists have come upon a strategy—the incorporation of oxetane rings in the drug structure—that increases the likelihood that a drug will not be metabolized via CYP450. The same modification gives other desirable physical properties to the molecule. Although there are no guarantees that there will be fewer DDIs or an absence of other unexpected problems, the strategy could pave the way for new drugs that are safer and easier to use with concomitant medications.
文摘Objective: In order to manage the varied pathophysiological features of sickle cell disease (SCD), an array of drugs has to be used. The specific drugs used, however, depend on the locality. This study was aimed at finding out the drug regimen prescribed by clinicians to sickle cell disease patients who attended a Sickle Cell Clinic in Kumasi, Ghana. Method: The setting for the study is the Sickle Cell Clinic at the Komfo Anokye Teaching Hospital, Ghana, and a questionnaire was used as the study instrument. Information on drug prescription on each day of clinic visit was extracted from the medical records of the patients. Results: The drugs prescribed were “routine drugs” for SCD patients, analgesics, narcotics, anti-malarials, antibiotics, haematinics and miscellaneous drugs. The top ten commonly prescribed drugs were folic acid, diclofenac, ibuprofen, B-complex, routine drugs, artesunate/amodiaquin, paracetamol, penicillin V, amoxiclav and zincovit. Conclusion: Within the year, the drugs prescribed included those that could prevent vitamin and zinc deficiency due to continuing haemolysis, those that could mitigate the pain and inflammation from vaso-occlusion and reperfusion injury, as well as antibiotics to combat infections. Being a malarial-endemic region, prophylaxis with daraprim and symptomatic malaria fever therapy were common practices. This study has thus shown that the well-being of SCD patients in our typical tropical terrain, depends on haematinic vitamin/mineral supplements, anti-malarials, analgesics-anti-inflammatory, antipyretics and antibiotics.
文摘目的对下肢缺血性疼痛患者不同镇痛药物方案的应用情况进行分析,对临床用药提供参考。方法选取2018年10月1日至2022年10月31日下肢缺血性疼痛住院患者作为研究对象,采用回顾分析法对患者镇痛药物方案进行分析,收集患者基本情况、镇痛药物使用情况、疼痛视觉模拟量表(VAS)评分、不良反应等进行分析。结果共入组患者71例,按照镇痛方案分阿片类药物组30例、阿片类药物+非甾体抗炎药组(NSAIDs)32例和坐骨神经阻滞组9例。3组患者性别、年龄、病程、合并疾病及吸烟史的比较,差异无统计学意义(P>0.05);坐骨神经阻滞组VAS评分下降值和阿片类药物组、阿片类药物联合NSAIDs组比较,差异有统计学意义(分别为6.667±1.658 vs 3.567±0.817,t=7.716,P<0.001;6.667±1.658 vs 3.938±0.982,t=6.271,P<0.001)。阿片类药物组和阿片类药物联合NSAIDs组比较,差异无统计学意义(P>0.05)。3组不良反应和安全性比较,差异无统计学意义(P>0.05)。结论下肢缺血性疼痛镇痛药物方案有多种模式,相对于单用阿片类药物或阿片类药物联用NSAIDs,坐骨神经阻滞的应用在患者疼痛主诉和VAS评分下降改善明显,不良反应较少,值得临床应用推广。
