Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosi...Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosis of the femoral head. Methods: 308 cases of ONFH were divided into alcohol group (165 cases), hormone group (113 cases), trauma group (30 cases), and basic data of patients were collected. Blood lipid indicators: total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B;coagulation indicators: activated partial thromboplastin time, plasma prothrombin time, fibrinogen, thrombin time indicators, using analysis of variance method for different types of osteonecrosis of the femoral head and blood lipids, coagulation indicators Search for relevance. Results: 1. Comparison of three groups of blood lipid indicators: total cholesterol and low density lipoprotein cholesterol in the alcohol group were higher than those in the trauma group (P<0.05);total cholesterol, triglycerides, and low density lipoprotein in the alcohol group The three indexes of cholesterol were higher than those of the hormone group (P<0.05). There was no significant difference in the serum lipid indexes of the hormone group and the trauma group (P>0.05). 2. Comparison of three groups of coagulation indicators: hormone The fibrinogen index of the group was higher than that of the trauma group (P<0.05). There was no significant difference in the coagulation index between the alcohol group and the trauma group (P>0.05). The coagulation index of the hormone group and the alcohol group was compared. The differences were not statistically significant (P>0.05). Conclusions: 1. Non-traumatic osteonecrosis of the femoral head (alcoholic, hormonal) patients are characterized by markedly elevated blood lipids (total cholesterol, low density lipoprotein cholesterol) and coagulation (fibrinogen) indicators;2. Intravascular coagulation and lipid metabolism disorders may be the pathological basis of non-traumatic Osteonecrosis of the femoral head.展开更多
Objective： Dyslipidemia is a leading cause of cardiovascular disease. At present, studies have shown that theincidence of cardiovascular disease in our country increased year by year. According to WHO statistics in 2...Objective： Dyslipidemia is a leading cause of cardiovascular disease. At present, studies have shown that theincidence of cardiovascular disease in our country increased year by year. According to WHO statistics in 2013, itshowed that about 17 million people worldwide die from coronary heart disease （CHD） every year. Currently, CHDis the first cause of death in western countries and the incidence of CHD also showed a trend of increasing. Inrecent years more experts and scholars at home and abroad found gene polymorphism is closely related tohigh-density lipoprotein cholesterol （HDLC） gene and triglyceride （TG） levels. Apolipoprotein （APO） gene is akind of popular polymorphic proteins, whose genetic polymorphisms is through the impact of lipid metabolism,and then closely related to cerebrovascular diseases. But the results are different in different populations and races,or even the opposite. Methods： This review will summarize the gene polymorphism loci of commonapolipoprotein-ApoA1, ApoA5, Apo B, ApoC3, ApoE, which is associated with lipid levels and cardiovasculardisease. Conclusion： It is important for us to get a further understand and prevent the occurrence and developmentof cardiovascular disease from gene level..展开更多
目的探讨卒中后抑郁患者血浆中血脂参数总胆固醇、低密度脂蛋白水平变化,及其对卒中后抑郁的预测价值。方法检索中国知网、维普数据库、万方数据库等中文数据库以及Cochrane Library、Web of Science、EMbase和PubMed英文数据库获取血...目的探讨卒中后抑郁患者血浆中血脂参数总胆固醇、低密度脂蛋白水平变化,及其对卒中后抑郁的预测价值。方法检索中国知网、维普数据库、万方数据库等中文数据库以及Cochrane Library、Web of Science、EMbase和PubMed英文数据库获取血脂参数与卒中后抑郁相关的前瞻性研究,检索时间截止至2023年12月20日。使用R 4.3.2软件“meta R Package”“robvis R Package”进行统计学分析。结果最终总胆固醇与卒中后抑郁相关文献筛选出11篇,低密度脂蛋白与卒中后抑郁相关文献筛选出12篇,共计2168例卒中非抑郁,743例卒中后抑郁患者。研究结果发现卒中后抑郁患者总胆固醇TC(SMD=0.14,95%CI 0.04~0.24)和低密度脂蛋白LDL(SMD=0.19,95%CI 0.10~0.28)显著高于卒中非抑郁患者。研究异质性小,无明显发表偏倚,结果具有稳定性。结论卒中后抑郁的发病可能与总胆固醇和低密度脂蛋白的升高有关,在临床工作中可对合并以上血脂生化指标的的卒中患者进行卒中后抑郁的早期干预,从而改善患者的预后和生活质量。展开更多
目的:通过Meta分析综合定量评价低容量高强度间歇训练对预防肥胖或超重人群心血管疾病的效果,进一步验证低容量高强度间歇训练在肥胖等特殊人群中应用的可行性。方法:在中国知网、PubMed、Web of Science、Cochrane Library和EBSCO-SPO...目的:通过Meta分析综合定量评价低容量高强度间歇训练对预防肥胖或超重人群心血管疾病的效果,进一步验证低容量高强度间歇训练在肥胖等特殊人群中应用的可行性。方法:在中国知网、PubMed、Web of Science、Cochrane Library和EBSCO-SPORTD运动科学全文数据库检索关于低容量高强度间歇训练相关研究的随机对照试验文献,检索时限为各数据库建库至2024年2月。由2名研究人员对所纳入的研究进行筛选、质量评价和数据提取,采用RevMan 5.4和Stata 17.0软件对结局指标进行Meta分析,包括合并效应量、亚组分析、Leave-One-Out敏感性分析以及发表Egger检验和绘制漏斗图。该方案已在国际系统综述前瞻性注册中心注册(CRD42024534409)。结果:①最终筛选纳入符合要求的13项随机对照试验,共包含349例受试者,纳入文献整体质量较高。②低容量高强度间歇训练干预对心肺适能(SMD=-0.65,95%CI:-0.87至-0.43,P<0.05)、收缩压(SMD=0.38,95%CI:0.11-0.65,P<0.05)、舒张压(SMD=0.42,95%CI:0.15-0.68,P<0.05)和体脂百分比(SMD=0.25,95%CI:0.02-0.49,P<0.05)4项指标具有改善效果。③低容量高强度间歇训练与中等强度持续训练相比在改善超重或肥胖人群心肺适能、收缩压、舒张压、体脂百分比、标准体质量、体质量指数、高密度脂蛋白、低密度脂蛋白和总胆固醇指标方面干预效果相似(P>0.05),但在改善三酰甘油效果方面中等强度持续训练优于低容量高强度间歇训练(SMD=-0.30,95%CI:-0.57至-0.02,P<0.05)。④亚组分析结果进一步显示,低容量高强度间歇训练和中等强度持续训练干预对各项指标的改善效果相似。结论:当前证据表明,低容量高强度间歇训练可以有效提升超重或肥胖人群的心肺适应能力以及促进减脂和血压调控,且改善效果与中等强度持续训练相似。短时间的低容量高强度间歇训练相比于长时间的中等强度持续训练更具有时间效益。建议未来通过更多研究确定适用于超重或肥胖人群最佳的低容量高强度间歇训练运动处方。展开更多
目的:对比分析高强度间歇训练(HIIT)和中等强度持续训练(MICT)对心血管患者血脂水平的影响,探究有氧运动改善心血管疾病危险因素的价值。方法:计算机检索PubMed、Cochrane Library、Web of Science、中国知网(CNKI)和中国生物医学文献...目的:对比分析高强度间歇训练(HIIT)和中等强度持续训练(MICT)对心血管患者血脂水平的影响,探究有氧运动改善心血管疾病危险因素的价值。方法:计算机检索PubMed、Cochrane Library、Web of Science、中国知网(CNKI)和中国生物医学文献数据库(CMB)中关于HIIT和MICT对心血管危险因素影响的随机对照实验(RCTs)成果,检索时限为建库至2023年2月,通过文献质量评价提取数据,采用Sata15.0、RevMan5.3统计软件进行Meta分析。结果:纳入文献11篇,涉及受试者327名。实验组(HIIT)与对照组(MICT)相比,对心血管改善作用相近,对高密度脂蛋白(HDL-C)改善程度略优于对照组(WMD=0.062,95%CI,0.005-0.119,P=0.033),对低密度脂蛋白(LDL-C)改善程度无显著差异(WMD=-0.001,95%CI,-0.159-0.158,P=0.995),对总胆固醇(TC)改善程度无显著差异(WMD=0.021,95%CI,-0.177-0.220,P=0.834),对甘油三酯(TRG)改善程度不及对照组(WMD=-0.138,95%CI,-0.262--0.014,P=0.03),研究中没有提示明显异质性和发表偏倚。结论:有氧运动对心血管患者有益,HIIT在血脂改善方面对比MICT没有显著差异,并不能带来更大效益,但HIIT作为新手段,耗时短,效率高,有效降低心血管疾病风险,预防或延缓心血管疾病发展,在临床和亚临床中值得推广。展开更多
目的系统评价红参改善代谢综合征作用,为临床实践提供依据。方法分别对英文数据库PubMed、Embase、The Cochrane Library、Web of Science、ClinicalTrials.gov以及中文数据库万方和中国知网进行全面检索,检索时限从建库至2022年5月,查...目的系统评价红参改善代谢综合征作用,为临床实践提供依据。方法分别对英文数据库PubMed、Embase、The Cochrane Library、Web of Science、ClinicalTrials.gov以及中文数据库万方和中国知网进行全面检索,检索时限从建库至2022年5月,查询关于红参辅助治疗代谢综合征的临床随机对照试验。依据纳入排除标准筛选文献并对其进行质量评估,随后通过RevMan 5.4.1软件对纳入研究进行Meta分析。结果共纳入17个随机对照试验,共包含957例患者,其中红参实验组共482例、安慰剂对照组共475例。与对照组比较,受试者服用红参后能显著改善空腹血糖、总胆固醇、低密度脂蛋白、收缩压及舒张压水平(P<0.05),其作用效果与所患疾病、年龄、给药时长、给药剂量有关。结论本文研究发现红参在治疗代谢综合征方面具有良好的疗效,为红参临床治疗代谢综合征提供了循证依据。展开更多
基金State administration of traditional Chinese medicine national clinical research base of traditional Chinese medicine business construction research project(No.JDZX2015272).
文摘Objective: To explore the correlation between different types of osteonecrosis of the femoral head and blood lipids and coagulation indexes, in order to provide relevant references for the pathogenesis of osteonecrosis of the femoral head. Methods: 308 cases of ONFH were divided into alcohol group (165 cases), hormone group (113 cases), trauma group (30 cases), and basic data of patients were collected. Blood lipid indicators: total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B;coagulation indicators: activated partial thromboplastin time, plasma prothrombin time, fibrinogen, thrombin time indicators, using analysis of variance method for different types of osteonecrosis of the femoral head and blood lipids, coagulation indicators Search for relevance. Results: 1. Comparison of three groups of blood lipid indicators: total cholesterol and low density lipoprotein cholesterol in the alcohol group were higher than those in the trauma group (P<0.05);total cholesterol, triglycerides, and low density lipoprotein in the alcohol group The three indexes of cholesterol were higher than those of the hormone group (P<0.05). There was no significant difference in the serum lipid indexes of the hormone group and the trauma group (P>0.05). 2. Comparison of three groups of coagulation indicators: hormone The fibrinogen index of the group was higher than that of the trauma group (P<0.05). There was no significant difference in the coagulation index between the alcohol group and the trauma group (P>0.05). The coagulation index of the hormone group and the alcohol group was compared. The differences were not statistically significant (P>0.05). Conclusions: 1. Non-traumatic osteonecrosis of the femoral head (alcoholic, hormonal) patients are characterized by markedly elevated blood lipids (total cholesterol, low density lipoprotein cholesterol) and coagulation (fibrinogen) indicators;2. Intravascular coagulation and lipid metabolism disorders may be the pathological basis of non-traumatic Osteonecrosis of the femoral head.
文摘Objective： Dyslipidemia is a leading cause of cardiovascular disease. At present, studies have shown that theincidence of cardiovascular disease in our country increased year by year. According to WHO statistics in 2013, itshowed that about 17 million people worldwide die from coronary heart disease （CHD） every year. Currently, CHDis the first cause of death in western countries and the incidence of CHD also showed a trend of increasing. Inrecent years more experts and scholars at home and abroad found gene polymorphism is closely related tohigh-density lipoprotein cholesterol （HDLC） gene and triglyceride （TG） levels. Apolipoprotein （APO） gene is akind of popular polymorphic proteins, whose genetic polymorphisms is through the impact of lipid metabolism,and then closely related to cerebrovascular diseases. But the results are different in different populations and races,or even the opposite. Methods： This review will summarize the gene polymorphism loci of commonapolipoprotein-ApoA1, ApoA5, Apo B, ApoC3, ApoE, which is associated with lipid levels and cardiovasculardisease. Conclusion： It is important for us to get a further understand and prevent the occurrence and developmentof cardiovascular disease from gene level..
文摘目的探讨卒中后抑郁患者血浆中血脂参数总胆固醇、低密度脂蛋白水平变化,及其对卒中后抑郁的预测价值。方法检索中国知网、维普数据库、万方数据库等中文数据库以及Cochrane Library、Web of Science、EMbase和PubMed英文数据库获取血脂参数与卒中后抑郁相关的前瞻性研究,检索时间截止至2023年12月20日。使用R 4.3.2软件“meta R Package”“robvis R Package”进行统计学分析。结果最终总胆固醇与卒中后抑郁相关文献筛选出11篇,低密度脂蛋白与卒中后抑郁相关文献筛选出12篇,共计2168例卒中非抑郁,743例卒中后抑郁患者。研究结果发现卒中后抑郁患者总胆固醇TC(SMD=0.14,95%CI 0.04~0.24)和低密度脂蛋白LDL(SMD=0.19,95%CI 0.10~0.28)显著高于卒中非抑郁患者。研究异质性小,无明显发表偏倚,结果具有稳定性。结论卒中后抑郁的发病可能与总胆固醇和低密度脂蛋白的升高有关,在临床工作中可对合并以上血脂生化指标的的卒中患者进行卒中后抑郁的早期干预,从而改善患者的预后和生活质量。
文摘目的:对比分析高强度间歇训练(HIIT)和中等强度持续训练(MICT)对心血管患者血脂水平的影响,探究有氧运动改善心血管疾病危险因素的价值。方法:计算机检索PubMed、Cochrane Library、Web of Science、中国知网(CNKI)和中国生物医学文献数据库(CMB)中关于HIIT和MICT对心血管危险因素影响的随机对照实验(RCTs)成果,检索时限为建库至2023年2月,通过文献质量评价提取数据,采用Sata15.0、RevMan5.3统计软件进行Meta分析。结果:纳入文献11篇,涉及受试者327名。实验组(HIIT)与对照组(MICT)相比,对心血管改善作用相近,对高密度脂蛋白(HDL-C)改善程度略优于对照组(WMD=0.062,95%CI,0.005-0.119,P=0.033),对低密度脂蛋白(LDL-C)改善程度无显著差异(WMD=-0.001,95%CI,-0.159-0.158,P=0.995),对总胆固醇(TC)改善程度无显著差异(WMD=0.021,95%CI,-0.177-0.220,P=0.834),对甘油三酯(TRG)改善程度不及对照组(WMD=-0.138,95%CI,-0.262--0.014,P=0.03),研究中没有提示明显异质性和发表偏倚。结论:有氧运动对心血管患者有益,HIIT在血脂改善方面对比MICT没有显著差异,并不能带来更大效益,但HIIT作为新手段,耗时短,效率高,有效降低心血管疾病风险,预防或延缓心血管疾病发展,在临床和亚临床中值得推广。
