The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering.However,the problem of wave diffraction around asymmetrically arranged breakwaters has not been a...The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering.However,the problem of wave diffraction around asymmetrically arranged breakwaters has not been adequately investigated.In this study,we propose an analytical method of wave diffraction for regular waves passing through asymmetrically arranged breakwaters,and we use the Nyström method to obtain the analytical solution numerically.We compared the results of this method with those of previous analytical solutions and with numerical results to demonstrate the validity of our approach.We also provided diffraction coefficient diagrams of breakwaters with different layout forms.Moreover,we described the analytical expression for the problem of diffraction through long-wave incident breakwaters and presented an analysis of the relationship between the diffraction coefficients and the widths of breakwater gates.The analytical method presented in this study contributes to the limited literature on the theory of wave diffraction through asymmetrically arranged breakwaters.展开更多
A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method ha...A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method has been established in early literature. However, its practical applications and significance in advancing the analysis of AC machines need further elaboration. This paper aims to complement VAM by augmenting its theory, offering additional insights into its conclusions, as well as demonstrating its utility in assessing armature windings and its application of calculating torque for permanent magnet synchronous machines(PMSM). This work contributes to advancing the analysis of AC machines and underscores the potential for improved design and performance optimization.展开更多
The Laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space.However,it fails to obtain the correct stress at the interfaces in a layered half-space,especially when th...The Laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space.However,it fails to obtain the correct stress at the interfaces in a layered half-space,especially when there are significant differences in material properties.Therefore,a coupled Legendre-Laguerre polynomial method with analytical integration is proposed.The Rayleigh waves in a one-dimensional(1D)hexagonal quasicrystal(QC)layered half-space with an imperfect interface are investigated.The correctness is validated by comparison with available results.Its computation efficiency is analyzed.The dispersion curves of the phase velocity,displacement distributions,and stress distributions are illustrated.The effects of the phonon-phason coupling and imperfect interface coefficients on the wave characteristics are investigated.Some novel findings reveal that the proposed method is highly efficient for addressing the Rayleigh waves in a QC layered half-space.It can save over 99%of the computation time.This method can be expanded to investigate waves in various layered half-spaces,including earth-layered media and surface acoustic wave(SAW)devices.展开更多
Starting with governing equations of a saturated soil with anisotropic permeability and based on multiple integral transforms, an analytical layer-element equation is established explicitly in the Laplace-Fourier tran...Starting with governing equations of a saturated soil with anisotropic permeability and based on multiple integral transforms, an analytical layer-element equation is established explicitly in the Laplace-Fourier transformed domain. A global matrix of layered soil can be obtained by assembling a set of analytical layer-elements, which is further solved in the transformed domain by considering boundary conditions. The numerical inversion of LaplaceFourier trans- form is employed to acquire the actual solution. Numerical analysis for 3-D consolidation with anisotropic permeability of a layered soil system is presented, and the influence of anisotropy of permeability on the consolidation behavior is discussed.展开更多
An anisotropic diffusion filter can be used to model a flow-dependent background error covariance matrix,which can be achieved by solving the advection-diffusion equation.Because of the directionality of the advection...An anisotropic diffusion filter can be used to model a flow-dependent background error covariance matrix,which can be achieved by solving the advection-diffusion equation.Because of the directionality of the advection term,the discrete method needs to be chosen very carefully.The finite analytic method is an alternative scheme to solve the advection-diffusion equation.As a combination of analytical and numerical methods,it not only has high calculation accuracy but also holds the characteristic of the auto upwind.To demonstrate its ability,the one-dimensional steady and unsteady advection-diffusion equation numerical examples are respectively solved by the finite analytic method.The more widely used upwind difference method is used as a control approach.The result indicates that the finite analytic method has higher accuracy than the upwind difference method.For the two-dimensional case,the finite analytic method still has a better performance.In the three-dimensional variational assimilation experiment,the finite analytic method can effectively improve analysis field accuracy,and its effect is significantly better than the upwind difference and the central difference method.Moreover,it is still a more effective solution method in the strong flow region where the advective-diffusion filter performs most prominently.展开更多
Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomic...Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomics garners widespread application across diverse fields including drug research and development,early disease detection,toxicology,food and nutrition science,biology,prescription,and chinmedomics,among others.Metabolomics serves as an effective characterization technique,offering insights into physiological process alterations in vivo.These changes may result from various exogenous factors like environmental conditions,stress,medications,as well as endogenous elements including genetic and protein-based influences.The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods,poised to further broaden the scope of this domain.Today,metabolomics has evolved into a valuable and widely accepted instrument in the life sciences.However,comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant.This review aims to fill that gap,providing an overview of current trends and recent advancements in metabolomics.Particular emphasis is placed on sample preparation,sophisticated analytical techniques,and their applications in life science research.展开更多
The problem of shield tunnel uplift is a common issue in tunnel construction.Due to the decrease in shear stiffness at the joints between the rings,uplift is typically observed as bending and dislocation deformation a...The problem of shield tunnel uplift is a common issue in tunnel construction.Due to the decrease in shear stiffness at the joints between the rings,uplift is typically observed as bending and dislocation deformation at these joints.Existing modeling methods typically rely on the Euler-Bernoulli beam theory,only considering the bending effect while disregarding shear deformation.Furthermore,the constraints on the shield tail are often neglected in existing models.In this study,an improved theoretical model of tunnel floating is proposed.The constraint effect of the shield machine shell on the tunnel structure is considered using the structural forms of two finite long beams and one semi-infinite long beam.Furthermore,the Timoshenko beam theory is adopted,providing a more accurate description of tunnel deformation,including both the bending effect and shear deformation,than existing models.Meanwhile,the buoyancy force and stratum resistance are calculated in a nonlinear manner.A reliable method for calculating the shear stiffness correction factor is proposed to better determination of the calculation parameters.The proposed theoretical model is validated through five cases using sitemonitored data.Its applicability and effectiveness are demonstrated.Furthermore,the influences of soil type,buried depth,and buoyancy force on the three key indicators of tunnel floating(i.e.the maximum uplift magnitude,the ring position with the fastest uplift race,and the ring position with the maximum uplift magnitude)are analyzed.The results indicate that the proposed model can provide a better understanding of the floating characteristics of the tunnel structure during construction.展开更多
This article describes the solution procedure of the fractional Pade-Ⅱ equation and generalized Zakharov equation(GSEs)using the sine-cosine method.Pade-Ⅱ is an important nonlinear wave equation modeling unidirectio...This article describes the solution procedure of the fractional Pade-Ⅱ equation and generalized Zakharov equation(GSEs)using the sine-cosine method.Pade-Ⅱ is an important nonlinear wave equation modeling unidirectional propagation of long-wave in dispersive media and GSEs are used to model the interaction between one-dimensional high,and low-frequency waves.Classes of trigonometric and hyperbolic function solutions in fractional calculus are discussed.Graphical simulations of the numerical solutions are flaunted by MATLAB.展开更多
Multiple objectives to be optimized simultaneously are prevalent in real-life problems. This paper develops a new Pareto Method for bi-objective optimization which yields analytical solutions. The Pareto optimal front...Multiple objectives to be optimized simultaneously are prevalent in real-life problems. This paper develops a new Pareto Method for bi-objective optimization which yields analytical solutions. The Pareto optimal front is obtained in closed-form, enabling the derivation of various solutions in a convenient and efficient way. The advantage of analytical solution is the possibility of deriving accurate, exact and well-understood solutions, which is especially useful for policy analysis. An extension of the method to include multiple objectives is provided with the objectives being classified into two types. Such an extension expands the applicability of the developed techniques.展开更多
This study proposed the newly-designed Pelagic and demersal trawls for the fishing vessels operating in Cameroonian waters in pelagic and demersal fishing grounds. The engineering performances of both trawls were inve...This study proposed the newly-designed Pelagic and demersal trawls for the fishing vessels operating in Cameroonian waters in pelagic and demersal fishing grounds. The engineering performances of both trawls were investigated using physical modelling method and analytical method based on the predicted equations. In a flume tank, a series of physical model tests based on Tauti’s law were performed to investigate the hydrodynamic and geometrical performances of both trawls and to assess the applicability of the analytical methods based on predicted equations. The results showed that in model scale, the working towing speed and door spread for the pelagic trawl were 3.5 knots and 1.85 m, respectively, and for the bottom trawl net they were 4.0 knots and 1.8 m. At that speed and door spread, the drag force, net opening height, and wing-end spread of the pelagic model trawl were 36.73 N, 0.89 m, and 0.86 m, respectively, and the swept area was 0.76 m<sup>2</sup>. Bottom trawl speed and door spread were 30.43 N, 0.38 m, and 0.45 m, respectively, and the swept area was 0.25 m<sup>2</sup>. The maximum difference between the experimental and analytical results of hydrodynamic performances was less than 56.22% and 41.45%, respectively, for pelagic and bottom trawls, the results of the geometrical performances obtained using predicted equations were close to the experimental results in the flume tank with a maximum relative error less than 12.85%. The newly developed pelagic and bottom trawls had advanced engineering performance for high catch efficiency and selectivity and could be used in commercial fishing operations in Cameroonian waters.展开更多
The chiral nature of biological systems enables their stereoselective interaction with chiral compounds. It has been well documented that the enantiomers ofa chiral drug may show differences in drug disposition especi...The chiral nature of biological systems enables their stereoselective interaction with chiral compounds. It has been well documented that the enantiomers ofa chiral drug may show differences in drug disposition especially in metabolic behavior. As a result, it is of vital importance to separate the enantiomers of a chiral drug in metabolic studies. This paper discusses enantioselective methods (include high-performance liquid chromatography, gas chromatography, capillary electrophoresis and high-performance liquid chromatography-mass spectrometry) that applied in chiral drug metabolism, using most recent examples where possible.展开更多
In the present work, the different sample collection, pretreatment and analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates is systematacially reviewed, and the applications of the...In the present work, the different sample collection, pretreatment and analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates is systematacially reviewed, and the applications of these pretreatment and analytical methods for PAHs are compared in detail. Some comments on the future expectation are also presented.展开更多
A differential equation of first order can be expressed by the equation of motion of a mechanical system. In this paper, three methods of analytical mechanics, i.e. the Hamilton-Noether method, the Lagrange-Noether me...A differential equation of first order can be expressed by the equation of motion of a mechanical system. In this paper, three methods of analytical mechanics, i.e. the Hamilton-Noether method, the Lagrange-Noether method and the Poisson method, are given to solve a differential equation of first order, of which the way may be called the mechanical methodology in mathematics.展开更多
Nanoliposomes are considered to be the most successful nanoparticle drug delivery system, but their fate in vivo has not been fully understood due to lack of reliable bioanalytical methods, which seriously limits the ...Nanoliposomes are considered to be the most successful nanoparticle drug delivery system, but their fate in vivo has not been fully understood due to lack of reliable bioanalytical methods, which seriously limits the development of liposomal drugs. Hence, an overview of currently used bioanalytical methods is imperative to lay the groundwork for the need of developing a bioanalytical method for liposome measurements in vivo. Currently, major analytical methods for nanoliposomes measurement in vivo include fluorescence labeling, radiolabeling, magnetic resonance imaging(MRI), mass spectrometry and computed tomography. In this review, these bioanalytical methods are summarized, and the advantages and disadvantages of each are discussed. We provide insights into the applicability and limitations of these analytical methods in the application of nanoliposomes measurement in vivo, and highlight the recent development of instrumental analysis techniques. The review is devoted to providing a comprehensive overview of the investigation of nanoliposomes design and associated fate in vivo, promoting the development of bioanalytical techniques for nanoliposomes measurement, and understanding the pharmacokinetic behavior, effectiveness and potential toxicity of nanoliposomes in vivo.展开更多
Firstly, a new analytical error model of the cumulative geoid height using the three-dimensional diagonal tensors of satellite gravity gradiometry (SGG) is introduced based on the variance-covariance matrix principl...Firstly, a new analytical error model of the cumulative geoid height using the three-dimensional diagonal tensors of satellite gravity gradiometry (SGG) is introduced based on the variance-covariance matrix principle. Secondly, a study for the requirements demonstration on the next-generation GOCE Follow-On satellite gravity gradiometry system is developed using different satellite orbital altitudes and measurement accuracies of satellite gravity gradiometer by the new analytical error model of SGG. The research results show that it is preferable to design satellite orbital altitudes of 300 km–400km and choose the measurement accuracies of 10-13/s2 –10-15/s2 from satellite gravity gradiometer. Finally, the complementarity of the four-stage satellite gravity missions, including past CHAMP, current GRACE, and GOCE, and next-generation GOCE Follow-On, is contrastively demonstrated for precisely recovering the Earth’s full-frequency gravitational field with high spatial resolution.展开更多
An impedance analytical method (IAM) is developed to study the interaction of plane water wave with a slotted-wall caisson breakwater. The non-linear boundary condition at the slotted-wall is expressed in terms of f...An impedance analytical method (IAM) is developed to study the interaction of plane water wave with a slotted-wall caisson breakwater. The non-linear boundary condition at the slotted-wall is expressed in terms of flow resistance. A set of algebraic expressions are obtained for free surface elevation inside and outside chamber, and reflection coefficient. The prediction of the reflection coefficients shows that the relative widths of the chamber inducing the minimum reflection coefficient for a slotted-wall caisson breakwater are in a range of 0.10~0.20, which are smaller than that (0.15~0.25) for a perforated-wall caisson breakwater. The reflection coefficients and free surface elevation obtained by the present model are compared with that of laboratory experiments carried out by previous researchers.展开更多
Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of ...Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies. Ever since it was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials. This article reviews the various methods reported during the last 25 years.展开更多
Assessment of acid sulfate soil risk is an important step for acid sulfate soil management and its reliability depends very much on the suitability and accuracy of various analytical methods for estimating sulfide-der...Assessment of acid sulfate soil risk is an important step for acid sulfate soil management and its reliability depends very much on the suitability and accuracy of various analytical methods for estimating sulfide-derived potential acidity, actual acidity and acid-neutralizing capacity in acid sulfate soils. This paper critically reviews various analytical methods that are currently used for determination of the above parameters, as well as their implications for environmental risk assessment of acid sulfate soi1s.展开更多
Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma). I...Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma). It was the tenth-best-selling drug in the U.S. in 2008. This article examines published analytical methods reported so far in the literature for the determination of pioglitazone in biological samples and pharmaceutical formulations. They include various techniques like electrochemical methods, spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography.展开更多
Objective:To evaluate relationship betweenα-cypermethrin residues in Interceptor~? nets by using HPTLC methods and mortality percentage in standard WHO’s method 'cone test' after repeated washings.Methods:In...Objective:To evaluate relationship betweenα-cypermethrin residues in Interceptor~? nets by using HPTLC methods and mortality percentage in standard WHO’s method 'cone test' after repeated washings.Methods:Interceptor~? containingα-cypermethrin was provided by BASF Company.The washing procedure and bioassay tests were carried out according to the WHO-recommended methods.Malaria vector,An.stephensi was exposed to impregnated bed net for three minutes and then mortality measured after 24 hour recovery period.Chemical analysis was carried out in chemical laboratory by using high performance thin layer chromatography method.Results:Result of cone bioassay method showed that washing reduced the efficacy of Interceptor~? bed net from 100%in unwashed nets to 15%at 20 washes.After 20 washes,nets contain(61.2±2.8) mg/m^2 resulting 15%mortality in cone test.Killing activity was reduced when nets were washed.Conclusions:Results will provide an essential clue for monitoring and evaluation of bioefficacy of any long lasting impregnated bed net for quality control.Findings of this study will be useful for WHO.local investigators and people who wish to use pyrethroid-impregnated bed nets for malaria vector control.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.51679132)the Science and Technology Commission of Shanghai Municipality(Grant No.21ZR1427000)Shanghai Frontiers Science Center of“Full Penetration”Far-Reaching Offshore Ocean Energy and Power.
文摘The layout forms of several breakwater structures can be generalized as asymmetrical arrangements in actual engineering.However,the problem of wave diffraction around asymmetrically arranged breakwaters has not been adequately investigated.In this study,we propose an analytical method of wave diffraction for regular waves passing through asymmetrically arranged breakwaters,and we use the Nyström method to obtain the analytical solution numerically.We compared the results of this method with those of previous analytical solutions and with numerical results to demonstrate the validity of our approach.We also provided diffraction coefficient diagrams of breakwaters with different layout forms.Moreover,we described the analytical expression for the problem of diffraction through long-wave incident breakwaters and presented an analysis of the relationship between the diffraction coefficients and the widths of breakwater gates.The analytical method presented in this study contributes to the limited literature on the theory of wave diffraction through asymmetrically arranged breakwaters.
基金supported by the Natural Science Foundation of China under Grant U22A20214 and Grant 51837010。
文摘A versatile analytical method(VAM) for calculating the harmonic components of the magnetomotive force(MMF) generated by diverse armature windings in AC machines has been proposed, and the versatility of this method has been established in early literature. However, its practical applications and significance in advancing the analysis of AC machines need further elaboration. This paper aims to complement VAM by augmenting its theory, offering additional insights into its conclusions, as well as demonstrating its utility in assessing armature windings and its application of calculating torque for permanent magnet synchronous machines(PMSM). This work contributes to advancing the analysis of AC machines and underscores the potential for improved design and performance optimization.
基金Project supported by the National Natural Science Foundation of China(No.12102131)the Natural Science Foundation of Henan Province of China(No.242300420248)the International Science and Technology Cooperation Project of Henan Province of China(No.242102521010)。
文摘The Laguerre polynomial method has been successfully used to investigate the dynamic responses of a half-space.However,it fails to obtain the correct stress at the interfaces in a layered half-space,especially when there are significant differences in material properties.Therefore,a coupled Legendre-Laguerre polynomial method with analytical integration is proposed.The Rayleigh waves in a one-dimensional(1D)hexagonal quasicrystal(QC)layered half-space with an imperfect interface are investigated.The correctness is validated by comparison with available results.Its computation efficiency is analyzed.The dispersion curves of the phase velocity,displacement distributions,and stress distributions are illustrated.The effects of the phonon-phason coupling and imperfect interface coefficients on the wave characteristics are investigated.Some novel findings reveal that the proposed method is highly efficient for addressing the Rayleigh waves in a QC layered half-space.It can save over 99%of the computation time.This method can be expanded to investigate waves in various layered half-spaces,including earth-layered media and surface acoustic wave(SAW)devices.
基金Project supported by the National Natural Science Foundation of China (No. 50578121)
文摘Starting with governing equations of a saturated soil with anisotropic permeability and based on multiple integral transforms, an analytical layer-element equation is established explicitly in the Laplace-Fourier transformed domain. A global matrix of layered soil can be obtained by assembling a set of analytical layer-elements, which is further solved in the transformed domain by considering boundary conditions. The numerical inversion of LaplaceFourier trans- form is employed to acquire the actual solution. Numerical analysis for 3-D consolidation with anisotropic permeability of a layered soil system is presented, and the influence of anisotropy of permeability on the consolidation behavior is discussed.
基金The National Key Research and Development Program of China under contract Nos 2022YFC3104804,2021YFC3101501,and 2017YFC1404103the National Programme on Global Change and Air-Sea Interaction of China under contract No.GASI-IPOVAI-04the National Natural Science Foundation of China under contract Nos 41876014,41606039,and 11801402.
文摘An anisotropic diffusion filter can be used to model a flow-dependent background error covariance matrix,which can be achieved by solving the advection-diffusion equation.Because of the directionality of the advection term,the discrete method needs to be chosen very carefully.The finite analytic method is an alternative scheme to solve the advection-diffusion equation.As a combination of analytical and numerical methods,it not only has high calculation accuracy but also holds the characteristic of the auto upwind.To demonstrate its ability,the one-dimensional steady and unsteady advection-diffusion equation numerical examples are respectively solved by the finite analytic method.The more widely used upwind difference method is used as a control approach.The result indicates that the finite analytic method has higher accuracy than the upwind difference method.For the two-dimensional case,the finite analytic method still has a better performance.In the three-dimensional variational assimilation experiment,the finite analytic method can effectively improve analysis field accuracy,and its effect is significantly better than the upwind difference and the central difference method.Moreover,it is still a more effective solution method in the strong flow region where the advective-diffusion filter performs most prominently.
基金supported by the Science Foundation of Heilongjiang Administration of Traditional Chinese Medicine(No.2018-21).
文摘Over the past decade,the swift advancement of metabolomics can be credited to significant progress in technologies such as mass spectrometry,nuclear magnetic resonance,and multivariate statistics.Currently,metabolomics garners widespread application across diverse fields including drug research and development,early disease detection,toxicology,food and nutrition science,biology,prescription,and chinmedomics,among others.Metabolomics serves as an effective characterization technique,offering insights into physiological process alterations in vivo.These changes may result from various exogenous factors like environmental conditions,stress,medications,as well as endogenous elements including genetic and protein-based influences.The potential scientific outcomes gleaned from these insights have catalyzed the formulation of innovative methods,poised to further broaden the scope of this domain.Today,metabolomics has evolved into a valuable and widely accepted instrument in the life sciences.However,comprehensive reviews focusing on the sample preparation and analytical methodologies employed in metabolomics within the life sciences are surprisingly scant.This review aims to fill that gap,providing an overview of current trends and recent advancements in metabolomics.Particular emphasis is placed on sample preparation,sophisticated analytical techniques,and their applications in life science research.
基金the National Natural Science Foundation of China (Grant Nos.52379111,51979270 and 52208380).
文摘The problem of shield tunnel uplift is a common issue in tunnel construction.Due to the decrease in shear stiffness at the joints between the rings,uplift is typically observed as bending and dislocation deformation at these joints.Existing modeling methods typically rely on the Euler-Bernoulli beam theory,only considering the bending effect while disregarding shear deformation.Furthermore,the constraints on the shield tail are often neglected in existing models.In this study,an improved theoretical model of tunnel floating is proposed.The constraint effect of the shield machine shell on the tunnel structure is considered using the structural forms of two finite long beams and one semi-infinite long beam.Furthermore,the Timoshenko beam theory is adopted,providing a more accurate description of tunnel deformation,including both the bending effect and shear deformation,than existing models.Meanwhile,the buoyancy force and stratum resistance are calculated in a nonlinear manner.A reliable method for calculating the shear stiffness correction factor is proposed to better determination of the calculation parameters.The proposed theoretical model is validated through five cases using sitemonitored data.Its applicability and effectiveness are demonstrated.Furthermore,the influences of soil type,buried depth,and buoyancy force on the three key indicators of tunnel floating(i.e.the maximum uplift magnitude,the ring position with the fastest uplift race,and the ring position with the maximum uplift magnitude)are analyzed.The results indicate that the proposed model can provide a better understanding of the floating characteristics of the tunnel structure during construction.
文摘This article describes the solution procedure of the fractional Pade-Ⅱ equation and generalized Zakharov equation(GSEs)using the sine-cosine method.Pade-Ⅱ is an important nonlinear wave equation modeling unidirectional propagation of long-wave in dispersive media and GSEs are used to model the interaction between one-dimensional high,and low-frequency waves.Classes of trigonometric and hyperbolic function solutions in fractional calculus are discussed.Graphical simulations of the numerical solutions are flaunted by MATLAB.
文摘Multiple objectives to be optimized simultaneously are prevalent in real-life problems. This paper develops a new Pareto Method for bi-objective optimization which yields analytical solutions. The Pareto optimal front is obtained in closed-form, enabling the derivation of various solutions in a convenient and efficient way. The advantage of analytical solution is the possibility of deriving accurate, exact and well-understood solutions, which is especially useful for policy analysis. An extension of the method to include multiple objectives is provided with the objectives being classified into two types. Such an extension expands the applicability of the developed techniques.
文摘This study proposed the newly-designed Pelagic and demersal trawls for the fishing vessels operating in Cameroonian waters in pelagic and demersal fishing grounds. The engineering performances of both trawls were investigated using physical modelling method and analytical method based on the predicted equations. In a flume tank, a series of physical model tests based on Tauti’s law were performed to investigate the hydrodynamic and geometrical performances of both trawls and to assess the applicability of the analytical methods based on predicted equations. The results showed that in model scale, the working towing speed and door spread for the pelagic trawl were 3.5 knots and 1.85 m, respectively, and for the bottom trawl net they were 4.0 knots and 1.8 m. At that speed and door spread, the drag force, net opening height, and wing-end spread of the pelagic model trawl were 36.73 N, 0.89 m, and 0.86 m, respectively, and the swept area was 0.76 m<sup>2</sup>. Bottom trawl speed and door spread were 30.43 N, 0.38 m, and 0.45 m, respectively, and the swept area was 0.25 m<sup>2</sup>. The maximum difference between the experimental and analytical results of hydrodynamic performances was less than 56.22% and 41.45%, respectively, for pelagic and bottom trawls, the results of the geometrical performances obtained using predicted equations were close to the experimental results in the flume tank with a maximum relative error less than 12.85%. The newly developed pelagic and bottom trawls had advanced engineering performance for high catch efficiency and selectivity and could be used in commercial fishing operations in Cameroonian waters.
基金National Natural Science Foundation of China(Grant No.30225047 and 30701038)
文摘The chiral nature of biological systems enables their stereoselective interaction with chiral compounds. It has been well documented that the enantiomers ofa chiral drug may show differences in drug disposition especially in metabolic behavior. As a result, it is of vital importance to separate the enantiomers of a chiral drug in metabolic studies. This paper discusses enantioselective methods (include high-performance liquid chromatography, gas chromatography, capillary electrophoresis and high-performance liquid chromatography-mass spectrometry) that applied in chiral drug metabolism, using most recent examples where possible.
基金Project supported by the National Natural Science Foundation of China (No. 20437020 20575073) NSFC-JSPS Joint Research Project (No. 20511140134) the Major Research Program of Chinese Academy of Sciences (KZCX3-SW-432)
文摘In the present work, the different sample collection, pretreatment and analytical methods for polycyclic aromatic hydrocarbons (PAHs) in airborne particulates is systematacially reviewed, and the applications of these pretreatment and analytical methods for PAHs are compared in detail. Some comments on the future expectation are also presented.
基金Project supported by the National Natural Science Foundation of China (Grant No 10272021) and the Doctorate Foundation of the State Education Ministry of China (Grant No 20040007022).
文摘A differential equation of first order can be expressed by the equation of motion of a mechanical system. In this paper, three methods of analytical mechanics, i.e. the Hamilton-Noether method, the Lagrange-Noether method and the Poisson method, are given to solve a differential equation of first order, of which the way may be called the mechanical methodology in mathematics.
基金supported by the National Natural Science Foundation of China (Grant No. 81430087, 81673396, 81603182)
文摘Nanoliposomes are considered to be the most successful nanoparticle drug delivery system, but their fate in vivo has not been fully understood due to lack of reliable bioanalytical methods, which seriously limits the development of liposomal drugs. Hence, an overview of currently used bioanalytical methods is imperative to lay the groundwork for the need of developing a bioanalytical method for liposome measurements in vivo. Currently, major analytical methods for nanoliposomes measurement in vivo include fluorescence labeling, radiolabeling, magnetic resonance imaging(MRI), mass spectrometry and computed tomography. In this review, these bioanalytical methods are summarized, and the advantages and disadvantages of each are discussed. We provide insights into the applicability and limitations of these analytical methods in the application of nanoliposomes measurement in vivo, and highlight the recent development of instrumental analysis techniques. The review is devoted to providing a comprehensive overview of the investigation of nanoliposomes design and associated fate in vivo, promoting the development of bioanalytical techniques for nanoliposomes measurement, and understanding the pharmacokinetic behavior, effectiveness and potential toxicity of nanoliposomes in vivo.
基金Project supported by the Main Direction Program of Knowledge Innovation of Chinese Academy of Sciences for Distinguished Young Scholar (Grant No. KZCX2-EW-QN114)the National Natural Science Foundation of China for Young Scholar (Grant Nos. 41004006, 41131067, 11173049, and 41202094)+5 种基金the Merit-based Scientific Research Foundation of the State Ministry of Human Resources and Social Security of China for Returned Overseas Chinese Scholars(Grant No. 2011)the Open Research Fund Program of the Key Laboratory of Computational Geodynamics of Chinese Academy of Sciences (Grant No. 2011-04)the Open Research Fund Program of the Key Laboratory of Geospace Environment and Geodesy, Ministry of Education, China (Grant No. 11-01-02)the Open Research Fund Program of the Key Laboratory of Geo-Informatics of National Administration of Surveying, Mapping and Geoinformation of China(Grant No. 201322)the Open Fund of State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Grant No. PLN1113)the Foundation of State Key Laboratory of Petroleum Resources and Prospecting, China University of Petroleum, Beijing (Grant No. PRP/open-1206)
文摘Firstly, a new analytical error model of the cumulative geoid height using the three-dimensional diagonal tensors of satellite gravity gradiometry (SGG) is introduced based on the variance-covariance matrix principle. Secondly, a study for the requirements demonstration on the next-generation GOCE Follow-On satellite gravity gradiometry system is developed using different satellite orbital altitudes and measurement accuracies of satellite gravity gradiometer by the new analytical error model of SGG. The research results show that it is preferable to design satellite orbital altitudes of 300 km–400km and choose the measurement accuracies of 10-13/s2 –10-15/s2 from satellite gravity gradiometer. Finally, the complementarity of the four-stage satellite gravity missions, including past CHAMP, current GRACE, and GOCE, and next-generation GOCE Follow-On, is contrastively demonstrated for precisely recovering the Earth’s full-frequency gravitational field with high spatial resolution.
文摘An impedance analytical method (IAM) is developed to study the interaction of plane water wave with a slotted-wall caisson breakwater. The non-linear boundary condition at the slotted-wall is expressed in terms of flow resistance. A set of algebraic expressions are obtained for free surface elevation inside and outside chamber, and reflection coefficient. The prediction of the reflection coefficients shows that the relative widths of the chamber inducing the minimum reflection coefficient for a slotted-wall caisson breakwater are in a range of 0.10~0.20, which are smaller than that (0.15~0.25) for a perforated-wall caisson breakwater. The reflection coefficients and free surface elevation obtained by the present model are compared with that of laboratory experiments carried out by previous researchers.
文摘Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies. Ever since it was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials. This article reviews the various methods reported during the last 25 years.
文摘Assessment of acid sulfate soil risk is an important step for acid sulfate soil management and its reliability depends very much on the suitability and accuracy of various analytical methods for estimating sulfide-derived potential acidity, actual acidity and acid-neutralizing capacity in acid sulfate soils. This paper critically reviews various analytical methods that are currently used for determination of the above parameters, as well as their implications for environmental risk assessment of acid sulfate soi1s.
文摘Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma). It was the tenth-best-selling drug in the U.S. in 2008. This article examines published analytical methods reported so far in the literature for the determination of pioglitazone in biological samples and pharmaceutical formulations. They include various techniques like electrochemical methods, spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, liquid chromatography-electrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography.
基金financially supported by the Tehran University of Medical Sciences
文摘Objective:To evaluate relationship betweenα-cypermethrin residues in Interceptor~? nets by using HPTLC methods and mortality percentage in standard WHO’s method 'cone test' after repeated washings.Methods:Interceptor~? containingα-cypermethrin was provided by BASF Company.The washing procedure and bioassay tests were carried out according to the WHO-recommended methods.Malaria vector,An.stephensi was exposed to impregnated bed net for three minutes and then mortality measured after 24 hour recovery period.Chemical analysis was carried out in chemical laboratory by using high performance thin layer chromatography method.Results:Result of cone bioassay method showed that washing reduced the efficacy of Interceptor~? bed net from 100%in unwashed nets to 15%at 20 washes.After 20 washes,nets contain(61.2±2.8) mg/m^2 resulting 15%mortality in cone test.Killing activity was reduced when nets were washed.Conclusions:Results will provide an essential clue for monitoring and evaluation of bioefficacy of any long lasting impregnated bed net for quality control.Findings of this study will be useful for WHO.local investigators and people who wish to use pyrethroid-impregnated bed nets for malaria vector control.