We employed our previously developed 27-plex ancestry-informative single nucleotide polymorphism(SNP)panel to infer the ancestral components of bone remains of a possible foreign pilot found in south-western China.For...We employed our previously developed 27-plex ancestry-informative single nucleotide polymorphism(SNP)panel to infer the ancestral components of bone remains of a possible foreign pilot found in south-western China.For ancestry assignment of this unknown individual,we first obtained the 27-SNP genotype of the individual.Then,based on a reference database of 3081 individuals from 33 populations,we calculated the match probability and likelihood ratio using the self-developed software program Forensic Intelligence.Inferred ancestral components of this individual were calculated by structure at K=3.A complete profile was obtained for the individual using our multiplexed SNP assay.The European population was within one order of magnitude of the highest likelihood.The major ancestral component of this individual was 97.6%European.展开更多
The Y‑chromosome has been widely used in ancestry inference based on its region‑specific haplogroup distributions.However,there is always a debate on how informative such a single marker is for inferring an individual...The Y‑chromosome has been widely used in ancestry inference based on its region‑specific haplogroup distributions.However,there is always a debate on how informative such a single marker is for inferring an individual’s genetic ancestry.Here,we compared genetic ancestry inferences at continental level made by Y‑chromosomal haplogroups to those made by autosomal single‑nucleotide polymorphisms in 1230 samples of Affymetrix Human Origins dataset.The highest ancestry proportions of a majority of individuals match the highest average continental‑ancestry proportions in haplogroups A,B,D,H,I,K,L,T,O,and M.The high consistencies have not been observed in haplogroups E,C,G,J,N,Q,and R,but in some of their sublineages,such as E1a,E1b1a1,E1b1b1b1a,E2b1a,J1a2b,Q1a1a1,Q1a2a1a1,R1b1a2a1a,and R2.Although the consistencies of Y‑chromosomal and autosomal continental ancestry vary among haplogroups,Y‑chromosome could provide valuable clues for individual’s continental ancestry.展开更多
基金supported by the Basic Research Project[grant number 2016JB039]the Science and Technology Innovation Base Program of Beijing[grant number Z141106004414084]Key Projects in the National Science&Technology Pillar Program in the 12th-year Plan Period[grant number 2012BAK02B01].
文摘We employed our previously developed 27-plex ancestry-informative single nucleotide polymorphism(SNP)panel to infer the ancestral components of bone remains of a possible foreign pilot found in south-western China.For ancestry assignment of this unknown individual,we first obtained the 27-SNP genotype of the individual.Then,based on a reference database of 3081 individuals from 33 populations,we calculated the match probability and likelihood ratio using the self-developed software program Forensic Intelligence.Inferred ancestral components of this individual were calculated by structure at K=3.A complete profile was obtained for the individual using our multiplexed SNP assay.The European population was within one order of magnitude of the highest likelihood.The major ancestral component of this individual was 97.6%European.
基金supported by the Max Planck Society and Harvard Medical School.
文摘The Y‑chromosome has been widely used in ancestry inference based on its region‑specific haplogroup distributions.However,there is always a debate on how informative such a single marker is for inferring an individual’s genetic ancestry.Here,we compared genetic ancestry inferences at continental level made by Y‑chromosomal haplogroups to those made by autosomal single‑nucleotide polymorphisms in 1230 samples of Affymetrix Human Origins dataset.The highest ancestry proportions of a majority of individuals match the highest average continental‑ancestry proportions in haplogroups A,B,D,H,I,K,L,T,O,and M.The high consistencies have not been observed in haplogroups E,C,G,J,N,Q,and R,but in some of their sublineages,such as E1a,E1b1a1,E1b1b1b1a,E2b1a,J1a2b,Q1a1a1,Q1a2a1a1,R1b1a2a1a,and R2.Although the consistencies of Y‑chromosomal and autosomal continental ancestry vary among haplogroups,Y‑chromosome could provide valuable clues for individual’s continental ancestry.
