Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.

The influence of pore structure on P-& S-wave velocities in complex carbonate reservoirs with secondary storage space

Secondary storage spaces with very complex geometries are well developed in Ordovician carbonate reservoirs in the Tarim Basin,which is taken as a study case in this paper.It is still not clear how the secondary storage space shape influences the P-＆ S-wave velocities （or elastic properties） in complex carbonate reservoirs.In this paper,three classical rock physics models （Wyllie timeaverage equation,Gassmann equation and the Kuster-Toks z model） are comparably analyzed for their construction principles and actual velocity prediction results,aiming at determining the most favourable rock physics model to consider the influence of secondary storage space shape.Then relationships between the P-＆ S-wave velocities in carbonate reservoirs and geometric shapes of secondary storage spaces are discussed from different aspects based on actual well data by employing the favourable rock physics model.To explain the influence of secondary storage space shape on V P-V S relationship,it is analyzed for the differences of S-wave velocities between derived from common empirical relationships （including Castagna＇s mud rock line and Greenberg-Castagna V P-V S relationship） and predicted by the rock physics model.We advocate that V P-V S relationship for complex carbonate reservoirs should be built for different storage space types.For the carbonate reservoirs in the Tarim Basin,the V P-V S relationships for fractured,fractured-cavernous,and fractured-hole-vuggy reservoirs are respectively built on the basis of velocity prediction and secondary storage space type determination.Through the discussion above,it is expected that the velocity prediction and the V P-V S relationships for complex carbonate reservoirs should fully consider the influence of secondary storage space shape,thus providing more reasonable constraints for prestack inversion,further building a foundation for realizing carbonate reservoir prediction and fluid prediction.

基于T-S模糊逻辑的混合储能孤岛直流微电网功率分配控制

在含混合储能的直流微电网中,传统阻容下垂控制无法解决由线路电阻和负荷功率波动导致的系统功率分配失衡问题。为此,提出一种基于Takagi-Sugeno(T-S)模糊逻辑的自适应阻容下垂控制方法以实现混合储能的分频分配。根据蓄电池和超级电容的物理特性,建立单个蓄电池支路输出电压、蓄电池组间输出功率差额和阻性下垂系数之间的T-S模糊逻辑关系,以及单个超级电容支路输出功率及其变化率、超级电容组间功率差额和容性下垂系数之间的T-S模糊逻辑关系,并由此构建基于T-S模糊逻辑的阻容下垂控制器。推导含混合储能的直流微电网中各部分的平均阻抗模型,并采用阻抗比分析法对微电网的小信号稳定性进行研究。MATLAB/Simulink仿真结果表明,基于T-S模糊逻辑的阻容下垂控制可保证在线路电阻和负荷功率波动情况下系统功率的合理分配。

Mathematical Evaluation Changes in Rheological and Mechanical Properties of Pears during Storage under Variable Conditions

In order to better design, fabricate and control pear handling machine, we should take into account mechanical and rheological properties of pear fruits as related to handling process. The changes in rheological properties of pears stored at 5, 15, 25 ℃ and variable （fluctuating） temperature for 12 days were evaluated in terms of elasticity and viscosity parameters using creep tests. The elasticity and viscosity parameters in creep tests in general decreased with increase in storage time both under constant and variable storage conditions. For the variable storage condition, a bulk mean temperature calculated to account for a series combination of storage time and temperature to which the pears subjected. The changes in rheological properties due to variable storage temperature were described as a function of storage time. The result indicated that except the viscosity parameter of the Maxwell component of the four-element model, it was possible to describe the changes in rheological properties as a function of storage time, which are better physical parameters to estimate the quality of pears.

The Current Situation and Development of Grain Storage Technologies and Facilities for Chinese Farmers

In China, the quantity of farmer＇s grain storage covers about 40% of the total grain yield every year. While, the losses of farms＇ grain storage are up to 8%, which is due to the lack of grain storage facility and technology. The losses of farmer＇s grain storage could reach nearly 20 million tons every year. In this paper, the current situation and development of grain storage technology and facility for Chinese farmers were presented. And a series of policy and research work for reducing the losses of farms＇ grain storage was introduced. The large scale farmers are now developing quickly in China, the new storage warehouse and mechanized facility should be developed adaptively. So, the new storage technology and policy to meet the need of large scale farmers were also introduced in this paper.

联合GNSS与GRACE/GRACE-FO数据反演中国西南地区陆地水储量变化

GNSS和重力恢复与气候试验(GRACE)及其后续任务(GRACE-FO)给陆地水储量变化(TWSC)研究带来了技术革新,但这两种技术估计的区域TWSC具有不同的时空尺度和精度特性。因此,有必要融合两种观测数据,以获得同一尺度且高精度的TWSC。本文基于GNSS独立反演模型,使用求和算子对喷气推进实验室(JPL)的GRACE/GRACE-FO Mascon数据进行求和运算来构建约束,通过赤池贝叶斯准则选择最优模型参数,构建了一种联合GNSS与GRACE/GRACE-FO数据的区域TWSC反演模型。随后,本文设计数值模拟试验,以验证利用该模型反演中国西南地区TWSC的可行性。结果显示,1000次试验中联合反演估算的均方根误差均值为10 mm,比GNSS独立反演结果低47%。基于此方法,本文联合GNSS与JPL Mascon数据反演了中国西南地区2011年1月—2022年6月的时变TWSC。对比联合反演、GNSS独立反演、GRACE/GRACE-FO和高分辨率全球陆地数据同化系统(GLDAS)的结果,发现联合反演与GLDAS的TWSC周年振幅空间分布特征最吻合,表明联合反演估计的TWSC空间分辨率优于GNSS独立反演和GRACE的结果。最后,结合水平衡方程估算的区域水文收支情况,并通过广义三角帽方法评估陆地水储量等效水柱高的变化率(d(EWH)/d t)的不确定性。结果显示,联合反演估计的d(EWH)/d t不确定性为8 mm/月,较GRACE/GRACE-FO、GNSS独立反演和水平衡方程结果分别低33%、68%和62%。研究结果表明,与GNSS和GRACE/GRACE-FO独立反演方法相比,联合反演能够改善TWSC估值的精度,可为水资源管理决策及水文气候学研究提供更可靠的数据支撑。

Li adsorption on monolayer and bilayer MoS_2 as an ideal substrate for hydrogen storage

Based on the first-principles plane wave calculations, we show that Li adsorbed on monolayer and bilayer MoS2 forming a uniform and stable coverage can serve as a high-capacity hydrogen storage medium, and Li-coated MoS2 can be recycled by operations at room temperature due to Li having strength binding, big separation and is stable against clustering. The full Li coverage MoS2 system（2 ＊ 2 hexagonal MoS2 supercell） can reach up to eight H2 molecules on every side, corresponding to the gravimetric density of hydrogen storage up to 4.8 wt% and 2.5 wt% in monolayer and bilayer MoS2, respectively. The adsorption energies of hydrogen molecules are in the range of 0.10 e V/H2–0.25 e V/H2,which are acceptable for reversible H2 adsorption/desorption near ambient temperature. In addition, compared with light metals decorated low dimension carbon-based materials, the sandwiched structure of MoS2 exhibits the greatly enhanced binding stability of Li atoms as well as slightly decreased Li-Li interaction and thus avoids the problem of metal clustering.It is interesting to note that the Li atom apart from the electrostatic interaction, acts as a bridge of hybridization between the S atoms of MoS2 and adsorbed H2 molecules. The encouraging results show that such light metals decorated with MoS2 have great potential in developing high performance hydrogen storage materials.

水泵水轮机S特性对相继甩尾水最小压力的影响

为探究水泵水轮机全特性曲线S特性与尾水压力最小值的联系,基于新丰抽水蓄能电站的过渡过程数值仿真模型模拟了尾水最不利相继甩工况。通过调整机组运行轨迹线附近开度线斜率,对比分析并总结S区形状变化对相继甩工况尾水压力极值的影响规律,提出了一种图形指标,能够应用在抽蓄前期设计中评价S特性对尾水压力影响优劣,并验证其准确性。结果表明,相继甩工况后甩机组流量变化率第一波下降时,机组运行轨迹线呈现完整倒S形,S区形状变化改变了机组流量变化率的大小,导致出现在靠近轨迹线S形下拐点前的尾水压力极值发生变化,给出的图形指标形状越趋近于竖向细长的规则长方形,相应的尾水最小压力的改善效果越好。

Comparative experimental analysis on various picking types under dedicated and random storage assignments for automated storage and retrieval systems

Product storage policy, single picking volume and picking routing are the three factors of vital importance that affect the efficiency of a crane to pick goods in automated storage and retrieval systems(AS/RS). Comparative experiments on picking efficiency were conducted targeting picking operation with order of 1 to 20. Based on dedicated and random storage policies, 4 picking methods of patching-based, S-type, return-type and optimized-type routes were used and compared in the experiments. The results show that either the dedicated policy or the random policy was applied, crane worked most efficiently with optimizedtype route, followed by S-type path, patching-based path, and return-type path. When the number of orders in a single picking is larger(more than 5), the random storage policy is preferable to the dedicated policy.

Research of Enterprise Storage Ecosystem Based on Storage Theory and Nonlinear Discrete Optimization

Warehousing and transferring strategies are an important part of business operations. The issue of optimal warehousing and transferring strategy is studied in this paper. Wal-Mart in Wuhan serves as an example to establish a (s, S) random storage strategy model, a Markov chain model, and a nonlinear discrete programming model, aiming at maximizing the profit per cycle of every branch and further maximizing the company’s total profit per cycle. Among them, the random storage strategy model establishes a security zone of inventory for every branch, that is, it can meet consumers’ demand without spending too much storage costs. The Markov chain model is used to get the probability of losing sales opportunities in every branch. The nonlinear discrete programming model takes into account the horizontal transferring among branches, which further maximizes the company’s overall profit expectations. The three models above can be used to formulate inventory strategies, assess risks, and provide advice for every branch in order to form a complete storage ecosystem and provide constructive suggestions for the company’s operations.

Studies on Material Cycling in Evergreen Broad-LeavedForest Ecosystem in Hangzhon: Ⅲ. S Concentrationand Its Storage in Vegetation

This paper reveals the variations of S concentration among the leaf surface and other organs of variousplant species, and presents the distribution natures of S storage in the evergreen broad-leaved forest vege-tation in Hangzhou on the basis of the tested data concerning plant S contents. The result was that theS concentrations on the tree leaf surfaces varied with the testing time and plant species. The range of Scontents in various organs of a plant was 2.086- 4.245 S g kg￣(-1), varying with plant species in this forest.The S content in the leaves was the highest, followed by that in the branches, trunks and roots, which showedthat there was an apical dominance of S distribution. The total amount of S storage in the vegetation wasas large as 349.97 S kg ha￣(-1). The S distribution in this vegetation had two characteristics as follows: 1)for the vegetation layers, arbor layer > renewal layer > herb layer > shrub layer; and 2) for the verticaldistribution per unit height (m), root stratum (0 - 0.20 m of soil depth)> stratum nearby the ground surface(0 - 0.5m) > canopy (4.0- 9.5m) > trunk stratum (2.0- 4.0m).

ESSA： An Efficient and Secure Splitting Algorithm for Distributed Storage Systems

The security of critical data is an important issue for distributed storage system design,especially for long-term storage.ESSA (An Efficient and Secure Splitting Algorithm for Distributed Storage Systems) is presented,which takes advantage of a two level information dispersal scheme to strengthen the security of data.In ESSA,the approach of knight’s tour problem,which is NP-Complete,is introduced to scramble data at the first level,and a split cube is used to split scrambled data at the second level.Thus,it is very difficult for the malicious user to get information because the task of reconstructing the original data needs more computation than they can tolerate.We prove that the security of ESSA is better than encryption algorithm and not inferior to erasure codes and secret sharing.Experimental results show that distributed storage systems exploiting ESSA has greater efficiency than that exploiting keyed encryption,erasure codes and secret sharing.

“Bull’s eye”appearance of hepatocellular adenomas in patients with glycogen storage disease type I-atypical magnetic resonance imaging findings:Two case reports

BACKGROUND Hepatocellular adenomas are rare tumors that can occur in patients with glycogen storage disease type I.CASE SUMMARY We herein report two cases of histologically proven hepatocellular adenomas in patients with glycogen storage disease type I.Magnetic resonance imaging(MRI)was performed after bolus injection of gadoxetate disodium,a liver-specific gadolinium-based MRI contrast agent.In the present cases,some of the hepatocellular adenomas showed unexpectedly a“bull’s eye”appearance on T2-weighted and post-contrast images,which was not previously described as imaging findings of hepatocellular adenomas in glycogen storage disease.A bull’s eye appearance on T2-weighted images can be encountered in both benign(i.e.,abscess)or malignant(i.e.,epithelioid hemangioendothelioma,cholangiocarcinoma,and metastases)hepatic lesions.CONCLUSION We present two cases of hepatocellular adenomas in patients with glycogen storage disease type 1,in which gadoxetate disodium-MRI showed atypical imaging findings for hepatocellular adenomas.At present there is no systematic study evaluating MRI findings of hepatocellular adenomas in patients with glycogen storage disease,further studies are needed to specifically investigate this issue.

茜素红S对异齿裂腹鱼稚鱼标记效果研究

为探索茜素红S对异齿裂腹鱼稚鱼浸泡标记的适宜条件,采用半静态式水生生物急性毒性试验法确定茜素红S对异齿裂腹鱼稚鱼安全质量浓度,利用不同质量浓度的茜素红S溶液对45日龄的异齿裂腹鱼稚鱼浸泡不同时间,探究各试验组稚鱼死亡率、生长情况、标记效果和标记有效保存时间,确定茜素红S对异齿裂腹鱼稚鱼的适宜标记条件。试验结果表明:茜素红S对异齿裂腹鱼稚鱼24、48、72、96 h半致死质量浓度分别为225.85、147.72、139.21、137.66 mg/L,安全质量浓度为28.99 mg/L;0~125 mg/L的茜素红S溶液浸泡稚鱼24 h,质量浓度为75~125 mg/L稚鱼耳石标记效果可见,当茜素红S质量浓度为125 mg/L时,稚鱼死亡率显著升高(P<0.05);75 mg/L茜素红S浸泡稚鱼12~96 h,浸泡24~96 h稚鱼耳石标记效果可见,当浸泡时间为96 h时,稚鱼死亡率显著升高(P<0.05);在4个月的续养过程中,75 mg/L茜素红S溶液浸泡72~84 h,4个月后稚鱼耳石标记效果依旧可见。综合生长、存活率、染色效果及标记保存时间,建议采用75 mg/L茜素红S浸泡标记异齿裂腹鱼72~84 h。

基于B/S架构的纱线仓储管理系统开发与应用

针对纺织企业在仓储管理过程中存在纱线命名不规范、仓储主观性强、仓库盘点复杂且效率低等问题,开发出基于B/S架构的纱线仓储管理系统。该系统是一个基于Java的Web端和移动端双端应用程序,通过浏览器提供简洁操作界面,实现了快捷品种管理、出入库管理、报表管理等功能,具有跨平台兼容性好、分布性强、维护方便等特性,并通过Web Server与数据库进行数据交互。应用效果表明:该系统规范了纺织企业纱线命名、提高了出入库效率、简化了仓储操作方式、加强了对仓库库存和供需的把控。认为:该系统提高了纺织企业仓储管理效率,可有效降低企业仓储成本。

Review of Gas Transportation and Storage Facilities Construction in 2015

By the end of 2015, total length of China＇s long-distance gas pipelines has exceeded 70,O00km. Onshore stratey, ic import paths have been formed, domestic trunk networks perfected and gas storages construction pace acceh＇rated. The Chinese section of Russia-China East Gas Pipeline was officially commenced, which marked that the northeast import path entered the stage ofconstruction. There are 13 LNG terminals in China. The National Development and Rerorm Commission （NDRC） approved China＇s.first private-owned LNG terminal- the Zhoushan LNG terminal. In the coming.five years, the focus of institutional reform will be the independence of pipelines and networks, the focus of construction will be regional networks and branch pipelines, and joint ventures will be the mainstream for gas pipeline construction and operation.

Photonic Communications and Quantum Information Storage Capacities

This paper presents photonic communications and data storage capacitates for classical and quantum communications over a quantum channel. These capacities represent a generalization of Shannon’s classical channel capacity and coding theorem in two ways. First, it extends classical results for bit communication transport to all frequencies in the electromagnetic spectrum. Second, it extends the results to quantum bit (qubit) transport as well as a hybrid of classical and quantum communications. Nature’s limits on the rate at which classical and/or quantum information can be sent error-free over a quantum channel using classical and/or quantum error-correcting codes are presented as a function of the thermal background light level and Einstein zero-point energy. Graphical results are given as well as numerical results regarding communication rate limits using Planck’s natural frequency and time-interval units!

A Design of the Automatic Power-off after the Storage Battery of Electric Bicycle Is Fully Charged

As the service life of the electric bicycle＇ s storage battery is shortened due to the long-term floating charge, an automatic power- off circuit for the storage battery of electric bicycle is designed, and also the composition and design of the circuit are specifically expounded. After a test, the circuit can achieve a desired effect. Therefore, it can prolong the service life of the electric bicycle＇ s storage battery and save electric energy in the actual applications.

Effect of Interacting Abiotic Storage Conditions on Respiration,Dry Matter Losses and Aflatoxin B_(1) Contamination of Stored Turkey’s Shelled Hazelnuts

Hazelnuts are an economically important nut which is consumed world-wide.It is prone to infection by Aspergillus flavus and contamination with aflatoxins.Taking Tukey’s hazelnuts as a research object,the objective of this study were to(a)quantify respiration rates and(b)dry matter losses(DMLs)and(c)aflatoxin B_(1)(AFB_(1))contamination of naturally stored shelled hazelnuts at different temperatures and water availabilities.Subsequently,shelled hazelnuts were inoculated with additional A.flavus inoculum prior to storage to examine effects on dry matter losses and on AFB_(1) contamination.Maximum respiration of hazelnuts and associated mycoflora was under wetter conditions of 0.90~0.95 water activity(aw=12.5%~18%moisture content).This resulted in between approx.10%DML at 25 and 30℃after 5 days storage.Inoculation and storage of shelled hazelnuts+A.flavus inoculum resulted in similar patterns of respiration with optimal levels at 25~30℃and>0.90 aw.Indeed,AFB_(1) contamination was highest at the maximum water levels tested of 0.90 aw.Indeed the contamination level exceeded the legislative limits set by the EU for AFB_(1) contamination of these nuts.Correlation between DMLs and all the AFB_(1) data in both sets of studies showed that very small changes in DML due to poor drying or storage of≥0.6%resulted in AFB_(1) contamination levels exceeding the EU legislative limits.Thus,efficient drying and safe monitored storage is necessary to minimise the risk of AFB_(1) contamination in this economically important commodity and to avoid exposure of consumers to such toxins.