The development of cancer is a complex process that requires the participation of many factors,including mutations in genes, regulation of signaling pathways, disruption of homeostasis, and failure of self-monitoring ...The development of cancer is a complex process that requires the participation of many factors,including mutations in genes, regulation of signaling pathways, disruption of homeostasis, and failure of self-monitoring mechanisms. Sufficient evidence has展开更多
The necessity for understanding normal human cognitive processes and behavior, and themechanisrns which result in dysfunction in these processes are dependant on utilization of a suitable animal model. In order to dev...The necessity for understanding normal human cognitive processes and behavior, and themechanisrns which result in dysfunction in these processes are dependant on utilization of a suitable animal model. In order to develop pharmaceutical agents to alleviate mental disturbances and enable the individual to cope within the norms of society, it is incumbent upon investigators to choose a species in which pharmacokinetic principles are established and resemble those of hurnans. The choice of rats in cognition research studies has specific advantages in that these anirnals possess similar pharrnacodynamic parameters to hurnans. Further advantages include availability, low cost, ease of breeding, maintenance and an extensive literature database which enable comparisons to present findings. However, there are substantial differences in the perforrnance of various rat strains in tasks of learning, memory, attention, and responses to stress or drugs. In addition to rat strain, quantity of thed also exerts profound consequences on animal behavior. The aim of this review is to demonstrate that there are differences in the central nervous systern responsivencess of rat strains to chemicals and these could be related to factors such as source of supplier, type and quantity of feed, or season of the year. It is also evident that the genotype differs amongst strains and this may be responsible for the observed differences in CNS sensitivity to chemicals. Strain differences must be identified and taken into consideration in interpretation of assessrnent of neurobehavioural functions. It is also incumbent upon the investigators to utilize healthy (diet-controlled) animal models.展开更多
The Orthodoxy has been in existence in Russia for more than 1000years and has fully merged itself into the nation,creating a strongsense of religious culture.During the long years of the reigns by differ-ent regimes f...The Orthodoxy has been in existence in Russia for more than 1000years and has fully merged itself into the nation,creating a strongsense of religious culture.During the long years of the reigns by differ-ent regimes from the Czarist Russia to the Soviet Union and then to thenew Russia,the religion went through the process of ups and downs inits development.Having once played a very important role in the展开更多
To explore the relationship between social influence,social comparison,clarity of self-concept,and psychological anxiety among young women during their usage of social networking sites,our study selected 338 young wom...To explore the relationship between social influence,social comparison,clarity of self-concept,and psychological anxiety among young women during their usage of social networking sites,our study selected 338 young women aged 14-34 from the social site platforms of Little Red Book and Weibo for questionnaire surveys.The Passive Social Network Utilization Scale,Social Comparison Scale(SCS),Social Influence Questionnaire,Self-Concept Clarity Scale(SCCS),and Generalized Anxiety Disorder Scale(GAD-7)were employed to measure the subjects.Our results show that the frequency of passive social media use is positively related to the level of psychological anxiety.Social comparison,social influence,and unclear self-concepts under social media use are negatively predictive of psychological anxiety.The chain mediation effects indicate that social comparison and social influence under social media use negatively predict the clarity of self-concept,thus having a negative impact on the psychological health of young women.Therefore,young women should strengthen their self-concepts,control their frequency of social media usage,avoid addiction,and pay special attention to their frequency of passive use,in order to protect their psychological health.Our study provides some practical implications and insights regarding the relationship between young women’s social media use and psychological health.展开更多
To investigate the biological character of human adipose-derived adult stem cells (hADAS cells) when cultured in vitro and the relationship between hADAS cell’s replication activity and the donor’s age factor, and t...To investigate the biological character of human adipose-derived adult stem cells (hADAS cells) when cultured in vitro and the relationship between hADAS cell’s replication activity and the donor’s age factor, and to assess the stem cells as a new source for tissue engineering. hADAS cells are isolated from human adipose tissue of different age groups (from adolescents to olds: <20 years old, 21―40 years old, 41―60 years old and >61 years old groups). The protein markers (CD29, CD34, CD44, CD45, CD49d, HLA-DR, CD106) of hADAS cells were detected by flow cytometry (FCM) to identify the stem cell, and the cell cycle was examined for P20 hADAS cells to evaluate the safety of the subculture in vitro. The generative activity of hADAS cells in different age groups was also examined by MTT method. The formula “ log2T D = t logN t ? logN 0” was used to get the time doubling (TD) of the cells. The results showed that the cells kept heredity stabilization by chromosome analysis for at least 20 passages. The TD of these cells increased progressively by ageing, and the TD of the <20 years old group was lower than that of the >61 years old group (statistical analysis of variance (ANOVA), P=0.002, P<0.05). These find- ings suggested that a higher level of hADAS cells replication activity was found in the younger dona- tors, and they represent novel and valuable seed cells for studies of tissue engineering.展开更多
Previous work has shown great variations in the chemical composition of Ocimum gratissimum Linn essential oils(EOs).Our aim was to study the influence of this variation on their antimicrobial,anti-parasitic effects an...Previous work has shown great variations in the chemical composition of Ocimum gratissimum Linn essential oils(EOs).Our aim was to study the influence of this variation on their antimicrobial,anti-parasitic effects and toxicity.Methods:EOs from aerial part collected in two vegetative stages and three moments of harvest were isolated by hydrodistillation and analysed by GC/MS and GC/FID.展开更多
In recent years, India’s diplomatic activities in the Asia-Pacific region are very active. From major power diplomacy, bilateral diplomacy to multilateral diplomacy, India has been quite impressive. Especially its mu...In recent years, India’s diplomatic activities in the Asia-Pacific region are very active. From major power diplomacy, bilateral diplomacy to multilateral diplomacy, India has been quite impressive. Especially its multilateral diplomacy has become widely accepted. This paper attempts to understand India’s multilateral diplomacy in the Asia-Pacific region, with emphasis on Indian strategic considerations, underlying motivation and strategic influence of its participation in the Asia-Pacific multilateral mechanisms.展开更多
Science is principally driven by the efforts of a small fraction of researchers publishing the m ajority of scientific research and garnering the m ajority of citations.The quantitative analysis of outstanding scienti...Science is principally driven by the efforts of a small fraction of researchers publishing the m ajority of scientific research and garnering the m ajority of citations.The quantitative analysis of outstanding scientists’publication and citation patterns provides a new perspective fo r understanding of scientific talents.The study of outstanding scientists can enhance our understanding of the publication and citation patterns and their scientific careers more generally.Based on 35,315 research papers from the biomedical field,we analyzed the academic productivity and influence characteristics of 244 outstanding scientists in biomedical field.Several interesting patterns are observed as follows:as outstanding scientists’career age increased,(1)their scientific output shows a trend of decreasing after increasing,(2)their academic influence shows a trend of continuous growth,(3)their number of the co-authors in their scientific career first increases and then remains stable,and(4)the number of their research areas first decreases and then increases.展开更多
基金supported by the grants from the Outstanding Academic Leaders Plan of Shanghai [Grant No.2018BR07]the National Science Foundation of China [Grant No.81572061]+1 种基金Program for Young Medical Technicians(Clinical Examination)in Shanghai [2016]05Shanghai Health and Family Planning Commission Clinical Research Project for Health Industry [Grant No.20184Y0199]
文摘The development of cancer is a complex process that requires the participation of many factors,including mutations in genes, regulation of signaling pathways, disruption of homeostasis, and failure of self-monitoring mechanisms. Sufficient evidence has
文摘The necessity for understanding normal human cognitive processes and behavior, and themechanisrns which result in dysfunction in these processes are dependant on utilization of a suitable animal model. In order to develop pharmaceutical agents to alleviate mental disturbances and enable the individual to cope within the norms of society, it is incumbent upon investigators to choose a species in which pharmacokinetic principles are established and resemble those of hurnans. The choice of rats in cognition research studies has specific advantages in that these anirnals possess similar pharrnacodynamic parameters to hurnans. Further advantages include availability, low cost, ease of breeding, maintenance and an extensive literature database which enable comparisons to present findings. However, there are substantial differences in the perforrnance of various rat strains in tasks of learning, memory, attention, and responses to stress or drugs. In addition to rat strain, quantity of thed also exerts profound consequences on animal behavior. The aim of this review is to demonstrate that there are differences in the central nervous systern responsivencess of rat strains to chemicals and these could be related to factors such as source of supplier, type and quantity of feed, or season of the year. It is also evident that the genotype differs amongst strains and this may be responsible for the observed differences in CNS sensitivity to chemicals. Strain differences must be identified and taken into consideration in interpretation of assessrnent of neurobehavioural functions. It is also incumbent upon the investigators to utilize healthy (diet-controlled) animal models.
文摘The Orthodoxy has been in existence in Russia for more than 1000years and has fully merged itself into the nation,creating a strongsense of religious culture.During the long years of the reigns by differ-ent regimes from the Czarist Russia to the Soviet Union and then to thenew Russia,the religion went through the process of ups and downs inits development.Having once played a very important role in the
基金funded by Zhejiang Xi Jinping Research Center for Socialist Thought with Chinese Characteristics in the New Era Project(Grant No.23CCG39).
文摘To explore the relationship between social influence,social comparison,clarity of self-concept,and psychological anxiety among young women during their usage of social networking sites,our study selected 338 young women aged 14-34 from the social site platforms of Little Red Book and Weibo for questionnaire surveys.The Passive Social Network Utilization Scale,Social Comparison Scale(SCS),Social Influence Questionnaire,Self-Concept Clarity Scale(SCCS),and Generalized Anxiety Disorder Scale(GAD-7)were employed to measure the subjects.Our results show that the frequency of passive social media use is positively related to the level of psychological anxiety.Social comparison,social influence,and unclear self-concepts under social media use are negatively predictive of psychological anxiety.The chain mediation effects indicate that social comparison and social influence under social media use negatively predict the clarity of self-concept,thus having a negative impact on the psychological health of young women.Therefore,young women should strengthen their self-concepts,control their frequency of social media usage,avoid addiction,and pay special attention to their frequency of passive use,in order to protect their psychological health.Our study provides some practical implications and insights regarding the relationship between young women’s social media use and psychological health.
基金the Science and Technical Research Funds of Guangdong Province, China (Grant Nos. 2004B34001004 and04009423)
文摘To investigate the biological character of human adipose-derived adult stem cells (hADAS cells) when cultured in vitro and the relationship between hADAS cell’s replication activity and the donor’s age factor, and to assess the stem cells as a new source for tissue engineering. hADAS cells are isolated from human adipose tissue of different age groups (from adolescents to olds: <20 years old, 21―40 years old, 41―60 years old and >61 years old groups). The protein markers (CD29, CD34, CD44, CD45, CD49d, HLA-DR, CD106) of hADAS cells were detected by flow cytometry (FCM) to identify the stem cell, and the cell cycle was examined for P20 hADAS cells to evaluate the safety of the subculture in vitro. The generative activity of hADAS cells in different age groups was also examined by MTT method. The formula “ log2T D = t logN t ? logN 0” was used to get the time doubling (TD) of the cells. The results showed that the cells kept heredity stabilization by chromosome analysis for at least 20 passages. The TD of these cells increased progressively by ageing, and the TD of the <20 years old group was lower than that of the >61 years old group (statistical analysis of variance (ANOVA), P=0.002, P<0.05). These find- ings suggested that a higher level of hADAS cells replication activity was found in the younger dona- tors, and they represent novel and valuable seed cells for studies of tissue engineering.
文摘Previous work has shown great variations in the chemical composition of Ocimum gratissimum Linn essential oils(EOs).Our aim was to study the influence of this variation on their antimicrobial,anti-parasitic effects and toxicity.Methods:EOs from aerial part collected in two vegetative stages and three moments of harvest were isolated by hydrodistillation and analysed by GC/MS and GC/FID.
文摘In recent years, India’s diplomatic activities in the Asia-Pacific region are very active. From major power diplomacy, bilateral diplomacy to multilateral diplomacy, India has been quite impressive. Especially its multilateral diplomacy has become widely accepted. This paper attempts to understand India’s multilateral diplomacy in the Asia-Pacific region, with emphasis on Indian strategic considerations, underlying motivation and strategic influence of its participation in the Asia-Pacific multilateral mechanisms.
基金supported partially by the National Natural Science Foundation of China(Grant Nos.72174016)。
文摘Science is principally driven by the efforts of a small fraction of researchers publishing the m ajority of scientific research and garnering the m ajority of citations.The quantitative analysis of outstanding scientists’publication and citation patterns provides a new perspective fo r understanding of scientific talents.The study of outstanding scientists can enhance our understanding of the publication and citation patterns and their scientific careers more generally.Based on 35,315 research papers from the biomedical field,we analyzed the academic productivity and influence characteristics of 244 outstanding scientists in biomedical field.Several interesting patterns are observed as follows:as outstanding scientists’career age increased,(1)their scientific output shows a trend of decreasing after increasing,(2)their academic influence shows a trend of continuous growth,(3)their number of the co-authors in their scientific career first increases and then remains stable,and(4)the number of their research areas first decreases and then increases.
