The effect of Supplementing Qi and Nourishing Yin combined with chemotherapy for lung cancer： a meta-analysis

Objective： To evaluate whether herbs of supplementing Qi and nourishing Yin combined with chemotherapy （versus chemotherapy alone） improve survival, increase tumor response, improve performance status or reduce chemotherapy toxicity in patients with lung cancer. Methods： Searching the randomized controlled trials （RCT） studies from the databases （China HowNet database, Wan Fang database, VIP database, Master Thesis and Pubmed） between January 2013 and January 2017. RevMan 5.3 software was used to evaluate the quality of these collected papers. Results： Of 48 potentially relevant publications, 10 randomized studies representing 691 patients met inclusion criteria with 369 cases in the supplementing Qi and nourishing Yin plus Chemotherapy group （Herbs ＋ Chem group） and 322 cases in Chemotherapy group （Chem only group）. There were significant differences between Herbs ＋ Chem group and Chem only group in improving the treatment efficacy and reducing the side effects of chemotherapy （P 〈 0.001 for all）. There were also significant differences between the two groups in tumor response and quality of life （P 〈 0.001 for all）. Conclusion： Herbs of supplementing Qi and nourishing Yin may increase chemotherapy effectiveness, reduce chemotherapy toxicity and improve the quality of life of patients with lung cancer when combined with chemotherapy.

Experience in the Treatment of Tumors by Replenishing Qi and Nourishing Blood,Detoxicating and Resolving Masses

The pathogenesis of malignant tumors is the deficiency of vital Qi and the excess of pathogenic Qi.Its basic treating principle is to strengthen vital Qi to eliminate pathogenic factor.The paper is to summarize the clinical experiences in tumor treatment of Dr.Chen Shizhou,a well-known traditional Chinese medicine expert in Weifang City,Shandong Province.He put forward the treatment method of"replenishing Qi and nourishing blood,detoxicating and resolving masses",paying attention to protecting stomach qi and advocating survival with tumor,with remarkable clinical effects.

Effect of Detoxification,Removing Stasis and Nourishing Yin Method on Corticosteroid-induced Hyperlipidemia in Patients with Systemic Lupus Erythematosus

Objective： To observe the effect of TCM therapy for detoxification, removing stasis, and nourishing yin on corticosteroid-induced hyperlipemia in patients with systemic lupus erythematosus （SLE）, and to investigate its mechanism. Methods： One hundred and seventy patients with SLE were randomly assigned to the integrative medicine group （IM group） and the Western medicine group （WM group）, 85 in each group. Also, 30 healthy subjects selected from blood donors were enrolled in the normal control （NC） group. All patients were treated mainly with prednisone, while those in the IM group were given TCM therapy additionally, and the therapeutic course for both groups was 6 successive months. The changes of serum total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, very low density lipoprotein cholesterol （VLDL-C） and apolipoprotein A （ApoA） were determined and observed. A 2-year follow-up study was carried out in 16 patients of the WM group and 25 of the IM group. Results： Before treatment, no significant difference had been found among the three groups in the serum levels of lipids and lipoproteins. After the 6-month treatment, as compared with the WM group, the IM group showed lower levels of TC, TG, LDL-C, and VLDL-C （P〈0.05 or P〈0.01） and higher levels of HDL-C and ApoA （P〈0.05）. A similar effect was also shown by the follow-up study in the IM group （P〈0.05 or P〈0.01）. Conclusion： TCM therapy for detoxification, removing stasis, and nourishing yin can effectively regulate the levels of serum lipids and lipoproteins in preventing and treating SLE patients with corticosteroid-induced hyperlipemia.

Influence of TCM Therapy for Supplementing Pi(脾) and Nourishing Shen(肾) on Dendritic Cell Function in Patients with Chronic Hepatitis B Treated by Lamivudine

Objective:To observe the influence of traditional Chinese medicine(TCM) therapy for supplementing Pi(脾) and nourishing Shen(肾,SPNS) on dendritic cell function in patients with chronic hepatitis B (CHB) treated by lamivudine.Methods:Sixty CHB patients with positive HBeAg were equally randomized by digital table into two groups:the observation group and the control group.Patients in the control group were treated with lamivudine only,while patients in the observation group were treated with lamivudine combine...

Effect and Mechanism on Mainly Using Traditional Chinese Medicine of Replenishing Qi and Nourishing Yin in Treating Graves' Disease

Objective: To explore the therapeutic effect and its mechanism mainly using traditional Chinese medicine (TCM) of Replenishing Qi and Nourishing Yin (RQNY) with a small dosage of Tapazole for treatment of Graves’ disease (GD).Methods: The changes of thyroid function and the activity of sodium pump of human erythrocyte in the patients with Graves’ disease were observed and compared before and after treatment between the treated group (42 cases) by combining treatment mainly using TCM of RQNY and a small amount of Tapazole and a control group (42 cases) by Tapazole alone.Results: After treatment for half a year, one and two years, the serum levels of T3, T4 in above two groups were markedly decreased than those of before treatment, the therapeutic effect of treated group was superior to that of the control group. The activity of sodium pump in human erythrocyte in the GD patients was obviously higher than that of normal group and that of before treatment. After treatment for one and two years mainly by TCM or western medicine, the erythrocyte sodium pump activity was obviously lower than that of normal group and that of before treatment. The decrease of erythrocyte sodium pump activity in the treated group was markedly lower than that in the control group.

"External main and internal auxiliary" treatment on refractory radiation proctitis

Radiotherapy is an essential method in the comprehensive treatment of malignant tumors.However,radiation proctitis(RP)is a common complication of pelvic tumors after radiotherapy.Due to RP's various etiology and complex pathogenesis,it is currently no standard for traditional Chinese medicine(TCM)treatment.Professor Yuan-hong Zhao believes that refractory RP,which is named chronic hemorrhagic radiation proctitis(CHRP),should be classified as"Intestinal Wind Bleeding"(Bleeding like a note before defecation,bright red blood,no swelling and pain in the anus)and"Intestinal Afflux"(Refers to the symptoms of pus and blood in the lower mucus,similar to ulcerative colitis,peptic ulcer and other diseases in modern medicine.)in TCM.The critical pathogenesis of CHRP lies in local stasis and collaterals injury of intestinal collaterals.In general,it is a syndrome of excess and scarcity.External treatment with TCM is the preferred treatment strategy for CHRP,and the primary way is to disperse blood stasis and detoxify and nourish the intestinal collaterals.

Multi-central Clinical Research into Treating 80 Cases of Chronic Thrombocytopenia with Qi-supplementing and Yin-nourishing Therapy and Western Medicine

Objective: To probe the effects of qi-supplementing and yin-nourishing therapy (blood-increasing decoction and blood generating powder) on chronic thrombocytopenia. Methods: Two hundred patients with chronic thrombocytopenia were randomly divided into control (n=100) and test groups (n = 100) with Amino-polypeptide as a basic treatment for both. Test group patients consumed a blood-increasing decoction and blood-generating powder for 1-3 months. Improvements in platelet counts and TCM syndrome were observed. Results: One hundred and sixty-four (80 in the test group and 84 in the control group) of 189 total participants were treated for 3 months. The total effective rate in improving TCM syndrome was 95.00% in the test group and 79.76% in the control group (P<0.05). There was significant difference (P<0.05) in the accumulated score of TCM syndrome between the two groups treated at different time points. The total effective rate of platelet counts was 86.25% in the test group and 59.52% in the control group (P<0.05). There was a significant difference in platelet counts before and after treatment in the two groups (P<0.05). There was no significant differences in platelet count between the two groups treated for 1-2 months; however, a significant difference was found between the two groups after treatment for 3 months (P<0.05). Conclusions: After a 3-month treatment of chronic thrombocytopenia patients with qi-supplementing and yin-nourishing therapy, TCM syndrome was improved and platelet counts increased with no obvious side effects, and the quality of life of the participants was enhanced with noticeable long-term curative effects.

Enhancement of Swimming Endurance by Herbal Supplement M3P

Objective:To investigate the effect of M3P(containing Deer antler,Cordyceps sinensis,Rhodiola rosea,and Panax ginseng);an herbal remedy with the function of tonifying Kidney(Shen)and invigorating Spleen(Pi),replenishing qi and nourishing blood;on fatigue alleviation,endurance capacity and toxicity.Methods:Swimming with weight-loading of 24 male ICR mice was used to evaluate the endurance capacity,and fatiguerelated plasma biomarkers were determined.Mice were randomly assigned to control or M3P treatment groups with 6 mice for each group and were orally administered with M3P everyday for 8 weeks at doses 0,10,33 or 100 mg/kg.Swimming time to exhaustion was measured in a specialized water tank.Lliver and kidney functions,body weight,and hematological profile were determined to evaluate the safety and toxicity after long-term M3P administration.Results:M3P supplementation 100 mg/kg significantly increased swimming endurance time up to approximate 2.4 folds of controls(P<0.05).The plasma concentrations of cortisol and hepatic glycogen content were significantly increased in mice received M3P(P<0.05,P<0.01 respectively).The lactic acid level and blood glucose were not changed after M3P treatment(P>0.05).The liver and kidney functions muscle damage biomarker creatine,body weight,and hemograms were not altered in M3P supplementation(P>0.05).Conclusion:M3P supplementation may improve swimming endurance accompanied by increasing hepatic glycogen content and serum cortisol level without major toxicity.