Angiomyofibroblastoma (AMF) is a rare kind of soft tissue tumor that occurs predominantly in the vulva. Due to their location, clinicians often confuse AMF with Bartholin’s cyst or perineal hernia. Radiological evalu...Angiomyofibroblastoma (AMF) is a rare kind of soft tissue tumor that occurs predominantly in the vulva. Due to their location, clinicians often confuse AMF with Bartholin’s cyst or perineal hernia. Radiological evaluation is performed to rule out perineal hernia and invasive neoplasm. Like other benign mesenchymal tumors of vulva, AMF shows indolent behavior and rarely recurs after complete surgical excision.展开更多
Objective To explore the clinicopathologic features of angiomyofibroblastomz and the relationship between angiomyofibroblastoma (AMFB)and aggressive angiomyxoma (AA ). Aethods Seven cases of AMFB and 5 coses of AA wer...Objective To explore the clinicopathologic features of angiomyofibroblastomz and the relationship between angiomyofibroblastoma (AMFB)and aggressive angiomyxoma (AA ). Aethods Seven cases of AMFB and 5 coses of AA were reviewed. Conventional histologic and immunohistochemical features of AMFB were compered with those of AA. Results The lesions of AMFB usually presented as painless masses and were located in the superficial vulvar regional and inguinal areas. Microscopically, the tumors were composed of spindled and epithelioid cells arranged in cords and nests preferentially arrayed around numerous small to medium-sized, thin-walled vessels with some hyalined thick walls. Seven cases manifested zone of both dense and sparse cellularity. Immunohistochemically, the tumor cells were strongly positive for vimentin and desmin. but negative for S-100 and cytokeratin 8. Some cells were positive for SMA, ER and PR. None of the 4 ams followed up over 2 years after simple excision developed a recurrence, in contract to AA that exhibited local recurrence in 3 of 4 cases. AA showed more dense myxoid hackground and thick walled vessels. Myoid bundles tended to be located adjacently to biood vessels in all cases. Ultrastructurally,AMFB tumor cells contained intercellular junction and cytoplastic microfilaments. Intercellular spaces contained a great of collagen fibers. Conclusion The results indicate that conventional morphologic analysis is paramount in the recognition of ANFB. AMFB and AA show different clinicoathologic entity and propose an origin from a perivascular stem cell that is ca- pable of myofibroblastic differentiation.展开更多
To study the clinicopathologic features and immunoprofile of angiomyofibroblastoma (AMF) with emphasis on differential diagnosis Methods Seven vulvar, two vaginal and one perineal angiomyofibroblastomas were evaluated...To study the clinicopathologic features and immunoprofile of angiomyofibroblastoma (AMF) with emphasis on differential diagnosis Methods Seven vulvar, two vaginal and one perineal angiomyofibroblastomas were evaluated by light microscopy and immunohistochemistry The immunohistochemical studies were performed on paraffin embedded sections using the standard ABC method with a panel of antibodies Results Angiomyofibroblastoma predominantly occurred in middle aged women in the genital region, especially in the superficial area of the vulva Clinically, most of the tumors presented as slowly growing painless masses and were often diagnosed as Bartholin’s gland cysts Histologically, the tumors were all well circumscribed and characterized by alternating hypocellular and hypercellular areas with abundant thin walled blood vessels The tumor cells were bland and spindle shaped or epithelioid and tended to concentrate around the vessels or cluster in small nests Immunohistochemically, the tumor cells expressed vimentin and estrogen receptor protein in all 10 cases and desmin in 9 cases Three cases showed weak or focal immunoreactivity to alpha smooth muscle actin and muscle specific actin All ten patients were treated by local excision Follow up showed a benign course with no signs of recurrence Conclusions Angiomyofibroblastoma is a distinctive neoplasm that has a propensity to occur in the female genital tract Recognition of this entity is important to avoid misdiagnosis with other vulvar angiomyxoid展开更多
文摘Angiomyofibroblastoma (AMF) is a rare kind of soft tissue tumor that occurs predominantly in the vulva. Due to their location, clinicians often confuse AMF with Bartholin’s cyst or perineal hernia. Radiological evaluation is performed to rule out perineal hernia and invasive neoplasm. Like other benign mesenchymal tumors of vulva, AMF shows indolent behavior and rarely recurs after complete surgical excision.
文摘Objective To explore the clinicopathologic features of angiomyofibroblastomz and the relationship between angiomyofibroblastoma (AMFB)and aggressive angiomyxoma (AA ). Aethods Seven cases of AMFB and 5 coses of AA were reviewed. Conventional histologic and immunohistochemical features of AMFB were compered with those of AA. Results The lesions of AMFB usually presented as painless masses and were located in the superficial vulvar regional and inguinal areas. Microscopically, the tumors were composed of spindled and epithelioid cells arranged in cords and nests preferentially arrayed around numerous small to medium-sized, thin-walled vessels with some hyalined thick walls. Seven cases manifested zone of both dense and sparse cellularity. Immunohistochemically, the tumor cells were strongly positive for vimentin and desmin. but negative for S-100 and cytokeratin 8. Some cells were positive for SMA, ER and PR. None of the 4 ams followed up over 2 years after simple excision developed a recurrence, in contract to AA that exhibited local recurrence in 3 of 4 cases. AA showed more dense myxoid hackground and thick walled vessels. Myoid bundles tended to be located adjacently to biood vessels in all cases. Ultrastructurally,AMFB tumor cells contained intercellular junction and cytoplastic microfilaments. Intercellular spaces contained a great of collagen fibers. Conclusion The results indicate that conventional morphologic analysis is paramount in the recognition of ANFB. AMFB and AA show different clinicoathologic entity and propose an origin from a perivascular stem cell that is ca- pable of myofibroblastic differentiation.
基金This study was supparted in paut by the Shanghai Medi cal Leading Speciality(No 993025).
文摘To study the clinicopathologic features and immunoprofile of angiomyofibroblastoma (AMF) with emphasis on differential diagnosis Methods Seven vulvar, two vaginal and one perineal angiomyofibroblastomas were evaluated by light microscopy and immunohistochemistry The immunohistochemical studies were performed on paraffin embedded sections using the standard ABC method with a panel of antibodies Results Angiomyofibroblastoma predominantly occurred in middle aged women in the genital region, especially in the superficial area of the vulva Clinically, most of the tumors presented as slowly growing painless masses and were often diagnosed as Bartholin’s gland cysts Histologically, the tumors were all well circumscribed and characterized by alternating hypocellular and hypercellular areas with abundant thin walled blood vessels The tumor cells were bland and spindle shaped or epithelioid and tended to concentrate around the vessels or cluster in small nests Immunohistochemically, the tumor cells expressed vimentin and estrogen receptor protein in all 10 cases and desmin in 9 cases Three cases showed weak or focal immunoreactivity to alpha smooth muscle actin and muscle specific actin All ten patients were treated by local excision Follow up showed a benign course with no signs of recurrence Conclusions Angiomyofibroblastoma is a distinctive neoplasm that has a propensity to occur in the female genital tract Recognition of this entity is important to avoid misdiagnosis with other vulvar angiomyxoid
