PSA解吸气及液氮洗尾气替代天然气使用探索

介绍了PSA解吸气及液氮洗尾气替代天然气使用运行情况。通过对中国石化集团南京化学工业有限公司30万t/a合成氨装置和9万t/a制氢装置燃料气用户的流程及设备进行改造,实现了利用尾气进行气化炉烘炉和作为火炬的正常用燃料气,采用PSA解吸气和液氮洗尾气替代天然气,减少了天然气的耗量,节约了生产成本。

PSA<20 ng/mL患者前列腺穿刺阳性率的影响因素分析

目的:回顾性分析PSA<20 ng/mL患者前列腺穿刺阳性率的影响因素。方法:通过检索湖南省人民医院专病数据库,回顾性分析我院2019年04月至2023年04月行前列腺穿刺活检的患者资料,选取PSA<20 ng/mL病例,通过纳入排除标准后,将符合条件的67例作为本次研究对象。先采用单因素分析筛选出穿刺阳性影响因子,再将阳性因子采用多因素分析,最后绘制出ROC曲线效验本次研究目的。结果:纳入67例中Pca有35例(52.24%),非Pca有32例(47.76%)。进行单因素分析结果显示:Pca组与非Pca组在f/tPSA、PI-PADS、穿刺途径方面有显著性差异,fPSA、年龄、tPSA、PV、PSAD方面没有明显统计学差异。穿刺阳性病例中f/tPSA更小(54.29%vs 25.00%),PI-PADS评分更高(42.86%vs 0.00%),穿刺途径更趋向经会阴(48.57%vs 21.88%)。多因素分析显示f/tPSA、PI-PADS为穿刺结果的影响因素,将这2个影响因素及联合指标(f/tPSA、PI-PADS)进行ROC曲线分析,得出每个影响因素与联合指标对应穿刺结果的预测效果,结果显示f/tPSA的AUC为0.646,f/tPSA对于穿刺结果的诊断价值稍低(P<0.05),具有统计学意义;PI-PADS的AUC为0.731,PI-PADS对于穿刺结果的诊断价值较高(P<0.05),具有统计学意义;另外联合指标(f/tPSA、PI-PADS)的AUC为0.775,对于前列腺穿刺结果的诊断价值较高(P<0.05),具有明显统计学意义。结论:PSA<20 ng/mL的患者中PI-PADS评分、f/tPSA及PI-PADS联合f/tPSA是影响前列腺穿刺阳性率的重要影响因素。

精子相关抗原9联合PSAD、fPSA/tPSA比值诊断PSA灰区前列腺癌的临床研究

目的:研究尿液中精子相关抗原9(SPAG9)含量联合血清中前列腺特异性抗原密度(PSAD)、游离前列腺特异性抗原(fPSA)/总PSA(tPSA)比值诊断PSA灰区前列腺癌的价值。方法:选择2018年1月—2022年12月期间在南通市第二人民医院门诊或住院收治的血清PSA水平处于灰区(4~10 ng/mL)的309例患者作为研究对象,根据前列腺穿刺术的病理结果分为前列腺癌组58例和前列腺良性组251例(对照组)。所有患者均在术前留取尿液并检测SPAG9含量,测定血清PSAD、fPSA、tPSA,计算fPSA/tPSA比值,比较两组间临床资料的差异,采用Logistic回归分析确定前列腺癌的相关因素,绘制受试者工作特征(ROC)曲线、计算曲线下面积(AUC)并分析各指标对前列腺癌的诊断价值。结果:前列腺癌组和对照组间患者的体质量、tPSA、白细胞计数、血红蛋白、血小板计数、总胆红素、白蛋白、肌酐、尿酸、前列腺体积的差异均无统计学意义(P>0.05);前列腺癌组患者的年龄、尿液SPAG9含量、血清fPSA/tPSA比值、PSAD均高于对照组,差异均有统计学意义(P<0.05);多因素Logistic回归分析显示,尿液SPAG9含量、血清fPSA/tPSA比值、PSAD是前列腺癌的影响因素;ROC曲线分析显示,尿液SPAG9含量、血清fPSA/tPSA比值、PSAD单独及联合均能诊断前列腺癌,3项指标联合的诊断效能理想,灵敏度和特异度分别为80.00%和80.88%。结论:尿液SPAG9可作为诊断PSA灰区前列腺癌的标志物,尿液SPAG9与血清fPSA/tPSA比值、PSAD联合检测对PSA灰区前列腺癌具有较好的诊断效能。

标准化ADC、PSAD对PSA灰区PI-RADS 3分病灶的应用价值

目的:探讨当血清PSA处于4~10 ng/mL时,标准化表观扩散系数ADCn、前列腺特异性抗原密度PSAD在2.1版前列腺影像报告和数据系统(PI-RADS v2.1)评分3分病灶中的应用价值。方法:选取2018年1月至2022年6月经病理证实的58例PI-RADS v2.1评分为3分患者,PSA值均为4~10 ng/mL。根据病理结果分为PCa组(20例)和非PCa组(38例)。收集患者的临床资料,包括年龄、前列腺特异性抗原PSA、前列腺体积PV,通过公式计算PSAD(PSAD=PSA/V);同时于ADC图像上测量病变区及外周带正常组织的表观扩散系数值ADC,并计算标准化表观扩散系数值,即ADCn(ADC病灶/ADC外周带)。比较ADCn、PSAD在两组间差异是否具有统计学意义,采用受试者工作特性曲线(ROC)比较二者对PI-RADS v2.1评分3分病灶中PCa的诊断效能。结果:年龄、PSA在两组间差异无统计学意义;PCa组的ADCn小于非PCa组(0.52 vs.0.69),PCa组的PSAD大于非PCa组(0.28 vs.0.18)。ADCn、PSAD诊断PCa的ROC曲线下面积AUC、敏感度、特异度分别为0.849、85.2%、81.6%,0.813、85.0%、78.4%,ADCn表现的效能较高。当二者联合应用取最佳诊断阈值0.373时,诊断PCa的AUC为0.962,敏感度90.0%、特异度89.5%。结论:ADCn、PSAD能够辅助PSA灰区时PI-RADS v2.1评分3分病灶中PCa的检出,二者联合应用可明显提高诊断敏感性和特异性。

基于前列腺癌原发灶的双参数MRI纹理分析及血清PSA与术后骨转移的关系分析

目的探讨基于前列腺癌原发灶的双参数磁共振成像(bpMRI)纹理分析及血清前列腺特异抗原(PSA)与术后骨转移的关系。方法选取2019年1月至2022年1月期间我院收治的前列腺癌患者134例。患者入院需进行bpMRI及血清PSA检查,且行腹腔镜前列腺根治术,随访1年,根据术后骨转移情况将患者分为转移组(n=62)和未转移组(n=66)。采用Logistic回归模型分析相关危险因素。用受试者工作特征曲线(ROC)评估预测价值。结果2组表观弥散系数(ADC)峰度、ADC偏度及T_(2)WI峰度、T_(2)WI偏度比较,差异无统计学意义(P>0.05)。转移组ADC熵、T_(2)WI熵均高于未转移组(P<0.05)。2组患者年龄、临床分期、合并高血压、合并糖尿病、肿瘤直径比较,差异无统计学意义(P>0.05)。转移组Gleason病理评分、碱性磷酸酶(ALP)及血清PSA水平高于未转移组,血红蛋白(Hb)水平则低于未转移组(P<0.05)。多因素Logistic回归分析显示,高ADC熵、T_(2)WI熵及Gleason病理评分、ALP、血清PSA均是影响患者术后发生骨转移的危险因素(P<0.05)。ROC曲线分析显示,血清PSA、ADC熵、T_(2)WI熵及三者联合预测前列腺癌根治术后发生骨转移风险的AUC分别为0.858、0.734、0.576、0.925,三指标联合预测效能高于单项检测(P<0.05)。结论高水平ADC熵、T_(2)WI熵及血清PSA是影响前列腺癌患者术后发生骨转移的危险因素,三者联合对患者术后发生骨转移具有较高的预测价值。

烃类蒸汽转化制氢+PSA提纯工艺应用与安全探究

对制氢、氢气提纯的技术路线进行了对比分析,以某石油化工厂为背景,探讨了烃类蒸汽转化制氢工艺+PSA提纯氢气工艺技术的实际应用效果。结果表明:此套工艺组合路线可以利用多种烃类化合物作为原料,具有高的氢气产率和纯净度(氢气体积分数达到99.9%以上)。相比传统的制氢方法,这种工艺能够降低能耗和废物产生,有助于减少碳排放和环境污染,适用于以石油、天然气等为基础原料的大型石油化工企业,并通过合理设计、PSA装置优化运行等多方面措施,可最大程度地减少潜在的安全风险。

Influence of Omega 3 Fatty Acid Supplementation on Phase Angle Values of People Living with HIV/AIDS with Lipodystrophy Secondary to Antiretroviral Therapy: A Randomized Clinical Trial

Objective: The measurement of phase angles is an important monitoring parameter and supplementation with omega-3 could promote benefits by modulating the electrical potential of membranes and increasing body cell mass. This study aimed to evaluate the effectiveness of omega-3 fatty acid supplementation on the phase angle of people living with HIV/AIDS. Methods: In this study, 63 individuals of all genders who were undergoing outpatient follow-up and showed lipodystrophy due to highly active antiretroviral therapy were analyzed. Our sample consisted of two groups, one that received supplementation containing 2550 mg of omega-3/day (1080 mg of eicosapentaenoic acid and 720 mg of docosahexaenoic acid) for three months (n = 32) and another that underwent nutrition guidance (n = 31). Phase angle and body cell mass were assessed for both groups and compared at the beginning of research (T0) and after our intervention (T1) for each group separately. Results: Phase angle averaged 6.45° ± 1.06 SD. The comparison between T0 and T1 showed a significant increase in phase angle and body cell mass, whereas the guidance group showed a decrease in body cell mass at T1 in relation to T0, with a significant p-value. Variance in phase angle between moments showed significant values between T0 and T1 in the supplementation group for all genders. Conclusion: Omega-3 positively modulated patients phase angle and body cell mass, but we emphasize the need for other studies that can solidify knowledge about supplementation dosage and intervention time.

关于老年男性体检者血清PSA结果研究

研究老年男性体检者血清PSA结果研究。方法 选取2022年6月-2023年6月在我院实施体检的789例老年男性体检者。其中有116例患者血清PSA指标异常,673例血清PSA指标检查正常。结果 从年龄方面分析,年龄超过70岁,出现前列腺特异性抗原异常占比较高,吸烟人群出现前列腺特异性抗原异常占高于不吸烟人群,高脂饮食出现前列腺特异性抗原异常占比高于正常饮食患者,患者存在家族史前列腺特异性抗原异常患者占比高于没有家族史(患有前列腺癌)患者,观察组与对照组在年龄、吸烟等方面存在差异性(P<0.05)。结论 患者血清PSA值存在异常,主要与年龄、高脂饮食习惯、吸烟等因素相关。

Identification of the BTA8 gene reveals the contribution of natural variation to tiller angle in rice

Plant architecture is a collection of major agronomic traits that determines rice grain production,and it is mainly influenced by tillering,tiller angle,plant height and panicle morphology(Wang and Li 2006).Tiller angle is one of the critical components that determines rice plant architecture,which in turn influences grain yield mainly due to its large impact on plant density(Wang et al.2022).

大型炼油厂PSA氢提纯单元运行经验与故障处理

通过分析某大型炼油厂制氢装置PSA(变压吸附)单元实际生产情况,发现PSA单元运行中出现的问题主要集中在吸附剂粉碎和程控阀故障两方面。经分析认为:吸附剂粉碎主要原因为均压过程压差和气体流速太大、吸附塔顶吸附剂压网和压板的影响、原料气带水;程控阀故障则主要包括阀检报警、电磁阀故障、阀芯密封面损坏、填料压盖泄漏以及阀板轴套开裂和阀销折断等。根据长期实践经验,总结列出判断故障的依据,分析造成各类故障的原因,制定出细化设备安装检查、加强日常维护保养、优化操作参数设置、升级相关配件材质等有效措施,可以消除PSA单元的常见故障,确保其长周期稳定运行。

HMGB1和PSA联合检测在前列腺癌诊断中的研究

对HMGB1和PSA联合检测在前列腺癌诊断中的应用价值进行研究。方法 自我院2021年3月-2022年3月间收治的前列腺癌与良性前列腺增生患者中各抽样45例,并于同期在我院接受体检的健康男性中抽样45例,以上3组分别设置为恶性组、良性组与参照组,对所有入选者均行HMGB1及PSA检测,对比不同组别在HMGB1和PSA水平方面的差异,并就2种检测对前列腺癌的诊断效能进行分析。结果 与参照组相比,恶性组与良性组的HMGB1和PSA水平更高,可见显著差异(P<0.05),在良、恶性组的对比中,恶性组数据高于良性组,可见显著差异(P<0.05)。恶性组中,癌症分期不同,HMGB1水平也呈现不同水平,T1和T2患者的数据明显低于T3、T4患者,可见显著差异(P<0.05)。诊断效能方面,HMGB1与PSA单独应用时,HMGB1灵敏度(85.71%)更高,PSA特异度(66.67%)更高,将二者联合应用,可有效提升灵敏度、特异度及正确率。结论 HMGB1和PSA均能对前列腺癌进行诊断,但效能方面有效欠缺,将二者联合应用时,有助于提升诊断效能。

Visualizing the Local Twist Angle Variation within and between Domains of Twisted Bilayer Graphene

Moirésuperlattices in twisted two-dimensional materials have emerged as ideal platforms for engineering quantum phenomena,which are highly sensitive to twist angles,including both the global value and the spatial inhomogeneity.However,only a few methods provide spatial-resolved information for characterizing local twist angle distribution.

In situ calibrated angle between the quantization axis and the propagating direction of the light field for trapping neutral atoms

The recently developed magic-intensity trapping technique of neutral atoms efficiently mitigates the detrimental effect of light shifts on atomic qubits and substantially enhances the coherence time. This technique relies on applying a bias magnetic field precisely parallel to the wave vector of a circularly polarized trapping laser field. However, due to the presence of the vector light shift experienced by the trapped atoms, it is challenging to precisely define a parallel magnetic field, especially at a low bias magnetic field strength, for the magic-intensity trapping of85Rb qubits. In this work, we present a method to calibrate the angle between the bias magnetic field and the trapping laser field with the compensating magnetic fields in the other two directions orthogonal to the bias magnetic field direction. Experimentally, with a constantdepth trap and a fixed bias magnetic field, we measure the respective resonant frequencies of the atomic qubits in a linearly polarized trap and a circularly polarized one via the conventional microwave Rabi spectra with different compensating magnetic fields and obtain the corresponding total magnetic fields via the respective resonant frequencies using the Breit–Rabi formula. With known total magnetic fields, the angle is a function of the other two compensating magnetic fields.Finally, the projection value of the angle on either of the directions orthogonal to the bias magnetic field direction can be reduced to 0(4)° by applying specific compensating magnetic fields. The measurement error is mainly attributed to the fluctuation of atomic temperature. Moreover, it also demonstrates that, even for a small angle, the effect is strong enough to cause large decoherence of Rabi oscillation in a magic-intensity trap. Although the compensation method demonstrated here is explored for the magic-intensity trapping technique, it can be applied to a variety of similar precision measurements with trapped neutral atoms.

降低制氢装置PSA程控阀故障率的研究

中海油气(泰州)石化有限公司50000 m^(3)/h制氢装置自开工以来,180、182单元2套PSA中的程控阀每年都会出现诸多不同原因的故障导致切塔,生产装置被迫降低负荷甚至停运,影响装置的正常平稳运行以及各用氢单位的正常生产。文章就两套PSA程控阀出现的各类故障进行展开梳理和分析优化,并提出了改进措施,最大程度降低PSA程控阀的故障率,确保PSA的正常平稳运行和全厂氢气管网稳定。

Acute primary angle closure during the Omicron outbreak

AIM:To investigate Omicron’s impact on clinical presentation of acute primary angle closure(APAC)in China.METHODS:A consecutive case series with historical controls was conducted at Shenzhen Eye Hospital,the largest specialized hospital in Shenzhen,China.Medical records from a two-month period during the Omicron pandemic(December 1,2022,to January 31,2023)were compared with records from two control groups(12/2018–1/2019 and 12/2021–1/2022)before pandemic.Patients with APAC were included,and the prevalence of APAC and demographic characteristics in Omicron-infected and noninfected patients were compared.RESULTS:Seventy-one(23.43%)out of 303 patients were diagnosed with APAC in the pandemic cohort,which was 2.98 and 2.61 times higher than that in control cohorts(7.87%in 2019,8.96%in 2022,P<0.001).The pandemic cohort has significantly higher Omicron-infected rate(78.87%vs 0 vs 0;P<0.001),lower proportion of glaucoma history(16.90%vs 42.86%vs 41.67%,P=0.005),higher surgical rate(95.77%vs 83.33%vs 78.57%,P=0.024),higher total medical costs and larger pupil diameter(5.63±0.15 vs 4.68±0.15 vs 4.69±0.22 mm,P<0.01).In 83%Omicron-infected patients,ocular symptoms appeared within 3d after systemic symptoms onset.In multivariate analysis,Omicron infection(P<0.001)was the only independent predictor of pupil diameter.CONCLUSION:In the Omicron epidemic in China,there is an increase of prevalence and severity of APAC,particularly focusing on the first 3d following infection.

Fine mapping of two recessive genes TaFLA1 and TaSPL8 controlling flag leaf angle in bread wheat

Flag leaf angle is one of the key target traits in high yield wheat breeding.A smaller flag leaf angle reduces shading and enables plants to grow at a higher density,which increases yield.Here we identified a mutant,je0407,with an 84.34%-89.35%smaller flag leaf angle compared with the wild type.The mutant also had an abnormal lamina joint and no ligule or auricle.Genetic analysis indicated that the ligule was controlled by two recessive genes,which were mapped to chromosomes 2AS and 2DL.The mutant allele on chromosome 2AS was named Tafla1b,and it was fine mapped to a 1 Mb physical interval.The mutant allele on chr.2DL was identified as Taspl8b,a novel allele of TaSPL8 with a missense mutation in the second exon,which was used to develop a cleaved amplified polymorphic sequence marker.F3 and F4 lines derived from crosses between Jing411 and je0407 were genotyped to investigate interactions between the Tafla1b and Taspl8b alleles.Plants with the Tafla1b/Taspl8a genotype had 58.41%-82.76%smaller flag leaf angles,6.4%-24.9%shorter spikes,and a greater spikelet density(0.382 more spikelets per cm)compared with the wild type.Plants with the Tafla1a/Taspl8b genotype had 52.62%-82.24%smaller flag leaf angles and no differences in plant height or spikelet density compared with the wild type.Tafla1b/Taspl8b plants produced erect leaves with an abnormal lamina joint.The two alleles had dosage effects on ligule formation and flag leaf angle,but no significant effect on thousand-grain weight.The mutant alleles provide novel resources for improvement of wheat plant architecture.

An approach for determination of lateral limit angle in kinematic planar sliding analysis for rock slopes

Planar sliding is one of the frequently observed types of failure in rock slopes.Kinematic analysis is a classic and widely used method to examine the potential failure modes in rock masses.The accuracy of planar sliding kinematic analysis is significantly influenced by the value assigned to the lateral limit angleγlim.However,the assignment ofγlim is currently used generally based on an empirical criterion.This study aims to propose an approach for determining the value ofγlim in deterministic and probabilistic kinematic planar sliding analysis.A new perspective is presented to reveal thatγlim essentially influences the probability of forming a potential planar sliding block.The procedure to calculate this probability is introduced using the block theory method.It is found that the probability is correlated with the number of discontinuity sets presented in rock masses.Thus,different values ofγlim for rock masses with different sets of discontinuities are recommended in both probabilistic and deterministic planar sliding kinematic analyses;whereas a fixed value ofγlim is commonly assigned to different types of rock masses in traditional method.Finally,an engineering case was used to compare the proposed and traditional kinematic analysis methods.The error rates of the traditional method vary from 45%to 119%,while that of the proposed method ranges between 1%and 17%.Therefore,it is likely that the proposed method is superior to the traditional one.

A highly sensitive fluorescent probe RN-NA reveals peroxynitrite as a novel biomarker for primary open angle glaucoma

AIM:To directly quantify peroxynitrite(ONOO-)using a highly sensitive fluorescence resonance energy transfer probe RN-NA,investigate the association between ONOOand primary open angle glaucoma(POAG),and clarify whether RN-NA could be used as a potential tool for POAG diagnosis.METHODS:Plasma and aqueous humor(AH)samples were collected from POAG patients(n=100,age:59.70±6.87y)and age-related cataract(ARC)patients(n=100,age:61.15±4.60y)admitted to our hospital.Next,RN-NA was used to detect ONOO-in plasma and AH samples,and the relationship between ONOO-level and POAG was analyzed using binary logistic regression.Besides,Pearson correlation analysis was applied to characterize the correlation of the levels of ONOO-with the patients’age,intraocular pressure(IOP),and mean deviation of visual field testing.The ONOO-scavenger MnTMPyP was employed to treat the 3-morpholinosyndnomine(SIN-1)-induced ocular hypertension in mice(n=7,6-8wk).Finally,the IOP and ONOO-in both eyes were measured 30min after the last drug treatment.RESULTS:ONOO-levels of AH and plasma were significantly higher in the POAG group than in the ARC group(P<0.01).Additionally,ONOO-levels were closely correlated with POAG in a binary logistic regression analysis[odds ratio(OR)=1.008,95%confidence interval(CI):1.002-1.013,P<0.01 for AH;OR=1.004,95%CI:1.002-1.006,P<0.001 for plasma].Pearson correlation analysis showed that ONOO-levels in AH or plasma were positively associated with visual field defects(R=0.51,P<0.01 for AH;R=0.45,P<0.001 for plasma),and ONOO-levels in plasma and AH were correlated in the POAG group(R=0.69,P<0.001).However,administering MnTMPyP to mouse eyes reversed the elevated IOP caused by SIN-1(P<0.05).CONCLUSION:ONOO-levels in AH and plasma,detected by RN-NA,are significantly related to POAG and positively correlated with visual field defects in POAG patients.Hence,ONOO-is a potential biomarker of POAG,especially advanced POAG.Besides,anti-nitration compounds may be novel ocular hypotensive agents based on the animal study.

Blade Wrap Angle Impact on Centrifugal Pump Performance:Entropy Generation and Fluid-Structure Interaction Analysis

The centrifugal pump is a prevalent power equipment widely used in different engineering patterns,and the impeller blade wrap angle significantly impacts its performance.A numerical investigation was conducted to analyze the influence of the blade wrap angle on flow characteristics and energy distribution of a centrifugal pump evaluated as a low specific speed with a value of 69.This study investigates six impellermodels that possess varying blade wrap angles(95°,105°,115°,125°,135°,and 145°)that were created while maintaining the same volute and other geometrical characteristics.The investigation of energy loss was conducted to evaluate the values of total and entropy generation rates(TEG,EGR).The fluid-structure interaction was considered numerically using the software tools ANSYS Fluent and ANSYSWorkbench.The elastic structural dynamic equation was used to estimate the structural response,while the shear stress transport k–ωturbulence model was utilized for the fluid domain modeling.The findings suggest that the blade wrap angle has a significant influence on the efficiency of the pump.The impeller featuring a blade wrap angle of 145°exhibits higher efficiency,with a notable increase of 3.76%relative to the original model.Variations in the blade wrap angle impact the energy loss,shaft power,and pump head.The model with a 145°angle exhibited a maximum equivalent stress of 14.8MPa and a total deformation of 0.084 mm.The results provide valuable insights into the intricate flow mechanism of the centrifugal pump,particularly when considering various blade wrap angles.

On the effect of pitch and yaw angles in oblique impacts of smallcaliber projectiles

A terminal ballistic analysis of the effects of 7.62 mm × 51 AP P80 rounds on inclined high-strength armor steel plates is the focus of the presented study.The findings of an instrumented ballistic testing combined with 3D advanced numerical simulations performed using the IMPETUS Afea? software yielded the conclusions.The experimental verification proved that slight differences in the pitch-andyaw angles of a projectile upon an impact caused different damage types to the projectile’s core.The residual velocities predicted numerically were close to the experimental values and the calculated core deviations were in satisfactory agreement with the experimental results.An extended matrix of the core deviation angles with combinations of pitch-and-yaw upon impact angles was subsequently built on the basis of the numerical study.The presented experimental and numerical investigation examined thoroughly the influence of the initial pitch and yaw angles on the after-perforation projectile’s performance.