In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,...In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,implantable electrochemical microsensors have emerged as a prominent area of research.These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration.They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional performance.The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts.This review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for fabrication.Following this,we proceeded to explore the various implantation technologies employed for electrochemical microsensors.In addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease mechanisms.Lastly,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.展开更多
The dynamic information of 331 animal genetic resources in 17 important animal genetic resource provinces (regions) was analyzed. According to the population inbreeding coefficient, combining with the information of p...The dynamic information of 331 animal genetic resources in 17 important animal genetic resource provinces (regions) was analyzed. According to the population inbreeding coefficient, combining with the information of population dynamic change trend and cross degree, these genetic resources for threatened degrees were classified. The results indicated that the population size of 138 breeds had increased, 147 breeds had decreased, 3 breeds were constant, 7 breeds (or varieties) were extinct, 9 breeds (or varieties) were critically endangered and needed urgently conserve, 50 breeds (or varieties) were endangered and should be conserved. We put forward a conservation and utilization plan for animal genetic resources.展开更多
By using computer multimedia and database technology to build the animation appreciation auxiliary system (AACAS), we classify the classical animation works according to types, categorize the appreciation main points ...By using computer multimedia and database technology to build the animation appreciation auxiliary system (AACAS), we classify the classical animation works according to types, categorize the appreciation main points and define the attribute, and input the corresponding information into the relevant database in real time so as to realize the logical connection of massive animation resources, and make appreciation information be able to realize free storage, rapid retrieval and easy for calling. In addition, the horizontal comparison of multiple works and the vertical comparison of the same work can be realized. This will significantly change the past inefficient situation of animation appreciation under a single thread, greatly improve the timeliness of the appreciation.展开更多
With the continuous deepening of the concept of sustainable development in modern society,the accounting requirements of agricultural and animal husbandry enterprises are increasing under the background of low carbon ...With the continuous deepening of the concept of sustainable development in modern society,the accounting requirements of agricultural and animal husbandry enterprises are increasing under the background of low carbon economic growth.In the face of the increasingly prominent environmental issues,it is imperative to focus on the development of green accounting and improve the accounting information disclosure level of agricultural and animal husbandry enterprises on the whole.Through analyzing the issues in green accounting information disclosure of agricultural and animal husbandry enterprises under the low carbon economy,we have a clearer understanding of the green accounting information disclosure of agricultural and animal husbandry enterprises,which is conducive to proposing countermeasures that can improve the level of environmental information disclosure from its roots.展开更多
The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought...The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients.展开更多
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, ...Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77.How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeutics for pancreatic cancer and hepatocellular carcinoma? Question 79. What are the true beneficial mechanisms of antiangiogenic therapy in cancer patients? Question 80. How to approach the complex mechanisms of interplay among various cellular and molecular components in the tumor microenvironment? Question 81. Can tissue oxygenation improve the efficacy of conventional chemotherapy on cancer? Question 82. Can tissue oxygenation improve the efficacy of radiotherapy on digestive system tumors including liver cancer? Question 83. Can we integrate metabolic priming into multimodal management of liver cancer? Question 84. Has the limit of anti-androgen strategy in prostate cancer treatment been reached by the new generation of anti-androgen drugs? Question 85. Can we identify individuals with early-stage cancers via analyzing their clinical and non-clinical information collected from social media, shopping history, and clinical, pathological, and molecular traces?展开更多
Background Computer Generated Animations(CGA),when applied to three-dimensional(3D)city models(3DCM),can be used as powerful tools to support urban decision-making.This leads to a new paradigm,based on procedural mode...Background Computer Generated Animations(CGA),when applied to three-dimensional(3D)city models(3DCM),can be used as powerful tools to support urban decision-making.This leads to a new paradigm,based on procedural modeling,that allows the integration of known urban structures.Methods This paper introduces a new workflow for the development of high-quality approximations of urban models in a short time and enables facilities to be imported from other cities into a given city model,following specific generation rules.Results Thus,this workflow provides a very simple approach to observe,study,and simulate the implementation of models already developed in other cities,in a city where they are not yet adopted.Examples of these models include all types of mobility systems and urban infrastructure.Conclusions This allows us to perceive the environmental impact of certain decisions in the real world,as well as to carry out simple simulations to determine the changes that can occur in the flows of people,traffic,and other city activities.展开更多
基金the Fundamental Research Funds for the Central Universities,National Natural Science Foundation of China(No.82302345).
文摘In vivo monitoring of animal physiological information plays a crucial role in promptly alerting humans to potential diseases in animals and aiding in the exploration of mechanisms underlying human diseases.Currently,implantable electrochemical microsensors have emerged as a prominent area of research.These microsensors not only fulfill the technical requirements for monitoring animal physiological information but also offer an ideal platform for integration.They have been extensively studied for their ability to monitor animal physiological information in a minimally invasive manner,characterized by their bloodless,painless features,and exceptional performance.The development of implantable electrochemical microsensors for in vivo monitoring of animal physiological information has witnessed significant scientific and technological advancements through dedicated efforts.This review commenced with a comprehensive discussion of the construction of microsensors,including the materials utilized and the methods employed for fabrication.Following this,we proceeded to explore the various implantation technologies employed for electrochemical microsensors.In addition,a comprehensive overview was provided of the various applications of implantable electrochemical microsensors,specifically in the monitoring of diseases and the investigation of disease mechanisms.Lastly,a concise conclusion was conducted on the recent advancements and significant obstacles pertaining to the practical implementation of implantable electrochemical microsensors.
文摘The dynamic information of 331 animal genetic resources in 17 important animal genetic resource provinces (regions) was analyzed. According to the population inbreeding coefficient, combining with the information of population dynamic change trend and cross degree, these genetic resources for threatened degrees were classified. The results indicated that the population size of 138 breeds had increased, 147 breeds had decreased, 3 breeds were constant, 7 breeds (or varieties) were extinct, 9 breeds (or varieties) were critically endangered and needed urgently conserve, 50 breeds (or varieties) were endangered and should be conserved. We put forward a conservation and utilization plan for animal genetic resources.
文摘By using computer multimedia and database technology to build the animation appreciation auxiliary system (AACAS), we classify the classical animation works according to types, categorize the appreciation main points and define the attribute, and input the corresponding information into the relevant database in real time so as to realize the logical connection of massive animation resources, and make appreciation information be able to realize free storage, rapid retrieval and easy for calling. In addition, the horizontal comparison of multiple works and the vertical comparison of the same work can be realized. This will significantly change the past inefficient situation of animation appreciation under a single thread, greatly improve the timeliness of the appreciation.
文摘With the continuous deepening of the concept of sustainable development in modern society,the accounting requirements of agricultural and animal husbandry enterprises are increasing under the background of low carbon economic growth.In the face of the increasingly prominent environmental issues,it is imperative to focus on the development of green accounting and improve the accounting information disclosure level of agricultural and animal husbandry enterprises on the whole.Through analyzing the issues in green accounting information disclosure of agricultural and animal husbandry enterprises under the low carbon economy,we have a clearer understanding of the green accounting information disclosure of agricultural and animal husbandry enterprises,which is conducive to proposing countermeasures that can improve the level of environmental information disclosure from its roots.
基金Supported by Aarhus University and the Danish Council for Independent Research,Medical Sciences,No.11-107912The Danish Strategic Research Council has supported the LIRMOI study on RSV effects in NAFLD and metabolic diseases,No.10-093499+5 种基金The NOVO Nordisk Foundation has supported Grnbk H by a research grantsupported by the Robert WStorr Bequest to the Sydney MedicalFoundation,University of Sydneya National Health and Medical Research Council of Australia (NHMRC) Program Grant No.1053206Project grants 632630 and 1049857
文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients.
文摘Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology to promote cancer research and accelerate collaborations. In this article, 10 questions are presented as followed. Question 76. How to develop effective therapeutics for cancer cachexia? Question 77.How can we develop preclinical animal models to recapitulate clinical situations of cancer patients for more effective anti-cancer drug development? Question 78. How can we develop novel effective therapeutics for pancreatic cancer and hepatocellular carcinoma? Question 79. What are the true beneficial mechanisms of antiangiogenic therapy in cancer patients? Question 80. How to approach the complex mechanisms of interplay among various cellular and molecular components in the tumor microenvironment? Question 81. Can tissue oxygenation improve the efficacy of conventional chemotherapy on cancer? Question 82. Can tissue oxygenation improve the efficacy of radiotherapy on digestive system tumors including liver cancer? Question 83. Can we integrate metabolic priming into multimodal management of liver cancer? Question 84. Has the limit of anti-androgen strategy in prostate cancer treatment been reached by the new generation of anti-androgen drugs? Question 85. Can we identify individuals with early-stage cancers via analyzing their clinical and non-clinical information collected from social media, shopping history, and clinical, pathological, and molecular traces?
基金project"Crowdsourcing Optimized Wireless Sensor Network Deployment(CRoWD)"of Dirección General de Investigaciones of Universidad Santiago de Cali under grant No.613-621119-852.
文摘Background Computer Generated Animations(CGA),when applied to three-dimensional(3D)city models(3DCM),can be used as powerful tools to support urban decision-making.This leads to a new paradigm,based on procedural modeling,that allows the integration of known urban structures.Methods This paper introduces a new workflow for the development of high-quality approximations of urban models in a short time and enables facilities to be imported from other cities into a given city model,following specific generation rules.Results Thus,this workflow provides a very simple approach to observe,study,and simulate the implementation of models already developed in other cities,in a city where they are not yet adopted.Examples of these models include all types of mobility systems and urban infrastructure.Conclusions This allows us to perceive the environmental impact of certain decisions in the real world,as well as to carry out simple simulations to determine the changes that can occur in the flows of people,traffic,and other city activities.
