This article presents a brief overview of the development of high-resolution SPECT for small-animal im- aging. A pinhole collimator has been used for high-resolution animal SPECT to provide better spatial resolution a...This article presents a brief overview of the development of high-resolution SPECT for small-animal im- aging. A pinhole collimator has been used for high-resolution animal SPECT to provide better spatial resolution and detection efficiency in comparison with a parallel-hole collimator. The theory of imaging characteristics of the pin- hole collimator is presented and the designs of the pinhole aperture are discussed. The detector technologies used for the development of small-animal SPECT and the recent advances are presented. The evolving trend of small-animal SPECT is toward a multi-pinhole and a multi-detector system to obtain a high resolution and also a high detection ef- ficiency.展开更多
We have built and investigated a detector module for animal SPECT imaging, especially for use in large field of view （FOV） conditions. The module consists of a PMT-based detector and a parallel-hole collimator with ...We have built and investigated a detector module for animal SPECT imaging, especially for use in large field of view （FOV） conditions. The module consists of a PMT-based detector and a parallel-hole collimator with an effective area of 80 mm× 80 mm. The detector is composed of a NaI scintillation crystal array coupled to four H8500 position sensitive photomultiplier tubes （PS-PMT）. The intrinsic energy resolution of the detector is 11.5% at 140 keV on average. The planar spatial resolution of the module changes from 2.2 mm to 5.1 mm at different source-to-collimator distances with an unchanged sensitivity of about 34cps/MBq. Additionally, the SPECT Micro Deluxe Phantom imaging was performed with a radius of rotation （ROR） of 40 mm. Using the FBP reconstruction algorithm, a high performance image was obtained, indicating the feasibility of this detector module.展开更多
文摘This article presents a brief overview of the development of high-resolution SPECT for small-animal im- aging. A pinhole collimator has been used for high-resolution animal SPECT to provide better spatial resolution and detection efficiency in comparison with a parallel-hole collimator. The theory of imaging characteristics of the pin- hole collimator is presented and the designs of the pinhole aperture are discussed. The detector technologies used for the development of small-animal SPECT and the recent advances are presented. The evolving trend of small-animal SPECT is toward a multi-pinhole and a multi-detector system to obtain a high resolution and also a high detection ef- ficiency.
基金Supported by Natural Science Foundation of China(10805049,10775149)
文摘We have built and investigated a detector module for animal SPECT imaging, especially for use in large field of view （FOV） conditions. The module consists of a PMT-based detector and a parallel-hole collimator with an effective area of 80 mm× 80 mm. The detector is composed of a NaI scintillation crystal array coupled to four H8500 position sensitive photomultiplier tubes （PS-PMT）. The intrinsic energy resolution of the detector is 11.5% at 140 keV on average. The planar spatial resolution of the module changes from 2.2 mm to 5.1 mm at different source-to-collimator distances with an unchanged sensitivity of about 34cps/MBq. Additionally, the SPECT Micro Deluxe Phantom imaging was performed with a radius of rotation （ROR） of 40 mm. Using the FBP reconstruction algorithm, a high performance image was obtained, indicating the feasibility of this detector module.
