A novel monoclonal antibody,CC4,targeting a conserved epitope of CEACAMs significantly inhibits tumor growth of colorectal cancer

Belonging to the immunoglobulin superfamily of cell adhesion molecules, carcinoembryonic antigen related cell adhesion molecules (CEACAMs) have been found associated

胃癌单克隆抗体偶合物导向化疗的实验研究

将制备的鼠抗人胃癌单克隆抗体（8711C1McAb）纯化后，以Iodogen法标记125I，Manabe法偶联平阳霉素。间接免疫荧光试验和3H-TdR掺入法（抑制率81．5％）证明标记物免疫活性保持良好。5只人胃癌大鼠模型尾静脉注射125I-McAb，放射免疫自显影有4只移植瘤体外显像（80％），T／NT值为3．12，显著高于对照组（P＜0．01）。PPM导向治疗动物试验，4只荷瘤大鼠注射PPM5次，肿瘤抑制率为58．2％，与对照组差异有显著性（P＜0．05）；组织学检查证实肿瘤组织出现弥漫性病理改变．癌细胞核固缩、溶解。结果证明PPM对胃癌细胞有较强的导向杀伤作用。