A majority of oral cancers is squamous cell carcinoma and tongue carcinomas comprise 30% of all oral cancers. However, Phytochemicals, herbal and dietary antioxidants have been reported to prevent cancers. A nutrient ...A majority of oral cancers is squamous cell carcinoma and tongue carcinomas comprise 30% of all oral cancers. However, Phytochemicals, herbal and dietary antioxidants have been reported to prevent cancers. A nutrient mixture containing, ascorbic acid, lysine, proline and green tea extract, among other nutrients, has previously been shown to exhibit a broad spectrum chemo preventative and therapeutic anti-cancer properties in a number of cell lines. In a recent study, we found that the nutrient mixture significantly inhibited acetaminophen induced hepatic and renal toxicity, and it suppressed carbon tetrachloride induced hepatic toxicity in ICR mice as well. This study was undertaken to determine if the nutrient mixture is useful in inhibiting various parameters of cancer progression on human tongue cancer cell line SC-255. SC-255 cells were grown in a Dulbecco’s Eagle medium and treated with the nutrient mixture at 0, 10, 50, 100, 500 and 1000 μg/ml, in triplicate. The nutrient mixture exhibited 20% and 30% toxicity at 500 and 1000 μg/ml, respectively. Zymography demonstrated the expression of MMP-2 and MMP-9;and PMA treatment further enhanced MMP-9 activity. The nutrient mixture inhibited the secretion of MMP-2 and MMP-9 in a dose-dependent fashion with a total inhibition at 500 μg/ml. Matrigel invasion was significantly reduced by 40%, 80% and 100% at 100, 500 and 1000 μg/ml, respectively. The nutrient mixture also inhibited cell migration and induced apoptosis in a dose response fashion. Thus, the nutrient mixture may have a potential in the tongue cancer treatment.展开更多
Obesity simplex is caused byovereating,surplus of nourishment,insufficient energy consumption and a largeamount of fat accumulation,resulting in thebody weight over the standard(】20% ofthe standard body weight).In ad...Obesity simplex is caused byovereating,surplus of nourishment,insufficient energy consumption and a largeamount of fat accumulation,resulting in thebody weight over the standard(】20% ofthe standard body weight).In addition展开更多
The phenomenon of nutrient maximums at 70～200 m occurred only in the regionof the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injectionof the low-temperature high-nutrient brine...The phenomenon of nutrient maximums at 70～200 m occurred only in the regionof the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injectionof the low-temperature high-nutrient brines from the Chukchi Sea shelf (【 50 m) in winter providedthe nutrient maximums. However, we found that there are five problems in the direct injectionprocess. Formerly Jin et al. considered that the formation of nutrient maximums can be a process oflocally long-term regeneration. Here we propose a regeneration-mixture process. Data of temperature,salinity, oxygen and nutrients were collected at three stations in the southern Canada Basin duringthe summer 1999 cruise. We identified the cores of the surface, near-surface, potential temperaturemaximum waters and Arctic Bottom Water by the diagrams and vertical profiles of salinity, potentialtemperature, oxygen and nutrients. The historical ^(129)I data indicated that the surface andnear-surface waters were Pacific-origin, but the waters below the potential temperature maximum coredepth was Atlantic-origin. Along with the correlation of nutrient maximums and very low oxygencontents in the near-surface water, we hypothesize that, the putative organic matter was decomposedto inorganic nutrients; and the Pacific water was mixed with the Atlantic water in the transitionzone. The idea of the regeneration-mixture process agrees with the historical observations of noapparent seasonal changes, the smooth nutrient profiles, the lowest saturation of CaCO_3 above 400m, low rate of CFC-11 ventilation and ~3H-~3He ages of 8～18 a around the nutrient maximum depths.展开更多
文摘A majority of oral cancers is squamous cell carcinoma and tongue carcinomas comprise 30% of all oral cancers. However, Phytochemicals, herbal and dietary antioxidants have been reported to prevent cancers. A nutrient mixture containing, ascorbic acid, lysine, proline and green tea extract, among other nutrients, has previously been shown to exhibit a broad spectrum chemo preventative and therapeutic anti-cancer properties in a number of cell lines. In a recent study, we found that the nutrient mixture significantly inhibited acetaminophen induced hepatic and renal toxicity, and it suppressed carbon tetrachloride induced hepatic toxicity in ICR mice as well. This study was undertaken to determine if the nutrient mixture is useful in inhibiting various parameters of cancer progression on human tongue cancer cell line SC-255. SC-255 cells were grown in a Dulbecco’s Eagle medium and treated with the nutrient mixture at 0, 10, 50, 100, 500 and 1000 μg/ml, in triplicate. The nutrient mixture exhibited 20% and 30% toxicity at 500 and 1000 μg/ml, respectively. Zymography demonstrated the expression of MMP-2 and MMP-9;and PMA treatment further enhanced MMP-9 activity. The nutrient mixture inhibited the secretion of MMP-2 and MMP-9 in a dose-dependent fashion with a total inhibition at 500 μg/ml. Matrigel invasion was significantly reduced by 40%, 80% and 100% at 100, 500 and 1000 μg/ml, respectively. The nutrient mixture also inhibited cell migration and induced apoptosis in a dose response fashion. Thus, the nutrient mixture may have a potential in the tongue cancer treatment.
文摘Obesity simplex is caused byovereating,surplus of nourishment,insufficient energy consumption and a largeamount of fat accumulation,resulting in thebody weight over the standard(】20% ofthe standard body weight).In addition
基金supported by the Ministry of Finance of China,organized by the Chinese Arctic and Antarctic Administration(CAA)supported by the National Natu-ral Science Foundation of China under contract Nos 40476003 and 40403013the National“973”Pro-gram of China under contract No.G1999043704.
文摘The phenomenon of nutrient maximums at 70～200 m occurred only in the regionof the Canada Basin among the world oceans. The prevailing hypothesis was that the direct injectionof the low-temperature high-nutrient brines from the Chukchi Sea shelf (【 50 m) in winter providedthe nutrient maximums. However, we found that there are five problems in the direct injectionprocess. Formerly Jin et al. considered that the formation of nutrient maximums can be a process oflocally long-term regeneration. Here we propose a regeneration-mixture process. Data of temperature,salinity, oxygen and nutrients were collected at three stations in the southern Canada Basin duringthe summer 1999 cruise. We identified the cores of the surface, near-surface, potential temperaturemaximum waters and Arctic Bottom Water by the diagrams and vertical profiles of salinity, potentialtemperature, oxygen and nutrients. The historical ^(129)I data indicated that the surface andnear-surface waters were Pacific-origin, but the waters below the potential temperature maximum coredepth was Atlantic-origin. Along with the correlation of nutrient maximums and very low oxygencontents in the near-surface water, we hypothesize that, the putative organic matter was decomposedto inorganic nutrients; and the Pacific water was mixed with the Atlantic water in the transitionzone. The idea of the regeneration-mixture process agrees with the historical observations of noapparent seasonal changes, the smooth nutrient profiles, the lowest saturation of CaCO_3 above 400m, low rate of CFC-11 ventilation and ~3H-~3He ages of 8～18 a around the nutrient maximum depths.
