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STUDY ON MULTIMEDIA ANIMATION SYSTEM OF ACUPOINT ANATOMY WITH FLASH
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作者 王斌 罗志勇 +2 位作者 普玉凤 洪虹 左志雄 《World Journal of Acupuncture-Moxibustion》 2006年第2期37-42,共6页
Mastering anatomic structures of acupoints is of active significance for avoiding blindly needling and preventing accidents of acupuncture and moxibustion. This multimedia animation system of acupoint anatomy adopts F... Mastering anatomic structures of acupoints is of active significance for avoiding blindly needling and preventing accidents of acupuncture and moxibustion. This multimedia animation system of acupoint anatomy adopts Flash software as developing tool and can dynamically display anatomic layers of needle insertion, with objectivity, convenient operation and English-Chinese control,higher reliability, easy to study and master anatomic knowledge of acupoint anatomy, increase teaching efficiency, and richen teaching ways. This system can be used as a teaching tool of acupuncture and moxibustion, a software of studying anatomy of acupoints and an adjuvant tool of medical workers in studying anatomy. 展开更多
关键词 Acupoints/acup-mox Anatomy Multimedia Flash animation
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Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis 被引量:4
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作者 Jong Mi Park Masoud Rahmati +2 位作者 Sang Chul Lee Jae Il Shin Yong Wook Kim 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1584-1592,共9页
Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse ... Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease itself.Stem cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s disease.Mesenchymal stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of teratogenicity.We performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal model.We searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,2023.The study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control groups.We use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the meta-analysis.Treatment with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational test.Among the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a protective effect on dopaminergic neurons.Subgroup analysis of the amphetamine-induced rotation test showed a significant reduction only in the intracranial-striatum route(SMD[95%CI]=-2.59[-3.25 to-1.94],P=0.0001,I^(2)=74.4%).The memory test showed significant improvement only in the intravenous route(SMD[95%CI]=4.80[1.84 to 7.76],P=0.027,I^(2)=79.6%).Mesenchymal stem cells have been shown to positively impact motor function and memory function and protect dopaminergic neurons in preclinical models of Parkinson’s disease.Further research is required to determine the optimal stem cell types,modifications,transplanted cell numbe rs,and delivery methods for these protocols. 展开更多
关键词 ANIMAL animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation
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Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review 被引量:1
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作者 Bo Han Weishi Liang +4 位作者 Yong Hai Duan Sun Hongtao Ding Yihan Yang Peng Yin 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期563-570,共8页
Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the i... Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and behavior.Very few studies have been published on the specific characteristics of distraction spinal cord injury.In this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this disease.In addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury.We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease. 展开更多
关键词 animal models behavior DISTRACTION heterogeneity HISTOLOGY mechanism NEUROPHYSIOLOGY spinal cord injury systematic review tension
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Role of CD36 in central nervous system diseases 被引量:1
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作者 Min Feng Qiang Zhou +5 位作者 Huimin Xie Chang Liu Mengru Zheng Shuyu Zhang Songlin Zhou Jian Zhao 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期512-518,共7页
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases.CD36 was recently found to be widely expresse... CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases.CD36 was recently found to be widely expressed in various cell types in the nervous system,including endothelial cells,pericytes,astrocytes,and microglia.CD36 mediates a number of regulatory processes,such as endothelial dysfunction,oxidative stress,mitochondrial dysfunction,and inflammatory responses,which are involved in many central nervous system diseases,such as stroke,Alzheimer’s disease,Parkinson’s disease,and spinal cord injury.CD36 antagonists can suppress CD36 expression or prevent CD36 binding to its ligand,thereby achieving inhibition of CD36-mediated pathways or functions.Here,we reviewed the mechanisms of action of CD36 antagonists,such as Salvianolic acid B,tanshinone IIA,curcumin,sulfosuccinimidyl oleate,antioxidants,and small-molecule compounds.Moreover,we predicted the structures of binding sites between CD36 and antagonists.These sites can provide targets for more efficient and safer CD36 antagonists for the treatment of central nervous system diseases. 展开更多
关键词 animal experiments ANTAGONISTS CD36 antagonist central nervous system diseases clinical trial curcumin microRNA salvianolic acid B small-molecule drugs sulfosuccinimidyl oleate
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Optimization of tracheoesophageal fistula model established with Tshaped magnet system based on magnetic compression technique
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作者 Miao-Miao Zhang Jian-Qi Mao +5 位作者 Lin-Xin Shen Ai-Hua Shi Xin Lyu Jia Ma Yi Lyu Xiao-Peng Yan 《World Journal of Gastroenterology》 SCIE CAS 2024年第16期2272-2280,共9页
BACKGROUND The magnetic compression technique has been used to establish an animal model of tracheoesophageal fistula(TEF),but the commonly shaped magnets present limitations of poor homogeneity of TEF and poor model ... BACKGROUND The magnetic compression technique has been used to establish an animal model of tracheoesophageal fistula(TEF),but the commonly shaped magnets present limitations of poor homogeneity of TEF and poor model control.We designed a Tshaped magnet system to overcome these problems and verified its effectiveness via animal experiments.AIM To investigate the effectiveness of a T-shaped magnet system for establishing a TEF model in beagle dogs.METHODS Twelve beagles were randomly assigned to groups in which magnets of the Tshaped scheme(study group,n=6)or normal magnets(control group,n=6)were implanted into the trachea and esophagus separately under gastroscopy.Operation time,operation success rate,and accidental injury were recorded.After operation,the presence and timing of cough and the time of magnet shedding were observed.Dogs in the control group were euthanized after X-ray and gastroscopy to confirm establishment of TEFs after coughing,and gross specimens of TEFs were obtained.Dogs in the study group were euthanized after X-ray and gastroscopy 2 wk after surgery,and gross specimens were obtained.Fistula size was measured in all animals,and then harvested fistula specimens were examined by hematoxylin and eosin(HE)and Masson trichrome staining.RESULTS The operation success rate was 100%for both groups.Operation time did not differ between the study group(5.25 min±1.29 min)and the control group(4.75 min±1.70 min;P=0.331).No bleeding,perforation,or unplanned magnet attraction occurred in any animal during the operation.In the early postoperative period,all dogs ate freely and were generally in good condition.Dogs in the control group had severe cough after drinking water at 6-9 d after surgery.X-ray indicated that the magnets had entered the stomach,and gastroscopy showed TEF formation.Gross specimens of TEFs from the control group showed the formation of fistulas with a diameter of 4.94 mm±1.29 mm(range,3.52-6.56 mm).HE and Masson trichrome staining showed scar tissue formation and hierarchical structural disorder at the fistulas.Dogs in the study group did not exhibit obvious coughing after surgery.X-ray examination 2 wk after surgery indicated fixed magnet positioning,and gastroscopy showed no change in magnet positioning.The magnets were removed using a snare under endoscopy,and TEF was observed.Gross specimens showed well-formed fistulas with a diameter of 6.11 mm±0.16 mm(range,5.92-6.36 mm),which exceeded that in the control group(P<0.001).Scar formation was observed on the internal surface of fistulas by HE and Masson trichrome staining,and the structure was more regular than that in the control group.CONCLUSION Use of the modified T-shaped magnet scheme is safe and feasible for establishing TEF and can achieve a more stable and uniform fistula size compared with ordinary magnets.Most importantly,this model offers better controllability,which improves the flexibility of follow-up studies. 展开更多
关键词 Magnetic surgery Magnetic compression technique Tracheoesophageal fistula MAGNET Animal model Beagles
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Face animation based on multiple sources and perspective alignment
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作者 Yuanzong MEI Wenyi WANG +5 位作者 Xi LIU Wei YONG Weijie WU Yifan ZHU Shuai WANG Jianwen CHEN 《虚拟现实与智能硬件(中英文)》 EI 2024年第3期252-266,共15页
Background Face image animation generates a synthetic human face video that harmoniously integrates the identity derived from the source image and facial motion obtained from the driving video.This technology could be... Background Face image animation generates a synthetic human face video that harmoniously integrates the identity derived from the source image and facial motion obtained from the driving video.This technology could be beneficial in multiple medical fields,such as diagnosis and privacy protection.Previous studies on face animation often relied on a single source image to generate an output video.With a significant pose difference between the source image and the driving frame,the quality of the generated video is likely to be suboptimal because the source image may not provide sufficient features for the warped feature map.Methods In this study,we propose a novel face-animation scheme based on multiple sources and perspective alignment to address these issues.We first introduce a multiple-source sampling and selection module to screen the optimal source image set from the provided driving video.We then propose an inter-frame interpolation and alignment module to further eliminate the misalignment between the selected source image and the driving frame.Conclusions The proposed method exhibits superior performance in terms of objective metrics and visual quality in large-angle animation scenes compared to other state-of-the-art face animation methods.It indicates the effectiveness of the proposed method in addressing the distortion issues in large-angle animation. 展开更多
关键词 Face animation Multiple-source driving Generative adversarial network Medical diagnostics
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Audio2AB:Audio-driven collaborative generation of virtual character animation
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作者 Lichao NIU Wenjun XIE +2 位作者 Dong WANG Zhongrui CAO Xiaoping LIU 《虚拟现实与智能硬件(中英文)》 EI 2024年第1期56-70,共15页
Background Considerable research has been conducted in the areas of audio-driven virtual character gestures and facial animation with some degree of success.However,few methods exist for generating full-body animation... Background Considerable research has been conducted in the areas of audio-driven virtual character gestures and facial animation with some degree of success.However,few methods exist for generating full-body animations,and the portability of virtual character gestures and facial animations has not received sufficient attention.Methods Therefore,we propose a deep-learning-based audio-to-animation-and-blendshape(Audio2AB)network that generates gesture animations and ARK it's 52 facial expression parameter blendshape weights based on audio,audio-corresponding text,emotion labels,and semantic relevance labels to generate parametric data for full-body animations.This parameterization method can be used to drive full-body animations of virtual characters and improve their portability.In the experiment,we first downsampled the gesture and facial data to achieve the same temporal resolution for the input,output,and facial data.The Audio2AB network then encoded the audio,audio-corresponding text,emotion labels,and semantic relevance labels,and then fused the text,emotion labels,and semantic relevance labels into the audio to obtain better audio features.Finally,we established links between the body,gestures,and facial decoders and generated the corresponding animation sequences through our proposed GAN-GF loss function.Results By using audio,audio-corresponding text,and emotional and semantic relevance labels as input,the trained Audio2AB network could generate gesture animation data containing blendshape weights.Therefore,different 3D virtual character animations could be created through parameterization.Conclusions The experimental results showed that the proposed method could generate significant gestures and facial animations. 展开更多
关键词 Audio-driven Virtual character Full-body animation Audio2AB Blendshape GAN-GF
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Development and Evaluation of 3D Delivery Animation Software Designed to Improve the Mother’s and Spouse’s Satisfaction with Delivery
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作者 Ayako Sasaki Sachi Chikazawa +4 位作者 Nojima Kumiko Tomita Takako Hatakeyama Keiko Imoto Yasufumi Imoto Nobutane 《Health》 2024年第5期439-458,共20页
Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to disp... Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands. 展开更多
关键词 MOTHER SPOUSE SATISFACTION 3D Delivery animation Software
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Mesenchymal stem cell-derived extracellular vesicles therapy in traumatic central nervous system diseases:a systematic review and meta-analysis 被引量:3
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作者 Zhelun Yang Zeyan Liang +5 位作者 Jian Rao Fabin Lin Yike Lin Xiongjie Xu Chunhua Wang Chunmei Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第11期2406-2412,共7页
Although there are challenges in treating traumatic central nervous system diseases,mesenchymal stem cell-de rived extracellular vesicles(MSC-EVs) have recently proven to be a promising non-cellular the rapy.We compre... Although there are challenges in treating traumatic central nervous system diseases,mesenchymal stem cell-de rived extracellular vesicles(MSC-EVs) have recently proven to be a promising non-cellular the rapy.We comprehensively evaluated the efficacy of mesenchymal stem cell-de rived extracellular vesicles in traumatic central nervous system diseases in this meta-analysis based on preclinical studies.Our meta-analysis was registered at PROSPERO(CRD42022327904,May 24,2022).To fully retrieve the most relevant articles,the following databases were thoro ughly searched:PubMed,Web of Science,The Cochrane Library,and Ovid-Embase(up to April 1,2022).The included studies were preclinical studies of mesenchymal stem cell-derived extracellular vesicles for traumatic central nervous system diseases.The Systematic Review Centre for Laboratory Animal Experimentation(SYRCLE)’s risk of bias tool was used to examine the risk of publication bias in animal studies.After screening 2347studies,60 studies were included in this study.A meta-analysis was conducted for spinal co rd injury(n=52) and traumatic brain injury(n=8).The results indicated that mesenchymal stem cell-derived extracellular vesicles treatment prominently promoted motor function recovery in spinal co rd injury animals,including rat Basso,Beattie and Bresnahan locomotor rating scale scores(standardized mean difference [SMD]:2.36,95% confidence interval [CI]:1.96-2.76,P <0.01,I2=71%) and mouse Basso Mouse Scale scores(SMD=2.31,95% CI:1.57-3.04,P=0.01,I2=60%) compared with controls.Further,mesenchymal stem cell-de rived extracellular vesicles treatment significantly promoted neurological recovery in traumatic brain injury animals,including the modified N eurological Severity Score(SMD=-4.48,95% CI:-6.12 to-2.84,P <0.01,I2=79%) and Foot Fault Test(SMD=-3.26,95% CI:-4.09 to-2.42,P=0.28,I2=21%) compared with controls.Subgroup analyses showed that characteristics may be related to the therapeutic effect of mesenchymal stem cell-de rived extra cellular vesicles.For Basso,Beattie and Bresnahan locomotor rating scale scores,the efficacy of allogeneic mesenchymal stem cell-derived extracellular vesicles was higher than that of xenogeneic mesenchymal stem cell-derived extracellular vesicles(allogeneic:SMD=2.54,95% CI:2.05-3.02,P=0.0116,I2=65.5%;xenogeneic:SMD:1.78,95%CI:1.1-2.45,P=0.0116,I2=74.6%).Mesenchymal stem cellde rived extracellular vesicles separated by ultrafiltration centrifugation combined with density gradient ultra centrifugation(SMD=3.58,95% CI:2.62-4.53,P <0.0001,I2=31%) may be more effective than other EV isolation methods.For mouse Basso Mouse Scale scores,placenta-derived mesenchymal stem cell-de rived extracellular vesicles worked better than bone mesenchymal stem cell-derived extracellular vesicles(placenta:SMD=5.25,95% CI:2.45-8.06,P=0.0421,I2=0%;bone marrow:SMD=1.82,95% CI:1.23-2.41,P=0.0421,I2=0%).For modified Neurological Severity Score,bone marrow-derived MSC-EVs worked better than adipose-derived MSC-EVs(bone marrow:SMD=-4.86,95% CI:-6.66 to-3.06,P=0.0306,I2=81%;adipose:SMD=-2.37,95% CI:-3.73 to-1.01,P=0.0306,I2=0%).Intravenous administration(SMD=-5.47,95% CI:-6.98 to-3.97,P=0.0002,I2=53.3%) and dose of administration equal to 100 μg(SMD=-5.47,95% CI:-6.98 to-3.97,P <0.0001,I2=53.3%)showed better res ults than other administration routes and doses.The heterogeneity of studies was small,and sensitivity analysis also indicated stable results.Last,the methodological quality of all trials was mostly satisfactory.In conclusion,in the treatment of traumatic central nervous system diseases,mesenchymal stem cell-derived extracellular vesicles may play a crucial role in promoting motor function recovery. 展开更多
关键词 ANIMALS central nervous system diseases extracellular vesicles mesenchymal stromal cell META-ANALYSIS spinal cord injury traumatic brain injury
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The potential of gene therapies for spinal cord injury repair:a systematic review and meta-analysis of pre-clinical studies 被引量:1
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作者 Catriona J.Cunningham Mindaugas Viskontas +5 位作者 Krzysztof Janowicz Yasmin Sani Malin EHåkansson Anastasia Heidari Wenlong Huang Xuenong Bo 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第2期299-305,共7页
Currently,there is no cure for traumatic spinal co rd injury but one therapeutic approach showing promise is gene therapy.In this systematic review and meta-analysis,we aim to assess the efficacy of gene therapies in ... Currently,there is no cure for traumatic spinal co rd injury but one therapeutic approach showing promise is gene therapy.In this systematic review and meta-analysis,we aim to assess the efficacy of gene therapies in pre-clinical models of spinal cord injury and the risk of bias.In this metaanalysis,registe red at PROSPERO(Registration ID:CRD42020185008),we identified relevant controlled in vivo studies published in English by searching the PubMed,Web of Science,and Embase databases.No restrictions of the year of publication were applied and the last literature search was conducted on August 3,2020.We then conducted a random-effects meta-analysis using the restricted maximum likelihood estimator.A total of 71 studies met our inclusion crite ria and were included in the systematic review.Our results showed that overall,gene therapies were associated with improvements in locomotor score(standardized mean difference[SMD]:2.07,95%confidence interval[CI]:1.68-2.47,Tau^(2)=2.13,I^(2)=83.6%)and axonal regrowth(SMD:2.78,95%CI:1.92-3.65,Tau^(2)=4.13,I^(2)=85.5%).There was significant asymmetry in the funnel plots of both outcome measures indicating the presence of publication bias.We used a modified CAMARADES(Collaborative Approach to M eta-Analysis and Review of Animal Data in Experimental Studies)checklist to assess the risk of bias,finding that the median score was 4(IQR:3-5).In particula r,reports of allocation concealment and sample size calculations were lacking.In conclusion,gene therapies are showing promise as therapies for spinal co rd injury repair,but there is no consensus on which gene or genes should be targeted. 展开更多
关键词 animal models gene delivery META-ANALYSIS regenerative medicine spinal cord injury systematic review viral vectors
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Animal models of vascularized nerve grafts:a systematic review 被引量:1
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作者 Francesca Toia Daniele Matta +2 位作者 Federico De Michele Roberto Pirrello Adriana Cordova 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第12期2615-2618,共4页
The aim of this review is to present and compare the various animal models of vascularized nerve grafts described in the literature as well as to summarize preclinical evidence for superior functional results compared... The aim of this review is to present and compare the various animal models of vascularized nerve grafts described in the literature as well as to summarize preclinical evidence for superior functional results compared to non-vascularized free nerve grafts. We also will present the state of the art on prefabricated vascularized nerve grafts. A systematic literature review on vascularized nerve graft models was conducted via the retrieval with the Pub Med database on March 30, 2019. Data on the animal, nerve, and vascularization model, the recipient bed, the evaluation time points and methods, and the results of the study results were extracted and analyzed from selected articles. The rat sciatic nerve was the most popular model for vascularized nerve grafts, followed by the rabbit;however, rabbit models allow for longer nerve grafts, which are suitable for translational evaluation, and produced more cautious results on the superiority of vascularized nerve grafts. Compared to free nerve grafts, vascularized nerve grafts have better early but similar long-term results, especially in an avascular bed. There are few studies on avascular receiving beds and prefabricated nerve grafts. The clinical translation potential of available animal models is limited, and current experimental knowledge cannot fully support that the differences between vascularized nerve grafts and free nerve grafts yield a clinical advantage that justifies the complexity of the procedure. 展开更多
关键词 nerve animal models nerve grafts nerve regeneration peripheral nerves prefabricated vascularized nerve grafts vascularized nerve grafts
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Acute liver failure:A systematic review and network meta-analysis of optimal type of stem cells in animal models 被引量:1
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作者 Jun-Feng Ma Jian-Ping Gao Zi-Wei Shao 《World Journal of Stem Cells》 SCIE 2023年第1期1-15,共15页
BACKGROUND The therapeutic effects of various stem cells in acute liver failure(ALF)have been demonstrated in preclinical studies.However,the specific type of stem cells with the highest therapeutic potential has not ... BACKGROUND The therapeutic effects of various stem cells in acute liver failure(ALF)have been demonstrated in preclinical studies.However,the specific type of stem cells with the highest therapeutic potential has not been determined.AIM To validate the efficacy of stem cells in ALF model and to identify the most promising stem cells.METHODS A search was conducted on the PubMed,Web of Science,Embase,Scopus,and Cochrane databases from inception to May 3,2022,and updated on November 16,2022 to identify relevant studies.Two independent reviewers performed the literature search,identification,screening,quality assessment,and data extraction.RESULTS A total of 89 animal studies were included in the analysis.The results of traditional meta-analysis showed that stem cell therapy could significantly reduce the serum levels of alanine aminotransferase[weighted mean difference(WMD)=-181.05(-191.71,-170.39)],aspartate aminotransferase[WMD=-309.04(-328.45,-289.63)],tumor necrosis factor-alpha[WMD=-8.75(-9.93,-7.56)],and interleukin-6[WMD=-10.43(-12.11,-8.76)]in animal models of ALF.Further subgroup analysis and network meta-analysis showed that although mesenchymal stem cells are the current research hotspot,the effect of liver stem cells(LSCs)on improving liver function is significantly better than that of the other five types of stem cells.In addition,the ranking results showed that the possibility of LSCs improving liver function ranked first.This fully proves the great therapeutic potential of LSCs,which needs to be paid more attention in the future.CONCLUSION LSCs may have a higher therapeutic potential.Further high-quality animal experiments are needed to explore the most effective stem cells for ALF. 展开更多
关键词 Acute liver failure Stem cells Animal model systematic review Network meta-analysis
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Construction of Computer Aided Animation Appreciation System
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作者 Wangqiao Rong 《Journal of Computer and Communications》 2018年第6期15-30,共16页
By using computer multimedia and database technology to build the animation appreciation auxiliary system (AACAS), we classify the classical animation works according to types, categorize the appreciation main points ... By using computer multimedia and database technology to build the animation appreciation auxiliary system (AACAS), we classify the classical animation works according to types, categorize the appreciation main points and define the attribute, and input the corresponding information into the relevant database in real time so as to realize the logical connection of massive animation resources, and make appreciation information be able to realize free storage, rapid retrieval and easy for calling. In addition, the horizontal comparison of multiple works and the vertical comparison of the same work can be realized. This will significantly change the past inefficient situation of animation appreciation under a single thread, greatly improve the timeliness of the appreciation. 展开更多
关键词 animation APPRECIATION MULTIMEDIA system DATABASE Information
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Evolution of art form of video animation design under the background of computer graphics system development
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作者 Jiang Tan 《International Journal of Technology Management》 2017年第6期1-3,共3页
According to the development of discipline and teaching situation of computer graphics, computer graphics analysis in thecurriculum system, the reform of teaching contents and teaching methods, improve students' comp... According to the development of discipline and teaching situation of computer graphics, computer graphics analysis in thecurriculum system, the reform of teaching contents and teaching methods, improve students' computer graphics theory teaching and practiceteaching effects by using limited time, adapt to the social demand for graphics software R & D personnel. Motion design and production are ofgreat importance to film and television animation. This article mainly elaborates the present situation, the characteristic and the master method ofthe movie animation movement design and manufacture. Including the animation, motion animation design and production of organized, plannedproduction features that emphasize the characteristics of movement, exaggeration, force and rhythm, this paper presents the common problemsand solutions in the animation language, and the main differences between the animation design and performance in different forms of animation.Through the animation design and expression of the past and present situation analysis, looking forward to the future animation art movementdesign development. Aesthetic lens performance is the artistic pursuit of many film and television creators. Animation, as a highly hypotheticalart form, which is one of the distinctive artistic features of film and television animation, which is based on the limitation of the camera and is fullof expressive lenses. 展开更多
关键词 Computer graphics system development background film and TELEVISION animation design art form EVOLUTION
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Construction of Animation Education System Based on Interactive Teaching Pattern
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作者 Jiaojiao Chen 《International Journal of Technology Management》 2017年第5期12-14,共3页
This paper is on the construction of animation education system based on the interactive teaching pattern. In brief, the animation industry is a sunrise industry, for promotes our country animation industry fast healt... This paper is on the construction of animation education system based on the interactive teaching pattern. In brief, the animation industry is a sunrise industry, for promotes our country animation industry fast healthy development, the university should further consummate the education directive, the attention enhances the student to synthesize the quality, takes student' s innovation ability and the practice ability raise, the enhancement and the enterprise cooperation. In the process of positioning the cartoon talent should be based on the basic needs of the animation industry employment, the establishment of the basic skills of talent training objectives, in order to make talent positioning and industry needs closer. In the future, we will apply the proposed method in the general teaching activities to enhance the overall performance. 展开更多
关键词 animation Education system Interactive Teaching PATTERN
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Design and Application of Integrated Teaching System of Animation
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作者 LanYaxun CaiJuan 《International Journal of Technology Management》 2013年第9期7-9,共3页
The animation industry is a comprehensive art, and the development is very rapid in recent years, and many excellent domestic animation works are moved on the screen, winning support among the people. Looking to the f... The animation industry is a comprehensive art, and the development is very rapid in recent years, and many excellent domestic animation works are moved on the screen, winning support among the people. Looking to the future, the animation industry has a very great development potential. The animation major is considered as an emerging major in some colleges, and its teaching methods are still in the exploring stage. And the emerging industry has a great demand for animation talent, thus, the teaching methods of animation major need to be reformed to adapt to the constant market demand. This paper proposes an integrated teaching system of animation to solve the contradiction between market demand and traditional animation teaching mode, making analysis and researches of the kind of integrated teaching system, which is briefly described. 展开更多
关键词 animation integrated teaching system DESIGN APPLICATION
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Research on the Curriculum System Construction Plan for Animation Design and Production of Specialty in High Vocational Colleges
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作者 Zhenhuan Liu 《International Journal of Technology Management》 2016年第1期23-25,共3页
In this paper, we conduct research on curriculum system construction plan for animation design and production of specialty in high vocational colleges. With the development of animation industry in our country, the ex... In this paper, we conduct research on curriculum system construction plan for animation design and production of specialty in high vocational colleges. With the development of animation industry in our country, the existing higher vocational anime education already cannot satisfy the needs of the enterprises. Anime professional teaching reform is imminent. This article stands on the basis of existing animation specialty teaching reform, the analysis summarizes common problems, and proposes the corresponding solution hope to make their efforts to the development of animation education. We insist on teachers in the teaching process, and in the case of the classroom into more comprehensive knowledge, to improve the students' technology at the same time, more to improve students' comprehensive qualities to look for the better education performance. 展开更多
关键词 Curriculum system Reform animation Design High Vocational Colleges Specialty.
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Towards system genetics analysis of head and neck squamous cell carcinoma using the mouse model,cellular platform,and clinical human data
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作者 Osayd Zohud Iqbal M.Lone +1 位作者 Aysar Nashef Fuad A.Iraqi 《Animal Models and Experimental Medicine》 CAS CSCD 2023年第6期537-558,共22页
Head and neck squamous cell cancer(HNSCC)is a leading global malignancy.Every year,More than 830000 people are diagnosed with HNSCC globally,with more than 430000 fatalities.HNSCC is a deadly diverse malignancy with m... Head and neck squamous cell cancer(HNSCC)is a leading global malignancy.Every year,More than 830000 people are diagnosed with HNSCC globally,with more than 430000 fatalities.HNSCC is a deadly diverse malignancy with many tumor locations and biological characteristics.It originates from the squamous epithelium of the oral cavity,oropharynx,nasopharynx,larynx,and hypopharynx.The most frequently impacted regions are the tongue and larynx.Previous investigations have demonstrated the critical role of host genetic susceptibility in the progression of HNSCC.Despite the advances in our knowledge,the improved survival rate of HNSCC patients over the last 40 years has been limited.Failure to identify the molecular origins of development of HNSCC and the genetic basis of the disease and its biological heterogeneity impedes the development of new therapeutic methods.These results indicate a need to identify more genetic factors underlying this complex disease,which can be better used in early detection and prevention strategies.The lack of reliable animal models to investigate the underlying molecular processes is one of the most significant barriers to understanding HNSCC tumors.In this report,we explore and discuss potential research prospects utilizing the Collaborative Cross mouse model and crossing it to mice carrying single or double knockout genes(e.g.Smad 4 and P53 genes)to identify genetic factors affecting the development of this complex disease using genome-wide association studies,epigenetics,micro RNA,long noncoding RNA,lnc RNA,histone modifications,methylation,phosphorylation,and proteomics. 展开更多
关键词 animal models Collaborative Cross mice GENOMICS head and neck squamous cell cancinoma host genetic susceptibility
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Ultra-Lightweight Face Animation Method for Ultra-Low Bitrate Video Conferencing
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作者 LU Jianguo ZHENG Qingfang 《ZTE Communications》 2023年第1期64-71,共8页
Video conferencing systems face the dilemma between smooth streaming and decent visual quality because traditional video compression algorithms fail to produce bitstreams low enough for bandwidth-constrained networks.... Video conferencing systems face the dilemma between smooth streaming and decent visual quality because traditional video compression algorithms fail to produce bitstreams low enough for bandwidth-constrained networks.An ultra-lightweight face-animation-based method that enables better video conferencing experience is proposed in this paper.The proposed method compresses high-quality upperbody videos with ultra-low bitrates and runs efficiently on mobile devices without high-end graphics processing units(GPU).Moreover,a visual quality evaluation algorithm is used to avoid image degradation caused by extreme face poses and/or expressions,and a full resolution image composition algorithm to reduce unnaturalness,which guarantees the user experience.Experiments show that the proposed method is efficient and can generate high-quality videos at ultra-low bitrates. 展开更多
关键词 talking heads face animation video conferencing generative adversarial network
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Study on the Construction of Circular Economy Development System of Agriculture and Animal Husbandry in Tibet
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作者 Huaguo ZHANG 《Meteorological and Environmental Research》 CAS 2023年第4期74-77,共4页
As a basic industry in Tibet Autonomous Region,the development of agriculture and animal husbandry circular economy is of great practical significance,which is actively reflected in national high-quality development a... As a basic industry in Tibet Autonomous Region,the development of agriculture and animal husbandry circular economy is of great practical significance,which is actively reflected in national high-quality development and new agriculture and animal husbandry circular model.The development direction and future trend directly determine the promotion and enhancement of regional agriculture and animal husbandry economy,which is highly valued and welcomed by academic circles.This paper mainly expounds the development connotation of agriculture and animal husbandry circular economy system from the perspective of Tibet's agriculture and animal husbandry economic development.It focuses on sorting out the construction and future direction of circular economy development system,effectively puts forward ideas and comprehensive understanding of the circular economy development system of agriculture and animal husbandry in Tibet,effectively promotes the promotion and basic change of circular economy of agriculture and animal husbandry,and effectively changes the traditional development model and new innovation model of agriculture and animal husbandry. 展开更多
关键词 TIBET Agriculture and animal husbandry Circular economy system CONSTRUCTION
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