AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previousl...AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function test.AM was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow eyes.RESULTS:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P【0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P【0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P【0.001).The more severity of amblyopia,the poorer levels of contrast sensitivity.Most pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously impaired.CONCLUSION:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.展开更多
Dear Editor,We read with great interest article titled'Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia'by Chen et al[1].The authors have analysed subjects with previ...Dear Editor,We read with great interest article titled'Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia'by Chen et al[1].The authors have analysed subjects with previously untreated anisometropic amblyopia and found a significant correlation between high degree of anisometropia and deep amblyopia,worse contrast sensitivity,fusion and stereopsis functions.We commend the authors in addressing a very important problem and agree with the authors in the notation that children with anisometropia are usually detected later owing to lack of noticeable physical abnormalities.展开更多
目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正...目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正视力(BCVA)、一阶光栅锐度和(或)二阶纹理敏感度,并分析不同程度弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。结果:弱视组与正常对照组一阶光栅锐度(11.58±6.10 vs 20.27±3.47,P<0.001)、二阶纹理敏感度(0.33±0.16 vs 0.12±0.04,P<0.001)均有明显差异,且轻中度弱视患者与重度弱视患者一阶光栅锐度(12.10±6.23 vs 8.13±3.70,P<0.001)和二阶纹理敏感度(0.32±0.16 vs 0.37±0.17,P<0.05)均有明显差异。结论:单眼屈光参差性弱视患者大脑皮层一阶视觉通路和二阶视觉通路均存在不同程度的损伤,重度弱视患者较轻中度弱视患者损伤更为严重。展开更多
AIM：To determine lamina cribrosa thickness（LCT）in the optic nerve head region of the eyes in children with hyperopic anisometropic amblyopia and to compare this thickness with that of fellow eyes,hyperopic nonambly...AIM：To determine lamina cribrosa thickness（LCT）in the optic nerve head region of the eyes in children with hyperopic anisometropic amblyopia and to compare this thickness with that of fellow eyes,hyperopic nonamblyopia,and age-matched controls.METHODS：Thirty-two patients（12.0±1.8y,mean±standard deviation）with hyperopic anisometropic amblyopia,31 subjects with age-and refractive error-matched hyperopic non-amblyopia（10.7±2.2y）,and 32 age-matched controls（11.2±2.0y）were included in this prospective,crosssectional study.LCT was measured using an enhanced depth-imaging program of a spectral domain optical coherence tomographic instrument in all participants,and the correlation between LCT and axial length was calculated.RESULTS：The mean LCT was 180.9±29.4μm in amblyopic eyes,247.7±19.0μm in fellow eyes,251.6±27.3μm in hyperopic non-amblyopic eyes,and 240.2±15.8μm in control eyes.Lamina cribrosa in amblyopic eyes was significantly thinner than fellow,hyperopic non-amblyopic,and control eyes（P〈0.05）.There was no significant correlation in LCT and axial length between amblyopic（P=0.16）and control（P=0.31）group.CONCLUSION：Lamina cribrosa of eyes with hyperopic anisometropic amblyopia is significantly thinner than that of fellow eyes,hyperopic non-amblyopia,and age-matched controls.The LCT profile in amblyopic eyes is different from that observed in fellow,hyperopic non-amblyopic,and control eyes.展开更多
Purpose: To investigate relationship between treatment efficacy and the severity of ametropic amblyopia, the type of anisometropia and patient age. Methods:A total of 65 children with ametropic amblyopia undergoing cl...Purpose: To investigate relationship between treatment efficacy and the severity of ametropic amblyopia, the type of anisometropia and patient age. Methods:A total of 65 children with ametropic amblyopia undergoing clinical treatment in the ophthalmology department of Shaoguan Hygienic Hospital of Women and Children between June 2005 and November 2011 were enrolled in this study. The treatment efficacy for those subjects with different severities of ametropic amblyopia, types of anisometropia and ages was recorded. Results: The near-recovery/recovery rate, improvement rate and ineffectiveness rate were 70.8%, 16.9% and 12.3%, respectively. The recovery rates in mild-, moderate- and severe amblyopia groups were 97.1%, 61.1% and 8.3% respectively (P<0.05)..The recovery rate for patients with hyperopic-, astigmatic- and myopic anisometropia were 75.8%, 78.3% and 33.3% respectively. The recovery rates did not differ between hyperopic- and astigmatic- anisometropia children(P>0.05), whereas a statistically significant difference was noted between myopic children compared with their hyperopic and myopic-anisometropia counterparts (all P<0.05). The recovery rate for patients aged 3 to 6 years was 86.8% and 48.1% for those aged between 7 and 10 years (P<0.05). Conclusion: The treatment efficacy in ametropic amblyopia is associated with the severity of amblyopia, type of anisometropia and patient's age. Older patients with more severe amblyopia had poorer treatment efficacy. The efficacy in patients with hyperopic and astigmatic anisometropia was better than that for myopic anisometropia subjects.展开更多
Amblyopia is an illness with reduced vision and a number of students are affected with this disease. To determine any association of amblyopia with educational activities, sport and social activities of students invol...Amblyopia is an illness with reduced vision and a number of students are affected with this disease. To determine any association of amblyopia with educational activities, sport and social activities of students involved by amblyopia, this study was carried on. This study was conducted at Boali Hospital in Gazvin, Iran: A total of 110 patients 9 to 15 years (54.5% female and 45.5% male;mean age: 13.7 ± 3.2) with amblyopia (20/25 - 20/400) due to strabismus and/or refractive errors, and that persisted after treatment with spectacles. All children wore eyeglasses containing their refractive correction (based on cycloplegic autorefractor measurements, refined or confirmed by cycloplegic retinoscopy or subjective refinement) for acuity testing. The results indicated that, 25 (22.73%) patients with strabismus amblyopia, 40 (36.36%) patients anisometropic amblyopia, 22 (20%) patients ametropic amblyopia, 18 (16.36%) patients with strabismic mixed with anisometropia and 5 (4.55) with deprived amblyopia. Parent’s knowledge about meaning of amblyopia and amblyopia-related phenomena in 50 (45.5%) of patiens was very low. The educational level in 45 (41%) of parents were reported to be primary school, 40 (36.3%) higher school and university degrees 25 (22.7%). The sport activity in 35 (31.8%) of patients with amblyopia was very low and in 14 (12.7%) higher than others. In a comparison with other students, the educational qualification in 18 (16.4%) was very low, 35 (32%) the as equal as others and 27 (24.5%) higher than their classmate. Visual acuity with the best correction, in 75 (67%) of patients was 20/25, in 30 (27.27%) patients 20/40 or worse and in 5 (4.5%) of them 20/200 or worse. Poor eyesight and amblyopia can influence on learning, sport and social activity, and performance in school, as well as restrict choice in profession and hobbies. The parent’s knowledge of amblyopia is high efficiency of treatment of the amblyopia patient’s morale.展开更多
目的通过远期临床观察评价准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)矫治儿童高度远视性屈光参差的安全性、有效性、可预测性和稳定性,并探讨其对术后长期弱视治疗效果的影响。方法采用回顾性研究方法观察自2000年...目的通过远期临床观察评价准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)矫治儿童高度远视性屈光参差的安全性、有效性、可预测性和稳定性,并探讨其对术后长期弱视治疗效果的影响。方法采用回顾性研究方法观察自2000年9月开始接受LASIK手术矫治的61例61眼高度远视屈光参差性弱视儿童病例,年龄6~14岁。使用SVS Apex plus准分子激光系统及科医人公司鹰视世纪波及鹰视酷眼准分子激光系统,在局麻或基础麻醉下对患儿重度远视眼施行LASIK手术,矫治屈光度范围:(+3.00^+7.50)D。术后根据患儿年龄、弱视类型及弱视严重程度制定后期弱视治疗方案。22例随访时间60个月以上。结果术前患儿裸眼远视力为(0.12±0.07),裸眼近视力为(0.25±0.14),矫正远视力为(0.23±0.14),矫正近视力为(0.35±0.23)。双眼扩瞳等值球镜屈光参差度为(+6.41±1.24)D,小瞳等值球镜屈光参差度为(+5.52±1.16)D。中心同时视47.5%,中心融合16.4%,立体视3.3%,≤3%不等像14.8%。术后60个月:裸眼远视力为(0.35±0.13),裸眼近视力为(0.70±0.19),矫正远视力为(0.48±0.18),矫正近视力为(0.81±0.18),与术前比较,差异均有统计学意义(P<0.05)。双眼扩瞳等值球镜屈光参差度为(+0.61±1.43)D,小瞳等值球镜屈光参差度为(+0.59±1.37)D,与术前比较,差异均有统计学意义(P<0.05)。中心同时视91.7%,中心融合75.0%,立体视33.3%,≤3%不等像66.7%,与术前比较,差异均有统计学意义(P<0.05)。术后60个月所随访的22眼均没有发现最佳矫正远、近视力丢失。结论 LASIK手术可显著降低儿童高度远视性屈光参差,长期随访结果表明其具有较好的安全性、有效性、可预测性和稳定性,术后可显著提高弱视治愈率。展开更多
目的：观察大龄儿童及青少年屈光参差性重度弱视综合性治疗的疗效。方法：将56例56眼9～19岁的屈光参差性重度弱视患者分成两组，两组患者均充分散瞳验光，观察组（A组）配戴高透氧性硬性角膜接触镜（rigid gas permeable contact lens...目的：观察大龄儿童及青少年屈光参差性重度弱视综合性治疗的疗效。方法：将56例56眼9～19岁的屈光参差性重度弱视患者分成两组，两组患者均充分散瞳验光，观察组（A组）配戴高透氧性硬性角膜接触镜（rigid gas permeable contact lens，RGPCL），对照组（B组）给予足矫框架眼镜，两组均进行遮盖、增视治疗、脱抑制治疗，在弱视眼矫正视力〉4．7时，除继续遮盖、增视治疗、脱抑制治疗外，增加双眼视觉及立体视觉训练，随访观察24mo。结果：弱视治疗18mo后，两组的总有效率均为100％。比较两组的弱视治疗24mo时临床治愈率、脱抑制率、立体视≤100”患者所占百分比。A组临床治愈率为33％，B组为8％，A组的临床治愈率高于B组，两组疗效差异有显著性（x^2=4．02，P〈0．05）。A组的脱抑制率为37％，而B组的脱抑制率为4％，两组疗效差异有显著性（x^2=14．43，P〈0．05）。A组立体视≤100”患者占30％，B组占4％，两组疗效差异有显著性（x^2=4．83，P〈0．05）。A组全部患者均能满意接受配戴RGPCL，所有患者均未出现角膜上皮损伤、感染、结膜明显充血、分泌物增多及眼部磨痛、痒、异物感等不适。在配戴过程中未出现镜片护理方面问题。结论：对大龄儿童及青少年屈光参差性重度弱视应采取积极弱视治疗，两组的有效率达到了100％。配戴RGPCL组24mo脱抑制率、临床治愈率、立体视优于戴框架眼镜组。对于屈光参差性弱视，应建议患者戴RGPCL以提高临床治愈率，最大可能地恢复立体视。展开更多
基金Zhejiang Province Science Foundation of Health Bureau of China(No.2012KYA102)
文摘AIM:To assess the quantitative association between anisometropia magnitude(AM) and the losses of resolution and contrast sensitivity;and to exemplify how the function of fusion and stereopsis vary with AM in previously untreated anisometropic amblyopia. METHODS:A total of 57 patients with previously untreated anisometropic amblyopia without strabismus(range:8-35 years),were measured refractive error,best corrected visual acuity(BCVA),fusion and stereopsis,and 48 patients have completed contrast sensitivity function test.AM was determined by dioptric vector addition model,and the amblyopia depth was determined by the difference of BCVA in logMAR units between the amblyopic and fellow eyes.RESULTS:AM was significantly correlated with both amblyopia depth(Pearson R=0.728,P【0.001) and the inter-ocular difference of the area under the log contrast sensitivity function(AULCSF)(R=0.505,P【0.001).Depth of amblyopia and the inter-ocular difference of AULCSF was also significantly correlated(R=0.761,P【0.001).The more severity of amblyopia,the poorer levels of contrast sensitivity.Most pure anisometropes with AM was less than 3.0D retain fusion and some stereopsis,but when AM were more than 3.0D,especially for the anisometropes whose AM was more than 6.0D,fusion and stereopsis function were seriously impaired.CONCLUSION:In the patients with previously untreated anisometropic amblyopia,higher degree of anisometropia is significantly associated with deeper amblyopia,worse contrast sensitivity,fusion and stereopsis functions.
文摘Dear Editor,We read with great interest article titled'Anisometropia magnitude and visual deficits in previously untreated anisometropic amblyopia'by Chen et al[1].The authors have analysed subjects with previously untreated anisometropic amblyopia and found a significant correlation between high degree of anisometropia and deep amblyopia,worse contrast sensitivity,fusion and stereopsis functions.We commend the authors in addressing a very important problem and agree with the authors in the notation that children with anisometropia are usually detected later owing to lack of noticeable physical abnormalities.
文摘目的:研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法:收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组,另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正视力(BCVA)、一阶光栅锐度和(或)二阶纹理敏感度,并分析不同程度弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。结果:弱视组与正常对照组一阶光栅锐度(11.58±6.10 vs 20.27±3.47,P<0.001)、二阶纹理敏感度(0.33±0.16 vs 0.12±0.04,P<0.001)均有明显差异,且轻中度弱视患者与重度弱视患者一阶光栅锐度(12.10±6.23 vs 8.13±3.70,P<0.001)和二阶纹理敏感度(0.32±0.16 vs 0.37±0.17,P<0.05)均有明显差异。结论:单眼屈光参差性弱视患者大脑皮层一阶视觉通路和二阶视觉通路均存在不同程度的损伤,重度弱视患者较轻中度弱视患者损伤更为严重。
文摘AIM：To determine lamina cribrosa thickness（LCT）in the optic nerve head region of the eyes in children with hyperopic anisometropic amblyopia and to compare this thickness with that of fellow eyes,hyperopic nonamblyopia,and age-matched controls.METHODS：Thirty-two patients（12.0±1.8y,mean±standard deviation）with hyperopic anisometropic amblyopia,31 subjects with age-and refractive error-matched hyperopic non-amblyopia（10.7±2.2y）,and 32 age-matched controls（11.2±2.0y）were included in this prospective,crosssectional study.LCT was measured using an enhanced depth-imaging program of a spectral domain optical coherence tomographic instrument in all participants,and the correlation between LCT and axial length was calculated.RESULTS：The mean LCT was 180.9±29.4μm in amblyopic eyes,247.7±19.0μm in fellow eyes,251.6±27.3μm in hyperopic non-amblyopic eyes,and 240.2±15.8μm in control eyes.Lamina cribrosa in amblyopic eyes was significantly thinner than fellow,hyperopic non-amblyopic,and control eyes（P〈0.05）.There was no significant correlation in LCT and axial length between amblyopic（P=0.16）and control（P=0.31）group.CONCLUSION：Lamina cribrosa of eyes with hyperopic anisometropic amblyopia is significantly thinner than that of fellow eyes,hyperopic non-amblyopia,and age-matched controls.The LCT profile in amblyopic eyes is different from that observed in fellow,hyperopic non-amblyopic,and control eyes.
文摘Purpose: To investigate relationship between treatment efficacy and the severity of ametropic amblyopia, the type of anisometropia and patient age. Methods:A total of 65 children with ametropic amblyopia undergoing clinical treatment in the ophthalmology department of Shaoguan Hygienic Hospital of Women and Children between June 2005 and November 2011 were enrolled in this study. The treatment efficacy for those subjects with different severities of ametropic amblyopia, types of anisometropia and ages was recorded. Results: The near-recovery/recovery rate, improvement rate and ineffectiveness rate were 70.8%, 16.9% and 12.3%, respectively. The recovery rates in mild-, moderate- and severe amblyopia groups were 97.1%, 61.1% and 8.3% respectively (P<0.05)..The recovery rate for patients with hyperopic-, astigmatic- and myopic anisometropia were 75.8%, 78.3% and 33.3% respectively. The recovery rates did not differ between hyperopic- and astigmatic- anisometropia children(P>0.05), whereas a statistically significant difference was noted between myopic children compared with their hyperopic and myopic-anisometropia counterparts (all P<0.05). The recovery rate for patients aged 3 to 6 years was 86.8% and 48.1% for those aged between 7 and 10 years (P<0.05). Conclusion: The treatment efficacy in ametropic amblyopia is associated with the severity of amblyopia, type of anisometropia and patient's age. Older patients with more severe amblyopia had poorer treatment efficacy. The efficacy in patients with hyperopic and astigmatic anisometropia was better than that for myopic anisometropia subjects.
文摘Amblyopia is an illness with reduced vision and a number of students are affected with this disease. To determine any association of amblyopia with educational activities, sport and social activities of students involved by amblyopia, this study was carried on. This study was conducted at Boali Hospital in Gazvin, Iran: A total of 110 patients 9 to 15 years (54.5% female and 45.5% male;mean age: 13.7 ± 3.2) with amblyopia (20/25 - 20/400) due to strabismus and/or refractive errors, and that persisted after treatment with spectacles. All children wore eyeglasses containing their refractive correction (based on cycloplegic autorefractor measurements, refined or confirmed by cycloplegic retinoscopy or subjective refinement) for acuity testing. The results indicated that, 25 (22.73%) patients with strabismus amblyopia, 40 (36.36%) patients anisometropic amblyopia, 22 (20%) patients ametropic amblyopia, 18 (16.36%) patients with strabismic mixed with anisometropia and 5 (4.55) with deprived amblyopia. Parent’s knowledge about meaning of amblyopia and amblyopia-related phenomena in 50 (45.5%) of patiens was very low. The educational level in 45 (41%) of parents were reported to be primary school, 40 (36.3%) higher school and university degrees 25 (22.7%). The sport activity in 35 (31.8%) of patients with amblyopia was very low and in 14 (12.7%) higher than others. In a comparison with other students, the educational qualification in 18 (16.4%) was very low, 35 (32%) the as equal as others and 27 (24.5%) higher than their classmate. Visual acuity with the best correction, in 75 (67%) of patients was 20/25, in 30 (27.27%) patients 20/40 or worse and in 5 (4.5%) of them 20/200 or worse. Poor eyesight and amblyopia can influence on learning, sport and social activity, and performance in school, as well as restrict choice in profession and hobbies. The parent’s knowledge of amblyopia is high efficiency of treatment of the amblyopia patient’s morale.
文摘目的：观察大龄儿童及青少年屈光参差性重度弱视综合性治疗的疗效。方法：将56例56眼9～19岁的屈光参差性重度弱视患者分成两组，两组患者均充分散瞳验光，观察组（A组）配戴高透氧性硬性角膜接触镜（rigid gas permeable contact lens，RGPCL），对照组（B组）给予足矫框架眼镜，两组均进行遮盖、增视治疗、脱抑制治疗，在弱视眼矫正视力〉4．7时，除继续遮盖、增视治疗、脱抑制治疗外，增加双眼视觉及立体视觉训练，随访观察24mo。结果：弱视治疗18mo后，两组的总有效率均为100％。比较两组的弱视治疗24mo时临床治愈率、脱抑制率、立体视≤100”患者所占百分比。A组临床治愈率为33％，B组为8％，A组的临床治愈率高于B组，两组疗效差异有显著性（x^2=4．02，P〈0．05）。A组的脱抑制率为37％，而B组的脱抑制率为4％，两组疗效差异有显著性（x^2=14．43，P〈0．05）。A组立体视≤100”患者占30％，B组占4％，两组疗效差异有显著性（x^2=4．83，P〈0．05）。A组全部患者均能满意接受配戴RGPCL，所有患者均未出现角膜上皮损伤、感染、结膜明显充血、分泌物增多及眼部磨痛、痒、异物感等不适。在配戴过程中未出现镜片护理方面问题。结论：对大龄儿童及青少年屈光参差性重度弱视应采取积极弱视治疗，两组的有效率达到了100％。配戴RGPCL组24mo脱抑制率、临床治愈率、立体视优于戴框架眼镜组。对于屈光参差性弱视，应建议患者戴RGPCL以提高临床治愈率，最大可能地恢复立体视。
