In this study, we investigated the effects of adenovirus-mediated transfection of PC12 cells with glucose transporter 3 after ischemic injury. The results of flow cytometry and TUNEL showed that exogenous glucose tran...In this study, we investigated the effects of adenovirus-mediated transfection of PC12 cells with glucose transporter 3 after ischemic injury. The results of flow cytometry and TUNEL showed that exogenous glucose transporter 3 significantly suppressed PC12 cell apoptosis induced by ischemic injury. The results of isotopic scintiscan and western blot assays showed that, the glucose uptake rate was significantly increased and nuclear factor kappaB expression was significantly decreased after adenovirus-mediated transfection of ischemic PC12 cells with glucose transporter 3. These results suggest that adenovirus-mediated transfection of cells with glucose transporter 3 elevates the energy metabolism of PC12 cells with ischemic injury, and inhibits cell apoptosis.展开更多
The Seebeck effect measures the electric potential built up in materials under a temperature gradient.For organic thermoelectric materials,the Seebeck coefficient shows more complicated temperature dependence than con...The Seebeck effect measures the electric potential built up in materials under a temperature gradient.For organic thermoelectric materials,the Seebeck coefficient shows more complicated temperature dependence than conventional systems,with both monotonic increases and nonmonotonic behavior,that is,first increasing and then decreasing.The mechanism behind the phenomenon is intriguing.Through first-principles calculations coupled with the Boltzmann transport equation,we demonstrate typical trends of the Seebeck coefficient with respect to temperature through band structure analysis.展开更多
基金funded by the National Natural Science Foundation of China,No. 30770765
文摘In this study, we investigated the effects of adenovirus-mediated transfection of PC12 cells with glucose transporter 3 after ischemic injury. The results of flow cytometry and TUNEL showed that exogenous glucose transporter 3 significantly suppressed PC12 cell apoptosis induced by ischemic injury. The results of isotopic scintiscan and western blot assays showed that, the glucose uptake rate was significantly increased and nuclear factor kappaB expression was significantly decreased after adenovirus-mediated transfection of ischemic PC12 cells with glucose transporter 3. These results suggest that adenovirus-mediated transfection of cells with glucose transporter 3 elevates the energy metabolism of PC12 cells with ischemic injury, and inhibits cell apoptosis.
基金supported by the National Natural Science Foundation of China through the project“Science Center for Luminescence from Molecular Aggregates”(SCELMAgrant no.201788102)the Ministry of Science and Technology of China through the National Key R&D Plan(grant no.2017YFA0204501).
文摘The Seebeck effect measures the electric potential built up in materials under a temperature gradient.For organic thermoelectric materials,the Seebeck coefficient shows more complicated temperature dependence than conventional systems,with both monotonic increases and nonmonotonic behavior,that is,first increasing and then decreasing.The mechanism behind the phenomenon is intriguing.Through first-principles calculations coupled with the Boltzmann transport equation,we demonstrate typical trends of the Seebeck coefficient with respect to temperature through band structure analysis.
