Effects of information transmission delay and channel blocking on synchronization in scale-free Hodgkin-Huxley neuronal networks

In this paper,we investigate the evolution of spatiotemporal patterns and synchronization transitions in dependence on the information transmission delay and ion channel blocking in scale-free neuronal networks.As the underlying model of neuronal dynamics,we use the Hodgkin-Huxley equations incorporating channel blocking and intrinsic noise.It is shown that delays play a significant yet subtle role in shaping the dynamics of neuronal networks.In particular,regions of irregular and regular propagating excitatory fronts related to the synchronization transitions appear intermittently as the delay increases.Moreover,the fraction of working sodium and potassium ion channels can also have a significant impact on the spatiotemporal dynamics of neuronal networks.As the fraction of blocked sodium channels increases,the frequency of excitatory events decreases,which in turn manifests as an increase in the neuronal synchrony that,however,is dysfunctional due to the virtual absence of large-amplitude excitations.Expectedly,we also show that larger coupling strengths improve synchronization irrespective of the information transmission delay and channel blocking.The presented results are also robust against the variation of the network size,thus providing insights that could facilitate understanding of the joint impact of ion channel blocking and information transmission delay on the spatiotemporal dynamics of neuronal networks.

Two Chiral Building Blocks for the Stereocontrolled Synthesis of Anti-and Syn-1,3-Diols

Two chiral building blocks 1 and 2 for anti-and syn-1, 3-diols has been achieved in 8 steps and 7 steps respectively, starting from the readily available and inexpensive D (+)-xylose 3.

Synthesis of an Anti-1,3-Diol Type Chiral Building Block

A chiral building block, anti-1,3-diol 2, has been synthesized in 7 steps, starting from readily available and inexpensive D-(+)-xylose.

基于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯电化学免疫传感器检测Anti-IgG含量的研究

应用物理吸附法将羊抗人IgG抗原直接固定于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯修饰的金电极表面,制备电化学免疫传感器。采用循环伏安法和交流阻抗法对传感器进行表征,结果表明该传感器适合检测Anti-IgG浓度。同时探讨了缓冲液pH值、扫描速度、免疫反应温度、抗原与抗体配比对循环伏安峰电流的影响,结果表明在5-100mV/s扫速范围内,峰电流与扫速呈线性。孵育最优条件为25℃,h-IgG与Anti-IgG配比为1∶1。循环伏安法研究还表明Anti-IgG浓度在0.01-260μg/L范围内,线性关系良好,相关系数r^2=0.993,检出限（S/N=3）为0.006μg/L,据此建立了检测Anti-IgG浓度的新方法。

信号分子IRAK1/4在antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF中的作用探讨

目的:探讨IRAK1和IRAK4在antiβ-2GPI/β2GPI复合物诱导单核细胞株THP-1表达组织因子(TF)中的作用。方法:利用荧光定量PCR(Real-time PCR)、TF活性试剂盒分别检测THP-1细胞表达TF mRNA及TF活性;Western blot检测anti-β2GPI/β2GPI复合物诱导THP-1细胞表达IRAK1、磷酸化-IRAK1(p-IRAK1)、IRAK4情况;观察IRAK1/4抑制物是否干预anti-β2GPI/β2GPI复合物诱导THP-1表达TF。结果:Antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1细胞表达TF显著增加(P<0.05 vs control);Antiβ-2GPI/β2GPI复合物(100μg/ml)刺激THP-1细胞表达IRAK1、p-IRAK1、IRAK4(蛋白)显著升高(P<0.05 vscontrol);IRAK1/4抑制物(50μmol/L)能够阻断antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1表达TF及IRAK1磷酸化的效应。结论:antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF过程中,信号分子IRAK1/4被激活进而发挥重要作用。

基于均值-方差相交的定价因子研究——兼论GMM中估计Block-Bootstrap模拟的区组选择

根据最优投资组合理论,本文证明可以采用均值-方差相交的方法确定模拟资产组合作为因素模型的定价因子。为了得到稳健的实证结论,文中对GMM估计的Wald统计量进行了Block-Bootstrap模拟,同时研究了模拟过程中区组(Block)长度的选择问题。实证结果表明,本文构造的大、中、小三个规模组合可以作为中国股市的定价因子;当区组长度选定时,GMM-Wald统计量的Block-Bootstrap模拟不会随着模拟次数的变化发生显著变化,但当区组长度超过10时,它与其它区组长度对应的模拟结果会有显著差异。

三维Anti de Sitter空间中Lorentzian曲面的S_t^1×S_s^1-值光锥Gauss映射的奇点分类

利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.

一类Block型李代数的2-局部导子

对一类Block型李代数的2-局部导子进行研究,证明了这类Block型李代数的2-局部导子都是导子.

On the Construction of Deepening Anti - corruption Mechanism

It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.

Preparation, Structure and Properties of 3D Supramolecular Architecture, on the Basis of Hydrogen Bonds and π-π Stacking Between 2D Layers, with Windmill Building Blocks

A novel three-dimensional（3D） supramolecular architecture, {[Nd（OH-BDC）（OH-HBDC）（H2O）2]·2HaO）n（1） （OH-H2BDC=5-hydroxyisophthalic acid）, which was formed through hydrogen bonds and π-π stacking between two-dimensional（2D） layers, was hydrothermally synthesized and characterized by single-crystal X-ray diffraction. Windmill building blocks, which consist of two nine-coordinated metal centers and four OH-H2BDC groups are connected through two carboxyl groups, to lead to a one-dimensional infinite inorganic chain（… M--O--C--O--M…） along the [100] direction. An observed intense blue luminescence with an emission band peaked at 390 nm for compound 1 may results from ligand-to-metal charge transfer（LMCT）. Variable-temperature magnetic susceptibility of compound 1 was investigated and the value was deviated from the Curie-Weiss law.

Temperature-Triggered Hardware Trojan Based Algebraic Fault Analysis of SKINNY-64-64 Lightweight Block Cipher

SKINNY-64-64 is a lightweight block cipher with a 64-bit block length and key length,and it is mainly used on the Internet of Things(IoT).Currently,faults can be injected into cryptographic devices by attackers in a variety of ways,but it is still difficult to achieve a precisely located fault attacks at a low cost,whereas a Hardware Trojan(HT)can realize this.Temperature,as a physical quantity incidental to the operation of a cryptographic device,is easily overlooked.In this paper,a temperature-triggered HT(THT)is designed,which,when activated,causes a specific bit of the intermediate state of the SKINNY-64-64 to be flipped.Further,in this paper,a THT-based algebraic fault analysis(THT-AFA)method is proposed.To demonstrate the effectiveness of the method,experiments on algebraic fault analysis(AFA)and THT-AFA have been carried out on SKINNY-64-64.In the THT-AFA for SKINNY-64-64,it is only required to activate the THT 3 times to obtain the master key with a 100%success rate,and the average time for the attack is 64.57 s.However,when performing AFA on this cipher,we provide a relation-ship between the number of different faults and the residual entropy of the key.In comparison,our proposed THT-AFA method has better performance in terms of attack efficiency.To the best of our knowledge,this is the first HT attack on SKINNY-64-64.

Twin-block阻鼾器在老年阻塞性睡眠呼吸暂停低通气综合征合并冠心病患者中的应用效果

目的探究Twin-block阻鼾器在老年阻塞性睡眠呼吸暂停低通气综合征合并冠心病患者中的应用效果。方法选取2015年1月至2018年12月我院收治的老年阻塞性睡眠呼吸暂停低通气综合征合并冠心病患者95例作为研究对象,根据治疗方法不同将其分为试验组(48例)与对照组(47例)。试验组使用Twin-block阻鼾器治疗,对照组使用Silensor阻鼾器治疗。观察两组呼吸紊乱指数、低通气指数、呼吸暂停指数、血氧饱和度、上气道截面积和肿瘤坏死因子水平。结果治疗后3个月,两组呼吸紊乱指数、低通气指数、呼吸暂停指数和肿瘤坏死因子水平均降低,且试验组低于对照组(P<0.05);治疗后3个月,两组血氧饱和度和上气道截面积均提高,且试验组高于对照组(P<0.05)。结论老年阻塞性睡眠呼吸暂停低通气综合征合并冠心病患者运用Twin-block阻鼾器治疗不仅有利于改善呼吸暂停、呼吸紊乱等症状,更有利于提升上气道横截面积与血氧饱和度,对改善缺血、缺氧的心肌细胞有重要作用,值得推广。

Influence of reservoir heterogeneity on immiscible water-alternating-CO_(2)flooding:A case study

Currently,limited studies of immiscible water-alternating-CO_(2)(imWACO_(2))flooding focus on the impact of reservoir heterogeneity on reservoir development outcomes.Given this,using the heterogeneous reservoirs in the Gao 89-1 block as a case study,this study conducted slab core flooding experiments and numerical simulations to assess the impact of reservoir heterogeneity on imWACO_(2)flooding efficiency.It can be concluded that imWACO_(2)flooding can enhance the sweep volume and oil recovery compared to continuous CO_(2)flooding.As the permeability difference increases,the difference in the swept volume between zones/layers with relatively high and low permeability increases.To optimize the exploitation of reservoirs in the Gao 89-1 block,the optimal timing and CO_(2)injection rate for imWACO_(2)flooding are determined at water cut of 40%and 10000 m^(3)/d,respectively.A short injection-production semi-period,combined with multiple cycles of water and CO_(2)injection alternations,is beneficial for enhanced oil recovery from imWACO_(2)flooding.

Anti-Bacterial and Flame Retardant for Cotton Fabric by One-Bath Finishing

A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and the bacteriostatic finishing agent named SFR-1 wassynthesized.The flame retardancy of the fabric finishedcan meet the DOC FF3-71 Children Sleepwear Stan-dard.Its bacterial inhibiting capacity can meet and ex-ceed the requirements of similar products

Testing of Anti-stripping Property of Friction Spun Core Yarn

Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a method to test the anti - stripping property of the core yarn. With a modified Universal Testing Machine, the stripping resistance of friction spun core yarn can be continuously measured. Some factors Influencing the measurements are discussed in detail. The testing results are compared with those from a Y731 Yarn Abrasion Tester and fur - ther confirmed by weaving practice.

2BMFJ-BL5型原茬地大豆免耕覆秸精量播种机性能试验研究

在北方垄作秸秆根茬残留量为0.994 kg·m^(-2)的人工收获后玉米原茬地上,测试分析2BMFJ-BL5型大豆原茬地免耕覆秸精量播种机田间作业性能。在作业速度5 km·h^(-1)条件下,按照中华人民共和国机械行业标准NY/T1768-2009《免耕播种机质量评价技术规范》实施了本次试验。结果表明:播种均匀性达到了国家标准优等品标准,播种深度合格率达到了国家一等品的标准。各行排肥量一致性变异系数达到了国家一等品的标准,总排肥量稳定性变异系数达到了国家优等品的标准。秸秆清秸率达97%以上,植被覆盖率达97%以上,田间出苗率达94%以上。试验结果为2BMFJ-BL5型大豆原茬地免耕覆秸精量播种机的产业化和推广应用提供了理论依据。

MZPH-820型单行马铃薯收获机设计

针对现有小型马铃薯收获机作业过程中,行进阻力大、易于壅堵、伤薯率高,以及垄高适应性差等问题,设计了MZPH-820型单行马铃薯收获机。该机挖掘铲各铲片相互分离,间隙通畅;升运链导向撑链轮通过悬臂板支撑,承力通轴实现向上移动,作业时入土部件仅有挖掘铲及切土防漏圆盘,可有效防止秧茎缠绕及壅土;挖掘铲角度调节机构可实现挖掘铲与升运链导向撑链轮角度的同步调节,使挖掘铲铲面倾角在18°~30°内连续可调,便于不同土质条件下优化作业性能;导向限深轮及支撑行走轮二者高度的协调调整使得收获机能够满足100~400 mm垄高地块的作业要求,保证挖掘铲预设铲面倾角的实现,垄高适应性得到增强。宽行高垄地块的田间试验表明：MZPH-820型单行马铃薯收获机挖掘、输运顺畅,分离效果明显,纯小时生产率为0.10 hm2/h,伤薯率为0.3%,损失率为3.9%,性能达到技术规范要求。

2BMFJ-3型麦茬地免耕精播机防堵装置

针对黄淮海一年两熟地区小麦机收后地表残留的秸秆量大且根茬过高,致使免耕播种下茬作物时易发生堵塞的现象,设计了一种用于麦茬地免耕精播机的防堵装置。为确定该装置合理的结构与作业参数,采用三因素三水平正交试验方法进行了优化试验,得到最优参数组合:机组作业速度4.5 km/h、清秸覆秸刀齿排布4-3-4、刀轴转速400 r/min。田间试验结果表明,当清秸覆秸刀齿切茬深度为20～30 mm时,防堵装置土壤扰动量为63%～76%,防堵效果好,能够创造良好的种床,提高播种质量。

2BYM-12型折叠式动力防堵免耕播种机设计与试验

针对黄淮海轮作区小麦玉米轮作机械化生产体系,优化出了既符合农学要求又符合机械化作业要求的基本种植规格。设计了2BYM-12型折叠式动力防堵免耕玉米播种机,该机具有独特的苗带清理及作业防拥堵功能、株距无级调节及其他关键部位作业监控功能、播种深度调节功能和作业仿形功能,适于大面积平整地块高效作业。采用了轻量化技术和液压折叠技术,便于田间转移和作业。在动力匹配和负载计算的基础上,利用ANSYS软件对2BYM-12型免耕播种机中间播种单元进行了有限元分析。结果表明,播种机的应力分布状况与实际情况一致,播种机整体受力符合设计要求。田间试验表明播种机作业性能达到了设计要求。