Objective： To determine the clinical serum levels of carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9）, individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases ...Objective： To determine the clinical serum levels of carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9）, individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods： The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic （ROC） curves were plotted. Results： Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined： in esophageal cancer, sensitivity=28%, negative predictive value （NPV）=61.72%, and AUC=0.742 （SE=0.05）, with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 （SE=0.0S）, with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 （SE=0.04）, with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated： in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 （SE=0.05）, with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 （SE=0.05）, with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 （SE=0.05）, with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined： in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 （95% CI： 0.0159-0.322）; gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 （9$% CI： -0.0866-0.198）; and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 （9S% CI： 0.137-0.415）. Conclusion： CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.展开更多
The FCSE controlling equation of pinned thinwalled curve box was derived and the indeterminate problem of continuous thin-walled curve box with diaphragm was solved based on flexibility theory. With Bayesian statistic...The FCSE controlling equation of pinned thinwalled curve box was derived and the indeterminate problem of continuous thin-walled curve box with diaphragm was solved based on flexibility theory. With Bayesian statistical theory,dynamic Bayesian error function of displacement parameters of indeterminate curve box was founded. The corresponding formulas of dynamic Bayesian expectation and variance were deduced. Combined with one-dimensional Fibonacci automatic search scheme of optimal step size,the Powell optimization theory was utilized to research the stochastic identification of displacement parameters of indeterminate thin-walled curve box. Then the identification steps were presented in detail and the corresponding calculation procedure was compiled. Through some classic examples,it is obtained that stochastic performances of systematic parameters and systematic responses are simultaneously deliberated in dynamic Bayesian error function. The one-dimensional optimization problem of the optimal step size is solved by adopting Fibonacci search method. And the Powell identification of displacement parameters of indeterminate thin-walled curve box has satisfied numerical stability and convergence,which demonstrates that the presented method and the compiled procedure are correct and reliable.During parameters鈥？iterative processes,the Powell theory is irrelevant with the calculation of finite curve strip element（FCSE） partial differentiation,which proves high computation effciency of the studied method.展开更多
An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Int...An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Introducing the variation of dynamic grain size and the heterogeneous distribution of disolo- cation densities densities under DRX,a simple method for modeling and simulating DRX processes is developed by using Laplace transformation theory. The results derived from the present model agree well with the experimental results in literatures. This simulation can reproduce a number of features in DRX flow behaviors, for example,single and multiple peak flow behaviors followed by a steady state flow, the transition between them, and so on.展开更多
Previous studies have shown that glycine and proline are pharmacophores that display antibacterial activity.In the present study,glycine and proline were derivated to diketopiperazine compounds by chemical synthesis m...Previous studies have shown that glycine and proline are pharmacophores that display antibacterial activity.In the present study,glycine and proline were derivated to diketopiperazine compounds by chemical synthesis method,and their antibacterial activities were evaluated by three strains of spoilage bacteria,Escherichia coli,Pseudomonas aeruginosa and Shewanella putrefaciens,and the relationship of their antibacterial activities and structures was also investigated.Uv-vis spectrophotometry was used to determine the growth curves of three kinds of active indicator bacteria.Minimum inhibitory concentration(MIC)was determined by micro broth dilution method.The results showed that 2-methyl-3-(methylthio)pyrazine had significant antibacterial activity against three strains of the bacteria,and its MIC was 1.25%.It indicates 2-methyl-3-(methylthio)pyrazine has the potential to be developed as a kind of preservative in future.展开更多
By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we...By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we make aspecial study about centering- point curve and circling- point curve and couplercurves based on Ball’s points.展开更多
利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kr...利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.展开更多
We carried out new photometric observations of asteroid （106） Dione at three apparitions （2004, 2012 and 2015） to understand its basic physical properties. Based on a new brightness model, new photometric observat...We carried out new photometric observations of asteroid （106） Dione at three apparitions （2004, 2012 and 2015） to understand its basic physical properties. Based on a new brightness model, new photometric observational data and published data of （106） Dione were analyzed to characterize the morphology of Dione＇s photometric phase curve. In this brightness model, a cellinoid ellipsoid shape and three-parameter （H, G1, G2） magnitude phase function system were involved. Such a model can not only solve the phase function system parameters of （106） Dione by considering an asymmetric shape of an asteroid, but also can be applied to more asteroids, especially those without enough photometric data to solve the convex shape. Using a Markov Chain Monte Carlo （MCMC） method, Dione＇s absolute magnitude of H = 7.66＋0.03-0.03 mag, and phase function parameters G1 = 0.682＋0.077-0.077 and G2 = 0.081＋0.042-0.042 were obtained. Simultaneously, Dione＇s simplistic shape, orientation of pole and rotation period were also determined preliminarily.展开更多
In this work, graphene-modified epoxy-based anti-corrosion coatings were prepared and the influence of graphene on the anti-corrosion performance of the epoxy-based coatings was investigated with water contact angle t...In this work, graphene-modified epoxy-based anti-corrosion coatings were prepared and the influence of graphene on the anti-corrosion performance of the epoxy-based coatings was investigated with water contact angle test ,chemical solution immersion test, and electrochemical test. The water contact angle and chemical solution resistance of the epoxy-based coatings were improved with an increase in graphene content from 0 to 0.4%. These results prove that addition of graphene can significantly improve the hydrophobicity and impermeability of epoxy- based coatings. However, when the graphene content was increased to 0.5%, the performance of the epoxy-based coatings decreased because of graphene aggregation. Tafel polarization results show that graphene addition can significantly reduce the corrosion current density and corrosion potential of epoxy-based coatings, which enhance their anti-corrosion performance.展开更多
It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be rea...It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.展开更多
This paper researches on some key technologies of anti-jamming of an air-borne radar receiver, the automatic testing of AGC, IAGC and multi-filtering under one million noisy pulses by the computer simulation system. T...This paper researches on some key technologies of anti-jamming of an air-borne radar receiver, the automatic testing of AGC, IAGC and multi-filtering under one million noisy pulses by the computer simulation system. The system tests the width of the jamming pulse whose width is 100% bigger, 60% bigger and 100% smaller than the Radar signal’s respectively and show the SNR curve.展开更多
A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and t...A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and the bacteriostatic finishing agent named SFR-1 wassynthesized.The flame retardancy of the fabric finishedcan meet the DOC FF3-71 Children Sleepwear Stan-dard.Its bacterial inhibiting capacity can meet and ex-ceed the requirements of similar products展开更多
Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a me...Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a method to test the anti - stripping property of the core yarn. With a modified Universal Testing Machine, the stripping resistance of friction spun core yarn can be continuously measured. Some factors Influencing the measurements are discussed in detail. The testing results are compared with those from a Y731 Yarn Abrasion Tester and fur - ther confirmed by weaving practice.展开更多
基金the financial support provided by the Biotechnology Information Service–Sub-Distributed Information Centre(supported by the Department of Biotechnology,Government of India)Advanced Bioinformatics Centre(supported by the Government of Rajasthan)at Birla Institute of Scientific Research for the infrastructure and facilities for conducting statistical work
文摘Objective： To determine the clinical serum levels of carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9）, individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods： The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic （ROC） curves were plotted. Results： Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined： in esophageal cancer, sensitivity=28%, negative predictive value （NPV）=61.72%, and AUC=0.742 （SE=0.05）, with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 （SE=0.0S）, with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 （SE=0.04）, with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated： in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 （SE=0.05）, with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 （SE=0.05）, with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 （SE=0.05）, with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined： in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 （95% CI： 0.0159-0.322）; gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 （9$% CI： -0.0866-0.198）; and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 （9S% CI： 0.137-0.415）. Conclusion： CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.
基金supported by the National Natural Science Foundation of China (10472045, 10772078 and 11072108)the Science Foundation of NUAA(S0851-013)
文摘The FCSE controlling equation of pinned thinwalled curve box was derived and the indeterminate problem of continuous thin-walled curve box with diaphragm was solved based on flexibility theory. With Bayesian statistical theory,dynamic Bayesian error function of displacement parameters of indeterminate curve box was founded. The corresponding formulas of dynamic Bayesian expectation and variance were deduced. Combined with one-dimensional Fibonacci automatic search scheme of optimal step size,the Powell optimization theory was utilized to research the stochastic identification of displacement parameters of indeterminate thin-walled curve box. Then the identification steps were presented in detail and the corresponding calculation procedure was compiled. Through some classic examples,it is obtained that stochastic performances of systematic parameters and systematic responses are simultaneously deliberated in dynamic Bayesian error function. The one-dimensional optimization problem of the optimal step size is solved by adopting Fibonacci search method. And the Powell identification of displacement parameters of indeterminate thin-walled curve box has satisfied numerical stability and convergence,which demonstrates that the presented method and the compiled procedure are correct and reliable.During parameters鈥？iterative processes,the Powell theory is irrelevant with the calculation of finite curve strip element（FCSE） partial differentiation,which proves high computation effciency of the studied method.
文摘An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Introducing the variation of dynamic grain size and the heterogeneous distribution of disolo- cation densities densities under DRX,a simple method for modeling and simulating DRX processes is developed by using Laplace transformation theory. The results derived from the present model agree well with the experimental results in literatures. This simulation can reproduce a number of features in DRX flow behaviors, for example,single and multiple peak flow behaviors followed by a steady state flow, the transition between them, and so on.
基金Supported by The Tackling-plan Project of Henan Department of Science and Technology (222102310388)Key Scientific Research Plan of Colleges in Henan Province (22B350002)Henan Provincial Medical Science and Technology Research Plan Joint Construction Project (LHGJ20191520).
文摘Previous studies have shown that glycine and proline are pharmacophores that display antibacterial activity.In the present study,glycine and proline were derivated to diketopiperazine compounds by chemical synthesis method,and their antibacterial activities were evaluated by three strains of spoilage bacteria,Escherichia coli,Pseudomonas aeruginosa and Shewanella putrefaciens,and the relationship of their antibacterial activities and structures was also investigated.Uv-vis spectrophotometry was used to determine the growth curves of three kinds of active indicator bacteria.Minimum inhibitory concentration(MIC)was determined by micro broth dilution method.The results showed that 2-methyl-3-(methylthio)pyrazine had significant antibacterial activity against three strains of the bacteria,and its MIC was 1.25%.It indicates 2-methyl-3-(methylthio)pyrazine has the potential to be developed as a kind of preservative in future.
文摘By means of programs GTMPAC based- on generalized triangle method,analysis and synthesis of mechanism design in accordance with absolutely graphicalmethod( absolutely germetrical method) are developed.In this paper,we make aspecial study about centering- point curve and circling- point curve and couplercurves based on Ball’s points.
文摘利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.
基金funded by the National Natural Science Foundation of China(Grant Nos.11073051,11473066 and 11673063)the Open Project of Key Laboratory of Space Object and Debris Observation,Chinese Academy of Sciences(title:Photometric study of space debris in near geostationary orbit)
文摘We carried out new photometric observations of asteroid （106） Dione at three apparitions （2004, 2012 and 2015） to understand its basic physical properties. Based on a new brightness model, new photometric observational data and published data of （106） Dione were analyzed to characterize the morphology of Dione＇s photometric phase curve. In this brightness model, a cellinoid ellipsoid shape and three-parameter （H, G1, G2） magnitude phase function system were involved. Such a model can not only solve the phase function system parameters of （106） Dione by considering an asymmetric shape of an asteroid, but also can be applied to more asteroids, especially those without enough photometric data to solve the convex shape. Using a Markov Chain Monte Carlo （MCMC） method, Dione＇s absolute magnitude of H = 7.66＋0.03-0.03 mag, and phase function parameters G1 = 0.682＋0.077-0.077 and G2 = 0.081＋0.042-0.042 were obtained. Simultaneously, Dione＇s simplistic shape, orientation of pole and rotation period were also determined preliminarily.
文摘In this work, graphene-modified epoxy-based anti-corrosion coatings were prepared and the influence of graphene on the anti-corrosion performance of the epoxy-based coatings was investigated with water contact angle test ,chemical solution immersion test, and electrochemical test. The water contact angle and chemical solution resistance of the epoxy-based coatings were improved with an increase in graphene content from 0 to 0.4%. These results prove that addition of graphene can significantly improve the hydrophobicity and impermeability of epoxy- based coatings. However, when the graphene content was increased to 0.5%, the performance of the epoxy-based coatings decreased because of graphene aggregation. Tafel polarization results show that graphene addition can significantly reduce the corrosion current density and corrosion potential of epoxy-based coatings, which enhance their anti-corrosion performance.
文摘It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.
文摘This paper researches on some key technologies of anti-jamming of an air-borne radar receiver, the automatic testing of AGC, IAGC and multi-filtering under one million noisy pulses by the computer simulation system. The system tests the width of the jamming pulse whose width is 100% bigger, 60% bigger and 100% smaller than the Radar signal’s respectively and show the SNR curve.
基金The project serial number 92B0716Shanghai Natural Science Foundation
文摘A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and the bacteriostatic finishing agent named SFR-1 wassynthesized.The flame retardancy of the fabric finishedcan meet the DOC FF3-71 Children Sleepwear Stan-dard.Its bacterial inhibiting capacity can meet and ex-ceed the requirements of similar products
文摘Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a method to test the anti - stripping property of the core yarn. With a modified Universal Testing Machine, the stripping resistance of friction spun core yarn can be continuously measured. Some factors Influencing the measurements are discussed in detail. The testing results are compared with those from a Y731 Yarn Abrasion Tester and fur - ther confirmed by weaving practice.
