Detecting exactly information from pulse position modulation (PPM) is difficult in shallow water channels because of the high noise level there. This paper reports results of analyses of some statistical characteristi...Detecting exactly information from pulse position modulation (PPM) is difficult in shallow water channels because of the high noise level there. This paper reports results of analyses of some statistical characteristics of shallow water channel noise and its adverse effect on detecting PPM information; and proposes some efficient countermeasures (the method of statistical decision, use of pulse width discriminator and digital selective-frequency filter) to overcome noise interference. The results have been applied to PPM detection systems and proved to be efficient, and are of reference value for other models of signal detection.展开更多
Achieving reliable underwater communication in shallow water acoustic channels is a difficult task because of the random time varying nature of multipath propagation, severe amplitude fluctuation, and spatial variabil...Achieving reliable underwater communication in shallow water acoustic channels is a difficult task because of the random time varying nature of multipath propagation, severe amplitude fluctuation, and spatial variability of the channel conditions. This paper describes a new signal processing technique frequency coding and decoding by means of real time measurement of signal width, jamming and suppressing multipath interference and using redundant coder. The application of the technique to the model ZTY 1 status monitor for underwater system of seabed is introduced in this paper. The main principle, the technique specifications and the key techniques of the system are discussed here. Theoretical estimations and experimental results proved that the performance of the system is excellent. The method can be used for some other related low data rate data transmission detecting in shallow water acoustic channel.展开更多
Voltage-gated sodium channels(VGSCs) are transmembrane proteins responsible for generation and conduction of action potentials in excitable cells.Physiological and pharmacological studies have demonstrated that VGSCs ...Voltage-gated sodium channels(VGSCs) are transmembrane proteins responsible for generation and conduction of action potentials in excitable cells.Physiological and pharmacological studies have demonstrated that VGSCs play a critical role in chronic pain associated with tissue or nerve injury.Many long-chain peptide toxins(60-76 amino acid residues) purified from the venom of Asian scorpion Buthus martensii Karsch(BmK) are investigated to be sodium channel-specific modulators.The α-like neurotoxins that can bind to receptor site 3 of sodium channels,named as BmK I and BmK abT,could induce nociceptive effects in rats.On the contrast,the β-like neurotoxins that can bind to receptor site 4 of sodium channels,named as BmK AS,BmK AS-1 and BmK IT2,could produce potent anti-nociceptive effects in animal pain models.BmK I could strongly prolong the fast inactivation of tetrodotoxin(TTX)-sensitive Na+ currents on the rat dorsal root ganglia(DRG) neurons together with the augmentation of peak current amplitude.However,BmK IT2 and BmK ASs,potently suppressed both the peak TTX-resistant and TTX-sensitive Na+ currents on rat small DRG neurons.Moreover,BmK ASs could decrease the excitability of small DRG neurons.Thus,the nociception/anti-nociception induced by scorpion neurotoxins may attribute to their distinct modulation on sodium channels in primary afferent sensory neurons.Therefore,the sodium channel-specific modulators from BmK venom could be used as not only pharmacological tools for better understanding the roles of VGSCs in pain signal conduction,but also lead molecules in the development of ideal analgesics targeting VGSCs.展开更多
The existing research of the flow behavior in emitter micro-channels mainly focuses on the single-phase flow behavior.And the recent micro-particle image velocimetry（PIV） experimental research on the flow characteri...The existing research of the flow behavior in emitter micro-channels mainly focuses on the single-phase flow behavior.And the recent micro-particle image velocimetry（PIV） experimental research on the flow characteristics in various micro-channels mainly focuses on the single-phase fluid flow.However,using an original-size emitter prototype to perform the experiments on the two-phase flow characteristics of the labyrinth channels is seldom reported.In this paper,the practical flow of water,mixed with sand escaped from filtering,in the labyrinth channel,is investigated.And some research work on the clogging mechanism of the labyrinth channel＇s structure is conducted.Computational fluid dynamics（CFD） analysis has been performed on liquid-solid two-phase flow in labyrinth-channel emitters.Based on flow visualization technology-micro-PIV,the flow in labyrinth channel has been photographed and recorded.The path line graph and velocity vector graph are obtained through the post-treatment of experimental results.The graphs agree well with CFD analysis results,so CFD analysis can be used in optimal design of labyrinth-channel emitters.And the optimized anti-clogging structures of the rectangular channel and zigzag channel have been designed here.The CFD numerical simulation and the micro-PIV experiments analysis on labyrinth-channel emitter,make the ＂black box＂ of the flow behavior in the emitter channel broken.Furthermore,the proposed research promotes an advanced method to evaluate the emitter＇s performance and can be used to conducting the optimal design of the labyrinth-channel emitters.展开更多
AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. ...AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administration.RESULTS:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine.展开更多
On the basis of the introduction about water saving irrigation that works as a kind of new irrigation pattern,the method of anti-seep quality estimation of the conveying water and distributing channel which acts as an...On the basis of the introduction about water saving irrigation that works as a kind of new irrigation pattern,the method of anti-seep quality estimation of the conveying water and distributing channel which acts as an important engineering measure of water saving irrigation will be introduced in te paper.that is,by means of unit length of channel's water utilization coefficient(η 0)to estimate the quality of channel,and the calculative method has been explained by the example of an actual project.It can be referred to irrigational workers.展开更多
Since ancient times, traditional medicines have been in the usage for the treatment of Diabetes mellitus. An edible fruit from traditional medicinal plant Capparis zeylanica (CZ) was studied for its anti diabetic, ins...Since ancient times, traditional medicines have been in the usage for the treatment of Diabetes mellitus. An edible fruit from traditional medicinal plant Capparis zeylanica (CZ) was studied for its anti diabetic, insulin secretagogue activities and mechanisms involved in it. In Streptozotocin induced diabetes rats, oral administration of Capparis zeylanica methanolic extract (CZME) (200 mg/kg body weight) for 28 days showed a significant reduction in blood glucose levels by 35.53% and enhanced circulating insulin levels by 81.82% than the diabetic control rats. The insulin secretagogue activity mechanisms of the extract were evaluated by using mouse insulinoma beta cell line (MIN6-β). The extract stimulated insulin release in dependent manner of glucose concentration (3 - 16.7 mM) and extract dose (5 - 500 μg/mL). The insulin releasing effect of the extract was significantly enhanced by 3-isobutyl-1-methyl xanthine, glibenclamide, elevated extracellular calcium and K+ depolarized media. This insulin release was significantly reduced in calcium blocking conditions (by nifedipine and EGTA), in the presence of potassium channel opener (diazoxide). Hence, anti diabetic activity of CZME might be a result of its stimulatory effect on insulin release from pancreatic beta cells via KATP channel dependent and independent ways. These results indicate that CZ fruits have the potential to use in diabetes therapy.展开更多
In asymmetric conditions,the movement and loads of left/right wheels or front/back wheels of the aircraft with multi-wheel or four-wheel bogie landing gears are inconsistent.There are few open literatures related to a...In asymmetric conditions,the movement and loads of left/right wheels or front/back wheels of the aircraft with multi-wheel or four-wheel bogie landing gears are inconsistent.There are few open literatures related to anti-skid braking system for multi-wheels due to technology blockade.In China,the research on multi-channel control and non-equilibrium regulation has just started,and the design of multi-channel control system for anti-skid braking,the simulation of asymmetry taxiing under braking are not studied.In this paper,a dynamics model of ground movement for aircraft with four-wheel bogie landing gears is established for braking simulation, considering the six-degree-of-freedom aircraft body and the movement of bogies and wheels.A multi-channel anti-skid braking system is designed for the wheels of the main landing gears with four-wheel bogies.The eight wheels on left and right landing gears are divided into four groups,and each group is controlled via one channel.The cross protection and self-locked protection modules are added between different channels.A multi-channel anti-skid braking system with slip-ratio control or with slip-velocity control is established separately.Based on the aircraft dynamics model,aircraft braking to stop with anti-skid control on dry runway and on wet runway are simulated.The simulation results demonstrate that in asymmetric conditions,added with cross protection and self-locked protection modules,the slip-ratio-controlled braking system can automatically regulate brake torque to avoid deep slipping and correct aircraft course.The proposed research has reference value for improving brake control effect on wet runway.展开更多
Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang), a formulation of Japanese herbal (Kampo) medicines, is composed of Paeoniae Radix and Glycyrrhizae Radix. Effects of Shakuyakukanzoto and the ingredients on rat intestinal tra...Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang), a formulation of Japanese herbal (Kampo) medicines, is composed of Paeoniae Radix and Glycyrrhizae Radix. Effects of Shakuyakukanzoto and the ingredients on rat intestinal tract were examined. Shakuyakukanzoto (0.01 - 0.3 mg/ml) relaxed a carbachol (CCh, 0.3 μM) - induced contraction in a concentration-dependent manner. Both components (Paeoniae radix and Glycyrrhizae radix) also relaxed the CCh-induced contraction. At 0.1 to 1 mM, their constituents (paeoniflorin and glycyrrhetic acid) and the metabolic products (18-α- and 18-β-glycyrrhetinic acids) exerted almost the same actions. The relaxations induced by Shakuyakukanzoto were not modified by 1 μM nicardipine, 10 μM suramin (ATP receptor inhibitor) and several K+ channel inhibitors, but was attenuated by 20 μM IBMX (a phosphodiesterase inhibitor). Also, IBMX inhibited the relaxations induced by paeoniflorin and glycyrrhetic acid, but not by other ingredients. Nicardipine decreased the relaxation of just 18-α-glycyrrhetinic acid. Even in non-treatment with CCh, Shakuyakukanzoto relaxed the intestinal tract. CCh (0.3 μM) elicited spontaneous contractions in 23% specimens, depressed by application of Shakuyakukanzoto. These results indicate that Shakuyakukanzoto causes a remarkable relaxation by the anti-cholinergic and the PDE inhibitory actions, but by minor contribution of Ca2+ channel inhibition. Thus, Shakuyakukanzoto exerts an anti-spasmodic action due to the interaction with pharmacological effects of its ingredients.展开更多
<div style="text-align:justify;"> Due to the poor anti-clogging performance of the common drip irrigation emitters, this paper designed a new bionic flow channel in the emitter based on the shape of sh...<div style="text-align:justify;"> Due to the poor anti-clogging performance of the common drip irrigation emitters, this paper designed a new bionic flow channel in the emitter based on the shape of shark dorsal fin. After preliminary structural design, the computational fluid dynamics (CFD) simulation showed that the bionic emitter exhibited superior anti-clogging performance and reasonable hydraulic performance. The passage rate of particles of the bionic emitter in simulation reached 96.3% which was 37.6% higher than 70% of traditional emitter, and the discharge exponent reached 0.4995 which was close to traditional emitter. Physical experiments were consistent with the CFD results, which confirmed the correctness of simulation. After a short cycle anti-clogging performance experiment, the bionic emitter still maintained 96.09% of the initial flow rate. </div>展开更多
Pulse pesition modulated (PPM) acoustic pulses are difficult to detect exacily in shallow sea channels because of strong multipath interference, large signal fluctuation and high noise level.This paper reports results...Pulse pesition modulated (PPM) acoustic pulses are difficult to detect exacily in shallow sea channels because of strong multipath interference, large signal fluctuation and high noise level.This paper reports results of analysis on the main characteristics of multipath interference and its adverse effects on detection of pulse position information. Feasible methods to overeome multipath interference are pointed out, and an efficient one is proposed to realize reliable and precise detection of PPM information.The results of this study are of reference value for other modes of signal detection.展开更多
文摘Detecting exactly information from pulse position modulation (PPM) is difficult in shallow water channels because of the high noise level there. This paper reports results of analyses of some statistical characteristics of shallow water channel noise and its adverse effect on detecting PPM information; and proposes some efficient countermeasures (the method of statistical decision, use of pulse width discriminator and digital selective-frequency filter) to overcome noise interference. The results have been applied to PPM detection systems and proved to be efficient, and are of reference value for other models of signal detection.
文摘Achieving reliable underwater communication in shallow water acoustic channels is a difficult task because of the random time varying nature of multipath propagation, severe amplitude fluctuation, and spatial variability of the channel conditions. This paper describes a new signal processing technique frequency coding and decoding by means of real time measurement of signal width, jamming and suppressing multipath interference and using redundant coder. The application of the technique to the model ZTY 1 status monitor for underwater system of seabed is introduced in this paper. The main principle, the technique specifications and the key techniques of the system are discussed here. Theoretical estimations and experimental results proved that the performance of the system is excellent. The method can be used for some other related low data rate data transmission detecting in shallow water acoustic channel.
基金grants from National Basic Research Development Program of China(No.2006CB500801)National Natural Sciences Foundation of China(No.30370446)
文摘Voltage-gated sodium channels(VGSCs) are transmembrane proteins responsible for generation and conduction of action potentials in excitable cells.Physiological and pharmacological studies have demonstrated that VGSCs play a critical role in chronic pain associated with tissue or nerve injury.Many long-chain peptide toxins(60-76 amino acid residues) purified from the venom of Asian scorpion Buthus martensii Karsch(BmK) are investigated to be sodium channel-specific modulators.The α-like neurotoxins that can bind to receptor site 3 of sodium channels,named as BmK I and BmK abT,could induce nociceptive effects in rats.On the contrast,the β-like neurotoxins that can bind to receptor site 4 of sodium channels,named as BmK AS,BmK AS-1 and BmK IT2,could produce potent anti-nociceptive effects in animal pain models.BmK I could strongly prolong the fast inactivation of tetrodotoxin(TTX)-sensitive Na+ currents on the rat dorsal root ganglia(DRG) neurons together with the augmentation of peak current amplitude.However,BmK IT2 and BmK ASs,potently suppressed both the peak TTX-resistant and TTX-sensitive Na+ currents on rat small DRG neurons.Moreover,BmK ASs could decrease the excitability of small DRG neurons.Thus,the nociception/anti-nociception induced by scorpion neurotoxins may attribute to their distinct modulation on sodium channels in primary afferent sensory neurons.Therefore,the sodium channel-specific modulators from BmK venom could be used as not only pharmacological tools for better understanding the roles of VGSCs in pain signal conduction,but also lead molecules in the development of ideal analgesics targeting VGSCs.
基金supported by National Natural Science Foundation of China (Grant Nos. 50675172,50975227)Foundation for the Author of National Excellent Doctoral Dissertation of China (Grant No.FANEDD200740)National Hi-tech Research and Development of China (863 Program,Grant No. 2011AA100507-04)
文摘The existing research of the flow behavior in emitter micro-channels mainly focuses on the single-phase flow behavior.And the recent micro-particle image velocimetry（PIV） experimental research on the flow characteristics in various micro-channels mainly focuses on the single-phase fluid flow.However,using an original-size emitter prototype to perform the experiments on the two-phase flow characteristics of the labyrinth channels is seldom reported.In this paper,the practical flow of water,mixed with sand escaped from filtering,in the labyrinth channel,is investigated.And some research work on the clogging mechanism of the labyrinth channel＇s structure is conducted.Computational fluid dynamics（CFD） analysis has been performed on liquid-solid two-phase flow in labyrinth-channel emitters.Based on flow visualization technology-micro-PIV,the flow in labyrinth channel has been photographed and recorded.The path line graph and velocity vector graph are obtained through the post-treatment of experimental results.The graphs agree well with CFD analysis results,so CFD analysis can be used in optimal design of labyrinth-channel emitters.And the optimized anti-clogging structures of the rectangular channel and zigzag channel have been designed here.The CFD numerical simulation and the micro-PIV experiments analysis on labyrinth-channel emitter,make the ＂black box＂ of the flow behavior in the emitter channel broken.Furthermore,the proposed research promotes an advanced method to evaluate the emitter＇s performance and can be used to conducting the optimal design of the labyrinth-channel emitters.
基金Supported by The Grants-in-Aid from Science Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan, No. 19590724
文摘AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administration.RESULTS:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine.
文摘On the basis of the introduction about water saving irrigation that works as a kind of new irrigation pattern,the method of anti-seep quality estimation of the conveying water and distributing channel which acts as an important engineering measure of water saving irrigation will be introduced in te paper.that is,by means of unit length of channel's water utilization coefficient(η 0)to estimate the quality of channel,and the calculative method has been explained by the example of an actual project.It can be referred to irrigational workers.
文摘Since ancient times, traditional medicines have been in the usage for the treatment of Diabetes mellitus. An edible fruit from traditional medicinal plant Capparis zeylanica (CZ) was studied for its anti diabetic, insulin secretagogue activities and mechanisms involved in it. In Streptozotocin induced diabetes rats, oral administration of Capparis zeylanica methanolic extract (CZME) (200 mg/kg body weight) for 28 days showed a significant reduction in blood glucose levels by 35.53% and enhanced circulating insulin levels by 81.82% than the diabetic control rats. The insulin secretagogue activity mechanisms of the extract were evaluated by using mouse insulinoma beta cell line (MIN6-β). The extract stimulated insulin release in dependent manner of glucose concentration (3 - 16.7 mM) and extract dose (5 - 500 μg/mL). The insulin releasing effect of the extract was significantly enhanced by 3-isobutyl-1-methyl xanthine, glibenclamide, elevated extracellular calcium and K+ depolarized media. This insulin release was significantly reduced in calcium blocking conditions (by nifedipine and EGTA), in the presence of potassium channel opener (diazoxide). Hence, anti diabetic activity of CZME might be a result of its stimulatory effect on insulin release from pancreatic beta cells via KATP channel dependent and independent ways. These results indicate that CZ fruits have the potential to use in diabetes therapy.
基金supported by National Natural Science Foundation of China (Grant No.51075203)Nanjing University of Aeronautics and Astronautics Research Funding(Grant No.NS2010033)
文摘In asymmetric conditions,the movement and loads of left/right wheels or front/back wheels of the aircraft with multi-wheel or four-wheel bogie landing gears are inconsistent.There are few open literatures related to anti-skid braking system for multi-wheels due to technology blockade.In China,the research on multi-channel control and non-equilibrium regulation has just started,and the design of multi-channel control system for anti-skid braking,the simulation of asymmetry taxiing under braking are not studied.In this paper,a dynamics model of ground movement for aircraft with four-wheel bogie landing gears is established for braking simulation, considering the six-degree-of-freedom aircraft body and the movement of bogies and wheels.A multi-channel anti-skid braking system is designed for the wheels of the main landing gears with four-wheel bogies.The eight wheels on left and right landing gears are divided into four groups,and each group is controlled via one channel.The cross protection and self-locked protection modules are added between different channels.A multi-channel anti-skid braking system with slip-ratio control or with slip-velocity control is established separately.Based on the aircraft dynamics model,aircraft braking to stop with anti-skid control on dry runway and on wet runway are simulated.The simulation results demonstrate that in asymmetric conditions,added with cross protection and self-locked protection modules,the slip-ratio-controlled braking system can automatically regulate brake torque to avoid deep slipping and correct aircraft course.The proposed research has reference value for improving brake control effect on wet runway.
文摘Shakuyakukanzoto (Shao-Yao-Gan-Cao-Tang), a formulation of Japanese herbal (Kampo) medicines, is composed of Paeoniae Radix and Glycyrrhizae Radix. Effects of Shakuyakukanzoto and the ingredients on rat intestinal tract were examined. Shakuyakukanzoto (0.01 - 0.3 mg/ml) relaxed a carbachol (CCh, 0.3 μM) - induced contraction in a concentration-dependent manner. Both components (Paeoniae radix and Glycyrrhizae radix) also relaxed the CCh-induced contraction. At 0.1 to 1 mM, their constituents (paeoniflorin and glycyrrhetic acid) and the metabolic products (18-α- and 18-β-glycyrrhetinic acids) exerted almost the same actions. The relaxations induced by Shakuyakukanzoto were not modified by 1 μM nicardipine, 10 μM suramin (ATP receptor inhibitor) and several K+ channel inhibitors, but was attenuated by 20 μM IBMX (a phosphodiesterase inhibitor). Also, IBMX inhibited the relaxations induced by paeoniflorin and glycyrrhetic acid, but not by other ingredients. Nicardipine decreased the relaxation of just 18-α-glycyrrhetinic acid. Even in non-treatment with CCh, Shakuyakukanzoto relaxed the intestinal tract. CCh (0.3 μM) elicited spontaneous contractions in 23% specimens, depressed by application of Shakuyakukanzoto. These results indicate that Shakuyakukanzoto causes a remarkable relaxation by the anti-cholinergic and the PDE inhibitory actions, but by minor contribution of Ca2+ channel inhibition. Thus, Shakuyakukanzoto exerts an anti-spasmodic action due to the interaction with pharmacological effects of its ingredients.
文摘<div style="text-align:justify;"> Due to the poor anti-clogging performance of the common drip irrigation emitters, this paper designed a new bionic flow channel in the emitter based on the shape of shark dorsal fin. After preliminary structural design, the computational fluid dynamics (CFD) simulation showed that the bionic emitter exhibited superior anti-clogging performance and reasonable hydraulic performance. The passage rate of particles of the bionic emitter in simulation reached 96.3% which was 37.6% higher than 70% of traditional emitter, and the discharge exponent reached 0.4995 which was close to traditional emitter. Physical experiments were consistent with the CFD results, which confirmed the correctness of simulation. After a short cycle anti-clogging performance experiment, the bionic emitter still maintained 96.09% of the initial flow rate. </div>
文摘Pulse pesition modulated (PPM) acoustic pulses are difficult to detect exacily in shallow sea channels because of strong multipath interference, large signal fluctuation and high noise level.This paper reports results of analysis on the main characteristics of multipath interference and its adverse effects on detection of pulse position information. Feasible methods to overeome multipath interference are pointed out, and an efficient one is proposed to realize reliable and precise detection of PPM information.The results of this study are of reference value for other modes of signal detection.
