Reactive oxygen species(ROS)have long been proposed to be mediators of experimental cardiovascular pathology.There is also a wealth of data indicating that ROS are involved in clinical cardiovascular pathology.However...Reactive oxygen species(ROS)have long been proposed to be mediators of experimental cardiovascular pathology.There is also a wealth of data indicating that ROS are involved in clinical cardiovascular pathology.However,multiple clinical studies have shown little benefit from anti-oxidant treatments,whereas nearly all experimental studies have shown a marked effect of anti-oxidant therapy.One reason for this discrepancy is that ROS are produced through multiple different mechanisms of which some are clinically beneficial;thus,in a defined experimental system where predominately pathological ROS are generated does not mimic a clinical setting where there are likely to be multiple ROS generating systems producing beneficial and pathological ROS.Simple inhibition of ROS would not be expected to have the same result in these two situations;ergo,it is important to understand the molecular mechanism underlying the production of ROS so that clinical treatments can be tailored to target the pathological production of ROS.One such example of this in cardiovascular biology is tissue specific inflammation-mediated ROS generation.This and the following series of articles discuss the current understanding of the role of ROS in cardiovascular disease,specifically focusing on the molecular mechanisms of ROS generation and the actions of ROS within the cardiovascular system.Although there are still many areas with regard to the effects of ROS in the cardiovascular system that are not completely understood,there is a wealth of data suggesting that blocking pathological ROS production is likely to have beneficial clinical effects compared to traditional anti-oxidants.展开更多
The content of somatostatin(SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay. Initial time of convulsion, severity of conv...The content of somatostatin(SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay. Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kPa hyperbaric oxygen after intraperitoneal injection of cysteamine (CSH) or intracerebroventricular injection of anti-somatostatin serum(ASS) were also observed. The results showed that the content of SS in hippocampus and striatum tissues increased remarkably when rats were at near-convulsion ; by the time the rats developed convulsion,it had a significant increase in all brain areas observed. Intraperitoneal injection of CSH or intracerebroventricular injection of ASS could delay initial time of convulsion (ITC),prolong survival time (ST) and reduce severity of convulsion (SOC). These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygeninduced convulsion.展开更多
Pd-based nanocatalyst is a potential oxygen reduction oxidation(ORR)catalyst because of its high activity in alkaline medium and low cost.In this work,bimetallic Pd Au nanocatalysts are prepared by one-pot hydrotherma...Pd-based nanocatalyst is a potential oxygen reduction oxidation(ORR)catalyst because of its high activity in alkaline medium and low cost.In this work,bimetallic Pd Au nanocatalysts are prepared by one-pot hydrothermal method using triblock pluronic copolymers,poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)(PEO19-PPO69-PEO19)(P123)as reducer and stabilizer,and heat-treatment method is applied to regulate catalyst structure and improve catalyst activity.The results show that the heat treatment can agglomerate the catalyst to a certain extent,but effectively improve the crystallinity and alloying degree of the catalyst.The ORR performance of the Pd Au nanocatalysts obtained under different heat treatment conditions is systematically investigated.Compared with commercial Pd black and Pd Au catalyst before heat treatment,the ORR performance of Au Pd nanocatalyst obtained after heat treatment for one hour at 500℃ has been enhanced.The Pd Au nanocatalysts after heat treatment also display enhanced anti-methanol toxicity ability in acidic medium.展开更多
A 22-year-old man suffered from acute pulmonary hemorrhage and deteriorated renal function occurred within 3 days after traumatic brain injury.Mechanical ventilation cannot correct his severe hypoxemia,therefore,venoa...A 22-year-old man suffered from acute pulmonary hemorrhage and deteriorated renal function occurred within 3 days after traumatic brain injury.Mechanical ventilation cannot correct his severe hypoxemia,therefore,venoarterial extracorporeal membrane oxygenation(VA-ECMO)support was initiated and finally resolved his hypoxemia.Concomitantly,continuous renal replacement therapy was performed to improve his kidney function.Although no anti-glomerular basement membrane(anti-GBM)antibody was detected in serum,Goodpasture’s syndrome was considered.After treated with methylprednisolone pulse therapy and plasmapheresis,his renal function was significantly improved.ECMO was eventually discontinued after 60 hours of treatment and extubated on day 10.He was discharged home with normal pulmonary and renal functions.展开更多
The anthocyanin pigment extracted from green-wheat-bran was studied to identify its antioxidant activity.The antioxidant activities of the pigment were evaluated by anti-lipid peroxidation,total antioxidant activity ...The anthocyanin pigment extracted from green-wheat-bran was studied to identify its antioxidant activity.The antioxidant activities of the pigment were evaluated by anti-lipid peroxidation,total antioxidant activity （TAA）,superoxide anion radical scavenging activity （SARSA）,active oxygen scavenging activity （AOSA）,and DPPH （1,1-diphenyl-2 picrylhydrazyl free radical） radical scavenging activity.The results showed that the pigment had higher antioxidant activity and TAA,SARSA,AOSA and DPPH.scavenging activities at a certain concentration than Vc （antiscorbutic vitamin,vitamin C）,and the capacity increased with the increase of pigment concentration.Its TAA was 51.06 U mL-1,1.73 times of Vc,and SARSA 18 025.21 U mL-1,2.26% higher than Vc,and AOSA 3 776.31 U mL-1,1.24 times of Vc.As to the DPPH.scavenging activity of the pigment,there was a trend that higher concentration performed higher activity significantly improved with the company of Vc.The pigment showed significant antioxidant activities evaluated by different assays.Results will provide a better understanding on antioxidant activity of green wheat and allow the screening or breeding of green wheat varieties with higher antioxidant activity for food processing.展开更多
基金Supported by Grants from American Heart Association grantin-aid,No.0455435BAmerican Heart Association SDG,No. 110350047ANIH Grants No.RO1-HL077566 and No.RO1-HL085119 to Zhang C
文摘Reactive oxygen species(ROS)have long been proposed to be mediators of experimental cardiovascular pathology.There is also a wealth of data indicating that ROS are involved in clinical cardiovascular pathology.However,multiple clinical studies have shown little benefit from anti-oxidant treatments,whereas nearly all experimental studies have shown a marked effect of anti-oxidant therapy.One reason for this discrepancy is that ROS are produced through multiple different mechanisms of which some are clinically beneficial;thus,in a defined experimental system where predominately pathological ROS are generated does not mimic a clinical setting where there are likely to be multiple ROS generating systems producing beneficial and pathological ROS.Simple inhibition of ROS would not be expected to have the same result in these two situations;ergo,it is important to understand the molecular mechanism underlying the production of ROS so that clinical treatments can be tailored to target the pathological production of ROS.One such example of this in cardiovascular biology is tissue specific inflammation-mediated ROS generation.This and the following series of articles discuss the current understanding of the role of ROS in cardiovascular disease,specifically focusing on the molecular mechanisms of ROS generation and the actions of ROS within the cardiovascular system.Although there are still many areas with regard to the effects of ROS in the cardiovascular system that are not completely understood,there is a wealth of data suggesting that blocking pathological ROS production is likely to have beneficial clinical effects compared to traditional anti-oxidants.
文摘The content of somatostatin(SS) in hippocampus,striatum and frontal cortex tissues of rats exposed to 600 kpa hyperbaric oxygen was determined by means of radioimmunoassay. Initial time of convulsion, severity of convulsion and survival time of rats with convulsion exposed to 700 kPa hyperbaric oxygen after intraperitoneal injection of cysteamine (CSH) or intracerebroventricular injection of anti-somatostatin serum(ASS) were also observed. The results showed that the content of SS in hippocampus and striatum tissues increased remarkably when rats were at near-convulsion ; by the time the rats developed convulsion,it had a significant increase in all brain areas observed. Intraperitoneal injection of CSH or intracerebroventricular injection of ASS could delay initial time of convulsion (ITC),prolong survival time (ST) and reduce severity of convulsion (SOC). These results suggest that SS might play a role in oxygen-induced convulsion and be one of the endogenous agents which caused oxygeninduced convulsion.
基金Financial supports from the National Natural Science Foundation of China (21503120, 21403126)Hubei Provincial Natural Science Foundation of China (2018CFB659)Innovation Foundation from China Three Gorges University (2019SSPY150)
文摘Pd-based nanocatalyst is a potential oxygen reduction oxidation(ORR)catalyst because of its high activity in alkaline medium and low cost.In this work,bimetallic Pd Au nanocatalysts are prepared by one-pot hydrothermal method using triblock pluronic copolymers,poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)(PEO19-PPO69-PEO19)(P123)as reducer and stabilizer,and heat-treatment method is applied to regulate catalyst structure and improve catalyst activity.The results show that the heat treatment can agglomerate the catalyst to a certain extent,but effectively improve the crystallinity and alloying degree of the catalyst.The ORR performance of the Pd Au nanocatalysts obtained under different heat treatment conditions is systematically investigated.Compared with commercial Pd black and Pd Au catalyst before heat treatment,the ORR performance of Au Pd nanocatalyst obtained after heat treatment for one hour at 500℃ has been enhanced.The Pd Au nanocatalysts after heat treatment also display enhanced anti-methanol toxicity ability in acidic medium.
基金Supported by the Natural Science Foundation of Guangdong Province of China(No.2015A030313735)the Science and Technology Planning Project of Guangdong Province of China(No.2014A020212651)
文摘A 22-year-old man suffered from acute pulmonary hemorrhage and deteriorated renal function occurred within 3 days after traumatic brain injury.Mechanical ventilation cannot correct his severe hypoxemia,therefore,venoarterial extracorporeal membrane oxygenation(VA-ECMO)support was initiated and finally resolved his hypoxemia.Concomitantly,continuous renal replacement therapy was performed to improve his kidney function.Although no anti-glomerular basement membrane(anti-GBM)antibody was detected in serum,Goodpasture’s syndrome was considered.After treated with methylprednisolone pulse therapy and plasmapheresis,his renal function was significantly improved.ECMO was eventually discontinued after 60 hours of treatment and extubated on day 10.He was discharged home with normal pulmonary and renal functions.
基金supported by the National Technologies R&D Program of China (2006BAD01A02)the Excellent Medium-Youth Scientist Scientific Research Reward Fundation of Shandong Province, China (BS2009NY036)the Youth Science and Technology Creative Fundation Item of Shandong Agricultural University, China
文摘The anthocyanin pigment extracted from green-wheat-bran was studied to identify its antioxidant activity.The antioxidant activities of the pigment were evaluated by anti-lipid peroxidation,total antioxidant activity （TAA）,superoxide anion radical scavenging activity （SARSA）,active oxygen scavenging activity （AOSA）,and DPPH （1,1-diphenyl-2 picrylhydrazyl free radical） radical scavenging activity.The results showed that the pigment had higher antioxidant activity and TAA,SARSA,AOSA and DPPH.scavenging activities at a certain concentration than Vc （antiscorbutic vitamin,vitamin C）,and the capacity increased with the increase of pigment concentration.Its TAA was 51.06 U mL-1,1.73 times of Vc,and SARSA 18 025.21 U mL-1,2.26% higher than Vc,and AOSA 3 776.31 U mL-1,1.24 times of Vc.As to the DPPH.scavenging activity of the pigment,there was a trend that higher concentration performed higher activity significantly improved with the company of Vc.The pigment showed significant antioxidant activities evaluated by different assays.Results will provide a better understanding on antioxidant activity of green wheat and allow the screening or breeding of green wheat varieties with higher antioxidant activity for food processing.
