An automatic control system for the electrostatic accelerator has been developed by adopting the PLC （Programmable Logic Controller） control technique, infrared and optical-fibre transmission technique and network c...An automatic control system for the electrostatic accelerator has been developed by adopting the PLC （Programmable Logic Controller） control technique, infrared and optical-fibre transmission technique and network communication with the purpose to improve the intelligence level of the accelerator and to enhance the ability of monitoring, collecting and recording parameters. In view of the control system＇ structure, some anti-interference measures have been adopted after analyzing the interference sources. The measures in hardware include controlling the position of the corona needle, using surge arresters, shielding, ground connection and stabilizing the voltage. The measures in terms of software involve inter-blocking protection, soft-spacing, time delay, and diagnostic and protective programs. The electromagnetic compatible ability of the control system has thus been effectively improved.展开更多
To suppress the interference in the ultra-wideband （AI-UWB） system is a challenging problem. An anti-interference multiband orthogonal frequency-division multiplexing ultra-wideband （AI-UWB） system, based on sprea...To suppress the interference in the ultra-wideband （AI-UWB） system is a challenging problem. An anti-interference multiband orthogonal frequency-division multiplexing ultra-wideband （AI-UWB） system, based on spreading and interleaving is addressed. It will exploit the frequency diversity across the subcarriers and provide the robustness to narrow-band interference, by spreading the coded bit streams within each sub-band and interleaving across all sub-bands. Simulating results show that the spreading and interleaving provide about 5 dB to 10 dB advantages over the conventional multiband orthogonal frequency-division multiplexing ultra-wideband system in signal-to-interference ratio. Spreading and interleaving is an effective cure for enhancing the robustness to narrowband interference.展开更多
Achieving reliable underwater communication in shallow water acoustic channels is a difficult task because of the random time varying nature of multipath propagation, severe amplitude fluctuation, and spatial variabil...Achieving reliable underwater communication in shallow water acoustic channels is a difficult task because of the random time varying nature of multipath propagation, severe amplitude fluctuation, and spatial variability of the channel conditions. This paper describes a new signal processing technique frequency coding and decoding by means of real time measurement of signal width, jamming and suppressing multipath interference and using redundant coder. The application of the technique to the model ZTY 1 status monitor for underwater system of seabed is introduced in this paper. The main principle, the technique specifications and the key techniques of the system are discussed here. Theoretical estimations and experimental results proved that the performance of the system is excellent. The method can be used for some other related low data rate data transmission detecting in shallow water acoustic channel.展开更多
Noise Frequency Modulated (NFM) interference causes a disaster to almost all types of Radar systems. The echo signal and the interference are overlapped and because of strong energy of the NFM interference noth-ing co...Noise Frequency Modulated (NFM) interference causes a disaster to almost all types of Radar systems. The echo signal and the interference are overlapped and because of strong energy of the NFM interference noth-ing could be detected except the interference in the Radar receiver system. Up to now no good method against NFM has been declared, conventional methods are based on the passive Radar to track the interfer-ence source which are not applicable under most conditions. Here a novel anti-noise FM method is proposed to suppress the NFM interference, the method multiply the mixed signal two times by different reference signals. The principle and some key factors of the new method are analyzed in detail and some rules for pa-rameters designing are given. What’s more, results show that the method can eradicate NFM effectively.展开更多
Hepatitis C virus (HCV) infection and associated liver diseases are still challenging and represent a significant health care burden around the world. Although, the treatment strategies have been improved by the devel...Hepatitis C virus (HCV) infection and associated liver diseases are still challenging and represent a significant health care burden around the world. Although, the treatment strategies have been improved by the development of novel direct-acting antivirals, but such therapeutic options are still expensive and beyond the financial range of the most infected individuals in developing or even in resource replete countries. It demands an urgent need to search novel and improved alternate treatment strategies to treat the infection. The present study was aimed to develop an in vitro stable cell culture system, persistently expressing HCV genotype 1a non-structural genes and to characterize the inhibitory effects of synthetic siRNAs (short interference RNA) directed against the most conserved regions of nonstructural genes in an in vitro cell culture model. The continuous expression of nonstructural genes for more than 30 days post transfection was detected by reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis in stable human hepatoma cell line (Huh-7). The gene expression studies revealed significantly reduced gene expression of HCV nonstructural genes (i.e., NS2, NS4A and NS5A) both at mRNA and protein levels when treated against genome specific synthetic siRNAs in stable cell lines (51%, 47% and 54% respectively, p < 0.05). Similarly, a vivid decrease in HCV viral titer was exhibited by synthetic siRNAs in an in vitro viral replicate cell culture model (58%, 48% and 50%, respectively, p < 0.05) determined by quantitative Real-Time PCR (qPCR). Our data indicate that siRNA mediated gene silencing may be considered a promising alternate treatment strategy against HCV in combination with other effective therapeutic regimens in future.展开更多
基金the special fund of the Education Department of Henan Provice
文摘An automatic control system for the electrostatic accelerator has been developed by adopting the PLC （Programmable Logic Controller） control technique, infrared and optical-fibre transmission technique and network communication with the purpose to improve the intelligence level of the accelerator and to enhance the ability of monitoring, collecting and recording parameters. In view of the control system＇ structure, some anti-interference measures have been adopted after analyzing the interference sources. The measures in hardware include controlling the position of the corona needle, using surge arresters, shielding, ground connection and stabilizing the voltage. The measures in terms of software involve inter-blocking protection, soft-spacing, time delay, and diagnostic and protective programs. The electromagnetic compatible ability of the control system has thus been effectively improved.
基金the National "863" High Technology Research Program of China (2005AA123320)Universities Natural Science Research Project of Jiangsu Province (05KJB510101).
文摘To suppress the interference in the ultra-wideband （AI-UWB） system is a challenging problem. An anti-interference multiband orthogonal frequency-division multiplexing ultra-wideband （AI-UWB） system, based on spreading and interleaving is addressed. It will exploit the frequency diversity across the subcarriers and provide the robustness to narrow-band interference, by spreading the coded bit streams within each sub-band and interleaving across all sub-bands. Simulating results show that the spreading and interleaving provide about 5 dB to 10 dB advantages over the conventional multiband orthogonal frequency-division multiplexing ultra-wideband system in signal-to-interference ratio. Spreading and interleaving is an effective cure for enhancing the robustness to narrowband interference.
文摘Achieving reliable underwater communication in shallow water acoustic channels is a difficult task because of the random time varying nature of multipath propagation, severe amplitude fluctuation, and spatial variability of the channel conditions. This paper describes a new signal processing technique frequency coding and decoding by means of real time measurement of signal width, jamming and suppressing multipath interference and using redundant coder. The application of the technique to the model ZTY 1 status monitor for underwater system of seabed is introduced in this paper. The main principle, the technique specifications and the key techniques of the system are discussed here. Theoretical estimations and experimental results proved that the performance of the system is excellent. The method can be used for some other related low data rate data transmission detecting in shallow water acoustic channel.
文摘Noise Frequency Modulated (NFM) interference causes a disaster to almost all types of Radar systems. The echo signal and the interference are overlapped and because of strong energy of the NFM interference noth-ing could be detected except the interference in the Radar receiver system. Up to now no good method against NFM has been declared, conventional methods are based on the passive Radar to track the interfer-ence source which are not applicable under most conditions. Here a novel anti-noise FM method is proposed to suppress the NFM interference, the method multiply the mixed signal two times by different reference signals. The principle and some key factors of the new method are analyzed in detail and some rules for pa-rameters designing are given. What’s more, results show that the method can eradicate NFM effectively.
文摘Hepatitis C virus (HCV) infection and associated liver diseases are still challenging and represent a significant health care burden around the world. Although, the treatment strategies have been improved by the development of novel direct-acting antivirals, but such therapeutic options are still expensive and beyond the financial range of the most infected individuals in developing or even in resource replete countries. It demands an urgent need to search novel and improved alternate treatment strategies to treat the infection. The present study was aimed to develop an in vitro stable cell culture system, persistently expressing HCV genotype 1a non-structural genes and to characterize the inhibitory effects of synthetic siRNAs (short interference RNA) directed against the most conserved regions of nonstructural genes in an in vitro cell culture model. The continuous expression of nonstructural genes for more than 30 days post transfection was detected by reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis in stable human hepatoma cell line (Huh-7). The gene expression studies revealed significantly reduced gene expression of HCV nonstructural genes (i.e., NS2, NS4A and NS5A) both at mRNA and protein levels when treated against genome specific synthetic siRNAs in stable cell lines (51%, 47% and 54% respectively, p < 0.05). Similarly, a vivid decrease in HCV viral titer was exhibited by synthetic siRNAs in an in vitro viral replicate cell culture model (58%, 48% and 50%, respectively, p < 0.05) determined by quantitative Real-Time PCR (qPCR). Our data indicate that siRNA mediated gene silencing may be considered a promising alternate treatment strategy against HCV in combination with other effective therapeutic regimens in future.
