To the Editor:A 73-year-old man presented with erythemas on his trunk and limbs with significant itching,which he had experienced for 11 months[Figure 1A and 1B].Histological examination of his skin biopsy revealed su...To the Editor:A 73-year-old man presented with erythemas on his trunk and limbs with significant itching,which he had experienced for 11 months[Figure 1A and 1B].Histological examination of his skin biopsy revealed sub-epidermal blister formation with eosinophilic and lymphocytic infiltration in the dermis.Direct immunoflu-orescence revealed the presence of a linear deposition along the basement membrane zone(BMZ).Indirect immuno fluorescence revealed that the patienfs serum was positive(titer≥1:320)for anti-BMZ antibodies.Anti-BP180 antibody was 102 U/mL.Based on these findings,a diagnosis of bullous pemphigoid(BP)was established.展开更多
基金grants from the Milstein Medical Asian American Partnership Foundation(2017,Dermatology)the National Natural Science Foundation of China(No.81371731)the Education Reform Projects of Peking Union Medical College(No.2016zlgc0106).
文摘To the Editor:A 73-year-old man presented with erythemas on his trunk and limbs with significant itching,which he had experienced for 11 months[Figure 1A and 1B].Histological examination of his skin biopsy revealed sub-epidermal blister formation with eosinophilic and lymphocytic infiltration in the dermis.Direct immunoflu-orescence revealed the presence of a linear deposition along the basement membrane zone(BMZ).Indirect immuno fluorescence revealed that the patienfs serum was positive(titer≥1:320)for anti-BMZ antibodies.Anti-BP180 antibody was 102 U/mL.Based on these findings,a diagnosis of bullous pemphigoid(BP)was established.
