The title compound has been synthesized by the addition reaction of N-（4-cyanopyrazole-3-yl）-3,5-difluorophenyl-imine and diisopropyl phosphate. Its structure was confirmed by means of IR, ^1H NMR and elemental anal...The title compound has been synthesized by the addition reaction of N-（4-cyanopyrazole-3-yl）-3,5-difluorophenyl-imine and diisopropyl phosphate. Its structure was confirmed by means of IR, ^1H NMR and elemental analysis. The single-crystal structure of the title compound was determined by X-ray crystallography. The compound crystallizes in monoclinic, space group C2/c with a = 18.9959（14）, b = 9.2212（7）, c = 22.1108（16）A^°, β= 90.1540（10）°, V = 3873.0（5） A^°^3, Dc = 1.366 g/cm^3, Z = 8, μ = 0.185, F（000） = 1664, and the final R = 0.0503 and wR = 0.1539 for 2996 observed reflections （I 〉 2σ（I））. The results demonstrate that the dihedral angle between the pyrazole and benzene rings is 105.5°, and there is a full delocalized pyrazole system with sp^2 hydridization of N（3）. The crystal structure is stabilized by two intermolecular hydrogen bonds of N（1）-H（1）…O（3） and N（3）-H（3A）…N（4）. The preliminary biological test shows that the title compound has a moderate antifungal activity.展开更多
OBJECTIVE Panax ginseng C.A.Meyer(ginseng)is a well-known medicinal plant worldwide and a key ingredient in many commercially-available health products.It is used as a tonic for invigoration and for tification in time...OBJECTIVE Panax ginseng C.A.Meyer(ginseng)is a well-known medicinal plant worldwide and a key ingredient in many commercially-available health products.It is used as a tonic for invigoration and for tification in times of fatigue and debility or declining capacity for work and concentration.Previous in-house study has surveyed over three hundred ginseng and ginseng products(including P.ginseng,P.quinquefolius,P.notoginseng,P.pseudoginseng)available in Singapore.This review presents an overview of the pharmacological activities and herb-drug interactions of P.ginseng and its ginsenosides.METHODS Literature searches of PubMed and ScienceDirect were done to identify pharmacological activities and herb-drug interactions of P.ginseng,its extracts and its chemical components,including ginsenosides.Studies of whole plant extracts include both White ginseng and Red ginseng.The studies for the pharmacological activities of whole plant extract were limited to those published from 2009 to 2015.There was no restriction on the time frame of other studies.Terms such as″P.ginseng″,″Ginsenosides″were searched.Studies found included in vitro assays,in vivo animal studies,human clinical trials as well as individual case reports.RESULTS A total of 112 studies were found on whole plant extracts and 257 studies on its individual components.Whole plant extracts of ginseng were found to possess over fifty different pharmacological activities,while its individual components exhibit parts of this spectrum.P.ginseng was found to interact with drugs such as 5-fluorouracil,irinotecan,mitomycin C,docetaxel,cisplatin,alcohol,midazolam,warfarin,phenelzine,raltegravir and imatinib.CONCLUSION P.ginseng and its components exhibit a wide range of pharmacological activities and interact with some drugs.There remain much opportunities for future research.展开更多
Initiated by Chinese Red Cross Foundation and sponsored by American .General Business Association, Chinese Nuwa （a goddess-creator of the Chinese nation） Culture Large-scale Activities for Public Interests undertake...Initiated by Chinese Red Cross Foundation and sponsored by American .General Business Association, Chinese Nuwa （a goddess-creator of the Chinese nation） Culture Large-scale Activities for Public Interests undertaken by Beijing Absolute Challenge International Advertising Co., Ltd. has recently commenced in an all-round way. A grand ceremony will be held at Nuwa Plaza in Shexian County, Hebei Province on Septemper 24, 2007.展开更多
China’s first Mars rover,Zhurong,successfully landed in the south of Utopia Planitia.The surface water content at the landing area can provide constraints on mineral formation conditions and help us better understand...China’s first Mars rover,Zhurong,successfully landed in the south of Utopia Planitia.The surface water content at the landing area can provide constraints on mineral formation conditions and help us better understand the evolution of the Martian aqueous and geological environment.In this work,the surface kinetic temperature of the Zhurong landing area was derived by analyzing data from the Mars Express Observatoire pour la Minéralogie,l’Eau,les Glaces et l’Activité(OMEGA)spectrometer.Using the Discrete Ordinate Radiative Transfer(DISORT)model,we performed atmospheric correction and thermal correction for the OMEGA data to obtain the surface effective single-particle absorption thickness(ESPAT)parameter to evaluate the surface water content.The surface water content distribution at the landing area was relatively uniform at a lateral scale of~10 km.At the Zhurong landing site,the surface water content in the topmost layer(a few hundred micrometers)of the regolith was 5−8 weight percent water(wt%H_(2)O),assuming surface particle sizes of<45μm,or 1.6−2.5 wt%H_(2)O,assuming surface particle sizes in the range of 125−250μm.The Mars Surface Composition Detector(MarSCoDe)onboard Zhurong also observed significant H_(2)O/OH signals in the landing area.Our results provide an important regional context for the hydration state of the area and can be further verified by the H content derived from the Laser-Induced Breakdown Spectrometer(LIBS)data of MarSCoDe.展开更多
基金supported by the Youth Foundation of Jiangxi Agricultural University (No. 20051527)
文摘The title compound has been synthesized by the addition reaction of N-（4-cyanopyrazole-3-yl）-3,5-difluorophenyl-imine and diisopropyl phosphate. Its structure was confirmed by means of IR, ^1H NMR and elemental analysis. The single-crystal structure of the title compound was determined by X-ray crystallography. The compound crystallizes in monoclinic, space group C2/c with a = 18.9959（14）, b = 9.2212（7）, c = 22.1108（16）A^°, β= 90.1540（10）°, V = 3873.0（5） A^°^3, Dc = 1.366 g/cm^3, Z = 8, μ = 0.185, F（000） = 1664, and the final R = 0.0503 and wR = 0.1539 for 2996 observed reflections （I 〉 2σ（I））. The results demonstrate that the dihedral angle between the pyrazole and benzene rings is 105.5°, and there is a full delocalized pyrazole system with sp^2 hydridization of N（3）. The crystal structure is stabilized by two intermolecular hydrogen bonds of N（1）-H（1）…O（3） and N（3）-H（3A）…N（4）. The preliminary biological test shows that the title compound has a moderate antifungal activity.
基金The project supported by Lee Foundation Grant(TCH and KHL,R-184-000-200-720)and research scholarship(WHN)
文摘OBJECTIVE Panax ginseng C.A.Meyer(ginseng)is a well-known medicinal plant worldwide and a key ingredient in many commercially-available health products.It is used as a tonic for invigoration and for tification in times of fatigue and debility or declining capacity for work and concentration.Previous in-house study has surveyed over three hundred ginseng and ginseng products(including P.ginseng,P.quinquefolius,P.notoginseng,P.pseudoginseng)available in Singapore.This review presents an overview of the pharmacological activities and herb-drug interactions of P.ginseng and its ginsenosides.METHODS Literature searches of PubMed and ScienceDirect were done to identify pharmacological activities and herb-drug interactions of P.ginseng,its extracts and its chemical components,including ginsenosides.Studies of whole plant extracts include both White ginseng and Red ginseng.The studies for the pharmacological activities of whole plant extract were limited to those published from 2009 to 2015.There was no restriction on the time frame of other studies.Terms such as″P.ginseng″,″Ginsenosides″were searched.Studies found included in vitro assays,in vivo animal studies,human clinical trials as well as individual case reports.RESULTS A total of 112 studies were found on whole plant extracts and 257 studies on its individual components.Whole plant extracts of ginseng were found to possess over fifty different pharmacological activities,while its individual components exhibit parts of this spectrum.P.ginseng was found to interact with drugs such as 5-fluorouracil,irinotecan,mitomycin C,docetaxel,cisplatin,alcohol,midazolam,warfarin,phenelzine,raltegravir and imatinib.CONCLUSION P.ginseng and its components exhibit a wide range of pharmacological activities and interact with some drugs.There remain much opportunities for future research.
文摘Initiated by Chinese Red Cross Foundation and sponsored by American .General Business Association, Chinese Nuwa （a goddess-creator of the Chinese nation） Culture Large-scale Activities for Public Interests undertaken by Beijing Absolute Challenge International Advertising Co., Ltd. has recently commenced in an all-round way. A grand ceremony will be held at Nuwa Plaza in Shexian County, Hebei Province on Septemper 24, 2007.
基金funded by the National Key Research and Development Project(Grant No.2019YFE0123300)the National Natural Science Foundation of China(Grant No.42072337)+1 种基金the preresearch project on Civil Aerospace Technologies(Grant Nos.D020101 and D020102)funded by the China National Space Administration through the Pandeng Program of the National Space Science Center,Chinese Academy of Sciences,Key Research Program of the Chinese Academy of Sciences(Grant No.ZDBS-SSW-TLC001).
文摘China’s first Mars rover,Zhurong,successfully landed in the south of Utopia Planitia.The surface water content at the landing area can provide constraints on mineral formation conditions and help us better understand the evolution of the Martian aqueous and geological environment.In this work,the surface kinetic temperature of the Zhurong landing area was derived by analyzing data from the Mars Express Observatoire pour la Minéralogie,l’Eau,les Glaces et l’Activité(OMEGA)spectrometer.Using the Discrete Ordinate Radiative Transfer(DISORT)model,we performed atmospheric correction and thermal correction for the OMEGA data to obtain the surface effective single-particle absorption thickness(ESPAT)parameter to evaluate the surface water content.The surface water content distribution at the landing area was relatively uniform at a lateral scale of~10 km.At the Zhurong landing site,the surface water content in the topmost layer(a few hundred micrometers)of the regolith was 5−8 weight percent water(wt%H_(2)O),assuming surface particle sizes of<45μm,or 1.6−2.5 wt%H_(2)O,assuming surface particle sizes in the range of 125−250μm.The Mars Surface Composition Detector(MarSCoDe)onboard Zhurong also observed significant H_(2)O/OH signals in the landing area.Our results provide an important regional context for the hydration state of the area and can be further verified by the H content derived from the Laser-Induced Breakdown Spectrometer(LIBS)data of MarSCoDe.
