河南省饲料中微量元素含量盈缺的研究

通过对河南省不同类型５４个县（市）的饲料样品进行化验分析，并将７种元素的吸收率换算成有效含量。经用典型日粮配方计算，再与猪、鸡营养需要量比较，对我省猪、鸡饲料中微量元素的盈缺作出了判定。结果表明：蛋鸡饲料中钴超过４２．０４％，而铜、铁、锰、锌、碘、硒分别缺４９．５７％，５５．６２％，８２．８８％，９１．１２％，７１．２６％，７０．１５％；生长猪饲料中铜、铁、锌、碘、硒依次缺３１．２６％，５８．２１％，９６．３８％，３２．３４％，８８．２７％，而锰和钴则分别超过１６８．５２％和４３．７６％。并具有区域性等特点。

杜仲叶营养成分测定及消化率研究

采集贵州有代表性的3个杜仲产区7月份杜仲叶样品,采用概略养分分析法比较分析CP、EE等营养成分含量,并采用活动尼龙袋技术比较研究主要营养成分在肉猪体内的消化率。结果表明:不同产区杜仲DM、CP、EE、CF、OM、Ca、P、Lignin、NDF、ADF含量分别在(33.67±2.08)%^(44.24±1.04)%、(12.22±0.65)%^(13.56±0.74)%、(5.47±1.14)%^(7.91±0.82)%、(6.87±1.48)%^(8.42±0.75)%、(87.18±0.19)%^(90.8±0.47)%、(2.17±0.57)%^(2.30±0.49)%、(0.15±0.49)%^(0.18±0.37)%、(3.61±0.23)%^(4.99±0.30)%、(38.16±1.86)%^(43.18±2.01)%、(30.10±0.85)%^(34.93±0.98)%之间;OM、CP、EE、Ca、P消化率分别在(70.14±1.37)%^(75.40±2.46)%、(66.75±3.22)%^(67.25±3.04)%、(76.75±1.89)%^(77.25±2.41)%、(47.13±2.13)%^(48.95±3.16)%、(54.60±4.01)%^(56.10±1.48)%之间。研究证明,不同产区杜仲叶营养成分含量和在肉猪体内的表观消化率差异不显著(P>0.05)。

Research progress on the mechanism of evodiamine against gastrointestinal tumor

Evodiamine is an indole quinazoline alkaloid with anti-tumor activity,which may be developed into a drug for the treatment of tumor.It was found that evodiamine could inhibit or even block the signal pathways of Wnt/β-catenin,mTOR,NF--κB,PI3K/AKT,Hippo-YAP and BMP in many kinds of cancer cells,thus interfering with cell division and differentiation,increasing the rate of apoptosis,and down-regulating the expression of various cancer cell markers.Such as B-cell lymphoma 2(Bcl-2),B-cell lymphoma super-large(Bcl-XL),cyclooxygenase 2(COX-2),Survivin,vascular endothelial growth factor(VEGF)and matrix metallopeptidase 9(MMP-9),which have a strong inhibitory effect on asymmetric division,malignant proliferation and angiogenesis of tumor cells.This paper summarizes evodiamine in digestive system tumors by regulating Wnt/β-catenin,mTOR,PI3K/AKT,BMP and other signal pathways,interfering with cell division,differentiation and apoptosis,inhibiting the expression of tumor-related marker genes,and preventing tumor cell migration and invasion,so as to provide a basis for the clinical application and further research of evodiamine in the future.

含酪氨酸残基的食源性ACE抑制二肽的稳定性研究

本文以含酪氨酸残基的食源性血管紧张素转化酶(Angiotensin Converting Enzyme,ACE)抑制二肽为研究对象,以食源性寡肽的保存率和ACE抑制活性为指标,通过反相高效液相色谱检测二肽的热稳定性和抗胃肠道消化能力。结果表明在37、50、70℃条件下,食源性二肽Ile-Tyr(IY)、Leu-Tyr(LY)、Ala-Tyr(AY)和Ser-Tyr(SY)均有较好的热稳定性。在100℃下,SY相对IY、LY和AY热稳定性略低,其中IY表现出最好的热稳定性。AY、IY、LY和SY均具有较好的抗胃蛋白酶和胰蛋白酶消化吸收能力,经人工胃液反应2 h后,肽保存率均高于90%;经人工肠液反应6 h,肽保存率范围在83.99%~87.27%。本研究为进一步研究食源性二肽稳定性提供了重要的理论依据。