Objective: To investigate the effects of complex salvia miltiorrhiza on blood coagulation, inflammation, oxidative stress and endothelial index in patients with acute pancreatitis. Methods: A total of 122 patients wit...Objective: To investigate the effects of complex salvia miltiorrhiza on blood coagulation, inflammation, oxidative stress and endothelial index in patients with acute pancreatitis. Methods: A total of 122 patients with acute pancreatitis admitted to digestive system department in our hospital from April 2016 to November 2017 were randomly divided into control group (n=61) and observation group (n=61), the control group was treated with ulinastatin and the observation group was treated with complex salvia miltiorrhiza injection on the basis of the control group. The levels of coagulation, inflammation, oxidative stress and endothelial markers were compared between the two groups. Results: After treatment, the levels of APTT and PT in the two groups were significantly higher than those before treatment, while the levels of DD were significantly lower than those before treatment, and the levels of APTT and PT [(38.19±7.05) s,(17.60±3.68) s] in the observation group were significantly higher than those in the control group, while the levels of DD [(0.51±0.10) mg/L] in the observation group were significantly lower than those in the control group;the levels of CRP, PCT and TNF-α in the two groups were significantly lower than those before treatment, and the levels of CRP, PCT and TNF-α [(29.10±4.76) mg/L, (0.59±0.17) μg/L, (57.28±10.61) ng/L] in the observation group were significantly lower than those in the control group;the levels of SOD in the two groups were significantly higher than those before treatment, but MDA was significantly lower than that before treatment, and the level of SOD [(179.10±4.76) U/mL] in the observation group was significantly higher than that in the control group after treatment, while the level of MDA [(1.97±0.55) mmol/mL] in the observation group was significantly lower than that in the control group after treatment;the levels of NO in the two groups were significantly higher than those before treatment, while the levels of ET and vWF were significantly lower than those before treatment, and the levels of NO [(10.56±1.17) U/mL] in the observation group were significantly higher than those in the control group after treatment, while the levels of ET and vWF [(105.83±5.20) pg/mL, (102.47±16.91)%] in the observation group were significantly lower than those in the control group after treatment. Conclusions:Complex salvia miltiorrhiza injection can improve the blood coagulation function, alleviate inflammation, enhance antioxidant function and vascular endothelial function in patients with acute pancreatitis, which has clinical value of promotion.展开更多
Polyferric silicate sulfate （PFSS） with high concentration was prepared using the composite-poly method. The coagulation properties and mechanisms of this new complex were probed using TEM, Fe-Ferron timed complex-c...Polyferric silicate sulfate （PFSS） with high concentration was prepared using the composite-poly method. The coagulation properties and mechanisms of this new complex were probed using TEM, Fe-Ferron timed complex-colorimetric method, and infrared spectrum method. The results showed that the flocculating effect of polyferric silicate sulfate had an advantage over polyferric sulfate （PFS）, as the optimum coagulation effect could be obtained when the Si/Fe mole ratio was 0.75 in accordance with its macrostructure of PFSS. According to the Fe-Ferron timed complex-colorimetric method, the Si species was mainly Sic, whereas, the Fe species were Fea and Fec in the copolymerization system. The infrared spectra indicated that the structure of these new flocculants was formed by polymers, mainly by olation, which was different from polyferric sulfate, and the vibration of M-OH-M of around 1100 cm^-1, also proved that there existed Fe-OH-Fe and its polymers in some forms.展开更多
基金Beijing Natural Science Foundation Project(7151729).
文摘Objective: To investigate the effects of complex salvia miltiorrhiza on blood coagulation, inflammation, oxidative stress and endothelial index in patients with acute pancreatitis. Methods: A total of 122 patients with acute pancreatitis admitted to digestive system department in our hospital from April 2016 to November 2017 were randomly divided into control group (n=61) and observation group (n=61), the control group was treated with ulinastatin and the observation group was treated with complex salvia miltiorrhiza injection on the basis of the control group. The levels of coagulation, inflammation, oxidative stress and endothelial markers were compared between the two groups. Results: After treatment, the levels of APTT and PT in the two groups were significantly higher than those before treatment, while the levels of DD were significantly lower than those before treatment, and the levels of APTT and PT [(38.19±7.05) s,(17.60±3.68) s] in the observation group were significantly higher than those in the control group, while the levels of DD [(0.51±0.10) mg/L] in the observation group were significantly lower than those in the control group;the levels of CRP, PCT and TNF-α in the two groups were significantly lower than those before treatment, and the levels of CRP, PCT and TNF-α [(29.10±4.76) mg/L, (0.59±0.17) μg/L, (57.28±10.61) ng/L] in the observation group were significantly lower than those in the control group;the levels of SOD in the two groups were significantly higher than those before treatment, but MDA was significantly lower than that before treatment, and the level of SOD [(179.10±4.76) U/mL] in the observation group was significantly higher than that in the control group after treatment, while the level of MDA [(1.97±0.55) mmol/mL] in the observation group was significantly lower than that in the control group after treatment;the levels of NO in the two groups were significantly higher than those before treatment, while the levels of ET and vWF were significantly lower than those before treatment, and the levels of NO [(10.56±1.17) U/mL] in the observation group were significantly higher than those in the control group after treatment, while the levels of ET and vWF [(105.83±5.20) pg/mL, (102.47±16.91)%] in the observation group were significantly lower than those in the control group after treatment. Conclusions:Complex salvia miltiorrhiza injection can improve the blood coagulation function, alleviate inflammation, enhance antioxidant function and vascular endothelial function in patients with acute pancreatitis, which has clinical value of promotion.
文摘Polyferric silicate sulfate （PFSS） with high concentration was prepared using the composite-poly method. The coagulation properties and mechanisms of this new complex were probed using TEM, Fe-Ferron timed complex-colorimetric method, and infrared spectrum method. The results showed that the flocculating effect of polyferric silicate sulfate had an advantage over polyferric sulfate （PFS）, as the optimum coagulation effect could be obtained when the Si/Fe mole ratio was 0.75 in accordance with its macrostructure of PFSS. According to the Fe-Ferron timed complex-colorimetric method, the Si species was mainly Sic, whereas, the Fe species were Fea and Fec in the copolymerization system. The infrared spectra indicated that the structure of these new flocculants was formed by polymers, mainly by olation, which was different from polyferric sulfate, and the vibration of M-OH-M of around 1100 cm^-1, also proved that there existed Fe-OH-Fe and its polymers in some forms.
