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Clinical Efficacy of Simple Obesity Treated by Catgut Implantation at Acupoints 被引量:1
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作者 闫润虎 刘晓明 +3 位作者 白洁 侯彬彬 于江 顾劲松 《Chinese Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第8期594-600,共7页
Objective: To observe the clinical efficacy of treatment with catgut implantation at acupoints on simple obesity. Methods: Following the theory of Chinese medicine (CM), pattern identification (PI) and treatment... Objective: To observe the clinical efficacy of treatment with catgut implantation at acupoints on simple obesity. Methods: Following the theory of Chinese medicine (CM), pattern identification (PI) and treatment was based on the patient's symptoms and signs. Patients were observed during three courses and one year following treatment through self-comparison before and after six or seven acupoints catgut implantation. Obesity was divided into five types based on PI: (1) Stomach (Wei) and Intestine excess-heat, (2) Spleen (Pi) deficiency and phlegm- wet stagnancy, (3) Liver (Gan)-qi stagnation, (4) Spleen-Kidney (Shen) yang deficiency, and (5) Liver-Kidney yin deficiency. Changes in the following measurements were recorded in 820 patients: body weight, body girth, skin- fold thickness, body mass index (BMI), fat percentage (F%) and waist/hip ratio (WHR) and in the following blood values: leptin (LP), insulin (INS), blood lipids, fasting blood sugar (FBS), and insulin sensitive index (ISI) before and after the treatment. Values were compared with those of healthy controls (normal group). Results: Catgut implantation showed efficacy with all five types of obesity. Efficacy was greater in males than in females. There was no significant difference between the different types by Kruskal-Wallis H test, but the effect was best and of the highest number in patients with Stomach and Intestine excess-heat. Skin-fold thickness, body weight, waist circumference, F%, BMI, and WHR in all 820 cases decreased after treatment (at 90 days and one year), with significant differences before and after treatment (P〈0.01). Improved metabolism of blood lipids was also seen. Following treatment, LP, INS, and FBS decreased significantly (P〈0.01) and ISI increased significantly (P〈0.05). Conclusion: Catgut implantation at acupoints provided effective and persistent results, convenience, safety, painlessness, and prolonged effect with no side effects, resulting in reduced body weight and fat and improvement in body shape. 展开更多
关键词 anti-obesity agents catgut acupoints
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穴位埋线调控NLRP3炎性小体对造影剂诱导的急性肾损伤大鼠模型保护的机制研究
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作者 黄钱伟 郑甜 +2 位作者 资小飞 黄晓 詹碧鸣 《实用中医内科杂志》 2024年第10期42-45,I0006,共5页
目的 观察穴位埋线调控NLRP3炎性小体信号通路对造影剂肾病大鼠肾功能保护的机制研究。方法 将Sprague Dawley (SD)大鼠随机分为空白组、模型组、穴位埋线组,每组10只。采用吲哚美辛、左旋硝基精氨酸甲酯(L-NAME)、碘海醇注射液建立造... 目的 观察穴位埋线调控NLRP3炎性小体信号通路对造影剂肾病大鼠肾功能保护的机制研究。方法 将Sprague Dawley (SD)大鼠随机分为空白组、模型组、穴位埋线组,每组10只。采用吲哚美辛、左旋硝基精氨酸甲酯(L-NAME)、碘海醇注射液建立造影剂肾病大鼠模型。穴位埋线组予穴位简易埋线治疗。比较大鼠肾脏组织的病理变化,比较血清和肾脏组织酶联免疫吸附分析(ELISA)检测BALF中IL-1β、IL-10和TNF-α的水平,Western Blot检测NLRP3通路相关蛋白的表达。结果 与模型组比较,穴位埋线组大鼠肾功能损伤评分降低,HE染色穴位埋线组炎性浸润显著减轻,模型组中肾脏血清及组织中,IL-1β、IL-10和TNF-α显著升高,而穴位埋线组下降明显,同时,Western Blot检测差异均具有统计学意义(P<0.05)。结论 穴位埋线疗法可显著改善造影剂肾病模型大鼠肾脏的炎症,降低IL-1β、IL-10和TNF-α及病理组织学评分,其作用机制可能与调控NLRP3炎性小体信号通路相关。 展开更多
关键词 穴位埋线 NLRP3炎性小体 造影剂肾病
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