Anti-oxidative stress treatment and current clinical trials

Oxidative stress disturbs the balance between the production of reactive oxygen species(ROS)and the detoxification biological process.It plays an important role in the development and progression of many chronic diseases.Upon exposure to oxidative stress or the inducers of ROS,the cellular nucleus undergoes some biological processes via different signaling pathways,such as stress adaption through the forkhead box O signaling pathway,inflammatory response through the IκB kinase/nuclear factor-κB signaling pathway,hypoxic response via the hypoxia-inducible factor/prolyl hydroxylase domain proteins pathway,DNA repair or apoptosis through the p53 signaling pathway,and antioxidant response through the Kelch-like ECH-associated protein 1/nuclear factor E2-related factor 2 signaling pathway.These processes are involved in many diseases.Therefore,oxidative stress has gained more attraction as a targeting process for disease treatment.Meanwhile,anti-oxidative stress agents have been widely explored in pre-clinical trials.However,only limited clinical trials are performed to evaluate the efficacy of anti-oxidative stress agents or antioxidants in diseases.In this letter,we further discuss the current clinical trials related to anti-oxidative stress treatment in different diseases.More pre-clinical studies and clinical trials are expected to use anti-oxidative stress strategies as disease treatment or dietary supplementation to improve disease treatment outcomes.

Anti-Cancer, Anti-Oxidant and Anti-Inflammatory Effects of Herbacetin and Its Molecular Mechanisms

Rhodiola rosea,a perennial herb of the genus Rhodiola in the Crassulaceae family,is commonly used to treat depression,fatigue,cancer and cardiovascular diseases.Herbacetin is a natural flavonol compound extracted from R.rosea plant,with many pharmacological effects such as anti-cancer effect,anti-oxidant effect and anti-inflammatory effect.In this paper,the pharmacological effects and molecular mechanisms of herbacetin were summarized by consulting domestic and foreign literature,in order to provide a theoretical basis for the development and utilization of herbacetin.

Anti-Oxidative Constituents of Ethanol Extract from Buckwheat Seeds by HPLC-Electro-Spray MS

The study investigates major anti-oxidative constituents of ethanol extracts from the seeds of common buckwheat and tartary buckwheat. Ethanol extracts from buckwheat seeds were arranged to react with 1,1-diphenyl-2-picrylhydrazyl （DPPH） free radical. HPLC was used to identify anti-oxidative constituents of the ethanol extracts, and electro-spray MS was used to characterize the structures of these identified anti-oxidative constituents to confirm them. The ethanol extracts of common buckwheat and tartary buckwheat seeds both had DPPH free radical-scavenging effect; HPLC analysis showed that the ethanol extracts of both common buckwheat and tartary buckwheat seeds presented two main anti-oxidation peaks, which correspondingly had same chromatographic retention times and spectral information; electro-spray MS analysis showed that the molecular weights and MS fragmentation patterns of the anti-oxidative constituents in the ethanol extracts from buckwheat seeds were the same as those of rutin and quercetin in the control samples. HPLC- MS/MS was capable of being used to rapidly identify anti-oxidative constituents in the extract of buckwheat seeds, and the main anti-oxidative constituents of buckwheat seed extract were mainly rutin and quercetin, and the anti-oxidative activity of quercetin was higher than that of rutin.

A Study on Anti-oxidative Activity of Soybean Peptideswith Linoleic Acid Peroxidation Systems

Soybean bioactive peptides（SBPs） were prepared from the isolated soybean protein by proteolysis with an alkaline protease, alcalase, at 50℃ and pH = 8.0. The dependence of hydrolysis time on hydrolysis degree and molecular weight distribution were examined. The hydrolysate was fractionated on a Sephadex G-25 column and the anti-oxidative activities of the fractions were detected by the method of pyrogallol auto-oxidation. The average chain length of soybean peptides that have anti-oxidative activity was estimated to be about 7. The anti-oxidative properties of the soy- bean peptide were also studied by using linoleic acid peroxidation systems. The optimal condition of the peroxidation system was set up, Vc/Cu^2 ＋ as the inducer at pH = 7.4 and 25 ℃. In addition, soybean peptides show higher antioxidative activity compared with GSH.

Inhibitive effects of anti-oxidative vitamins on mannitol-induced apoptosis of vascular endothelial cells

Objective: Study blood vessel injury and gene expression indicating vascular endothelial cell apoptosis induced by mannitol with and without administration of anti-oxidative vitamins. Methods: Healthy rabbits were randomly divided into four groups. Mannitol was injected into the vein of the rabbit ear in each animal. Pre-treatment prior to mannitol injection was per- formed with normal saline (group B), vitamin C (group C) and vitamin E (group D). Blood vessel injury was assessed under electron and light microscopy. In a second experiment, cell culture specimen of human umbilical vein endothelial cells were treated with mannitol. Pre-treatment was done with normal saline (sample B), vitamin C (sample C) and vitamin E (sample D). Total RNA was extracted with the original single step procedure, followed by hybridisation and analysis of gene expression. Results: In the animal experiment, serious blood vessel injury was seen in group A and group B. Group D showed light injury only, and normal tissue without pathological changes was seen in group C. Of all 330 apoptosis-related genes analysed in human cell culture specimen, no significant difference was seen after pre-treatment with normal saline, compared with the gene chip without pre-treatment. On the gene chip pre-treated with vitamin C, 45 apoptosis genes were down-regulated and 34 anti-apoptosis genes were up-regulated. Pre-treatment with vitamin E resulted in the down-regulation of 3 apoptosis genes. Conclusion: Vitamin C can protect vascular endothelial cells from mannitol-induced injury.

Reducing Dietary Cation-Anion Difference on Acid-Base Balance, Plasma Minerals Level and Anti-Oxidative Stress of Female Goats

Reducing dietary cation-anion difference （DCAD） has been proved an effective way to prevent milk fever in dairy cows. Based on the similar physiological gastro-intestinal tract anatomy and metabolic process between female goats and dairy cows, this study was conducted to evaluate the effects of varying DCAD on fluid acid-base status, plasma minerals concentration and anti-oxidative stress capacity of female goats. Urinary pH, plasma Ca, P and Mg; and anti-oxidative stress indices of total superoxide dismutase （T-SOD）, hydrogen peroxide （HzO2）, glutathione peroxidase （GSH-Px） and malondialdehyde （MDA） were determined to evaluate the effect. Forty-eight Guizhou black female goats （（15±1.9） mon of old, （22.3±3.75） kg of BW） were randomly allocated to 4 blocks of 12 goats each and were fed 1 of 4 diets differed in DCAD level （calculated as Na＋K-C1-S, mEq kg-1 DM）. Levels of DCAD were preliminarily designed to be control （＋ 150 mEq kg^-1 DM, CON）, high DCAD （＋300 mEq kg^-1 DM, HD）, low DCAD （0 mEq kg^-1 DM, LD） and negative DCAD （-150 mEq kg^-1 DM, ND）, respectively. A commercial anionic salts （Animate） and sodium bicarbonate （NaHCO3） were supplemented to reduce and increase DCAD level, respectively. There was no difference in dry matter intake for 4 groups of goats. Urine pH was aggressively decreased （P〈0.0001） with reduced DCAD and there was a strong association between DCAD and urine pH （R2=0.793, P〈0.0001）. Compared with CON and HD feeding of LD and ND resulted in greater （P〈0.05） plasma Ca concentration. Plasma P level was increased （P〈0.05） when anionic salts were supplemented. The DCAD alteration did not affected （P〉0.05） plasma Mg level. There was no significant （P〉0.05） difference in plasma GSH-Px activity and H202, but anionic salts supplementation in LD and ND significantly increased （P〈0.05） plasma T-SOD activity and tended to reduce MDA （P〈0.1） over HD and CON. Results from this study indicated that reducing DCAD could decrease urine pH and increase plasma Ca concentration of female goats. Additionally, reducing DCAD was helpful to enhance anti-oxidative stress capability of female goats.

Effects of Waterborne Cu and Cd on Anti-oxidative Response, Lipid Peroxidation and Heavy Metals Accumulation in Abalone Haliotis discus hannai Ino

The aim of this study was to compare the effects of waterbome copper （Cu） and cadmium （Cd） on survival, anti-oxida- tive response, lipid peroxidation and metal accumulation in abalone Haliotis discus hannai. Experimental animals （initial weight： 7.49 g±0.01 g） were exposed to graded concentrations of waterborne Cu （0.02, 0.04, 0.06, 0.08 mg L-1） or Cd （0.025, 0.05, 0.25, 0.5 mgL-1） for 28 days, respectively. Activities of the anti-oxidative enzymes （catalase, CAT; superoxide dismutase, SOD; glutathione peroxidases, GPx; glutathione S-transferase, GST）, contents of the reduced glutathione （GSH） and malondiadehyde （MDA） in the hepatopancreas, and metal accumulation in hepatopancreas and muscles were analyzed after 0, 1, 3, 6, 10, 15, 21, 28 days of metal exposure, respectively. Results showed that 0.04 mg L-1, 0.06 mg L-1 and 0.08 mgL-1 Cu caused 100% death of abalone on the 21st, 10th and 6th day, respectively. However, no dead abalone was found during the 28-day waterborne Cd exposure at all experimental concentrations. Generally, activities of SOD and GST in hepatopancreas under all Cu concentrations followed a decrease trend as the exposure time prolonged. However, these activities were firstly increased and then decreased to the control level and increased again during Cd exposure. Activities of CAT in all Cu exposure treatments were higher than those in the control. These activities were firstly increased and then decreased to the control level and increased again during Cd exposure. Contents of MDA in hepatopancreas in all Cu treatments significantly increased first and then decreased to the control level. However, the MDA contents in hepatopan- creas were not significantly changed during the 28-day Cd exposure. The metals accumulation in both hepatopancreas and muscles of abalone significantly increased with the increase of waterborne metals concentration and exposure time. These results indicated that H. discus hannai has a positive anti-oxidative defense against Cu or Cd. In conclusion, anti-oxidative mechanism in abalone to resist waterborne Cu did not follow the same pattern as that for waterborne Cd.

Chemical analysis,antimicrobial and anti-oxidative properties of Daucus gracilis essential oil and its mechanism of action

Objective:To evaluate the essential oils(EO) composition,antimicrobial and antioxidant power of a local plant,Daucus gracilis(D.gracilis).Methods:The aerial parts of D.gracilis were subjected to hydro distillation by a Clevenger apparatus type to obtain the EO which had been analyzed by gas chromatography and gas chromatography coupled with mass spectrometry,and screened for antimicrobial activity against five bacteria and three fungi by agar diffusion method.The mechanism of action of the EO was determined on the susceptible strains by both of time kill assay and lysis experience.The minimal inhibitory concentrations were determined by agar macrodilution and micro-dilution methods.Anti-oxidative properties of the EO were also studied by free diphenyl-2-picrylhydrazyl radical scavenging and reducing power techniques.Results:The EO yielded 0.68(v/w).The chemical analysis presented two dominant constituents which were the elemicin(35.3%) and the geranyl acetate(26.8%).D.gracilis EO inhibited the growth of Bacillus cereus and Proteus mirabilis significantly with minimal inhibitory concentrations of 17.15 μg/mL by the agar dilution method and57.05 μg/mL and 114.1 μg/mL,respectively by liquid micro-dilution.A remarkable decrease in a survival rate as well as in the absorbance in 260 nm was recorded,which suggested that the cytoplasm membrane was one of the targets of the EO.The EO showed,also,important anti-oxidative effects with an IC50 of 0.002 mg/mL and a dosedependent reducing power.Conclusions:D.gracilis EO showed potent antimicrobial and anti-oxidative activities and had acted on the cytoplasm membrane.These activities could be exploited in the food industry for food preservation.

Supplementation of Yeast Extract to Practical Diet Improves the Growth, Anti-Oxidative Capacity and Intestinal Morphology of Shrimp Litopenaeus vannamei

Two control diets based on the commercial formula were designed to contain high(27%,D1)and low(22%,D2)levels of fish meal,respectively.Into D2,500,1000 and 1500 mg kg 1 of yeast extract were added,respectively,yielding three experimental diets(YE1 through YE3).Shrimp(initial body weight 0.30 g±0.02 g)were fed with the experimental diets,five tanks each diet and 30 shrimp individuals each tank,for 8 weeks,and then challenged with Vibrio parahaemolyticus.The results showed that the specific growth rate(SGR)of shrimp in D2 was significantly lower than that of shrimp in D1(P<0.05).The SGR of shrimp in YE3 was similar to that of shrimp in D1.The feed intake of shrimp was similar between D1 and D2.The feed conversion ratio and protein efficiency ratio of shrimp were similar among all diets(P>0.05).YE significantly improved the activity of glutathione S-transferase.The concentration of glutathione(GSH)and the total serum anti-oxidative capacity(T-AOC)of D1 were significantly higher than those of shrimp feeding other diets(P<0.05).The content of serum malondialdehyde of shrimp feeding YE2 and YE3 was signifi-cantly lower than that of shrimp feeding D2(P<0.05).The thickness of intestine muscular layer of shrimp feeding YE1 and YE2 was similar to that of shrimp feeding D1.The shrimp feeding YE1 showed the highest villus height of intestine among all groups.The cumulative mortality after challenging was similar among all groups(70.00%86.67%)(P>0.05).In conclusion,1000 1500 mg kg 1 of YE was suggested to be supplemented into the practical diets to improve the growth,anti-oxidative capacity and intestinal mor-phology of shrimp L.vannamei.

Salt-induced difference between Glycine cyrtoloba and G.max in anti-oxidative ability and K^+ vs. Na^+ selective accumulation

To characterize differences in soybean resistance to salt stress, two soybean species, the wild salt-tolerant soybean Glycine cyrtoloba(serial number ACC547) and the cultivated salt-sensitive soybean G. max(cv. Melrose) were treated with 0, 50, 100, or 150 mmol L-1Na Cl for 5 days. A series of physiological parameters were determined in both shoots and roots, including content of chlorophyll(Chl) and malondialdehyde(MDA); electrolyte leakage(EL); hydrogen peroxide(H2O2) concentration; superoxide oxygen radical(O2-)production rate; activities of several enzymes including superoxide dismutase(SOD),catalase(CAT), and peroxidase(POD); and selective ion(Na+and K+) accumulation. Our results showed that the relative salt tolerance of ACC547 was associated with lower loss of Chl content; lower MDA content, EL, H2O2 concentration, and O2-production rate in both shoots and roots; higher POD activity caused by new isoforms in roots; and higher K+concentration and K+/Na+ratio in shoots. These results suggested that relative lower membrane injury, efficient K+vs. Na+selective accumulation, and newly induced POD isoenzymes are mechanisms of salt tolerance in soybean.

Effects of vitamin C deficiency or excess on growth performance, anti-oxidative response and fatty acid composition of juvenile abalone Haliotis discus hannai Ino

A 240-day feeding trial was conducted to investigate the effects of dietary vitamin C on growth performance,anti-oxidative response,and fatty acid composition of juvenile abalone Haliotis discus hannai Ino(initial body weight:0.93±0.00 g).Three semi-purified experimental diets were formulated containing 0.00,94.52,and 9649.58 mg/kg of vitamin C supplied as L-ascorbyl-2-monophosphate.The results show that there was no significant difference in weight gain ratio,daily increment in shell length,and survival rate among the three treatments.Adding dietary vitamin C(9649.58 mg/kg)significantly increased the activities of superoxide dismutase(SOD),glutathine peroxidase(GPX),glitathione-S-transferase(GST),glutathione reductase(GR),alkaline phosphatase(AKP),and lysozyme in viscera(P<0.05).In muscle,activities of phenoloxidase,catalase,SOD,GST,GR,and AKP were increased in the treatment with 9649.58 mg/kg of dietary vitamin C(P<0.05).The highest concentrations of ascorbic acid in viscera and muscle were found in the group with 9649.58 mg/kg of dietary vitamin C(P<0.05).The contents of crude protein and crude lipid in the soft body were significantly increased in the 9649.58 mg/kg group(P<0.05).Dietary vitamin C supplementation significantly decreased the contents of saturated fatty acids(14:0,16:0,and 18:0),and increased the composition of 18:2n-6 and 22:6n-3 in the soft body of abalone(P<0.05).Therefore,although there were no significant effects on the growth performance,dietary vitamin C supplementation improved the anti-oxidation and immune responses,increased specific unsaturated fatty acid(i.e.,16:1,18:1n-7,18:1n-9,18:2n-6 and 22:6n-3),and decreased specific saturated fatty acid(i.e.,14:0,16:0 and 18:0)contents in the soft body of abalone.

Study on Hydrogen Storage Properties,Anti-Oxide Ability and Rate Limiting Step of ZrCr-Based Alloy after Introducing Cobalt as Additive

In this work,the microstructure,hydrogen storage properties,anti-oxide ability and rate limiting step of Zr(Cr_(1−x)Co_(x))_(2)(x=0,0.2,0.4 and 0.6)alloys have been investigated.After studying the crystal structure,we found that all alloy samples could show C14-type phase but the alloy sample x=0 could also show a small amount of Cr phase.Rietveld fitting showed that lattice parameter and unit cell volume of C14-type phase decreased with increasing x.After further research,it was clear that the first hydrogen absorption capacity decreased with increasing x.But introducing more Co content had a positive influence on the effective hydrogen storage capacity and cyclic hydrogen absorption and desorption properties of the alloy sample.We also found that adding Co to ZrCr_(2)alloy could improve its anti-oxide ability.In addition to this,the rate limiting step model was also studied.

壳寡糖对乙醇诱导的炎症反应的保护作用

为研究壳寡糖对酒精损伤海马组织的保护作用,将39只新生SD大鼠随机分为3组,分别是空白对照组(CON组)、模型组(ETOH组)和壳寡糖干预组(COS组)。建立新生SD大鼠酒精损伤模型,对COS组进行壳寡糖干预,在出生后第9天(PD9)干预结束,在PD9到PD24之间不再进行干预,分别检测PD9和PD24的磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)、胶质纤维酸性蛋白(GFAP)和凋亡诱导因子(AIF1)的表达,炎症因子白细胞介素6(IL-6)、白细胞介素10(IL-10)、肿瘤坏死因子α(TNF-α)的表达量,在PD24进行新物体识别试验。结果表明:在PD9时,COS组中PI3K和Akt及其磷酸化水平、GFAP和AIF1蛋白水平与ETOH组相比无显著差异,IL-10显著增加,IL-6和TNF-α显著降低。在PD24时,与ETOH组相比,COS组中PI3K、Akt蛋白的磷酸化水平显著上升,GFAP表达下降,IL-10显著增加,IL-6和TNF-α显著降低。壳寡糖可以在PD24缓解PI3K/Akt通路的抑制,抑制星形胶质细胞标志物GFAP的过表达,在PD9和PD24抑制IL-6和TNF-α的过表达,缓解IL-10的抑制。

蒲公英应用实践及药理作用研究进展

为探索蒲公英实践应用价值,本文通过查阅文献资料,总结分析了蒲公英外敷制剂及其复方的相关应用及药理作用方面的研究进展。结果表明,蒲公英制剂可外敷用于乳痈、静脉炎、冻伤和术后软组织皮肤感染等的辅助治疗;复方蒲公英可通过注射或内服用于肠胃疾病、扁桃体炎、支气管炎和乳腺炎等的辅助治疗。蒲公英具有抗氧化、抗菌、抗炎、抗肿瘤、调血脂和保肝等药理活性。蒲公英种质资源丰富,药理成分多样,可临床上推广应用,既可外敷又可内服。

Anti-oxidation properties of ZrB_2 modified silicon-based multilayer coating for carbon/carbon composites at high temperatures

To improve the anti-oxidation ability of silicon-based coating for carbon/carbon （C/C） composites at high temperatures, a ZrB2 modified silicon-based multilayer oxidation protective coating was prepared by pack cementation. The phase composition, microstructure and oxidation resistance at 1773, 1873 and 1953 K in air were investigated. The prepared coating exhibits dense structure and good oxidation protective ability. Due to the formation of stable ZrSiO4-SiO2 compound, the coating can effectively protect C/C composites from oxidation at 1773 K for more than 550 h. The anti-oxidation performance decreases with the increase of oxidation temperature. The mass loss of coated sample is 2.44% after oxidation at 1953 K for 50 h, which is attributed to the decomposition of ZrSiO4 and the volatilization of SiO2 protection layer.

Study on Anti-oxidation and Inhibitory Effect on Nonenzymatic Glycation Reaction of Fermentation Extract from Biotransformation of Ginkgo biloba L. (EGB) by Hericium erinaceus

[ Objective] In order to study the anti-oxidation and inhibitory effect on nonenzymatic glycation reaction of EGB fermentation extraction biotransformed by Hericium erinaceus. [ Method ] The free radical scavenging ability and reducing capacity of DPPH as well as inhibitory rate of nonenzymatic glycation reaction were measured targets for comparing changes of anti-oxidation and inhibitory effect on nonenzymatic glycation reaction of fermentation lyophilizer and fermentation extraction before and after EGB fermention adsorbed by AB-8 macroporous resin. The EGB fermention was biotransformed by Hericium erinaceus. [ Result ] After adsorbed by AB-8 macroporous resin, the bioactive matters were concentrated and separated. The free radical scavenging rate, reducing capacity and inhibitory rate of nonenzymatic glycation reaction were increased significantly after adsorbed by AB-8 macroporous resin. [ Conclusion] AB-8 macroporous resin could be used for preliminary concentration of EGB fermentation which was biotransformed by Hericium erinaceus.

Durable Ru Nanocrystal with HfO_(2)Modification for Acidic Overall Water Splitting

Durable and efficient bi-functional catalyst,that is capable of both oxygen evolution reaction and hydrogen evolution reaction under acidic condition,are highly desired for the commercialization of proton exchange membrane water electrolysis.Herein,we report a robust L-Ru/HfO_(2)heterostructure constructed via confining crystalline Ru nanodomains by HfO_(2)matrix.When assembled with a proton exchange membrane,the bi-functional L-Ru/HfO_(2)catalyst-based electrolyzer presents a voltage of 1.57 and 1.67 V to reach 100 and 300 mA cm^(-2)current density,prevailing most of previously reported Ru-based materials as well as commercial Pt/C||RuO_(2)electrolyzer.It is revealed that the synergistic effect of HfO_(2)modification and small crystalline domain formation significantly alleviates the over-oxidation of Ru.More importantly,this synergistic effect facilitates a dual-site oxide path during the oxygen evolution procedure via optimization of the binding configurations of oxygenated adsorbates.As a result,the Ru active sites maintain the metallic state along with reduced energy barrier for the rate-determining step(^(*)O→^(*)OOH).Both of water adsorption and dissociation(Volmer step)are strengthened,while a moderate hydrogen binding is achieved to accelerate the hydrogen desorption procedure(Tafel step).Consequently,the activity and stability of acidic overall water splitting are simultaneously enhanced.

炎症与动脉粥样硬化狭窄或闭塞性疾病关系的研究进展

动脉粥样硬化(AS)狭窄或闭塞性疾病的发病机制复杂,大量的基础研究表明炎症机制在AS的发生、发展阶段发挥着至关重要的作用。尽管临床上针对AS狭窄或闭塞性疾病进行了很好的降脂及抗血小板治疗,但相关不良事件仍有发生,因此,寻找新的治疗靶点至关重要。针对炎症的靶向治疗可以改善这类患者的临床结局,一些药物已经展现出了其应用潜力。本文对炎症与AS狭窄或闭塞性疾病的关系进行系统综述,并讨论抗感染治疗在此类疾病中的应用情况。

至真方固体双向发酵工艺的建立及其药效评价

目的以中药固体双向发酵方法,建立至真方的新型发酵工艺。方法①通过文献研究拟定候选发酵菌种。对候选发酵菌种进行平板混合实验,考察各菌种间生长兼容性。采用CCK-8细胞增殖抑制实验,比较不同发酵条件下所得产物对人结直肠癌细胞(HCT-8)的半数抑制浓度(IC50),评判发酵体系的优劣,从而确定发酵菌种、发酵时长等关键发酵参数,建立发酵工艺。②通过HCT-8细胞增殖抑制率,以及巨噬细胞(RAW264.7)NO释放率和吞噬活性测定,比较至真方发酵前后的体外药效差异。结果黑曲霉和酵母菌为最优发酵菌种组合,4 d为最优发酵时长。在此发酵条件下,发酵组对HCT-8细胞的IC50为67.41μg·mL^(-1),生药组对HCT-8细胞的IC50为1032μg·mL^(-1);与生药组比较,发酵组能显著抑制RAW264.7释放炎症因子NO,并显著提升其吞噬活性。结论该研究建立了至真方固体双向发酵新工艺。在该发酵体系下,至真方的体外抗结直肠癌活性、抗炎活性和促免疫活性得到显著提升。

藤茶及其活性成分二氢杨梅素的药理作用

中药藤茶为葡萄科蛇葡萄属藤本植物,含有黄酮类、酚类、甾体类等多种化学成分。其中,二氢杨梅素为藤茶中含量最高的黄酮类化合物,也是其发挥药效作用的主要成分。研究发现,藤茶及二氢杨梅素的抗肿瘤作用效果显著,其机制主要涉及诱导凋亡和抑制增殖、抑制迁移侵袭、调节免疫、逆转耐药。另外,藤茶及二氢杨梅素还可以通过抗氧化作用治疗心血管疾病、神经退行性疾病和肝病;通过抗炎作用治疗肠道炎症、关节炎、神经炎等炎症性疾病;通过调节代谢改善葡萄糖和脂质代谢紊乱。此外,藤茶及二氢杨梅素还具有抗菌、抗病毒等多种作用。文章对藤茶及其活性成分二氢杨梅素的药理作用进行整理综述,并分析总结其临床应用价值和安全性,以期为藤茶药用资源的开发利用提供科学依据。