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Pachymic acid, a novel compound for anti-rejection: effect in rats following cardiac allograft transplantation 被引量:5
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作者 ZHANG Fan ZHANG Xue-feng WANG Bai-chun LIU Hong-yu LI Chun-yu LIU Zong-hong ZHANG Guo-wei LU Hang CHI Chao WANG Fei 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第23期2898-2902,共5页
Background Pachymic acid (PA), a natural triterpenoid, is known to significantly reduce cell proliferation and induce apoptosis in vitro through initiation of mitochondria dysfunction. However, its effect on immune ... Background Pachymic acid (PA), a natural triterpenoid, is known to significantly reduce cell proliferation and induce apoptosis in vitro through initiation of mitochondria dysfunction. However, its effect on immune cells and anti-rejection following organ transplantation remains unknown. Methods In this study, we investigated PA as a treatment to control acute rejection occurred in rats which had accepted cardiac transplantation. We measured apoptosis of peripheral blood lymphocyte (PBLs), and CD4^+ lymphocyte, as well as the number of CD4^+ and CD8^+ lymphocytes and the effect of PA on acute rejection in rats 7 days after cardiac transplantation. Results PA treatment might decrease allograft rejection, protect PBLs from apoptosis, and reduce the percentage of CD8^+ lymphocyte. PA neither regulated the number nor the apoptosis rate of CD4^+ lymphocyte. Conclusions Our findings indicated that PA has an anti-apoptotic effect acting on PBLs through a novel mechanism involving stabilization of the PBLs mitochondrial transmembrane potential, an anti-rejection effect in rats after cardiac transplantation and an inhibiting effect to CD8^+ lymphocyte. 展开更多
关键词 pachymic acid mitochondrial transmembrane potential APOPTOSIS anti-rejection
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