Air pollutants pose a major environmental threat to the respiratory system. Pathogen invasion and the exposure to particulate matters in atmospheric air, particularly, cigarette smoke (CS), have been found to be assoc...Air pollutants pose a major environmental threat to the respiratory system. Pathogen invasion and the exposure to particulate matters in atmospheric air, particularly, cigarette smoke (CS), have been found to be associated with acute and chronic respiratory diseases, including asthma. Therefore, the search for agents that can protect the respiratory system against potentially harmful substances is of interest in preventive health. Lily bulb Nectar (LBN), which contains Lily bulb, Pyrus pyrifolia N., Siraitia grosvenorii and Apricot kernel as its ingredients, is a health supplement intended to improve the wellness of the respiratory system in humans. Lily bulb, Pyrus pyrifolia N., Siraitia grosvenorii and Apricot kernel are commonly prescribed for the treatment of respiratory tract disorders such as bronchitis, pneumonia and cough in the practice of traditional Chinese medicine. Pharmacological studies have shown that these herbs can produce beneficial effects on the respiratory tract or even the lungs. In the present study, we investigated the effects of LBN on mouse respiratory tract function under normal and challenged conditions. LBN was first examined for its expectorant and anti-tussive activities in mice. The effect of LBN on long-term exposure to CS was also investigated. Our findings showed that long-term LBN treatment enhanced the expectorant activity and suppressed the SO2-induced coughing in mice. LBN treatment also suppressed the CS-induced inflammation in the respiratory tract, as assessed by differential cell count and cytokine production. In conclusion, long-term LBN consumption may produce beneficial effects on the respiratory tract function in humans, particularly in the face of challenge by irritants in the inhaling air.展开更多
目的:观察苏贝止咳颗粒(Su Bei Zhi Ke granules,SBZKG)对急性气管-支气管炎(风寒袭证)的影响。方法:采用小鼠耳廓肿胀实验、小鼠腹腔毛细血管通透性实验,观察其抗炎作用;小鼠排泌酚红实验、氨水所致小鼠咳嗽实验和大鼠排痰实验,观察其...目的:观察苏贝止咳颗粒(Su Bei Zhi Ke granules,SBZKG)对急性气管-支气管炎(风寒袭证)的影响。方法:采用小鼠耳廓肿胀实验、小鼠腹腔毛细血管通透性实验,观察其抗炎作用;小鼠排泌酚红实验、氨水所致小鼠咳嗽实验和大鼠排痰实验,观察其祛痰、止咳作用;采用感染小鼠死亡率实验,观察其抗菌、抗病毒作用。结果:与对照组比较,SBZKG大、中剂量组均降低小鼠耳廓肿胀度(P<0.05)和提高肿胀抑制率,降低小鼠腹腔毛细血管通透性(P<0.05,P<0.01);SBZKG可增加小鼠呼吸道的酚红排痰量(P<0.01),延长小鼠咳嗽潜伏期,减少小鼠咳嗽次数(P<0.05,P<0.01)和增加大鼠的排痰量(P<0.05,P<0.01);SBZKG可减少小鼠感染细菌和病毒后的死亡率。结论:SBZKG具有一定的抗炎、止咳、祛痰、抗菌、抗病毒作用,对急性气管-支气管炎具有一定的治疗作用。展开更多
目的探讨排痰机联合小剂量甲强龙治疗儿童难治性支原体肺炎的临床疗效。方法选取2020年1月至2022年1月菏泽市第六人民医院收治的81例儿童难治性支原体肺炎患儿作为研究对象,采用随机数字表法分为观察组(n=41)与对照组(n=40)。对照组给...目的探讨排痰机联合小剂量甲强龙治疗儿童难治性支原体肺炎的临床疗效。方法选取2020年1月至2022年1月菏泽市第六人民医院收治的81例儿童难治性支原体肺炎患儿作为研究对象,采用随机数字表法分为观察组(n=41)与对照组(n=40)。对照组给予常规吸氧、化痰、维持水电解质平衡治疗,同时给予阿奇霉素联合小剂量甲强龙治疗,观察组加用排痰机,比较两组临床疗效、炎症因子水平、肺功能指标、血气分析指标、不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-6、肿瘤坏死因子-α及高敏C反应蛋白水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组达峰容积比(expiratory volume at tidal peak expiratory flow/expiratory time,VPEF/VE)及达峰时间比(time to tidal peak expiratory flow/expiratory time,TPTEF/TE)均高于治疗前,每公斤体质量潮气量均大于治疗前,且观察组VPEF/VE、TPTEF/TE均高于对照组,每公斤体质量潮气量大于对照组,差异有统计学意义(P<0.05)。治疗后,两组氧合指数(partial pressure of arterial oxygen/fraction of inspiration O2,PaO2/FiO2)、动脉血氧分压(partial pressure of arterial oxygen,PaO2)均高于治疗前,动脉血二氧化碳分压(partial pressure of carbon dioxide in arterial blood,PaCO2)低于治疗前,且观察组PaO2/FiO2、PaO2均高于对照组,PaCO2低于对照组,差异有统计学意义(P<0.05)。两组均未发生不良反应。结论排痰机联合小剂量甲强龙可提高儿童难治性支原体肺炎治疗效果,减轻炎症反应,改善肺功能,调节血气指标,且安全性较高。展开更多
文摘Air pollutants pose a major environmental threat to the respiratory system. Pathogen invasion and the exposure to particulate matters in atmospheric air, particularly, cigarette smoke (CS), have been found to be associated with acute and chronic respiratory diseases, including asthma. Therefore, the search for agents that can protect the respiratory system against potentially harmful substances is of interest in preventive health. Lily bulb Nectar (LBN), which contains Lily bulb, Pyrus pyrifolia N., Siraitia grosvenorii and Apricot kernel as its ingredients, is a health supplement intended to improve the wellness of the respiratory system in humans. Lily bulb, Pyrus pyrifolia N., Siraitia grosvenorii and Apricot kernel are commonly prescribed for the treatment of respiratory tract disorders such as bronchitis, pneumonia and cough in the practice of traditional Chinese medicine. Pharmacological studies have shown that these herbs can produce beneficial effects on the respiratory tract or even the lungs. In the present study, we investigated the effects of LBN on mouse respiratory tract function under normal and challenged conditions. LBN was first examined for its expectorant and anti-tussive activities in mice. The effect of LBN on long-term exposure to CS was also investigated. Our findings showed that long-term LBN treatment enhanced the expectorant activity and suppressed the SO2-induced coughing in mice. LBN treatment also suppressed the CS-induced inflammation in the respiratory tract, as assessed by differential cell count and cytokine production. In conclusion, long-term LBN consumption may produce beneficial effects on the respiratory tract function in humans, particularly in the face of challenge by irritants in the inhaling air.
文摘目的:观察苏贝止咳颗粒(Su Bei Zhi Ke granules,SBZKG)对急性气管-支气管炎(风寒袭证)的影响。方法:采用小鼠耳廓肿胀实验、小鼠腹腔毛细血管通透性实验,观察其抗炎作用;小鼠排泌酚红实验、氨水所致小鼠咳嗽实验和大鼠排痰实验,观察其祛痰、止咳作用;采用感染小鼠死亡率实验,观察其抗菌、抗病毒作用。结果:与对照组比较,SBZKG大、中剂量组均降低小鼠耳廓肿胀度(P<0.05)和提高肿胀抑制率,降低小鼠腹腔毛细血管通透性(P<0.05,P<0.01);SBZKG可增加小鼠呼吸道的酚红排痰量(P<0.01),延长小鼠咳嗽潜伏期,减少小鼠咳嗽次数(P<0.05,P<0.01)和增加大鼠的排痰量(P<0.05,P<0.01);SBZKG可减少小鼠感染细菌和病毒后的死亡率。结论:SBZKG具有一定的抗炎、止咳、祛痰、抗菌、抗病毒作用,对急性气管-支气管炎具有一定的治疗作用。
文摘目的探讨排痰机联合小剂量甲强龙治疗儿童难治性支原体肺炎的临床疗效。方法选取2020年1月至2022年1月菏泽市第六人民医院收治的81例儿童难治性支原体肺炎患儿作为研究对象,采用随机数字表法分为观察组(n=41)与对照组(n=40)。对照组给予常规吸氧、化痰、维持水电解质平衡治疗,同时给予阿奇霉素联合小剂量甲强龙治疗,观察组加用排痰机,比较两组临床疗效、炎症因子水平、肺功能指标、血气分析指标、不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,两组白细胞介素-6、肿瘤坏死因子-α及高敏C反应蛋白水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组达峰容积比(expiratory volume at tidal peak expiratory flow/expiratory time,VPEF/VE)及达峰时间比(time to tidal peak expiratory flow/expiratory time,TPTEF/TE)均高于治疗前,每公斤体质量潮气量均大于治疗前,且观察组VPEF/VE、TPTEF/TE均高于对照组,每公斤体质量潮气量大于对照组,差异有统计学意义(P<0.05)。治疗后,两组氧合指数(partial pressure of arterial oxygen/fraction of inspiration O2,PaO2/FiO2)、动脉血氧分压(partial pressure of arterial oxygen,PaO2)均高于治疗前,动脉血二氧化碳分压(partial pressure of carbon dioxide in arterial blood,PaCO2)低于治疗前,且观察组PaO2/FiO2、PaO2均高于对照组,PaCO2低于对照组,差异有统计学意义(P<0.05)。两组均未发生不良反应。结论排痰机联合小剂量甲强龙可提高儿童难治性支原体肺炎治疗效果,减轻炎症反应,改善肺功能,调节血气指标,且安全性较高。
