Test analysis on relationship between anti-vibration performanceand chaos characteristics of vehicle suspension

Based on the primary principle of anti-vibration on vehicles, a chaos description on the vibration in suspensions is put forward. The vibration curve of the suspensions of test vehicles is obtained based on the data from a test rig for vehicle braking vs. suspension anti-vibration efficiency. The system parameters such as first inherent frequency and damp rate, as well as the chaos parameters such as the minimum embedding dimension and correlation dimension, are calculated by the vibration curve. The relationship among anti-vibration performance, chaos parameters and system parameters of vehicle suspension is presented. The research results show that the minimum embedding dimension Mmin can be used to estimate the change of the anti-vibration performance of the front suspension of the off-road jeep. The smaller Min is, the worse anti-vibration performance is. The corresponding stiffness and damp of the front suspension of the off-road jeep is smaller. Correlation dimension D2 can be used to identify different suspension types such as those of the off-road jeep and the car. The D2 of the off-road jeep is larger than the one of the car.

Vibration isolation performance analysis of a bilateral supported bio-inspired anti-vibration control system

To achieve better anti-vibration performance in a low frequency region and expand the range of vibration isolation,a bilateral supported bio-inspired anti-vibration(BBAV)structure composed of purely linear elements is proposed,inspired by the motion form of bird legs and the nonlinear extension and compression of muscles and tendons.The kinematic relations and nonlinear dynamic model considering vertical and rotational vibrations are established.The loading capacity and equivalent stiffness are investigated with key parameters.The amplitude-frequency characteristics and force transmissibility are used to evaluate the stability and anti-vibration performance with the effects of the excitation amplitude,rod length,installation angle,and spring stiffness.The results show that the loading requirements and resonant characteristics of the BBAV structure are adjustable,and superior vibration isolation performance can be achieved readily by tuning the parameters.The X-shaped vibration structure is sensitive to the spring stiffness,which exhibits a wider vibration isolation bandwidth with smaller spring stiffness.Besides,depending on the parameters,the nonlinear behavior of the BBAV system can be interconverted between the softening type and the hardening type.The theoretical analysis in this study demonstrates the advantages and effectiveness of the vibration isolation structure.

Research on Breeze Vibration Law and Modal Identification Method of Conductor Considering Anti-Vibration Hammer Damage

In the harsh environment,the structural health of the anti-vibration hammer,which suffers from the coupled effects of corrosion and fatigue damage,is significantly reduced.As part of the conductor structure,the anti-vibration hammer is rigidly attached to the conductor,effectively suppressing conductor vibration.The conductor’s breeze vibration law and natural modal frequency are altered damage to the anti-vibration hammer structure.Through built a vibration experiment platform to simulate multiple faults such as anti-vibration hammer head drop off and position slippage,which to obtained the vibration acceleration signal of the conductor.The acceleration vibration signal is processed and analyzed in the time and frequency domains.The results are used to derive the breeze vibration law of the conductor under multiple faults and propose an anti-vibration hammer damage online monitoring technology.The results show that the vibration acceleration value and vibration intensity of the conductor are significantly increased after the anti-vibration hammer damage.The natural frequency increases for each order,with an absolute change ranging from 0.15 to 6.49 Hz.The anti-vibration hammer slipped due to a loose connection,the 1st natural frequency increases from 8.18 to 16.62 Hz.Therefore,in engineering applications,there can be no contact to determine the anti-vibration hammer damage situation by monitoring the modal natural frequency of the conductor.This is even a tiny damage that cannot be seen.This method will prevent the further expansion of the damage that can cause accidents.

Comparison of nonlinear modeling methods for the composite rubber clamp

The cubic stiffness force model(CSFM)and Bouc-Wen model(BWM)are introduced and compared innovatively.The unknown coefficients of the nonlinear models are identified by the genetic algorithm combined with experiments.By fitting the identified nonlinear coefficients under different excitation amplitudes,the nonlinear vibration responses of the system are predicted.The results show that the accuracy of the BWM is higher than that of the CSFM,especially in the non-resonant region.However,the optimization time of the BWM is longer than that of the CSFM.

Effect of an Airbag-selective Portal Vein Blood Arrester on the Liver after Hepatectomy:A New Technique for Selective Clamping of the Portal Vein

Objective:A novel technique was explored using an airbag-selective portal vein blood arrester that circumvents the need for an intraoperative assessment of anatomical variations in patients with complex intrahepatic space-occupying lesions.Methods:Rabbits undergoing hepatectomy were randomly assigned to 4 groups:intermittent portal triad clamping(PTC),intermittent portal vein clamping(PVC),intermittent portal vein blocker with an airbag-selective portal vein blood arrester(APC),and without portal blood occlusion(control).Hepatic ischemia and reperfusion injury were assessed by measuring the 7-day survival rate,blood loss,liver function,hepatic pathology,hepatic inflammatory cytokine infiltration,hepatic malondialdehyde levels,and proliferating cell nuclear antigen levels.Results:Liver damage was substantially reduced in the APC and PVC groups.The APC animals exhibited transaminase levels similar to or less oxidative stress damage and inflammatory hepatocellular injury compared to those exhibited by the PVC animals.Bleeding was significantly higher in the control group than in the other groups.The APC group had less bleeding than the PVC group because of the avoidance of portal vein skeletonization during hepatectomy.Thus,more operative time was saved in the APC group than in the PVC group.Moreover,the total 7-day survival rate in the APC group was higher than that in the PTC group.Conclusion:Airbag-selective portal vein blood arresters may help protect against hepatic ischemia and reperfusion injury in rabbits undergoing partial hepatectomy.This technique may also help prevent liver damage in patients requiring hepatectomy.

Hyper accuracy three-dimensional virtual anatomical rainbow model facilitates surgical planning and safe selective clamping during robot-assisted partial nephrectomy

Objective:To highlight the role of hyper accuracy three-dimensional(3D)reconstruction in facilitating surgical planning and guiding selective clamping during robot-assisted partial nephrectomy(RAPN).Methods:A transperitoneal RAPN was performed in a 62-year-old male patient presenting with a 4 cm right anterior interpolar renal mass(R.E.N.A.L nephrometry score 7A).An abnormal vasculature was observed,with a single renal vein and two right renal arteries originating superiorly to the vein and anterior,when dividing in their segmental branches.According to the hyper accuracy 3D(HA3D^(®))rainbow model(MEDICS Srl,Turin,Italy),one branch belonging to one of the segmental arteries was feeding the tumor.This allowed for an accurate prediction of the area vascularized by each arterial branch.The 3D model was included in the intraoperative console view during the whole procedure,using the TilePro feature.A step-by-step explanation of the procedure is provided in the video attached to the present article.Results:The operative time was 90 min with a warm ischemia time on selective clamping of 13 min.Estimated blood loss was 180 mL.No intraoperative complication was encountered and no drain was placed at the end of the procedure.The patient was discharged on postoperative Day 2,without any early postoperative complications.The final pathology report showed a pathological tumor stage 1 clear cell renal cell carcinoma with negative surgical margins.Conclusion:The present study and the attached video illustrate the value of 3D rainbow model during the planning and execution of a RAPN with selective clamping.It shows how the surgeon can rely on this model to be more efficient by avoiding unnecessary surgical steps,and to safely adopt a“selective”clamping strategy that can translate in minimal functional impact.

基于矢量分类的NPC型三电平双三相PMSM的改进模型预测电压控制

多电平多相电机驱动系统存在电压矢量数目多、冗余复杂及多目标非线性约束等问题。以二极管钳位型三电平六相逆变器驱动双三相永磁同步电机为研究对象,以电机谐波电流抑制和逆变器直流侧中点电位平衡控制为目标,提出一种基于电压矢量三角区域分类的改进模型预测电压控制策略。首先,以基波子平面大投影幅值为原则,对729个电压矢量进行初筛;接着,基于三角区域分类方法对筛选后的电压矢量进行分类,并对期望电压进行所属三角区域定位、确定候选矢量。设计满足电机定子电流谐波抑制及逆变器中点电位平衡控制的目标函数;根据电机数学模型和逆变器特征研究多目标控制权重因子的理论设计方法。不同工况下的有效性及对比实验表明,所研究的控制策略不仅能改善多电平多相电机驱动系统的多目标控制性能,还能有效降低控制器计算负担。

膜片箝pClamp采样软件中的P/N漏减分析

本文采用大鼠海马脑片盲法的全细胞记录技术 ,研究了Axon公司pClamp采样软件Clampex中P/N漏减的功能意义和作用机制 ,对P/N漏减脉冲电流的采集以及漏减脉冲的时间、极性、箝位电压、数目、位置等参数的设置进行了详细分析。结果表明 ,在采集电压门控性离子通道电流时 。

具有sliding-clamped端强阻尼屈曲梁方程整体解的存在性

对固体力学中提出的具有强阻尼效应的非线性粘弹性梁方程进行了研究。在给定具有sliding-clamped端和简支端的边界条件下,利用Galerkin方法,证明了该非线性梁方程的整体弱解和强解的存在性。

预紧力变化对包带装置轴向连接刚度影响机理分析

为精准计算包带装置的非线性承载能力,通过包带装置各组件间力学行为的分析,提出了一种考虑预紧力变化的装置轴向连接刚度计算方法;建立了考虑结构非线性的精细化有限元模型,并通过拉伸试验验证了有限元模型的准确性。结合有限元模型修正了装置连接刚度的理论计算,基于所建的有限元与理论模型,揭示了包带预紧力分布、变化及初始预紧载荷对装置强度及连接刚度的影响机理。结果表明:刚度计算理论模型可以准确计算装置的轴向连接刚度并预测连接失效载荷,具有重要的工程应用价值。

膜片钳技术10年发展:基于CiteSpace和VOSviewer的可视化分析

背景:膜片钳技术作为研究离子通道的“金标准”,已有40多年的发展历史。然而,科研机构的研究内容相对独立,没有对现有研究成果进行系统总结,导致现有研究存在重复性高、创新性弱的现象。因此,急需对膜片钳技术做一个全面的回顾,以明晰现今的研究现状、热点和未来发展方向。目的:总结近10年膜片钳技术领域的研究现状和发展趋势。方法:使用Web of Science核心合集数据库收集了2013-2023年关于膜片钳技术的出版物。采用CiteSpace和VOSviewer软件对出版物数量进行量化分析,并分析文献条目网络,包括国家、机构、期刊、作者、关键词、高被引文献和共被引参考文献。结果与结论:①近10年间,膜片钳技术领域研究已逐步进入稳定发展阶段。②中国和美国是这方面的领先国家,中国科学院是具有核心影响力的机构,《Journal of Neuroscience》是主要出版刊物,PARK,WON SUN团队(韩国全北国立大学)和CHU,LI团队(中国河北省心脑血管病中医药防治研究重点实验室)在该领域作出了杰出的贡献,但团队之间的协作与交流较少,尚未形成网络合作模式。③膜片钳技术主要应用在神经系统的电生理特性及其疾病的病理机制方面,是研究人员持续关注的焦点。④在心血管系统电生理特性及其疾病病理机制的研究方面,对原代心肌细胞、诱导多能干细胞衍生的心肌细胞的电生理特性和心房颤动、心脏毒性、心源性猝死和高血压等心血管疾病的病理机制方面的研究,是近几年来研究的热点。⑤在膜片钳技术与其他生物技术的结合应用方面,关注的是与光遗传学、双光子钙成像等技术的交叉融合,将是一个重要的研究方向。⑥在药物筛选及治疗靶点的识别研究方面,尤其对于膜片钳技术和中药复方的研究,将成为未来组分中药研究中的一大助力。

圣女果串采收末端执行器的设计与实验

为提高圣女果采摘效率和降低果实损伤,设计了圣女果串采收末端执行器。其末端结构采用平面四连杆驱动夹持剪切机构,夹持机构采用自补偿设计,使夹持与剪切动作一体化完成。同时,基于螺旋理论,建立接触模型,验证分析了夹持结构的力封闭性,并对整体装置进行了动力学和运动学分析与仿真。室内实验结果表明:整串采摘的夹持成功率为100%,剪切成功率为86.7%。

轿车开门锁拉手组件半自动装配机夹装备设计

轿车开门锁拉手组件人工装配时,需要2人密切配合才能完成。为了提高生产效率,在人工装配动作的基础上设计了半自动的机夹装备.机夹装备是以单油缸活塞推送复位机构完成连接杆的推送和复位运动,以双油缸活塞夹紧复位机构完成摆块扭簧的夹紧和复位运动.人工只需要将拉手放进装备中定位,还需要将扭簧套进摆块的圆柱体上,压缩扭簧并将摆块和扭簧放进拉手相距33.3 mm的2端凸台之间空间,扭簧右端需插入拉手相应的孔中.半自动的机夹装备节省了一个人工,还减轻工人劳动强度,提高生产效率和装配质量,并为后续全自动设备的设计制造奠定了基础。

The calculation of the Reproducibility Error in the technological system with the clamp on the gas power

The paper deduced a calculation formula by the classic control theory on the Reproducibility Error of parts processing in the technology system,the flexible clamp system, with the clamping device on the gas power,and analyzed its influencing factor with examples,the Reproducibility Error law:\ The larger the diameter of the cylinder,the smaller the error; the slower the tool speed,(k values smaller),the smaller the error.

重复经颅磁刺激对阿尔茨海默病小鼠海马齿状回钾离子通道的影响

背景:经颅磁刺激已经被用于治疗阿尔茨海默病,但其机制尚未完全明确。目的:分析重复经颅磁刺激对阿尔茨海默病小鼠海马齿状回神经兴奋性的作用机制。方法:采用随机数字表法,将16只C57BL/6小鼠随机分为对照组(n=8)、对照+磁刺激组(n=8),将16只APP/PS1小鼠随机分为痴呆组(n=8)、痴呆+磁刺激组(n=8),对照+磁刺激组与痴呆+磁刺激组给予重复经颅磁刺激,2 h/d,连续刺激14 d。磁刺激结束后,采用水迷宫实验检测小鼠认知能力,全细胞膜片钳技术采集动作电位,分析阿尔茨海默病对动作电位的影响;全细胞膜片钳技术采集钾离子通道电流,分析其动力学特性对神经兴奋性的作用。结果结论:①水迷宫实验结果显示,正常小鼠接受重复经颅磁刺激后能够更加精准地找到确定原平台位置,阿尔茨海默病导致小鼠学习记忆能力下降,找到平台次数下降,海马齿状回神经元退化,而重复经颅磁刺激可提高阿尔茨海默病小鼠的学习记忆能力;②全细胞膜片钳技术检测结果显示,重复经颅磁刺激能够使阿尔茨海默病小鼠神经元更容易发生去极化,使神经元更易兴奋;③钾离子通道电流分析结果显示,阿尔茨海默病使得瞬时外向钾通道半数激活电压增大,失活曲线向着去极化方向偏移,复活时间常数延长,使得延迟整流钾通道激活曲线向着去极化的方向偏移,而重复经颅磁刺激干预延迟了钾离子通道的打开与关闭,抑制了细胞内钾离子的外流,使得细胞内保持较高浓度K^(+),提高了神经元兴奋性;④结果表明,重复经颅磁刺激可能通过提高海马齿状回颗粒神经元兴奋性来缓解认知能力的衰退。

Study on Loading Leaves Density with Cage Clamp on Quality of Cured Tobaccos in Bulk-Curing Barn

In order to determine the best loading density of tobacco leaf with cage clamp in bulk-curing barns, a curing test was conducted on middle-part tobacco leaves. The results showed that for good appearance quality of cured tobacco, the loading density at 59.52 kg/m2 （4 000 kg/barn） was the best, fol owed by 66.96 kg/m2 （4 500 kg/barn） and 74.40 kg/m2 （5 000 kg/barn）. As leaf loading density increased, the contents of leaf nicotine and total nitrogen increased, sugar content had smal changes, the ratio of sugar to nicotine decreased and tended to be balanced and the content of neutral aroma substances was decreasing, but the difference among treatments was not significant. With the increase of loading density, the sensory quality of cured leaf was better. When leaf loading density was 66.96 kg/m2 （4 500 kg/barn）, apperance quality of cured leaf improved considerably, with prominent aro-ma. Therefore, the best loading density of tobacco leaf in cage clamp of bulk-curing barn would be 66.96 kg/m2 （4 500 kg/barn） .

远程液压快速抢装井口装置设计及应用

为解决油田发生井喷、着火等危急情况,研制了一种远程液压快速抢装井口装置。采用油田现有的远程机械手切割套管本体部位后,在仅剩光套管的情况下,将该装置插入光套管中,利用防喷器远程控制台提供动力,启动双向活塞,带动锥形拉杆上移,锥形拉杆外锥面向外推动卡瓦,使卡瓦牙卡紧到套管内壁上;在拉杆上移过程中,小活塞下移并轴向压紧密封胶筒,胶筒外胀,实现了卡紧并密封抢装井口装置中心管外壁与套管环空。关闭上部的防喷器闸板,实现对井口的封闭。抢装井口装置的液压控制腔承压21 MPa,卡紧密封承压70 MPa,壳体承压105 MPa。对抢装井口装置的关键部件胶筒进行仿真分析,密封长度维持在稳定水平,密封性能良好。该装置在大庆油田应用实施且起到良好的抢险密封作用,满足安全性和经济性的要求。

基于Clamped B样条的空间非合作目标抓捕策略研究

空间机械臂技术是未来实施在轨服务与维护任务的关键技术之一.利用机械臂对空间非合作目标,特别是翻滚目标的抓捕仍然存在巨大的挑战.本文提出一种基于Clamped B样条的空间非合作目标抓捕策略方案.在对非合作目标与空间机械臂运动学与动力学分析的基础上,结合非合作目标被空间机械臂抓捕后的动静态对偶性分析,构建抓捕后的力可操作度椭球作为抓捕策略设计的优化指标.其次,考虑目标的运动预测和空间机械臂的抓捕能力图谱构建,确定空间机械臂应对目标的最优抓捕时机与抓捕终端状态.基于Clamped B样条对空间机械臂各关节轨迹进行时间归一化参数描述,并对抓捕过程中的机械臂关节角、速度、避撞、抓捕走廊等约束进行数学变换,最终将抓捕策略转换为多约束、多目标的非线性优化问题,利用自适应惯性权重的粒子群优化算法进行求解.将所设计的抓捕策略应用于空间七自由度运动学冗余机械臂,实现了对空间中翻滚目标的成功捕获,验证了所提抓捕策略的可行性与有效性.

Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations

BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques before entry into the market.Typically,blood glucose(BG)levels are maintained at 5%below baseline to suppress endogenous insulin secretion in healthy volunteers.However,in scenarios where BG baseline is relatively low,maintaining it at 5%below baseline can increase hypoglycemic risk.Consequently,we adjusted to maintain it at 2.5%below a baseline of<4.00 mmol/L.It remains uncertain whether this adjustment impacts endogenous insulin inhibition or the PD of study insulin.AIM To evaluate and compare the PD and C-peptide status using two different target BG setting methods.METHODS Data came from euglycemic clamp trials assessing the PK/PD of insulin aspart(IAsp)in healthy participants.Target BG was set at 2.5%below baseline for those with a basal BG of<4.00 mmol/L(group A),and at 5%below baseline for others(group B).The area under the curve(AUC)of IAsp(AUC_(IAsp,0-8 h))and GIR from 0 to 8 hours(AUCGIR,0-8 h)was used to characterize the PK and PD of IAsp,respectively.The C-peptide reduction and PK/PD of IAsp were compared between the two groups.RESULTS Out of 135 subjects,15 were assigned to group A and 120 to group B;however,group B exhibited higher basal Cpeptide(1.59±0.36 vs 1.32±0.42 ng/mL,P=0.006).Following propensity score matching to adjust for basal Cpeptide differences,71 subjects(15 in group A and 56 in group B)were analyzed.No significant differences were observed in demographics,IAsp dosage,or clamp quality.Group B showed significantly higher baseline(4.35±0.21 vs 3.91±0.09 mmol/L,P<0.001),target(4.13±0.20 vs 3.81±0.08 mmol/L,P<0.001),and clamped(4.10±0.17 vs 3.80±0.06 mmol/L,P<0.001)BG levels.Both groups exhibited comparable C-peptide suppression(32.5%±10.0%vs 35.6%±12.1%,P=0.370)and similar IAsp activity(AUCGIR,0-8 h:1433±400 vs 1440±397 mg/kg,P=0.952)under nearly equivalent IAsp exposure(AUC_(IAsp,0-8 h):566±51 vs 571±85 ng/mL×h,P=0.840).CONCLUSION Maintaining BG at 2.5%below a baseline of<4.00 mmol/L did not compromise the endogenous insulin suppression nor alter the observed pharmacodynamic effects of the study insulin.

不同孔径、孔型对环槽铆钉连接副预紧力的影响研究

目前轨道交通装备、铁路桥梁、钢结构站房建筑等节点连接主要有焊接、螺栓连接、环槽铆钉连接三种连接方案,其中焊接、螺栓连接已大规模应用数百年,相关的研究内容已趋于完善。但环槽铆钉连接为新型连接型式,国内相关研究较少,本文就不同孔径、孔型对环槽铆钉预紧力力学性能的影响开展了研究,为各领域技术人员使用环槽铆钉产品提供技术参考。