Application and Practice of Traditional Chinese Medicine Characteristic Technology Inheritance in Research and Development of Traditional Chinese Medicine Preparations in Medical Institutions

Medical institution preparations play an important role in the development of hospitals,being one of the main forms of traditional Chinese medicine clinical characteristic medication,as well as an important carrier for the inheritance and innovation of traditional Chinese medicine.In recent years,the research and development of traditional Chinese medicine preparations has become a hot spot in the research and development of preparations by medical institutions.Traditional Chinese medicine preparations prepared by traditional processes and their entrusted preparation matters have changed from the current licensing management to filing management.The registration model of traditional Chinese medicine preparations has undergone significant changes,emphasizing more on real data and evaluation results from the objective world,respecting traditional medication experience,and emphasizing the inheritance and innovative development of traditional technological experience.In the process of following teachers in the inheritance project of traditional Chinese medicine,we combined the inheritance of traditional Chinese medicine characteristic technology with the research and development practice of traditional Chinese medicine preparations in medical institutions,and focused on the analysis and discussion of technical problems such as prescription screening,dosage form selection,process route design and clinical observation of traditional Chinese medicine preparations,hoping to provide reference for scholars in the same field of traditional Chinese medicine.

Research on Technology Development of Traditional Chinese Medicine Extraction Based on Patent Information

Objective To understand the development status of traditional Chinese medicine extraction technology,so as to provide a reference for enterprises and scientific research institutions to determine the direction of technological innovation.Besides,the government can formulate scientific and technological innovation strategies.Methods Based on patent information,statistical methods were applied to analyze the development of traditional Chinese medicine extraction technology.Then,the core technology was identified by constructing a patent citation network.Finally,the main path analysis method was applied to discover the technological evolution path.Results and Conclusion The extraction technology of traditional Chinese medicine is still in the growth stage.At present,its R&D is based on enterprises,supplemented by scientific research institutions.The core technologies are ultrasonic extraction and enzymatic extraction.The main path represented by enzymatic extraction technology reveals the evolution process of traditional Chinese medicine extraction technology.Based on this,relevant suggestions are put forward.Firstly,technological innovation cooperation should be strengthened to explore new models of achievement transformation and cooperation.Secondly,key enterprises of technology clusters should be cultivated to accelerate breakthroughs in core technologies.Thirdly,combined technologies can achieve high-efficiency enzyme-assisted extraction and open up new ways of extracting traditional Chinese medicine.Fourthly,traditional techniques should be improved to develop innovative modern techniques.

Hospital-based health technology assessment:The next frontier for traditional Chinese medicine hospitals

Hospital-based health technology assessment(HB-HTA)is highly valuable in the application of hospital medical technology,cost control,improvement of medical quality,and protection of medical safety,and its use is increasing daily globally.However,in China,HB-HTA is still in its infancy,and it is yet to be adopted in traditional Chinese medicine(TCM).Therefore,this article introduces the application and development of HB-HTA,as well as discusses the current situation of TCM and related future development strategies to provide ideas and references for the development of HB-HTA in TCM.We conclude and recommend that all major stakeholders,including the state,health departments,and hospital leaders,support and promote the exploration and development of HB-HTA in TCM hospitals and integrative medicine hospitals.We also suggest the utilization of existing talents and introduction of other necessary talents to promote better and faster organizational development,as well as suggest the formation of a national and internationally recognized HB-HTA guidance manual and toolkit for TCM hospitals based on both the national HTA guidelines and the evaluation of TCM hospitals pilot projects.Moreover,we recommend that HB-HTA pilot study should be executed with Chinese patent medicine as the starting point to form the implementation process and framework in the TCM arena.

Health technology assessment in traditional Chinese medicine in China: current status, opportunities, and challenges

Objectives:The widespread usage of traditional Chinese medicine(TCM)and the government's emphasis on TCM in China have created a positive macro-environment and great opportunities to develop and strengthen health technology assessment(HTA)in TCM.Over the past ten years,a series of policies have been issued by the government to promote the application of HTA and the development of TCM in China.This study reviews the concepts and characteristics of TCM,summarizes the current status of HTA in TCM,and analyzes the opportunities and challenges faced by HTA development in TCM with respect to deepening of healthcare reforms.Methods:Literature review and website searches were used to acquire information regarding the basic theories of TCM and the current status,opportunities,and challenges for HTA in TCM.Results:The number of articles on HTA in TCM rose substantially,especially those published in China National Knowledge Infrastructure(CNKI).With the optimistic policy environment and huge market demand for TCM,the development of HTA in TCM is expected to flourish in China.However,HTA in TCM also faces numerous challenges such as the absence of a clinical efficacy evaluation system for TCM and insufficient basic research evidence and qualified personnel.Conclusions:TCM has unique characteristic that distinguishes it from Western medicine.Currently,it is important to take all measures to address the existing main challenges and thereby take advantage of the present opportunities to develop and improve HTA in TCM.

Bibliometrics and visual analysis for clinical research on intervention of traditional Chinese medicine nursing technology on rheumatoid arthritis

Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of clinical research,to provide the basis and clues for subsequent high-level evidence integration and further in-depth research.Materials and Methods:Seven databases including China National Knowledge Infrastructure,Chinese Scientific Journal Database(VIP),Wanfang Database,Chinese Biomedical Literature Database(Sino-Med),PubMed,Embase,and the Cochrane Library were searched.The bibliometric method and visualization software CiteSpace were used to conduct a multi-dimensional analysis of the included literature.Results:A total of 805 pieces of literature were included(of them,one was written in German and four in English),and the number of published literature showed an increasing trend year by year.There were only 30(3.73%)pieces of literature published in nursing journals.The hot spots of the co-occurrence map were concentrated in:(1)the nursing of fumigation in RA;(2)the efficacy evaluation of TCM nursing technology on pain,joint malformation,and joint dysfunction caused by RA.The included literature themes focused on five TCM technologies:fumigation,moxibustion,acupoint patching,acupoint injection,and Chinese herbal soaking.The beginning year and strength in TCM fumigation were 2012 and 5.2,and those in moxibustion were 2011 and 3.38.Conclusion:The related studies are on the rise.It has entered the field of international readers with clear research hot spots.However,there are still shortcomings such as little literature published in Chinese nursing core journals,few non-Chinese-related documents,and a lack of international exchanges and cooperation.The current research hot spots in this field are TCM fumigation,and the cutting-edge trend of future research may be fumigation and moxibustion technology.It is suggested that further research can focus on evidence integration and original research on the self-optimization of these two techniques.

Arrangement and analysis of processing technology of Anguo traditional Chinese medicine: Taking Chinese patent medicine making process as an example

Processing of traditional Chinese medicine is a traditional pharmaceutical technology in China.The processing technology and methods in different places have their own characteristics.Anguo County,known as Qizhou in ancient times for its well-developed pharmaceutical industry,is known as"millennium medicine capital"and"the world's first pharmaceutical market".It is one of China's famous distribution centers of medicinal materials.Its traditional medicinal material processing and processing technology has high popularity.However,Influenced by inheritance mode and mechanical modernization,A large number of processing techniques of traditional Chinese medicine are in danger of being lost.This article focused on the traditional manufacturing process of Anguo's Chinese patent medicine.Relying on the literature,we collected and organized the Chinese patent medicine of Anguo,analyzed its varieties,sources of prescriptions and processing technology,which improves the understanding of Anguo's traditional Chinese medicine processing technology and its cultural connotation and provides a research basis for its inheritance and development.

China Association of Chinese Medicine Paper notice for seminar on clinical application of new technology of integrated Chinese and western medicine in treating sequelae of cerebrovascular diseases

Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of new technology of integrated Chinese and western medicine in treating sequelae of cerebrovascular diseases is planned to be held in Nanning,Guangxi in August.

Machine learning models for stroke detection by observing the eye-movement features under five-color visual stimuli in traditional Chinese medicine

Objective:To develop a novel diagnostic modality to identify and diagnose stroke in daily life scenarios for improving the therapeutic effects and prognoses of patients.Methods:In this study,16 stroke patients and 24 age-matched healthy participants as controls were recruited for comparative analysis.Leveraging a portable eye-tracking device and integrating traditional Chinese medicine theory with modern color psychology principles,we recorded the eye movement signals and calculated eye movement features.Meanwhile,the stroke recognition models based on eye movement features were further trained by using random forest(RF),k-nearest neighbors(KNN),decision tree(DT),gradient boosting classifier(GBC),XGBoost,and CatBoost.Results:The stroke group and the healthy group showed significant differences in some eye movement features(P<.05).The models trained based on eye movement characteristics had good performances in recognizing stroke individuals,with accuracies ranging from 77.40%to 88.45%.Under the red stimulus,the eye movement model trained by RF became the best machine learning model with a recall of 84.65%,a precision of 86.48%,a F1 score of 85.47%.Among the six algorithms,RF and CatBoost performed better in classification.Conclusion:This study pioneers the application of traditional Chinese medicine's five-color stimuli to visual observation tasks.On the basis of the combined design,the eye-movement models can accurately identify stroke,and the developed high-performance models may be used in daily life scenarios.

Analysis of the application of Chinese medicine nursing technology in obstetrics

目的:分析中医护理技术在产科的应用价值。方法:以产科的204 例患者为研究,将其随机分为中医组与参照组(n = 102)。参照组患者接受常规护理,中医组患者接受中医护理,比较两组患者的焦虑抑郁评分及患者对护理的满意状态评分。结果:护理前组间评分比较无差别,护理后,中医组在焦虑、抑郁评分改善方面,数值降低幅度显著高于参照组,具有统计学显著性(P < 0.05)。中医组患者的综合护理满意率为99.02%,参照组患者的综合护理满意率为80.39%,差异具有统计学意义(P < 0.05)。结论:中医护理技术在产科的应用,有助于改善患者的负性情绪,提升患者的总体满意率,护理干预价值较高。

Development of chromatographic technologies for the quality control of Traditional Chinese Medicine in the Chinese Pharmacopoeia

As an important branch of medicine, Traditional Chinese Medicine(TCM) has been applied for the treatment of diseases for thousands of years in China and other countries in East Asia. The Chinese Pharmacopoeia(ChP) is a drug code formulated by the Chinese government, and it includes a special volume for the monographs of TCM, which plays an important role in ensuring the quality of drugs. The use of quality control technology has always been a complex and important factor in TCM. Owing to the chemical diversity of TCM, chromatography technology has been proven to be a comprehensive strategy for the assessment of the overall quality of TCM and has become the main analytical method in the ChP.This article provides an overview of the classical and modern chromatographic technologies applied in the ChP, and summarizes the advantages and disadvantages of each technique in the TCM monographs.In 2020, the new edition of the Ch P(the 2020 edition) has been implemented at the end of 2020. This paper also contains a brief introduction about the application of chromatographic technologies in the new edition of the ChP.

Integration of multi-omics in investigations on the mechanisms of action of Chinese herbal medicine interventions in metabolic diseases

The rapid development of bioinformatics has provided novel approaches and methods for exploring the mechanisms of disease treatment via Chinese herbal medicines.Compound Chinese herbal medicines formulas have complex compositions and are characterized by their multiple constituents and diverse array of biological targets.Therefore,the mechanisms of action of most compound Chinese herbal medicines formulas cannot be adequately explained using a single pathway.Omics technologies describe high-throughput-based analytical and detection techniques,which include transcriptomics,proteomics,and metabolomics and provide multilayer parameter information that can be integrated to characterize the overall relationships involved in the therapeutic effects of Chinese herbal medicines formulas.Through their combination with network biology and drug effect networks,omics technologies also enable investigations into the mechanisms of disease treatment in traditional Chinese medicine.The integration of multiple omics technologies is in line with the concept of holism in traditional Chinese medicine and provides an approach for combining modern science and technology with traditional Chinese medicine theories.In recent years,omics technologies have been widely used to elucidate the mechanisms of action of Chinese herbal medicines.The latest studies employing multi-omics integration for investigating the mechanisms of action of Chinese herbal medicines interventions in metabolic diseases have devoted greater attention to in-depth explorations of disease pathogenesis.This paper provides a review of the following multi-omics technologies,which are used in research on the treatment of common metabolic diseases(e.g.,type-2 diabetes mellitus,nonalcoholic fatty liver disease):network pharmacology combined with metabolomics,16S rRNA sequencing combined with transcriptomics,16S rRNA sequencing combined with metabolomics,and 16S rRNA sequencing combined with network pharmacology and metabolomics.

Potential Preventive and Therapeutic Effects of Traditional Chinese Medicine Compound Prescription and Traditional Chinese Medicine Products on COVID-19

This paper mainly analyzes the traditional Chinese medicine compound prescription and traditional Chinese medicine products with remarkable epidemic prevention effect since the outbreak of COVID-19,and discusses their potential prevention and treatment effects,so as to provide a basis for the further development and application of traditional Chinese medicine compound prescription and traditional Chinese medicine products against COVID-19.

Application of Multispectral Imaging Method in Rapid Identification and Analysis of Chinese Herbal Medicine Powders

Five kinds of traditional flower Chinese medicine powders (TFCMD) were identified using tuneable liquid spectral imaging instrument, to discuss the application range and advantages of spectral imaging technology in Chinese medicine identification and analysis field. The testing system is the liquid crystal multispectral imaging system designed by ourselves. All the tests are standard samples supplied by National Institute for Drug Control. The spectral cubes of Campsis grandiflora, Carthamus tinctorius, Albizzia julibrissin, Dendranthema morifolium, and Dendranthema indicum were captured, and then the normalized characteristic spectral curves of them were picked up. The spectral resolution is 5 nm, and the spectral range is 400 nm - 650 nm. The result shows that different TFCMD has different normalized characteristic fluorescence spectral curve. Spectral imaging technology can be used to identify TFCMD, and the testing course is convenient, quick, noninvasive and without pre-treatment.

Study on enrichment characteristics of Chinese herbal medicine based on LIBS technology

To improve the accuracy of laser induced breakdown spectroscopy(LIBS) measurement and investigate the enrichment characteristics of trace elements in different parts of Chinese herbal medicine, the original spectral data of different Chinese herbal medicines were preprocessed by combining median absolute deviation(MAD), segmented feature extraction, and wavelet denoising, and the enrichment laws of trace elements in different parts of Chinese herbal medicine were studied based on the calibration free laser induced breakdown spectroscopy(CF-LIBS). For these experimental samples, the contents of K, Ca, Mg, and Fe in chrysanthemum and its roots, stems, and leaves, Iris lactea roots and leaves, Salvia miltiorrhiza and corresponding planting soil were obtained by CF-LIBS. By calculating the element enrichment coefficient, it was found that chrysanthemum had strong enrichment ability of K element, and the enrichment ability of K element was flower > leaf > stem > root. The roots and leaves of Iris lactea showed strong enrichment of Ca and Mg. The enrichment ability for Ca is leaf > root, and for Mg is leaf > root. The enrichment coefficient of Ca and Mg in Salvia miltiorrhiza is higher. The results show that the combination of multiple data preprocessing methods can effectively improve the accuracy of LIBS measurement results. The calculation method of trace element enrichment law in different parts of Chinese herbal medicines provides guidance for the cultivation and fertilization of Chinese herbal medicines and the identification of high-quality Chinese herbal medicines.

Operating procedures of moxibustion technology

Moxibustion therapy is a treatment and health-care method that originated from China.It is a kind of therapy for preventing and treating diseases by stimulating meridians and acupoints using heat to regulate the viscera and enhance immunity.This article introduces the definition and mechanism of moxibustion technology,clinical operation technics,and precautions of moxibustion in practice,and demonstrates plenty of iconic cases of application of moxibustion in the treatment of insomnia,dysmenorrhea,urinary retention,knee arthritis,chronic eczema,etc.,so as to provide a reference for the wide application of moxibustion technology.

Operational procedures of auricular point sticking technology

As an external treatment technique of traditional Chinese medicine(TCM),auricular point sticking,which is rooted in holographic biology theory and TCM viscera and meridian theory,is a safe and effective treatment method.This article introduces the technology overview and development process.The auricular point sticking technique for constipation is taken as an example to specify the basic requirements,assessment,operational points,acupoint selection and matters needing attention during the implementation of the auricular acupressure technique,providing a reference for the operating procedures of this technique in the clinical treatment of other diseases such as insomnia,diarrhea,colds,hypertension,headache,and dysmenorrhea.

Research hotspot and frontier progress of cancer under the background of precision medicine

The timely introduction and rapid development of precision medicine have provided strong theoretical support and technical support for tumor research.The treatment methods have been developed from single to multiple;the research technology has been transformed from macro to micro;the treatment drugs have been updated from systemic chemotherapy to targeted therapy and immunotherapy,and cancer has changed from a highly lethal disease to a"chronic disease".Based on the current international cancer research hotspots and treatment frontiers,this paper takes stock from five aspects,namely,treatment methods,detection technology,new drug research and development,information data and traditional Chinese medicine,with a view to"from the point to the surface","from the outside to the inside",and"the combination of Chinese and western",so as to explore the overall picture of cancer treatment and research.

State Key Laboratory of Quality Research in Chinese Medicine(Macao University of Science and Technology)

The State Key Laboratory of Quality Research in Chinese Medicine （Macao University of Science and Technology） was formally established on January 25, 2011 upon approval from the Ministry of Science and Technology of China. It is so far the only State Key Laboratory （SKL） specifically in the field of Traditional Chinese Medicine （TCM） over the country. It is also the jothed-laboratory partner of the State Key Laboratory of Natural and Biomimetic Drugs at the Peking University.

State Key Laboratory of Quality Research in Chinese Medicine(Macao University of Science and Technology)

The State Key Laboratory of Quality Research in Chinese Medicine （Macao University of Science and Technology） was formally established on January 25, 2011 upon approval from the Ministry of Science and Technology of China. It is so far the only State Key Laboratory （SKL） specifically in the field of Traditional Chinese Medicine （TCM） over the country. It is also the joined-laboratory partner of the State Key Laboratory of Natural and Bimnimetic Drugs at the Peking University.