Antibiotics are among the most often used medications in human healthcare and agriculture.Overusing these substances can lead to complications such as increasing antibiotic resistance in bacteria or a toxic effect whe...Antibiotics are among the most often used medications in human healthcare and agriculture.Overusing these substances can lead to complications such as increasing antibiotic resistance in bacteria or a toxic effect when administering large amounts.To solve these problems,new solutions in antibacterial therapy are needed.The use of natural products in medicine has been known for centuries.Some of them have antibacterial activity,hence the idea to combine their activity with commercial antibiotics to reduce the latter's use.This review presents collected information on natural compounds(terpenes,alkaloids,flavonoids,tannins,sulfoxides,and mycotoxins),of which various drug interactions have been observed.Many of the indicated compounds show synergistic or additive interactions with antibiotics,which suggests their potential for use in antibacterial therapy,reducing the toxicity of the antibiotics used and the risk of further development of bacterial resistance.Unfortunately,there are also compounds which interact antagonistically,potentially hindering the therapy of bacterial infection.Depending on its mechanism of action,each compound can behave differently in combination with different antibiotics and when acting against various bacterial strains.展开更多
Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential t...Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.Methods: Different classes of compounds in the aqueous extract of E. contortisiliquum were evaluated based on the visual changes in the coloration and the formation of precipitate after the addition of specific reagents. The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and norfloxacin was determined by using the microdilution method.Results: Our results demonstrated that the following secondary metabolites were presented in E. contortisiliquum seed bark: flavones, flavonols, xanthones, flavononols,chalcones, aurones, flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested(MIC ≥ 1024 μg/m L), but there was an increase in the antibiotic activity of gentamicin and norfloxacin when combined in the subinhibitory concentration(i.e., MIC/8).Conclusions: Our data suggests that E. contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.展开更多
Intensive livestock and poultry farming in China largely relied on the use of in-feed antibiotics until July 2020.The consequences of antibiotic overuse in animal feed include accumulation in animal products and the d...Intensive livestock and poultry farming in China largely relied on the use of in-feed antibiotics until July 2020.The consequences of antibiotic overuse in animal feed include accumulation in animal products and the development of bacterial antibiotic resistance,both of which threaten food safety and human health.China has now completely banned the circulation of commercial feed containing growth-promoting drug additives(except Chinese herbal medicine).Therefore,alternatives to in-feed antibiotics in animal production are greatly needed.Natural phenolic compounds(NPCs)exist widely in plants and are non-toxic,nonpolluting,highly reproducible,and leave little residue.Many natural flavonoids,phenolic acids,lignans,and stilbenes have polyphenol chemical structures and exhibit great potential as alternatives to antibiotics.In this review we delineate the characteristics of plant-derived NPCs and summarize their current applications as alternatives to in-feed antibiotics,aiming to provide new strategies for antibiotic-free feeding and promote the development of more sustainable animal husbandry practices.展开更多
文摘Antibiotics are among the most often used medications in human healthcare and agriculture.Overusing these substances can lead to complications such as increasing antibiotic resistance in bacteria or a toxic effect when administering large amounts.To solve these problems,new solutions in antibacterial therapy are needed.The use of natural products in medicine has been known for centuries.Some of them have antibacterial activity,hence the idea to combine their activity with commercial antibiotics to reduce the latter's use.This review presents collected information on natural compounds(terpenes,alkaloids,flavonoids,tannins,sulfoxides,and mycotoxins),of which various drug interactions have been observed.Many of the indicated compounds show synergistic or additive interactions with antibiotics,which suggests their potential for use in antibacterial therapy,reducing the toxicity of the antibiotics used and the risk of further development of bacterial resistance.Unfortunately,there are also compounds which interact antagonistically,potentially hindering the therapy of bacterial infection.Depending on its mechanism of action,each compound can behave differently in combination with different antibiotics and when acting against various bacterial strains.
文摘Objective: To identify the main chemical classes of compounds from aqueous extract of Enterolobium contortisiliquum(E. contortisiliquum) seed bark and to evaluate its antibacterial activity, as well as its potential to increase the activity of antibiotics against strains of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli.Methods: Different classes of compounds in the aqueous extract of E. contortisiliquum were evaluated based on the visual changes in the coloration and the formation of precipitate after the addition of specific reagents. The antibacterial activity of the extract and its potential to increase of antibiotic activity of antibiotics drugs, gentamicin and norfloxacin was determined by using the microdilution method.Results: Our results demonstrated that the following secondary metabolites were presented in E. contortisiliquum seed bark: flavones, flavonols, xanthones, flavononols,chalcones, aurones, flavones and catechins. The extract itself had very low antibacterial activity against all bacterial strains tested(MIC ≥ 1024 μg/m L), but there was an increase in the antibiotic activity of gentamicin and norfloxacin when combined in the subinhibitory concentration(i.e., MIC/8).Conclusions: Our data suggests that E. contortisiliquum seed bark may be an alternative source for new drugs with the potential to increase antibiotic activity against different strains of bacteria.
基金supported by the National Key Research and Development Program of China(2022YFD1300403)the National Natural Science Foundation of China(32130099)+7 种基金the“Shen Nong Scholar Funding of Hunan Agricultural University”the“Changsha Municipal Natural Science Foundation(kq2014068)”the“Hunan Natural Science Foundation(2021JJ40233)”the“Science and Technology Innovation Program of Hunan Province(2021RC3090)”the“Open Project Program of Key Laboratory of Feed Biotechnologythe Ministry of Agriculture and Rural Affairs of the People’s Republic of China”the“Earmarked Fund for China Agriculture Research System(CARS-35)”the“China Agriculture Research System of MOF and MARA”。
文摘Intensive livestock and poultry farming in China largely relied on the use of in-feed antibiotics until July 2020.The consequences of antibiotic overuse in animal feed include accumulation in animal products and the development of bacterial antibiotic resistance,both of which threaten food safety and human health.China has now completely banned the circulation of commercial feed containing growth-promoting drug additives(except Chinese herbal medicine).Therefore,alternatives to in-feed antibiotics in animal production are greatly needed.Natural phenolic compounds(NPCs)exist widely in plants and are non-toxic,nonpolluting,highly reproducible,and leave little residue.Many natural flavonoids,phenolic acids,lignans,and stilbenes have polyphenol chemical structures and exhibit great potential as alternatives to antibiotics.In this review we delineate the characteristics of plant-derived NPCs and summarize their current applications as alternatives to in-feed antibiotics,aiming to provide new strategies for antibiotic-free feeding and promote the development of more sustainable animal husbandry practices.
