Different from the common delayed synchronization(DS)in which response appears after stimulation,anticipated synchronization(AS)in unidirectionally coupled neurons denotes a counterintuitive phenomenon in which respon...Different from the common delayed synchronization(DS)in which response appears after stimulation,anticipated synchronization(AS)in unidirectionally coupled neurons denotes a counterintuitive phenomenon in which response of the receiver neuron appears before stimulation of the sender neuron,showing an interesting function of brain to anticipate the future.The dynamical mechanism for the AS remains unclear due to complex dynamics of inhibitory and excitatory modulations.In this article,the paradoxical roles of excitatory synapse and inhibitory autapse in the formation of AS are acquired.Firstly,in addition to the common roles such that inhibitory modulation delays and excitatory modulation advances spike,paradoxical roles of excitatory stimulation to delay spike via type-II phase response and of inhibitory autapse to advance spike are obtained in suitable parameter regions,extending the dynamics and functions of the excitatory and inhibitory modulations.Secondly,AS is related to the paradoxical roles of the excitatory and inhibitory modulations,presenting deep understandings to the AS.Inhibitory autapse induces spike of the receiver neuron advanced to appear before that of the sender neuron at first,and then excitatory synapse plays a delay role to prevent the spike further advanced,resulting in the AS as the advance and delay effects realize a dynamic balance.Lastly,inhibitory autapse with strong advance,middle advance,and weak advance and delay effects induce phase drift(spike of the receiver neuron advances continuously),AS,and DS,respectively,presenting comprehensive relationships between AS and other behaviors.The results present potential measures to modulate AS related to brain function.展开更多
In this paper, we focus on anticipated backward stochastic Volterra integral equations(ABSVIEs) with jumps. We solve the problem of the well-posedness of so-called M-solutions to this class of equation, and analytical...In this paper, we focus on anticipated backward stochastic Volterra integral equations(ABSVIEs) with jumps. We solve the problem of the well-posedness of so-called M-solutions to this class of equation, and analytically derive a comparison theorem for them and for the continuous equilibrium consumption process. These continuous equilibrium consumption processes can be described by the solutions to this class of ABSVIE with jumps.Motivated by this, a class of dynamic risk measures induced by ABSVIEs with jumps are discussed.展开更多
In the light of the visual angle model(VAM),an improved car-following model considering driver's visual angle,anticipated time and stabilizing driving behavior is proposed so as to investigate how the driver's...In the light of the visual angle model(VAM),an improved car-following model considering driver's visual angle,anticipated time and stabilizing driving behavior is proposed so as to investigate how the driver's behavior factors affect the stability of the traffic flow.Based on the model,linear stability analysis is performed together with bifurcation analysis,whose corresponding stability condition is highly fit to the results of the linear analysis.Furthermore,the time-dependent Ginzburg–Landau(TDGL)equation and the modified Korteweg–de Vries(m Kd V)equation are derived by nonlinear analysis,and we obtain the relationship of the two equations through the comparison.Finally,parameter calibration and numerical simulation are conducted to verify the validity of the theoretical analysis,whose results are highly consistent with the theoretical analysis.展开更多
Anticipated backward stochastic differential equation(ABSDE) studied the first time in 2007 is a new type of stochastic differential equations.In this paper,we establish a general comparison theorem for ABSDEs.
Background: Difficulty in management of the airway occurs most frequently in patients who have Mallampati grade III and IV, and other unfavourable airway findings like short neck, restriction in range of motion of the...Background: Difficulty in management of the airway occurs most frequently in patients who have Mallampati grade III and IV, and other unfavourable airway findings like short neck, restriction in range of motion of the temporoman-dibular joints and inadequate neck flexion and extension. Because of unavailability of fibreoptic bronchoscopes or inexperience in their use, laryngeal mask airway (LMA) has become a common and acceptable airway management option. This is a case report of a postmenopausal woman who had her airway managed with LMA following initial failed intubation necessitating a rescheduling of the operation. Result: The patient had a successful surgery and postoperative recovery was uneventful. Conclusion: The LMA is a useful option in the management of an anticipated or unexpected difficult airway, especially in resource-poor settings where fibreoptic bronchoscopes may not be readily available.展开更多
A methodology is proposed to enable real-time evaluation of the observability of local motions,and generate a local observability cost map to enable informed local motion planning in order to avoid potential degradati...A methodology is proposed to enable real-time evaluation of the observability of local motions,and generate a local observability cost map to enable informed local motion planning in order to avoid potential degradation or degeneracy in state estimator performance.The proposed approach leverages efficient numerical techniques in nonlinear observability analysis and motion primitive-based planning technique to realize the local observability prediction with real-time performance.The degradation of the state estimation performance can be readily predicted with the local observability evaluation result.The proposed approach is specialized to a representative optimization-based monocular visual-inertial state estimation formulation and evaluated through simulation and experiments.The experimental results demonstrated the ability of the proposed methodology to correctly anticipate the potential state estimation degradation.展开更多
This paper is concerned with a Pontryagin's maximum principle for the stochastic optimal control problem with distributed delays given by integrals of not necessarily linear functions of state or control variables...This paper is concerned with a Pontryagin's maximum principle for the stochastic optimal control problem with distributed delays given by integrals of not necessarily linear functions of state or control variables.By virtue of the duality method and the generalized anticipated backward stochastic differential equations,we establish a necessary maximum principle and a sufficient verification theorem.In particular,we deal with the controlled stochastic system where the distributed delays enter both the state and the control.To explain the theoretical results,we apply them to a dynamic advertising problem.展开更多
Thermal expansion behavior was investigated in detail for evaluation of the core support plate expansion reactivity in the ULOHS(Unprotected Loss of Heat Sink)reactor trip failure event.The core support plate expansio...Thermal expansion behavior was investigated in detail for evaluation of the core support plate expansion reactivity in the ULOHS(Unprotected Loss of Heat Sink)reactor trip failure event.The core support plate expansion reactivity plays an important role in the safety evaluation of the ULOHS event.In this paper,a possibility of mechanical restraint was investigated in thermal expansion of the core structure for the prototype FBR(Fast Breeder Reactor)Monju.The reactor core expansion was simulated in a three-dimensional FEA(Finite Element Analysis)model of the RV(Reactor Vessel)considering detailed temperature distribution of the sodium coolant based on the thermal-hydraulic analysis result of the whole core model.It was found that the thermal expansion of the core was not restrained in the ULOHS event,although part of the core structure is mechanically restrained.展开更多
AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk factors.METHODS:We determined the prevalenc...AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk factors.METHODS:We determined the prevalence of DR in 150type 2 diabetes mellitus(T2DM)patients,that of retinopathy in 50 non diabetics,the levels of body mass index(BMI),waist circumference(WC),blood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiobarbituric acid reacting substances(TBARS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,albumin,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein B(ApoB).RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),respectively.Thehighest levels of 8-isoprostane,8-OHdG,TBARS,SOD,and OxLDL were in DR.The lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in DR.In the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,ApoB,8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diabetics without DR(controls),T2DM patients without DR and T2DM patients with DR.CONCLUSION:Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2diabetics.Prevention of oxidative stress and abdominal obesity is needed.Supplementation in vitamin C,D,and E should be recommended as complement therapies of T2DM.展开更多
AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a...AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a three-generation Chinese family with JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected to have JOAG got an assessment of visual field and optical coherence tomography. Intraocular pressures(IOPs) of four patients were measured at 8,10,12,14,17 o'clock respectively after using anti-glaucoma drugs. Mutation screening of all MYOC gene coding exons of the participants was performed by using direct sequencing of PCR products. ·RESULTS: Clinical examinations and pedigree analysis revealed eight family members were suffered from JOAG. Apparent genetics anticipation phenomenon was observed in this family. Their clinical features included elevated IOP of 35-55mmHg,loss of visual field,thinning of retinal nerve fiber layer,and glaucomatous optic disc damage. Noticeably,their intraocular pressure levels could be controlled within normal range at 8 and 10 o'clock by anti-glaucoma drugs,but their IOPs would elevate >21mmHg after 12 o'clock. Seven patients received trabeculectomy produced thin-walled,pale,and saccate filtering blebs maintaining lower intraocular pressure efficiently. Mutation screening indentified aheterozygous C→T missense mutation in the MYOC gene at position 1 109 in exon 3,corresponding to a substitution of a highly conserved proline to leucine at codon 370 in the olfactomedin domain of MYOC. ·CONCLUSION: The clinical characteristics of JOAG in this family were 1) genetics anticipation; 2) high IOP; 3) temporay response to anti-glaucoma drugs; 4) filtering surgery produced thin-walled and saccate filtering blebs,helping maintain lower IOP.展开更多
AIM To analyze the origin of the anticipationphenomenon,which means earlier death insuccessive generation in familial adenomatouspolyposis.METHODS The study subjects were 2161patients with familial adenomatous polypos...AIM To analyze the origin of the anticipationphenomenon,which means earlier death insuccessive generation in familial adenomatouspolyposis.METHODS The study subjects were 2161patients with familial adenomatous polyposisand their 7465 first-degree relatives who weremembers of 750 families registered at ourPolyposis Registry.The ages at death andcumulative mortality rates in the parent,theproband,and the child generations werecompared for both all subjects and the patientsalone.RESULTS In the patients over 5 years of age,the mean age at death was 50.9 years for theparent,42.3 years for the proband,and 33.3years for the child generations,respectively(P【0.001).The deceased rates in the threegenerations were 90.7%,51.3% and 23.1% ofthe patients,respectively,and this differencewas the main cause of the anticipation measuredby parent-child paring method.The cumulativemortality rates for all subjects failed to showanticipation,however the cumulative mortalityrates for the patients showed the anticipation.The anticipation phenomenon was shown by anyparent-child pairing methods for the deceasedpatients.Other important causes of theanticipation were different proportion of causesof death between generations(P【0.001),and alow proportion of detected or deceased patients (P【0.001)in the child generation.CONCLUSION Anticipation in familialadenomatous polyposis may be caused byparent-child paring methods as well as severalintergenerational biases.展开更多
Wood biomass has been viewed as “carbon neutral”—its uses as energy have a zero carbon footprint. Some observers argue that the use of wood biofuels will result in a decrease of the forest stock and a net reduction...Wood biomass has been viewed as “carbon neutral”—its uses as energy have a zero carbon footprint. Some observers argue that the use of wood biofuels will result in a decrease of the forest stock and a net reduction of the carbon captured in the forest. Such assessments take a static, accounting view of forest systems and do not consider the effects of management in renewing the forest and increasing its extent or ability to sequester carbon. This paper addresses the carbon neutrality debate using a dynamic optimization forest management model to examine the effect on the existing and future forests of a changing demand for wood biomass. The results show that under market optimizing conditions, when future demand is anticipated to increase for significant periods, the response of managers will be to increase the intensity of forest production thereby offsetting much of the carbon released in bioenergy production.展开更多
We introduce anticipating quadrant and symmetric integrals in the plane,and establish the associated chain rules which are the same as the deterministic ones.In particular, we deduce the relation between quadrant inte...We introduce anticipating quadrant and symmetric integrals in the plane,and establish the associated chain rules which are the same as the deterministic ones.In particular, we deduce the relation between quadrant integrals, symmetric integral,and Skorohod integral with respect to two-parameter Wiener processes.展开更多
A stochastic control model is studied.The objective of the investor is to maximize expected utility from terminalconsumption.However,the investor possesses informa-tion about the terminal values of the components of t...A stochastic control model is studied.The objective of the investor is to maximize expected utility from terminalconsumption.However,the investor possesses informa-tion about the terminal values of the components of the Brownian motion which drives securities’prices.With the method of stochastic control being applied,investor’s optimal decision is obtained.Especially,the logarith-展开更多
Taking into account the startup behaviour of following vehicles in the waiting area of urban traffic signal, we propose an extended Nagel-Schreckenberg model for single-lane traffic flow, in which the dynamic behavior...Taking into account the startup behaviour of following vehicles in the waiting area of urban traffic signal, we propose an extended Nagel-Schreckenberg model for single-lane traffic flow, in which the dynamic behavior of each vehicle depends on not only its own headway but also the headway of the immediately preceding one. The numerical simulation of the present model reproduces some complicated nonlinear phenomena observed in real traffic such as free flow, ghostly blockage, synchronized flow and so on. For specific parameter combinations the flow-density relation of this model shows two meta-stable branches near the transition density from free flow to wide moving traffic jam. Finally, the analytical results of the model under some specific parameters are given by using the mean field theory.展开更多
BACKGROUND The existence of genetic anticipation has been long disputed in inflammatory bowel disease(IBD)in the absence of the explanatory mechanism.AIM To determine whether it was predictive of genetic anticipation,...BACKGROUND The existence of genetic anticipation has been long disputed in inflammatory bowel disease(IBD)in the absence of the explanatory mechanism.AIM To determine whether it was predictive of genetic anticipation,we evaluated telomere length in IBD.We hypothesized that multiplex IBD families exhibit a genetic defect impacting telomere maintenance mechanisms.METHODS We studied three IBD families with multiple affected members in three successive generations.We determined telomere length(TL)in lymphocytes and granulocytes from peripheral blood of the affected members using flow cytometry and fluorescence in-situ hybridization(flow FISH).We also performed whole exome sequencing in the blood of all available family members and used PhenoDB to identify potential candidate gene variants with recessive or dominant modes of inheritance.RESULTS Out of twenty-four patients of European descent selected to participate in the study,eleven patients,eight parent-child pairs affected by IBD,were included in the genetic anticipation analysis.Median difference in age at diagnosis between two successive generations was 16.5 years,with earlier age at onset in the younger generations.In most of the affected members,the disease harbored similar gastrointestinal and extraintestinal involvement but was more aggressive among the younger generations.TL was not associated with earlier age at onset or more severe disease in members of successive generations affected by IBD.NOD2 gene mutations were present in the Crohn’s disease patients of one family.However,no gene variants were identified as potential candidates for inheritance.CONCLUSION Telomere shortening appears unlikely to be involved in mechanisms of possible genetic anticipation in IBD.Further studies using a larger sample size are required to confirm or refute our findings.展开更多
In the issue of January, 2002, the magazine "Relation Between Both Sides of the Taiwan Straits" published by the Association of the Relation Between the Both Sides of the Taiwan Straits, a signed essay was c...In the issue of January, 2002, the magazine "Relation Between Both Sides of the Taiwan Straits" published by the Association of the Relation Between the Both Sides of the Taiwan Straits, a signed essay was carried out, stating that the development of the relation between the both sides last year, anticipates the trends of such relation in the future.展开更多
Reading is a process in which the reader must be actively involved. You must use what knowledge you can gain fromthe text and what you knows about the world in general in order to infer meanings and other sorts of inf...Reading is a process in which the reader must be actively involved. You must use what knowledge you can gain fromthe text and what you knows about the world in general in order to infer meanings and other sorts of information. This paper willputs forward some skills for reading comprehension.展开更多
Empirical results are presented showing that people who acknowledge pain anticipation when expecting an injury experience higher sensitivity to pain (GREP, Robinson et al., 2001). The positive correlation between sens...Empirical results are presented showing that people who acknowledge pain anticipation when expecting an injury experience higher sensitivity to pain (GREP, Robinson et al., 2001). The positive correlation between sensitivity and anticipation is highly significant. However, no relationship is found between anticipation and pain endurance.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12072236,12162002,and11802086)the Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(Grant No.NJYT-20-A09)the Program for Excellent Young Talents in Colleges and Universities of Anhui Province of China(Grant No.gxyq ZD2020077)。
文摘Different from the common delayed synchronization(DS)in which response appears after stimulation,anticipated synchronization(AS)in unidirectionally coupled neurons denotes a counterintuitive phenomenon in which response of the receiver neuron appears before stimulation of the sender neuron,showing an interesting function of brain to anticipate the future.The dynamical mechanism for the AS remains unclear due to complex dynamics of inhibitory and excitatory modulations.In this article,the paradoxical roles of excitatory synapse and inhibitory autapse in the formation of AS are acquired.Firstly,in addition to the common roles such that inhibitory modulation delays and excitatory modulation advances spike,paradoxical roles of excitatory stimulation to delay spike via type-II phase response and of inhibitory autapse to advance spike are obtained in suitable parameter regions,extending the dynamics and functions of the excitatory and inhibitory modulations.Secondly,AS is related to the paradoxical roles of the excitatory and inhibitory modulations,presenting deep understandings to the AS.Inhibitory autapse induces spike of the receiver neuron advanced to appear before that of the sender neuron at first,and then excitatory synapse plays a delay role to prevent the spike further advanced,resulting in the AS as the advance and delay effects realize a dynamic balance.Lastly,inhibitory autapse with strong advance,middle advance,and weak advance and delay effects induce phase drift(spike of the receiver neuron advances continuously),AS,and DS,respectively,presenting comprehensive relationships between AS and other behaviors.The results present potential measures to modulate AS related to brain function.
基金supported by the National Natural Science Foundation of China (11901184, 11771343)the Natural Science Foundation of Hunan Province (2020JJ5025)。
文摘In this paper, we focus on anticipated backward stochastic Volterra integral equations(ABSVIEs) with jumps. We solve the problem of the well-posedness of so-called M-solutions to this class of equation, and analytically derive a comparison theorem for them and for the continuous equilibrium consumption process. These continuous equilibrium consumption processes can be described by the solutions to this class of ABSVIE with jumps.Motivated by this, a class of dynamic risk measures induced by ABSVIEs with jumps are discussed.
基金the Natural Science Foundation of Zhejiang Province,China(Grant Nos.LY22G010001,LY20G010004)the Program of Humanities and Social Science of Education Ministry of China(Grant No.20YJA630008)+1 种基金the National Key Research and Development Program of China-Traffic Modeling,Surveillance and Control with Connected&Automated Vehicles(Grant No.2017YFE9134700)the K.C.Wong Magna Fund in Ningbo University,China。
文摘In the light of the visual angle model(VAM),an improved car-following model considering driver's visual angle,anticipated time and stabilizing driving behavior is proposed so as to investigate how the driver's behavior factors affect the stability of the traffic flow.Based on the model,linear stability analysis is performed together with bifurcation analysis,whose corresponding stability condition is highly fit to the results of the linear analysis.Furthermore,the time-dependent Ginzburg–Landau(TDGL)equation and the modified Korteweg–de Vries(m Kd V)equation are derived by nonlinear analysis,and we obtain the relationship of the two equations through the comparison.Finally,parameter calibration and numerical simulation are conducted to verify the validity of the theoretical analysis,whose results are highly consistent with the theoretical analysis.
基金supported by the National Natural Science Foundation of China(Grant No.11301274)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20113207120002)the Program of Natural Science Research of Jiangsu Higher Education Institutions of China(Grant No.13KJB110017)
文摘Anticipated backward stochastic differential equation(ABSDE) studied the first time in 2007 is a new type of stochastic differential equations.In this paper,we establish a general comparison theorem for ABSDEs.
文摘Background: Difficulty in management of the airway occurs most frequently in patients who have Mallampati grade III and IV, and other unfavourable airway findings like short neck, restriction in range of motion of the temporoman-dibular joints and inadequate neck flexion and extension. Because of unavailability of fibreoptic bronchoscopes or inexperience in their use, laryngeal mask airway (LMA) has become a common and acceptable airway management option. This is a case report of a postmenopausal woman who had her airway managed with LMA following initial failed intubation necessitating a rescheduling of the operation. Result: The patient had a successful surgery and postoperative recovery was uneventful. Conclusion: The LMA is a useful option in the management of an anticipated or unexpected difficult airway, especially in resource-poor settings where fibreoptic bronchoscopes may not be readily available.
文摘A methodology is proposed to enable real-time evaluation of the observability of local motions,and generate a local observability cost map to enable informed local motion planning in order to avoid potential degradation or degeneracy in state estimator performance.The proposed approach leverages efficient numerical techniques in nonlinear observability analysis and motion primitive-based planning technique to realize the local observability prediction with real-time performance.The degradation of the state estimation performance can be readily predicted with the local observability evaluation result.The proposed approach is specialized to a representative optimization-based monocular visual-inertial state estimation formulation and evaluated through simulation and experiments.The experimental results demonstrated the ability of the proposed methodology to correctly anticipate the potential state estimation degradation.
基金supported by the National Natural Science Foundation of China(11701214)Shandong Provincial Natural Science Foundation,China(ZR2019MA045).
文摘This paper is concerned with a Pontryagin's maximum principle for the stochastic optimal control problem with distributed delays given by integrals of not necessarily linear functions of state or control variables.By virtue of the duality method and the generalized anticipated backward stochastic differential equations,we establish a necessary maximum principle and a sufficient verification theorem.In particular,we deal with the controlled stochastic system where the distributed delays enter both the state and the control.To explain the theoretical results,we apply them to a dynamic advertising problem.
基金The authors would like to recognize the contribution of Hiroki Yada for the thermal expansion analysis,and also Masaki Minami and Kousuke Araki of NESI for the thermal-hydraulic analysis in this paper.
文摘Thermal expansion behavior was investigated in detail for evaluation of the core support plate expansion reactivity in the ULOHS(Unprotected Loss of Heat Sink)reactor trip failure event.The core support plate expansion reactivity plays an important role in the safety evaluation of the ULOHS event.In this paper,a possibility of mechanical restraint was investigated in thermal expansion of the core structure for the prototype FBR(Fast Breeder Reactor)Monju.The reactor core expansion was simulated in a three-dimensional FEA(Finite Element Analysis)model of the RV(Reactor Vessel)considering detailed temperature distribution of the sodium coolant based on the thermal-hydraulic analysis result of the whole core model.It was found that the thermal expansion of the core was not restrained in the ULOHS event,although part of the core structure is mechanically restrained.
文摘AIM:To evaluate the rates of retinopathy without diabetes and diabetic retinopathy(DR),associated with some markers of oxidative stress,antioxidants and cardiometabolic risk factors.METHODS:We determined the prevalence of DR in 150type 2 diabetes mellitus(T2DM)patients,that of retinopathy in 50 non diabetics,the levels of body mass index(BMI),waist circumference(WC),blood pressure,lipids,8-isoprostane,8-hydroxydeoxyguanosine(8-oHdG),gamma-glutamyl transferase(GGT),oxidized low density lipoprotein(LDL)(OxLDL),thiobarbituric acid reacting substances(TBARS),reduced glutathione(GSH),superoxide dismutase(SOD),uric acid,creatinine,albumin,total antioxidant status(TAOS),zinc,selenium,magnesium,vitamin C,vitamin D,vitamin E,glucose,apolipoprotein B(ApoB).RESULTS:The prevalences of DR at 53y and Rtp at62y were 44%(n=66)and 10%(n=5),respectively.Thehighest levels of 8-isoprostane,8-OHdG,TBARS,SOD,and OxLDL were in DR.The lowest levels of vitamin D,vitamin C,TAOS,and vitamin E were in DR.In the casecontrol study discriminant analysis,the levels of vitamin C,vitamin D,ApoB,8-OHdG,creatinine,Zn,vitamin E,and WC distinguished significantly non-diabetics without DR(controls),T2DM patients without DR and T2DM patients with DR.CONCLUSION:Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2diabetics.Prevention of oxidative stress and abdominal obesity is needed.Supplementation in vitamin C,D,and E should be recommended as complement therapies of T2DM.
基金Medical Scientific Research Foundation of Guangdong Province(No.A2013215)
文摘AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a three-generation Chinese family with JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected to have JOAG got an assessment of visual field and optical coherence tomography. Intraocular pressures(IOPs) of four patients were measured at 8,10,12,14,17 o'clock respectively after using anti-glaucoma drugs. Mutation screening of all MYOC gene coding exons of the participants was performed by using direct sequencing of PCR products. ·RESULTS: Clinical examinations and pedigree analysis revealed eight family members were suffered from JOAG. Apparent genetics anticipation phenomenon was observed in this family. Their clinical features included elevated IOP of 35-55mmHg,loss of visual field,thinning of retinal nerve fiber layer,and glaucomatous optic disc damage. Noticeably,their intraocular pressure levels could be controlled within normal range at 8 and 10 o'clock by anti-glaucoma drugs,but their IOPs would elevate >21mmHg after 12 o'clock. Seven patients received trabeculectomy produced thin-walled,pale,and saccate filtering blebs maintaining lower intraocular pressure efficiently. Mutation screening indentified aheterozygous C→T missense mutation in the MYOC gene at position 1 109 in exon 3,corresponding to a substitution of a highly conserved proline to leucine at codon 370 in the olfactomedin domain of MYOC. ·CONCLUSION: The clinical characteristics of JOAG in this family were 1) genetics anticipation; 2) high IOP; 3) temporay response to anti-glaucoma drugs; 4) filtering surgery produced thin-walled and saccate filtering blebs,helping maintain lower IOP.
基金Foundation for Promotion of Cancer Research in JapanGrant in Aid from the Ministry of Health and WelfareJapanese Society for Cancer of the Colon and Rectum
文摘AIM To analyze the origin of the anticipationphenomenon,which means earlier death insuccessive generation in familial adenomatouspolyposis.METHODS The study subjects were 2161patients with familial adenomatous polyposisand their 7465 first-degree relatives who weremembers of 750 families registered at ourPolyposis Registry.The ages at death andcumulative mortality rates in the parent,theproband,and the child generations werecompared for both all subjects and the patientsalone.RESULTS In the patients over 5 years of age,the mean age at death was 50.9 years for theparent,42.3 years for the proband,and 33.3years for the child generations,respectively(P【0.001).The deceased rates in the threegenerations were 90.7%,51.3% and 23.1% ofthe patients,respectively,and this differencewas the main cause of the anticipation measuredby parent-child paring method.The cumulativemortality rates for all subjects failed to showanticipation,however the cumulative mortalityrates for the patients showed the anticipation.The anticipation phenomenon was shown by anyparent-child pairing methods for the deceasedpatients.Other important causes of theanticipation were different proportion of causesof death between generations(P【0.001),and alow proportion of detected or deceased patients (P【0.001)in the child generation.CONCLUSION Anticipation in familialadenomatous polyposis may be caused byparent-child paring methods as well as severalintergenerational biases.
文摘Wood biomass has been viewed as “carbon neutral”—its uses as energy have a zero carbon footprint. Some observers argue that the use of wood biofuels will result in a decrease of the forest stock and a net reduction of the carbon captured in the forest. Such assessments take a static, accounting view of forest systems and do not consider the effects of management in renewing the forest and increasing its extent or ability to sequester carbon. This paper addresses the carbon neutrality debate using a dynamic optimization forest management model to examine the effect on the existing and future forests of a changing demand for wood biomass. The results show that under market optimizing conditions, when future demand is anticipated to increase for significant periods, the response of managers will be to increase the intensity of forest production thereby offsetting much of the carbon released in bioenergy production.
文摘We introduce anticipating quadrant and symmetric integrals in the plane,and establish the associated chain rules which are the same as the deterministic ones.In particular, we deduce the relation between quadrant integrals, symmetric integral,and Skorohod integral with respect to two-parameter Wiener processes.
基金Projecta supported by the Education Commission of Anhui Provinee(No.2000jw049)
文摘A stochastic control model is studied.The objective of the investor is to maximize expected utility from terminalconsumption.However,the investor possesses informa-tion about the terminal values of the components of the Brownian motion which drives securities’prices.With the method of stochastic control being applied,investor’s optimal decision is obtained.Especially,the logarith-
文摘Taking into account the startup behaviour of following vehicles in the waiting area of urban traffic signal, we propose an extended Nagel-Schreckenberg model for single-lane traffic flow, in which the dynamic behavior of each vehicle depends on not only its own headway but also the headway of the immediately preceding one. The numerical simulation of the present model reproduces some complicated nonlinear phenomena observed in real traffic such as free flow, ghostly blockage, synchronized flow and so on. For specific parameter combinations the flow-density relation of this model shows two meta-stable branches near the transition density from free flow to wide moving traffic jam. Finally, the analytical results of the model under some specific parameters are given by using the mean field theory.
基金The authors thank Professor Mary Armanios for assistance with telomere analysis. Theauthors would like to dedicate this paper in memoriam to Dr. Theodore M. Bayless, agreat mentor and a believer in genetic anticipation in inflammatory bowel disease.
文摘BACKGROUND The existence of genetic anticipation has been long disputed in inflammatory bowel disease(IBD)in the absence of the explanatory mechanism.AIM To determine whether it was predictive of genetic anticipation,we evaluated telomere length in IBD.We hypothesized that multiplex IBD families exhibit a genetic defect impacting telomere maintenance mechanisms.METHODS We studied three IBD families with multiple affected members in three successive generations.We determined telomere length(TL)in lymphocytes and granulocytes from peripheral blood of the affected members using flow cytometry and fluorescence in-situ hybridization(flow FISH).We also performed whole exome sequencing in the blood of all available family members and used PhenoDB to identify potential candidate gene variants with recessive or dominant modes of inheritance.RESULTS Out of twenty-four patients of European descent selected to participate in the study,eleven patients,eight parent-child pairs affected by IBD,were included in the genetic anticipation analysis.Median difference in age at diagnosis between two successive generations was 16.5 years,with earlier age at onset in the younger generations.In most of the affected members,the disease harbored similar gastrointestinal and extraintestinal involvement but was more aggressive among the younger generations.TL was not associated with earlier age at onset or more severe disease in members of successive generations affected by IBD.NOD2 gene mutations were present in the Crohn’s disease patients of one family.However,no gene variants were identified as potential candidates for inheritance.CONCLUSION Telomere shortening appears unlikely to be involved in mechanisms of possible genetic anticipation in IBD.Further studies using a larger sample size are required to confirm or refute our findings.
文摘In the issue of January, 2002, the magazine "Relation Between Both Sides of the Taiwan Straits" published by the Association of the Relation Between the Both Sides of the Taiwan Straits, a signed essay was carried out, stating that the development of the relation between the both sides last year, anticipates the trends of such relation in the future.
文摘Reading is a process in which the reader must be actively involved. You must use what knowledge you can gain fromthe text and what you knows about the world in general in order to infer meanings and other sorts of information. This paper willputs forward some skills for reading comprehension.
基金Financial support from the Spanish Ministry of Science and Innovation(SEJ2007-62081,SEJ2006-06309 and ECO2009-09120)Basque Government(IT-313-07),the Government of Andalusia Project for Excellence in Research(P07.SEJ.02547)and the Women’s Institute of Spain(2008.031)
文摘Empirical results are presented showing that people who acknowledge pain anticipation when expecting an injury experience higher sensitivity to pain (GREP, Robinson et al., 2001). The positive correlation between sensitivity and anticipation is highly significant. However, no relationship is found between anticipation and pain endurance.