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Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate 被引量:3
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作者 Yuka Koga Noriaki Maeshige +5 位作者 Hiroto Tabuchi Mikiko Uemura Michiko Aoyama-Ishikawa Makoto Miyoshi Chikako Katakami Makoto Usami 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2017年第9期1337-1343,共7页
AIM:To evaluate the antifibrogenic effects of butyrate or phenylbutyrate,a chemical derivative of butyrate,in human pterygium fibroblasts.METHODS:Human pterygium fibroblasts obtained from patient pterygium tissue we... AIM:To evaluate the antifibrogenic effects of butyrate or phenylbutyrate,a chemical derivative of butyrate,in human pterygium fibroblasts.METHODS:Human pterygium fibroblasts obtained from patient pterygium tissue were treated with butyrate or phenylbutyrate for 48h.Expression ofα-smooth muscle actin,collagen I,collagen III and matrix metalloproteinase-1m RNA was measured by quantitative real-time reverse transcription polymerase chain reaction,and acetylated histone was evaluated by Western blotting.RESULTS:Butyrate inhibitedα-smooth muscle actin,type III collagen and matrix metalloproteinase-1 expressions,and phenylbutyrate inhibited types I and III collagen and matrix metalloproteinase-1 expressions without changing cell viability as well as both of these increased histone acetylation.These results suggested that butyrate and phenylbutyrate suppress fibrosis through a mechanism involving histone deacetylase inhibitor.CONCLUSION:This indicates that butyrate or phenylbutyrate have antifibrogenic effects in human pterygium fibroblasts and could be novel types of prophylactic and/or therapeutic drugs for pterygium,especially phenylbutyrate,which does not have the unpleasant smell associated with butyrate. 展开更多
关键词 BUTYRATE phenylbutymte PTERYGIUM FIBROBLASTS antifibrogenic effect
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