The emergence of drug resistant bacterium threatens the global public healthcare systems.The urgent need to obtain new antimicrobials has driven antimicrobial peptides（AMPs） research into spotlight.Here we give a br...The emergence of drug resistant bacterium threatens the global public healthcare systems.The urgent need to obtain new antimicrobials has driven antimicrobial peptides（AMPs） research into spotlight.Here we give a brief introduction of the recent progress of AMPs regarding their structures,properties,production and modification,and antimicrobial mechanism.Thereby,this review will give an insight into the trends and challenges facing on this particular kind of antimicrobial materials.展开更多
In this work,the one-step stereochemical antimicrobial finishing of cotton textiles(CT)was achieved by the oxidative copolymerization of a dopamine-menthol derivative(DAM)and dopamine(DA).The obtained DAM-modified CT(...In this work,the one-step stereochemical antimicrobial finishing of cotton textiles(CT)was achieved by the oxidative copolymerization of a dopamine-menthol derivative(DAM)and dopamine(DA).The obtained DAM-modified CT(P(DAM-co-DA)-CT)exhibited broad-spectrum microbial anti-adhesion properties against bacteria(E.coli and P.aeruginosa),including superbugs(MRSA and VREF),and fungi(A.niger,A.flavus,M.racemosus and P.chrysogenum).Because of its unique stereochemical antimicrobial mechanism,the obtained P(DAM-co-DA)-CT is a non-releasing antimicrobial material that causes no skin sensitization and exhibits good biocompatibility.The coating was also found to enhance the UVresistant and mechanical properties of the CT.Furthermore,it displayed durable washing fastness and antimicrobial properties after the endurance of 30 laundering cycles.The observed achievements provide a broader understanding of stereochemical antimicrobial surfaces and endow this method with wider applications.展开更多
Reducing the emission of agrochemicals hazardous to the environment and human health is one of the key targets of the UN’s Sustainable Development Goal 12.Herein,we report a kind of quaternary ammonium pesticides wit...Reducing the emission of agrochemicals hazardous to the environment and human health is one of the key targets of the UN’s Sustainable Development Goal 12.Herein,we report a kind of quaternary ammonium pesticides with an acid-cleavable silaketal linkage on their backbones that enables control of hydrolysis.These pesticides possess outstanding bactericidal and insecticidal properties but become harmless to humans and other organisms after hydrolysis.Depending on the conditions of use,the hydrolytic process can be controlled over the time range of 10 min to 3 months.Both laboratory simulations and agricultural field demonstrations confirm that these pesticides can effectively protect crops from bacterial diseases and pests.At the sametime,single-dose intragastric administration using diisopropylsilyloxy bisquaternary ammonium salt 9(ISBQAS-9)in mice demonstrates its safety for multiple organs.Owing to the advantages of controllable degradability,environmental friendliness,and the low financial cost of these pesticides,this welldesigned strategy holds great promise for the generation of environmentally harmless pesticides and the development of green agriculture.展开更多
基金supported by National Natural Science Foundation of China(Nos.21304103 and 21474123)Presidential Foundation of Technical Institute of Physics and Chemistry
文摘The emergence of drug resistant bacterium threatens the global public healthcare systems.The urgent need to obtain new antimicrobials has driven antimicrobial peptides（AMPs） research into spotlight.Here we give a brief introduction of the recent progress of AMPs regarding their structures,properties,production and modification,and antimicrobial mechanism.Thereby,this review will give an insight into the trends and challenges facing on this particular kind of antimicrobial materials.
基金the National Natural Science Foundation of China(No.21574008)the Fundamental Research Funds for the Central Universities of China(No.BHYC1705B)。
文摘In this work,the one-step stereochemical antimicrobial finishing of cotton textiles(CT)was achieved by the oxidative copolymerization of a dopamine-menthol derivative(DAM)and dopamine(DA).The obtained DAM-modified CT(P(DAM-co-DA)-CT)exhibited broad-spectrum microbial anti-adhesion properties against bacteria(E.coli and P.aeruginosa),including superbugs(MRSA and VREF),and fungi(A.niger,A.flavus,M.racemosus and P.chrysogenum).Because of its unique stereochemical antimicrobial mechanism,the obtained P(DAM-co-DA)-CT is a non-releasing antimicrobial material that causes no skin sensitization and exhibits good biocompatibility.The coating was also found to enhance the UVresistant and mechanical properties of the CT.Furthermore,it displayed durable washing fastness and antimicrobial properties after the endurance of 30 laundering cycles.The observed achievements provide a broader understanding of stereochemical antimicrobial surfaces and endow this method with wider applications.
基金the National Natural Science Foundation of China(grant nos.21825503 and 22335008).
文摘Reducing the emission of agrochemicals hazardous to the environment and human health is one of the key targets of the UN’s Sustainable Development Goal 12.Herein,we report a kind of quaternary ammonium pesticides with an acid-cleavable silaketal linkage on their backbones that enables control of hydrolysis.These pesticides possess outstanding bactericidal and insecticidal properties but become harmless to humans and other organisms after hydrolysis.Depending on the conditions of use,the hydrolytic process can be controlled over the time range of 10 min to 3 months.Both laboratory simulations and agricultural field demonstrations confirm that these pesticides can effectively protect crops from bacterial diseases and pests.At the sametime,single-dose intragastric administration using diisopropylsilyloxy bisquaternary ammonium salt 9(ISBQAS-9)in mice demonstrates its safety for multiple organs.Owing to the advantages of controllable degradability,environmental friendliness,and the low financial cost of these pesticides,this welldesigned strategy holds great promise for the generation of environmentally harmless pesticides and the development of green agriculture.
