ED50 of Pure Swainsonine (SW) to EMT6 cell strain is 1.2 (0.8-1.6) mg/L and the dose of entire lethal is 6.4 mg/L with MTT method. After ig crude extraction of SW to S180 sareoma rooted in mouse and EMT6 model mice wi...ED50 of Pure Swainsonine (SW) to EMT6 cell strain is 1.2 (0.8-1.6) mg/L and the dose of entire lethal is 6.4 mg/L with MTT method. After ig crude extraction of SW to S180 sareoma rooted in mouse and EMT6 model mice with breast carcinoma for 12 d at dose of 16 mg/kg, the inhibitory rates of weight amounts to 49.7% and 49.4% respectively (P<0.01). Given crude extraction of SW at 4 mg/kg combined with irradiation at 5 Gy60Co-γ, the inhibitory rate of weight of S180 amount to 64.5% (P<0.01). It shows that SW has obviously antineoplastic.展开更多
文摘ED50 of Pure Swainsonine (SW) to EMT6 cell strain is 1.2 (0.8-1.6) mg/L and the dose of entire lethal is 6.4 mg/L with MTT method. After ig crude extraction of SW to S180 sareoma rooted in mouse and EMT6 model mice with breast carcinoma for 12 d at dose of 16 mg/kg, the inhibitory rates of weight amounts to 49.7% and 49.4% respectively (P<0.01). Given crude extraction of SW at 4 mg/kg combined with irradiation at 5 Gy60Co-γ, the inhibitory rate of weight of S180 amount to 64.5% (P<0.01). It shows that SW has obviously antineoplastic.
