CeCl_3·7H_2O supported on silica（CeCl_3·7H_2O-SiO_2） is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synth...CeCl_3·7H_2O supported on silica（CeCl_3·7H_2O-SiO_2） is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synthesizeα-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions.Tenα-diaminophosphonates（6a-j） of 4,4＇-sulfonyldianiline（Dapsone）（3） were synthesized and structural elucidation was confirmed by spectral data.Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC_（50） values,respectively of the titled compounds.Compounds 6h,6i exhibited promising antioxidant activity at lower IC_（50） values 53.7μg/mL, 53.2μg/mL,respectively as compared with standard IC_（50） value 51.6μg/mL.展开更多
A three-component condensation was applied for the preparation of cyclopentadiene derivatives through the reaction of primary amines,alkyl propiolate and dialkyl acetylenedicarboxylate in the presence of catalytic amo...A three-component condensation was applied for the preparation of cyclopentadiene derivatives through the reaction of primary amines,alkyl propiolate and dialkyl acetylenedicarboxylate in the presence of catalytic amount of ZnO-nanorods（Zn-NR） under solvent-free conditions at 50 ℃.The method has proved to be synthetically green,simple,and effective with high atom economy and yield.The catalyst also revealed significant reusability.Moreover,the antioxidant activity and free radical scavenging capacity of the newly synthesized derivatives 4a,4b,4c,and 4d was screened using free radical scavenging 2,2-diphenyl-1-picrylhydrazyl（DPPH） and ferric reducing antioxidant power（FRAP）assays and compared with hydroxytoluene（BHT） and tert-butylhydroquinone（TBHQ）.These compounds do not exhibit good DPPH radical scavenging,but they have a desirable FRAP.展开更多
基金support from University Grants Commission[UGC-BSR,UGC F.No.40-71/2011 (SR)]
文摘CeCl_3·7H_2O supported on silica（CeCl_3·7H_2O-SiO_2） is used as a heterogeneous,efficient and recyclable catalyst for a three component one-pot reaction of an amine,aldehydes and diethyl phosphite to synthesizeα-diaminophosphonate derivatives under microwave irradiation exploiting neat reaction conditions.Tenα-diaminophosphonates（6a-j） of 4,4＇-sulfonyldianiline（Dapsone）（3） were synthesized and structural elucidation was confirmed by spectral data.Antifungal and antioxidant activities were evaluated include minimum inhibitory concentrations and IC_（50） values,respectively of the titled compounds.Compounds 6h,6i exhibited promising antioxidant activity at lower IC_（50） values 53.7μg/mL, 53.2μg/mL,respectively as compared with standard IC_（50） value 51.6μg/mL.
基金the support of the Research Council of Iran University of Science and Technology, Tehran, Iran
文摘A three-component condensation was applied for the preparation of cyclopentadiene derivatives through the reaction of primary amines,alkyl propiolate and dialkyl acetylenedicarboxylate in the presence of catalytic amount of ZnO-nanorods（Zn-NR） under solvent-free conditions at 50 ℃.The method has proved to be synthetically green,simple,and effective with high atom economy and yield.The catalyst also revealed significant reusability.Moreover,the antioxidant activity and free radical scavenging capacity of the newly synthesized derivatives 4a,4b,4c,and 4d was screened using free radical scavenging 2,2-diphenyl-1-picrylhydrazyl（DPPH） and ferric reducing antioxidant power（FRAP）assays and compared with hydroxytoluene（BHT） and tert-butylhydroquinone（TBHQ）.These compounds do not exhibit good DPPH radical scavenging,but they have a desirable FRAP.
